The youngest case of ovarian germ cell tumor in a Mayer-Rokitansky-Kuster-Hauser syndrome.
Authors: Pellegrino C, Contini G, Frediani S, Aloi IP, Pardi V, Inserra A PMID: 32773745 [PubMed - as supplied by publisher] (Source: Minerva Chirurgica)
Source: Minerva Chirurgica - August 13, 2020 Category: Surgery Tags: Minerva Chir Source Type: research

A Mayer-Rokitansky-Kuster-Hauser patient with leiomyoma and dysplasia of neovagina: a case report
Most patients with congenital uterus and vaginal aplasia (i.e., Mayer –Rokitansky–Kuster–Hauser [MRKH] syndrome) have rudimentary pelvic uterine structures that contain smooth muscle. Although leiomyomas and dy... (Source: BMC Women's Health)
Source: BMC Women's Health - July 28, 2020 Category: OBGYN Authors: Varpu Jokimaa, Johanna Virtanen, Harry Kujari, Seija Ala-Nissil ä and Virpi Rantanen Tags: Case report Source Type: research

A Case of Mayer-Rokitansky-K üster-Hauser Syndrome Diagnosed in Infancy After Evaluation of Palpable Gonads
Mayer-Rokitansky-K üster-Hauser (MRKH) syndrome is defined as incomplete development of Müllerian structures (uterus, fallopian tubes, proximal vagina) in an otherwise phenotypic female. MRKH syndrome typically presents in adolescence with primary amenorrhea but has been diagnosed in younger patients who present wit h other associated abnormalities, most commonly renal and skeletal. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - July 27, 2020 Category: OBGYN Authors: Cortney C. Bleach, Karen S. Vogt Source Type: research

From engulfment to enrichment: associations between illness representations, self-concept and psychological adjustment in Mayer-Rokitansky-K üster-Hauser Syndrome
This study aimed to explore associations between illness representations, self-concept, psychological distress and self-esteem in MRKH. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - July 17, 2020 Category: OBGYN Authors: Susan Carroll, Marc Laufer, Phaedra Thomas-Kowal, Amy C. Lossie, Rona Moss-Morris Source Type: research

Vaginal Reconstruction in Patients with Mayer-Rokitansky-K üster-Hauser Syndrome-One Centre Experience.
Conclusion: Nowadays, there is no established standard method of vaginal reconstruction. In Romania, the McIndoe technique is the most applied. Unfortunately, even if the MRKH syndrome is not uncommon, less and less surgeons are willing to perform the procedure to create a neovagina. PMID: 32630225 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 1, 2020 Category: Universities & Medical Training Authors: Avino A, Răducu L, Tulin A, Gheoca-Mutu DE, Balcangiu-Stroescu AE, Marina CN, Jecan CR Tags: Medicina (Kaunas) Source Type: research

Rare genital malformations in women ’s health research: sociodemographic, regional, and disease-related characteristics of patients with Mayer-Rokitansky-Küster-Hauser syndrome
The Mayer-Rokitansky-K üster-Hauser syndrome, MRKHS, is a rare (orphan) disease characterized by the aplasia or hypoplasia of the uterus and the vagina. In women's health research, little is known as to how muc... (Source: BMC Women's Health)
Source: BMC Women's Health - June 29, 2020 Category: OBGYN Authors: Sara Yvonne Brucker, Leonie-Sophia P ösch, Joachim Graf, Alexander N. Sokolov, Norbert Schaeffeler, Andrea Kronenthaler, Hanna Hiltner, Anke Wagner, Esther Ueding, Monika A. Rieger, Dorit Schöller, Diana Stefanescu, Kristin Katharina Rall, Diethelm Wall Tags: Research article Source Type: research

Mayer-Rokitansky-K üster-Hauser syndrome with a solitary duplex kidney and anal stenosis: a rare case report
We present the first reported case of MRKH syndrome with solitary duplex kidney and anal stenosis. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - June 16, 2020 Category: OBGYN Authors: Ye Bi, Kai-Ning Zhang, Ming-Long Li Source Type: research

