Metformin ameliorates endometrial thickness in a rat model of thin endometrium
In conclusion, the study demonstrated that metformin ameliorates endometrial thickness in a rat model of thin endometrium by increasing endometrial proliferation and angiogenesis, without restoration of embryo implantation.PMID:38621769 | DOI:10.1111/1440-1681.13862 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 15, 2024 Category: Drugs & Pharmacology Authors: M Imran Aditya Khandvilkar Siddhanath Metkari Geetanjali Sachdeva Uddhav Chaudhari Source Type: research
Weight Management with Orlistat in Type 2 Diabetes - An Electronic Healthcare Records Study
CONCLUSIONS: Orlistat was significantly associated with weight loss in T2DM/prediabetes when taken for at least 12 weeks. However, orlistat is infrequently prescribed and often taken for <12 weeks. Orlistat may be a useful adjunct to lifestyle modifications in T2DM/prediabetes however barriers to continuing orlistat means it may not be effective for everyone in managing weight loss.PMID:38621802 | DOI:10.3399/BJGP.2023.0684 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - April 15, 2024 Category: Primary Care Authors: Shraboni Ghosal Neil Heron Kayleigh Mason James Bailey Kelvin Jordan Source Type: research
Weight Management with Orlistat in Type 2 Diabetes - An Electronic Healthcare Records Study
CONCLUSIONS: Orlistat was significantly associated with weight loss in T2DM/prediabetes when taken for at least 12 weeks. However, orlistat is infrequently prescribed and often taken for <12 weeks. Orlistat may be a useful adjunct to lifestyle modifications in T2DM/prediabetes however barriers to continuing orlistat means it may not be effective for everyone in managing weight loss.PMID:38621802 | DOI:10.3399/BJGP.2023.0684 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - April 15, 2024 Category: Primary Care Authors: Shraboni Ghosal Neil Heron Kayleigh Mason James Bailey Kelvin Jordan Source Type: research
Weight Management with Orlistat in Type 2 Diabetes - An Electronic Healthcare Records Study
CONCLUSIONS: Orlistat was significantly associated with weight loss in T2DM/prediabetes when taken for at least 12 weeks. However, orlistat is infrequently prescribed and often taken for <12 weeks. Orlistat may be a useful adjunct to lifestyle modifications in T2DM/prediabetes however barriers to continuing orlistat means it may not be effective for everyone in managing weight loss.PMID:38621802 | DOI:10.3399/BJGP.2023.0684 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - April 15, 2024 Category: Primary Care Authors: Shraboni Ghosal Neil Heron Kayleigh Mason James Bailey Kelvin Jordan Source Type: research
SGLT2i vs Sulfonylureas for Gout Prevention Among Patients With Type 2 Diabetes Receiving Metformin
This cohort study uses target trial emulation to evaluate risk of incident gout and rate of recurrent gout flares in patients with type 2 diabetes initiating sodium-glucose cotransporter-2 inhibitors (SGLT2i) vs sulfonylurea. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - April 15, 2024 Category: Internal Medicine Source Type: research
Cardiovascular safety of evogliptin dual and triple therapy in patients with type 2 diabetes: a nationwide cohort study
Conclusions
These findings suggest that dual or triple therapies of evogliptin for the management of type 2 diabetes in routine clinical practice present no cardiovascular harms, but could alternatively offer cardiovascular benefits in this patient population. (Source: BMJ Open)
Source: BMJ Open - April 15, 2024 Category: General Medicine Authors: Park, S., Jeong, H. E., Oh, I.-S., Hong, S., Yu, S. H., Lee, C. B., Shin, J.-Y. Tags: Open access, Diabetes and Endocrinology Source Type: research
Role of epigenetics in the regulation of skin aging and geroprotective intervention: A new sight
Biomed Pharmacother. 2024 Apr 13;174:116592. doi: 10.1016/j.biopha.2024.116592. Online ahead of print.ABSTRACTMultiple epigenetic factors play a regulatory role in maintaining the homeostasis of cutaneous components and are implicated in the aging process of the skin. They have been associated with the activation of the senescence program, which is the primary contributor to age-related decline in the skin. Senescent species drive a series of interconnected processes that impact the immediate surroundings, leading to structural changes, diminished functionality, and heightened vulnerability to infections. Geroprotective me...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2024 Category: Drugs & Pharmacology Authors: Lisa Dal Pozzo Zhe Xu Shan Lin Jida Wang Ying Wang Ogbe Susan Enechojo Joseph Kofi Abankwah Yanfei Peng Xiaoqian Chu Huifang Zhou Yuhong Bian Source Type: research
Role of epigenetics in the regulation of skin aging and geroprotective intervention: A new sight
