Pubertal and Gonadal Outcomes in 46,XY Individuals with Partial Androgen Insensitivity Syndrome Raised as Girls
Conclusion: In general, although it appears that female assignment in PAIS is becoming uncommon, our data provide no evidence to support the practice of prophylactic prepubertal gonadectomy with respect to the risk of a germ cell tumor.Sex Dev (Source: Sexual Development)
Source: Sexual Development - March 14, 2023 Category: Biology Source Type: research
Development of Ovaries and Sex Change in Fish: Bringing Potential into Action
Background: Encompassing about half of the 60,000 species of vertebrates, fish display the greatest diversity of sex determination mechanisms among metazoans. As such that phylum offers a unique playground to study the impressive variety of gonadal morphogenetic strategies, ranging from gonochorism, with either genetic or environmental sex determination, to unisexuality, with either simultaneous or consecutive hermaphroditism.Summary: From the two main types of gonads, the ovaries embrace the important role to produce the larger and non-motile gametes, which is the basis for the development of a future organism. The produc...
Source: Sexual Development - March 6, 2023 Category: Biology Source Type: research
Avian Sex Determination: A Chicken and Egg Conundrum
Background: Primary sex determination is the developmental process that results in the sexual differentiation of the gonads. Vertebrate sex determination is generally considered to follow the model based on the mammalian system, where a sex-specific master regulatory gene activates one of the two different gene networks that underlie testis and ovary differentiation.Summary: It is now known that, while many of the molecular components of these pathways are conserved across different vertebrates, a wide variety of different trigger factors are utilized to initiate primary sex determination. In birds, the male is the homogam...
Source: Sexual Development - February 16, 2023 Category: Biology Source Type: research
Avian sex determination: a chicken egg conundrum
Background
Primary sex-determination is the developmental process that results in the sex determination of the gonads. Vertebrate sex determination is generally considered to follow the model based on the mammalian system, where a sex-specific master regulatory gene activates one of the two different gene networks that underlie testis and ovary differentiation.
Summary
It is now known that, while many of the molecular components of these pathways are conserved across different vertebrates, a wide variety of different trigger factors are utilised to initiate primary sex determination. In birds, the male is the homogameti...
Source: Sexual Development - February 16, 2023 Category: Biology Source Type: research
Phenotypic Variation in 46,XX Disorders of Sex Development due to the Fourth Zinc Finger Domain Variant of WT1: A Familial Case Report
Conclusion: The phenotypic variations due to the ZF4 variant are extremely broad in 46,XX cases. (Source: Sexual Development)
Source: Sexual Development - February 16, 2023 Category: Biology Source Type: research
Phenotypic Variation in 46,XX Disorders of Sex Development due to the 4th Zinc Finger Domain Variant of WT1 : A Familial Case Report
Conclusion: The phenotypic variations due to ZF4 variant are extremely broad in 46,XX cases. (Source: Sexual Development)
Source: Sexual Development - February 16, 2023 Category: Biology Source Type: research
Whole-Exome Sequencing Indicated New Candidate Genes Associated with Unilateral Cryptorchidism in Pigs
Conclusion: Our data suggest the involvement of new SNPs and genes in developing cryptorchidism in pigs. However, further studies are needed to validate our results in a larger cohort population. Variations in theGPR179 gene, with implications at the protein level, may be associated with the appearance of this anomaly in the swine. Finally, we are showing that the estrogen signaling pathway may be involved in the pathophysiological mechanisms of this congenital anomaly as previously reported in GWAS.Sex Dev (Source: Sexual Development)
Source: Sexual Development - February 9, 2023 Category: Biology Source Type: research
Testicular architecture of men with 46,XX testicular Disorders of Sex Development
Conclusion: Testicular architecture and marker expression of SCs and LCs in 46,XX TDSD men display unique pattern, which are discernable from chromosomal aneuploidies. Given the reduced Y chromosomal gene content in 46,XX TDSD, the supernumerary X chromosome effects may be decisive regarding the damage on testicular composition and endocrine function. (Source: Sexual Development)
Source: Sexual Development - February 6, 2023 Category: Biology Source Type: research
Genetic Variants in < b > < i > SRD5A2 < /i > < /b > in a Spectrum of DSD Patients from Australian Clinics Highlight Importance of Genetic Testing alongside Typical First-Line Investigations
Conclusion: This work highlights the importance of early genetic testing in children born with 46,XY DSD where it complements traditional first-line testing.Sex Dev (Source: Sexual Development)
Source: Sexual Development - February 1, 2023 Category: Biology Source Type: research