Study on depressive symptoms in patients with Mayer-Rokitansky-K üster-Hauser syndrome: an analysis of 141 cases
Mayer-Rokitansky-K üster-Hauser (MRKH) syndrome is a rare congenital disease characterized by uterovaginal agenesis. The diagnosis of MRKH syndrome generally leads to considerable emotional burdens on patients.... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - May 24, 2020 Category: Internal Medicine Authors: Na Chen, Shuang Song, Yanping Duan, Jia Kang, Shan Deng, Hongxin Pan and Lan Zhu Tags: Research Source Type: research

GREB1L variants in familial and sporadic hereditary urogenital adysplasia and Mayer-Rokitansky-Kuster-Hauser syndrome.
This article is protected by copyright. All rights reserved. PMID: 32378186 [PubMed - as supplied by publisher] (Source: Clinical Genetics)
Source: Clinical Genetics - May 7, 2020 Category: Genetics & Stem Cells Authors: Adeline J, Bouchra B, Corinne F, Jerôme T, Claire J, Aimé L, Elise BB, Christèle D, Véronique D, Laurent P, Anna L, Karine M, Daniel G, Vincent B Tags: Clin Genet Source Type: research

Lower urinary tract symptoms in patients with Mayer-Rokitansky-Kuster-Hauser syndrome after neo-vagina creation by Davydov ’s procedure
ConclusionThe rate of LUTS is lower than that reported by others using alternative surgical procedures. To the best of our knowledge, this is the first report validating LUTS after Davydov ’s neo-vaginoplasty. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - May 6, 2020 Category: OBGYN Source Type: research

Sexual function and quality of life after the creation of a neovagina in women with Mayer-Rokitansky-K üster-Hauser syndrome: comparison of vaginal dilation and surgical procedures
To compare sexual function and outcomes of quality of life of patients with Mayer-Rokitansky-K üster-Hauser (MRKH) syndrome after vaginal dilation and surgical procedures. (Source: Fertility and Sterility)
Source: Fertility and Sterility - May 1, 2020 Category: Reproduction Medicine Authors: Jia Kang, Na Chen, Shuang Song, Ye Zhang, Congcong Ma, Yidi Ma, Lan Zhu Tags: Original article Source Type: research

Neovaginoplasty Using Nile Tilapia Fish Skin as a New Biologic Graft in Patients with Mayer-Rokitansky-Küster-Hauser Syndrome
Publication date: May–June 2020Source: Journal of Minimally Invasive Gynecology, Volume 27, Issue 4Author(s): Maria Tereza Pinto Medeiros Dias, Andreisa Paiva Monteiro Bilhar, Livia Cunha Rios, Bruno Almeida Costa, Edmar Maciel Lima Júnior, Ana Paula Negreiros Nunes Alves, Zenilda Vieira Bruno, Manoel Odorico de Moraes Filho, Leonardo Robson Pinheiro Sobreira Bezerra (Source: Journal of Minimally Invasive Gynecology)
Source: Journal of Minimally Invasive Gynecology - April 28, 2020 Category: OBGYN Source Type: research

A young girl with right ovarian torsion and left ovarian ectopy
Mayer-Rokitansky-K üster-Hauser (MRKHS) syndrome refers to congenital hypoplasia/aplasia of the uterus, the cervix and the upper 2/3 of the vagina, in females with normal ovaries and fallopian tubes, secondary ... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - April 23, 2020 Category: Pediatrics Authors: Giuliana Morabito, Alessandro Daidone, Flora Murru, Marianna Iaquinto, Elena Faleschini, Egidio Barbi and Giorgio Cozzi Tags: Case report Source Type: research

A young girl with right ovarian torsion and left ovarian ectopy
ConclusionsIn front of a patient with ovarian torsion and anatomical features suggestive of MRKHS, both the ovaries should always be searched for, with a high suspicion threshold for extrapelvic ovary. Identifying the ectopic ovary, in this case, helped to preserve patient fertility, avoiding a possible torsion. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - April 23, 2020 Category: Pediatrics Source Type: research

Neovagina creation: a novel improved laparoscopic Vecchietti's procedure in patients with Mayer-Rokitansky-Kuster-Hauster syndrome (MRKHs)
Publication date: Available online 10 April 2020Source: Journal of Minimally Invasive GynecologyAuthor(s): Yi-yi Wang, Hua Duan, Xiang-ning Zhang, Sha Wang (Source: Journal of Minimally Invasive Gynecology)
Source: Journal of Minimally Invasive Gynecology - April 11, 2020 Category: OBGYN Source Type: research

Neovagina creation: a novel improved laparoscopic Vecchietti's procedure in patients with Mayer-Rokitansky-Kuster-Hauster syndrome (MRKHs)
To report a new improved laparoscopic Vecchietti's vaginalplasty in patients with congenital vaginal agenesis and to investigate its efficacy and safety. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - April 10, 2020 Category: OBGYN Authors: Yi-yi Wang, Hua Duan, Xiang-ning Zhang, Sha Wang Tags: ORIGINAL ARTICLE Source Type: research

Neovagina Creation: A Novel Improved Laparoscopic Vecchietti Procedure in Patients with Mayer-Rokitansky-K üster-Hauster Syndrome
To report a new improved laparoscopic Vecchietti vaginoplasty in patients with congenital vaginal agenesis and to investigate its efficacy and safety. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - April 10, 2020 Category: OBGYN Authors: Yi-yi Wang, Hua Duan, Xiang-ning Zhang, Sha Wang Tags: Original Article Source Type: research

13. Mayer-Rokitansky-K üster-Hauser (MRKH) Syndrome: International Experiences with Vaginal Lengthening and Genitourinary Symptoms
M üllerian agenesis or MRKH occurs in 1 in ∼5,000 females. Currently, the worldwide experience of women with MRKH with regard to vaginal lengthening treatments (VL) and genitourinary (GU) symptoms is unknown, however, anecdotal data suggests that people with MRKH may experience a variety of genitou rinary (GU) symptoms. We conducted this study to describe the GU experiences of people with MRKH in the international community, specifically to identify trends in VL experience, prevalence of GU symptoms, and how symptoms may vary by VL treatment. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - March 29, 2020 Category: OBGYN Authors: Christine Pennesi, Sarah Bell, Emily English, Amy Lossie, Carolyn Swenson, Elisabeth Quint Source Type: research

50. Hymenal Anomalies Interfering with Successful Vaginal Dilation in Women with Mayer-Rokitansky-K üster-Hauser Syndrome: A Case Series
We present a series of three women with MRKH and inability to achieve satisfactory vaginal depth with dilation due to pain. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - March 29, 2020 Category: OBGYN Authors: Chelsea Fortin, Christine Pennesi, Patricia Huguelet, Elisabeth Quint, Stephen Scott, Veronica Alaniz Source Type: research

43. Discordant Mayer-Rokitansky-Kuster-Hauser (MRKH) & VACTERL Syndrome in Monochorionic Monoamniotic Twins with Primary Amenorrhea
Mayer-rokitansky-kuster-hauser (MRKH) syndrome is a congenital condition affecting 1 in 5000 females that results in vaginal agenesis. Mullerian anomalies such as those found in MRKH are also associated with MURCS (M üllerian duct aplasia–renal agenesis–cervicothoracic somite dysplasia) which is phenotypically similar to VACTERL (vertebral defects, anal atresia, cardiac defects, TE fistula, renal dysplasia, limb anomalies). All three of these conditions are believed to be multifactorial in nature, with pati ents having a typical chromosome complement. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - March 29, 2020 Category: OBGYN Authors: Elizabeth Kresie, Ashli Lawson, Holly Welsh, Julie Strickland Source Type: research

41. Diagnosis of 46,XY Difference of Sex Development Condition by Retail Direct-to-Consumer Genetic Testing
Approximately 1:4000 women are diagnosed with M üllerian agenesis, typically when they are evaluated for primary amenorrhea. The most common conditions associated with Müllerian agenesis are Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) and Androgen Insensitivity Syndrome (AIS). A serum testosterone and karyotype should be performed to differ entiate between these 46,XX and 46,XY conditions. With the advent of direct-to-consumer genetic testing companies, patients may discover they have a 46,XY karyotype without genetic counseling to explain the implications. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - March 29, 2020 Category: OBGYN Authors: Anne-Marie Amies Oelschlager, Sarah Miller, Katie Canalichio, Paul Merguerian, Patricia Fechner, Linda Ramsdell, Amy Lossie Source Type: research

Assisted reproductive techniques and pregnancy results in women with Mayer-Rokitansky-K üster-Hauser syndrome undergoing uterus transplantation: the Czech experience
This study aimed to evaluate the reproductive potential of patients with Mayer-Rokitansky-K üster-Hauser syndrome (MRKHS) who were candidates for uterus transplantation (UTx) before inclusion in the experimental trial and to summarize the existing experience with posttransplant embryo transfers in functionally successful cases. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - March 26, 2020 Category: OBGYN Authors: Roman Chmel, Milos Cekal, Zlatko Pastor, Roman Chmel, Petra Paulasova, Marketa Havlovicova, Milan Macek, Marta Novackova Source Type: research

Typical and atypical pelvic MRI characteristics of Mayer-Rokitansky-K üster-Hauser syndrome: a comprehensive analysis of 201 patients
ConclusionMRKH patients typically display bilateral uterine rudiments combined with a fibrous band and normally located ovaries. The uterine rudiments are generally small with only one-layer differentiation, a subset of which might be large and exhibited other atypical presentations, including two- or three-layer differentiation or even hematometra. Abnormally located ovaries are not rare.Key Points• Morphologically, MRKH patients typically displayed bilateral uterine rudiments combined with a fibrous band.• Typically, the uterine rudiments (84.4%) were small and displayed only one-layer differentiation.• Ab...
Source: European Radiology - March 5, 2020 Category: Radiology Source Type: research

Male-to-Female Gender-Affirming Surgery Using Nile Tilapia Fish Skin as a Biocompatible Graft
Insufficient penile skin is common during vaginoplasty for male-to-female transition. This issue may be compensated via a scrotal skin flap, with the drawback of hair growth [1]. In recent studies, Nile tilapia skin was successfully used for surgical management of Mayer-Rokitansky-K üster-Hauser syndrome [2,3] and vaginal stenosis [4,5]. The present study aims to describe a novel technique for primary vaginoplasty in male-to-female gender-affirming surgery using Nile tilapia skin as a biocompatible graft to assure adequate vaginal depth. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - March 3, 2020 Category: OBGYN Authors: Álvaro Hernán Rodríguez, Edmar Maciel Lima Júnior, Manoel Odorico de Moraes Filho, Bruno Almeida Costa, Zenilda Vieira Bruno, Marcelo Praxedes Monteiro Filho, Maria Elisabete Amaral de Moraes, Felipe Augusto Rocha Rodrigues, Carlos Roberto Koscky Paie Tags: Video Article Source Type: research

Conservative Management of Vaginal Hypoplasia
Authors: Dural Ö, Poyrazoğlu Ş Abstract In patients with Mayer-Rokitansky-Küster-Hauser syndrome and complete androgen insensitivity syndrome (CAIS), management of vaginal hypoplasia includes non-surgical or surgical vaginal elongation techniques. For these patients, primary vaginal dilation is considered a first-line option to avoid the risks of having surgery and complications that may occur due to these procedures. Non-surgical dilation is a highly successful treatment if treatment is initiated when the patient is emotionally mature and ready. Here, we present a case of CAIS with vaginal hypoplasia m...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - February 13, 2020 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

Mayer-Rokitansky-K üster-Hauser syndrome - case studies, methods of treatment and the future prospects of human uterus transplantation.
CONCLUSIONS: Until a few years ago, patients with an absolute uterine factor of infertility, including women with MRKH syndrome, had a real choice of only two equally controversial options giving a chance for motherhood - surrogacy and adoption. However, modern transplantation has shown that a third option - a uterine transplant - exists and is available. PMID: 32016956 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 6, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Inguinal herniation of left ovary, fallopian tube and rudimentary left horn of bicornuate uterus associated with type 2 Mayer-Rakitansky-Kuster-Hauser (MRKH) syndrome in a teenage girl: A case report and literature review
Publication date: 2020Source: European Journal of Radiology Open, Volume 7Author(s): Ramezan Jafari, Mohammad Javanbakht, Fatemeh DehghanpoorAbstractThe incidence rate of ovarian herniation in the inguinal canal is 3 %. Nevertheless, the herniation of ovary with uterus is extremely scarce. Most of these cases are accompanied with congenital genitourinary malformations such as Mayer-Rakitansky-Kuster-Hauser (MRKH) syndrome and Mullerian duct malformations. Herein, a 13-year-old girl presented with type2 MRKH syndrome together with left groin swelling and pain. Sonography reports ovarian herniation into left inguinal canal a...
Source: European Journal of Radiology Open - January 30, 2020 Category: Radiology Source Type: research

Anxiety symptoms in patients with Mayer-Rokitansky-K üster-Hauser syndrome: a cross-sectional study.
CONCLUSIONS: The findings stress the importance of anxiety symptom screening in MRKH patients and identify patients at risk of anxiety symptoms, providing a possible basis for future intervention. PMID: 31977552 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 22, 2020 Category: General Medicine Authors: Song S, Chen N, Duan YP, Kang J, Deng S, Pan HX, Zhu L Tags: Chin Med J (Engl) Source Type: research

Comparison of neovaginoplasty using acellular porcine small intestinal submucosa graft or Interceed in patients with Mayer –Rokitansky–Küster–Hauser syndrome
ConclusionsOur results demonstrated that Wharton –Sheares–George method provided the patients to have satisfactory sexual intercourse. The Interceed played a role in the reconstruction of neovagina no less than the SIS graft. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - November 23, 2019 Category: OBGYN Source Type: research

Mayer-Rokitansky-K ünster-Hauser syndrome due to 2q12.1q14.1 deletion: PAX8 the causing gene?
In this study, we report a second case of 2q12.1q14.1 microdeletion, involving PAX8 as a gene associated with Müllerian agenesis in a MRKH I and hypothyroidism. Further studies will confirm the direct participation of PAX8 in gene target sequencing in a population of MRKH with hypothyroidism. PMID: 31731040 [PubMed - as supplied by publisher] (Source: European Journal of Medical Genetics)
Source: European Journal of Medical Genetics - November 12, 2019 Category: Genetics & Stem Cells Authors: Smol T, Ribero-Karrouz W, Edery P, Gorduza DB, Catteau-Jonard S, Manouvrier-Hanu S, Ghoumid J Tags: Eur J Med Genet Source Type: research

Genital tract and reproductive characteristics in daughters of women and men prenatally exposed to diethylstilbestrol (DES).
CONCLUSION: These results must be considered as preliminary, due to the small numbers of patients, limited follow-up duration after birth due to young age of the studied population, and observational methods. An important point is that the high risk of reproductive dysfunction of women prenatally exposed to DES was not observed in their daughters. There is a signal on the high incidence of uterine defects, especially aplastic uterus, and its possible link with DES exposure through epigenetic effects is discussed in our findings. Inconsistent findings regarding pregnancy outcomes in the third generation are worthy of furthe...
Source: Therapie - November 1, 2019 Category: Psychiatry & Psychology Authors: Wautier A, Tournaire M, Devouche E, Epelboin S, Pouly JL, Levadou A Tags: Therapie Source Type: research

Management of partial vaginal agenesis according to the Wharton-Sheares-George technique - a long-term follow-up.
Authors: Zhang X, Tang X, Ding Y, Hua K Abstract The purpose of this study was to explore the long-term follow-up of treatment of congenital partial vaginal agenesis using the Wharton-Sheares-George technique. The technique was performed on 52 patients with congenital partial vaginal atresia from January 2009 to December 2017. As a result, the mean operating time of the Wharton-Sheares-George technique procedure was 25.6 ± 2.2 min. The mean estimated blood loss was 16.7 ± 4.7 mL. The average length of stay in hospital for the patients was 2.3 ±&t...
Source: Journal of Obstetrics and Gynaecology - October 16, 2019 Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

1469 Comparison of Neovaginoplasty Using Acellular Porcine Small Intestinal Submucosa Graft or Interceed in Patients with Mayer-Rokitansky-Küster-Hauser Syndrome
Publication date: November–December 2019Source: Journal of Minimally Invasive Gynecology, Volume 26, Issue 7, SupplementAuthor(s): X Zhang, J Ding, K HuaStudy ObjectiveTo compare using the acellular porcine small intestinal submucosa (SIS) graft or the Interceed in patients with MRKH syndrome undergoing creation of a neovagina.DesignRetrospective study.SettingAcademic affiliated community hospital.Patients or ParticipantsPatients with MRKH syndrome undergoing creation of a neovagina from 2016 to 2018 were retrospectively investigated.InterventionsWharton-Sheares-George neovaginoplasty was performed using the acellula...
Source: Journal of Minimally Invasive Gynecology - October 15, 2019 Category: OBGYN Source Type: research

1469 Comparison of Neovaginoplasty Using Acellular Porcine Small Intestinal Submucosa Graft or Interceed in Patients with Mayer-Rokitansky-K üster-Hauser Syndrome
To compare using the acellular porcine small intestinal submucosa (SIS) graft or the Interceed in patients with MRKH syndrome undergoing creation of a neovagina. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 15, 2019 Category: OBGYN Authors: X Zhang, J Ding, K Hua Tags: Virtual Poster Session 4: Basic Science/Research/Education (1:40 PM — 1:50 PM) 1:40 PM STATION G Source Type: research

Laparoscopic Hysterectomy with Cervicovaginal Agenesis
We present a laparoscopic surgical approach for hysterectomy in Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome with cervicovaginal agenesis. Laparoscopic approaches for removal of uterine remnants have been published with only reports of laparotomy described for hysterectomy with cervicovaginal agenesis. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 15, 2019 Category: OBGYN Authors: R Dhaliwal, LM Belland Tags: Open Communications 12: Laparoscopy (4:10 PM – 5:15 PM) 5:06 PM Source Type: research

Laparoscopic Creation of a Neovagina in Mayer-Rokitansky-K üster-Hauser Syndrome
To show the step by step procedure of a neovagina creation in Mayer-Rokitansky-K üster-Hauser Syndrome. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 15, 2019 Category: OBGYN Authors: JR Escalona, F Heredia, G Donetch, M Hinostroza Tags: Open Communications 25:  Urogynecology (4:10 PM – 5:10 PM) 4:10 PM Source Type: research

Repair of iatrogenic urethral and bladder neck injury due to missed diagnosis of Mayer-Rokitansky-K üster-Hauser syndrome
This report describes the repair of a complex iatrogenic urethrovaginal injury due to a missed diagnosis of MRKH. Our treatmen t utilized a primary urethroplasty through a transvaginal approach with bladder neck reconstruction and a Martius flap for secondary coverage. Urinary continence was restored post-operatively. (Source: Urology)
Source: Urology - September 24, 2019 Category: Urology & Nephrology Authors: Karishma Taneja, Ernest Pang Chan, Blayne Welk, Peter Zhan Tao Wang Source Type: research

Neovaginoplasty using Nile Tilapia Fish Skin as a new biological graft in patients with Mayer-Rokitansky-Küster-Hauser syndrome
Publication date: Available online 20 September 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Maria Tereza Pinto Medeiros Dias, Andreisa Paiva Monteiro Bilhar, Livia Cunha Rios, Bruno Almeida Costa, Edmar Maciel Lima Júnior, Ana Paula Negreiros Nunes Alves, Zenilda Vieira Bruno, Manoel Odorico de Moraes Filho, Leonardo Robson Pinheiro Sobreira BezerraABSTRACTMayer–Rokitansky–Kuster–Hauser syndrome is the second most common cause of primary amenorrhea, trailing only gonadal dysgenesis. In patients who failed dilation therapy, neovaginoplasty is an appropriate treatment option. Sever...
Source: Journal of Minimally Invasive Gynecology - September 22, 2019 Category: OBGYN Source Type: research

Neovaginoplasty using Nile Tilapia Fish Skin as a new biological graft in patients with Mayer-Rokitansky-K üster-Hauser syndrome
Mayer –Rokitansky–Kuster–Hauser syndrome is the second most common cause of primary amenorrhea, trailing only gonadal dysgenesis. In patients who failed dilation therapy, neovaginoplasty is an appropriate treatment option. Several biomaterials have been used in this procedure, including peritoneum, amnion, skin grafts and myocutaneous flaps. Nile Tilapia Fish Skin has non-infectious microbiota, morphological structure comparable to human skin, and high in vivo bioresorption. In addition, it showed good outcomes when used as a xenograft for burn treatment. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - September 20, 2019 Category: OBGYN Authors: Maria Tereza Pinto Medeiros Dias, Andreisa Paiva Monteiro Bilhar, Livia Cunha Rios, Bruno Almeida Costa, Edmar Maciel Lima J únior, Ana Paula Negreiros Nunes Alves, Zenilda Vieira Bruno, Manoel Odorico de Moraes Filho, Leonardo Robson Pinheiro Sobreira B Tags: INSTRUMENTS AND TECHNIQUES Source Type: research

Neovaginoplasty Using Nile Tilapia Fish Skin as a New Biologic Graft in Patients with Mayer-Rokitansky-K üster-Hauser Syndrome
Mayer-Rokitansky-K üster-Hauser syndrome is the second most common cause of primary amenorrhea, trailing only to gonadal dysgenesis. Neovaginoplasty is an appropriate treatment option for patients who have failed dilation therapy. Several biomaterials have been used in this procedure, including peritoneum, amnion, sk in grafts, and myocutaneous flaps. Nile Tilapia Fish Skin has noninfectious microbiota, morphologic structure comparable to human skin, and high in vivo bioresorption. In addition, it showed good outcomes when used as a xenograft for burn treatment. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - September 20, 2019 Category: OBGYN Authors: Maria Tereza Pinto Medeiros Dias, Andreisa Paiva Monteiro Bilhar, Livia Cunha Rios, Bruno Almeida Costa, Edmar Maciel Lima J únior, Ana Paula Negreiros Nunes Alves, Zenilda Vieira Bruno, Manoel Odorico de Moraes Filho, Leonardo Robson Pinheiro Sobreira B Tags: Instruments and Techniques Source Type: research

Detection of de novo genetic variants in Mayer-Rokitansky-K üster-Hauser syndrome by whole genome sequencing.
Conclusion: We identified five de novo mutations in BAZ2B, KLHL18, PIK3CD, SLC4A10 and TNK2 by performing WGS, the functional involvement of all deleterious mutations in MRKH candidate genes of the trios warrant further study. WGS may complement conventional array to capture the complete landscape of the genome in MRKH. PMID: 31517310 [PubMed] (Source: Reproductive Biology)
Source: Reproductive Biology - September 15, 2019 Category: Reproduction Medicine Authors: Pan HX, Luo GN, Wan SQ, Qin CL, Tang J, Zhang M, Du M, Xu KK, Shi JQ Tags: Eur J Obstet Gynecol Reprod Biol X Source Type: research

Whole-exome sequencing identifies a GREB1L variant in a three-generation family with M üllerian and renal agenesis: a novel candidate gene in Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome. A case report
AbstractThe aetiology of Mayer –Rokitansky–Küster–Hauser (MRKH) syndrome, characterized by uterovaginal agenesis in 46,XX women, remains poorly understood. Since familial occurrences are rare, genetic findings reported so far only apply to a minority of mainly sporadic cases and most studies have not included other family members enabling segregation analysis. Herein, we report on the investigation of a unique three-generation family of two female cousins with MRKH syndrome and unilateral renal agenesis (RA) and two deceased male relatives with RA. We performed whole-exome sequencing (WES) in eight f...
Source: Human Reproduction - August 19, 2019 Category: Reproduction Medicine Source Type: research

Sexual functioning, sexual esteem, genital self-image and psychological and relational functioning in women with Mayer –Rokitansky–Küster–Hauser syndrome: a case–control study
AbstractSTUDY QUESTIONDo sexual functioning, sexual esteem, genital self-image and psychological and relational functioning in women with Mayer –Rokitansky–Küster–Hauser (MRKH) syndrome differ from a comparison group of women without the condition?SUMMARY ANSWERIn comparison to controls, women with MRKH with a non-surgically or surgically created neovagina did not differ in psychological and relational functioning but reported lower sexual esteem and more negative genital self-image, intercourse-related pain, clinically relevant sexual distress and sexual dysfunction, with sexual esteem levels strong...
Source: Human Reproduction - August 16, 2019 Category: Reproduction Medicine Source Type: research

A rare form of Mayer-Rokitansky-Küster-Hauser syndrome: Case report and review of literature
ConclusionMRKH syndrome with bilateral rudimentary uterine horns and normal-length vagina is an unusual form of Müllerian agenesis. (Source: Case Reports in Womens Health)
Source: Case Reports in Womens Health - August 7, 2019 Category: OBGYN Source Type: research

Neovagina creation methods and their potential impact on subsequent uterus transplantation: a review.
In conclusion, Vecchietti-based laparoscopically assisted neovagina creation provides ideal functional conditions for uterus transplantation. Non-surgical self-dilation and Wharton-Sheares-George vaginoplasty may also be suitable. This article is protected by copyright. All rights reserved. PMID: 31338951 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 24, 2019 Category: OBGYN Authors: Kölle A, Taran FA, Rall K, Schöller D, Wallwiener D, Brucker SY Tags: BJOG Source Type: research

Eruptive blue nevi of the scalp in a patient with Mayer & #8211;Rokitansky & #8211;K & #252;ster & #8211;Hauser syndrome during isotretinoin therapy
Nevena Skroza, Ilaria Proietti, Ersilia Tolino, Nicoletta Bernardini, Veronica Balduzzi, Anna Marchesiello, Alessia Anzalone, Daniela Colapietra, Simone Michelini, Alessandra Mambrin, Natale Porta, Vincenzo Petrozza, Concetta PotenzaIndian Journal of Dermatology 2019 64(4):339-339 (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - July 5, 2019 Category: Dermatology Authors: Nevena Skroza Ilaria Proietti Ersilia Tolino Nicoletta Bernardini Veronica Balduzzi Anna Marchesiello Alessia Anzalone Daniela Colapietra Simone Michelini Alessandra Mambrin Natale Porta Vincenzo Petrozza Concetta Potenza Source Type: research

Novel Minimally Invasive Technique of Neovaginoplasty Using An Absorbable Adhesion Barrier
The objective was to provide a minimally invasive neovaginoplasty technique to construct a nearly physiological vagina to facilitate sexual functioning and appropriate vaginal length in patients with congenital vaginal agenesis. This is a retrospective study at a tertiary care hospital. 52 patients with congenital vaginal agenesis owing to Mayer-Rokitansky-Küster-Hauser syndrome or androgen insensitivity syndrome presented for vaginal reconstruction. Modified McIndoe vaginoplasty was done in all patients between 2010 and 2018using a vaginal mold created with glove, nonadherent petroleum gauze, and Interceed absorbable...
Source: Journal of Minimally Invasive Gynecology - June 20, 2019 Category: OBGYN Source Type: research

Novel Minimally Invasive Technique of Neovaginoplasty Using An Absorbable Adhesion Barrier
The objective was to provide a minimally invasive neovaginoplasty technique to construct a nearly physiological vagina to facilitate sexual functioning and appropriate vaginal length in patients with congenital vaginal agenesis. This is a retrospective study at a tertiary care hospital. 52 patients with congenital vaginal agenesis owing to Mayer-Rokitansky-K üster-Hauser syndrome or androgen insensitivity syndrome presented for vaginal reconstruction. Modified McIndoe vaginoplasty was done in all patients between 2010 and 2018using a vaginal mold created with glove, nonadherent petroleum gauze, and Interceed absorbabl...
Source: The Journal of Minimally Invasive Gynecology - June 19, 2019 Category: OBGYN Authors: Manjula Anagani, Prabha Agrawal, Krishnakumari Meka, Rashmi Thippasandra Narayana, Radhika Bandameedipally Tags: Instruments and Techniques Source Type: research

Ovarian Teratomas in Women With Anti-N-methyl-D-Aspartate Receptor Encephalitis: Topography and Composition of Immune Cell and Neuroglial Populations Is Compatible With an Autoimmune Mechanism of Disease
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune syndrome in young women that is often accompanied by an ovarian teratoma (NMDAR-E teratoma). A prevailing theory implicates that the generation of autoantibodies to NMDAR on neurons in the central nervous system is triggered by neuroglial tissue in the associated teratoma. The histopathology of NMDAR-E teratomas has not been fully elucidated but limited studies have focused on alterations in neuroglial tissues and immune cell populations. We hypothesized that evidence of antibody generation in NMDAR-E teratomas could be detected by colocalized neurogl...
Source: The American Journal of Surgical Pathology - June 13, 2019 Category: Pathology Tags: Original Articles Source Type: research

A Rare Cause of Postprandial Pain
​BY DHIMITRI A. NIKOLLA, DO; BRENDAN A. MICCIO; MELODY L. MILLIRON; & BRETT FOREHAND, MD, PHDA 49-year-old woman with a past medical history of chronic obstructive pulmonary disease presented to the emergency department with epigastric pain. She said the pain radiated to her chest and had been intermittent for six months, but it had been progressively worsening over the previous three weeks. Her pain was exacerbated by eating, and was associated with early satiety and nausea. She complained of a 30-pound weight loss over the preceding three months.Her vital signs included a blood pressure of 116/80 mm Hg, a heart rat...
Source: The Case Files - June 12, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: research