Biomed Pharmacother. 2024 Apr 13;174:116592. doi: 10.1016/j.biopha.2024.116592. Online ahead of print.ABSTRACTMultiple epigenetic factors play a regulatory role in maintaining the homeostasis of cutaneous components and are implicated in the aging process of the skin. They have been associated with the activation of the senescence program, which is the primary contributor to age-related decline in the skin. Senescent species drive a series of interconnected processes that impact the immediate surroundings, leading to structural changes, diminished functionality, and heightened vulnerability to infections. Geroprotective me...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2024 Category: Drugs & Pharmacology Authors: Lisa Dal Pozzo Zhe Xu Shan Lin Jida Wang Ying Wang Ogbe Susan Enechojo Joseph Kofi Abankwah Yanfei Peng Xiaoqian Chu Huifang Zhou Yuhong Bian Source Type: research
< em > Ianus Bifrons < /em > : The Two Faces of Metformin
Cancers (Basel). 2024 Mar 26;16(7):1287. doi: 10.3390/cancers16071287.ABSTRACTThe ancient Roman god Ianus was a mysterious divinity with two opposite faces, one looking at the past and the other looking to the future. Likewise, metformin is an "old" drug, with one side looking at the metabolic role and the other looking at the anti-proliferative mechanism; therefore, it represents a typical and ideal bridge between diabetes and cancer. Metformin (1,1-dimethylbiguanidine hydrochloride) is a drug that has long been in use for the treatment of type 2 diabetes mellitus, but recently evidence is growing about its potential use ...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Umberto Goglia Iderina Hasballa Claudia Teti Mara Boschetti Diego Ferone Manuela Albertelli Source Type: research
Synergistic effects of Metformin and Forskolin on oxidative stress induced by diabetes and hepatocellular cancer: an animal study
CONCLUSION: Metformin and Forskolin reduced oxidative stress in diabetic and HCC-induced rats. The results indicated that the combination of agents (Metformin & Forskolin) had greater therapeutic effects than Forskolin alone in reducing glucose levels in diabetic rats. However, the ameliorative effects of combining Metformin and Forskolin on blood and urine oxidative stress were not statistically higher than those of Metformin alone.PMID:38614244 | DOI:10.1016/j.toxicon.2024.107720 (Source: Toxicon)
Source: Toxicon - April 13, 2024 Category: Toxicology Authors: Qian Yang Mohammed Abed Jawad Abdullah Ali Alzahrani Zahraa F Hassan Ahmed Elawady Ahmed Hjazi Mehran Naghibi Source Type: research
Correlation between anti-m üllerian hormone in polycystic ovarian syndrome with metformin: a systematic review and meta-analysis
Volume 40, Issue 1, December 2024 . (Source: Gynecological Endocrinology)
Source: Gynecological Endocrinology - April 13, 2024 Category: Endocrinology Authors: Hongcen LiuLi MoXiaofang TianShizhen FanJiayi HuLin ZhangBohai Yua Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen City, Guangdong Province, Chinab The school of Guangzhou University of Chinese Medicine, Guangzhou City, Gu Source Type: research
Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle
Sci Adv. 2024 Apr 12;10(15):eadl0372. doi: 10.1126/sciadv.adl0372. Epub 2024 Apr 12.ABSTRACTAging skin, vulnerable to age-related defects, is poor in wound repair. Metabolic regulation in accumulated senescent cells (SnCs) with aging is essential for tissue homeostasis, and adequate ATP is important in cell activation for aged tissue repair. Strategies for ATP metabolism intervention hold prospects for therapeutic advances. Here, we found energy metabolic changes in aging skin from patients and mice. Our data show that metformin engineered EV (Met-EV) can enhance aged mouse skin repair, as well as ameliorate cellular senes...
Source: Adv Data - April 12, 2024 Category: Epidemiology Authors: Yu Zhuang Shengjie Jiang Xiaoling Deng An Lao Xiaolin Hua Yun Xie Lingyong Jiang Xudong Wang Kaili Lin Source Type: research
Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle
Sci Adv. 2024 Apr 12;10(15):eadl0372. doi: 10.1126/sciadv.adl0372. Epub 2024 Apr 12.ABSTRACTAging skin, vulnerable to age-related defects, is poor in wound repair. Metabolic regulation in accumulated senescent cells (SnCs) with aging is essential for tissue homeostasis, and adequate ATP is important in cell activation for aged tissue repair. Strategies for ATP metabolism intervention hold prospects for therapeutic advances. Here, we found energy metabolic changes in aging skin from patients and mice. Our data show that metformin engineered EV (Met-EV) can enhance aged mouse skin repair, as well as ameliorate cellular senes...
Source: Adv Data - April 12, 2024 Category: Epidemiology Authors: Yu Zhuang Shengjie Jiang Xiaoling Deng An Lao Xiaolin Hua Yun Xie Lingyong Jiang Xudong Wang Kaili Lin Source Type: research
Statin use as a moderator on the association between metformin and breast cancer risk in women with type 2 diabetes mellitus
ConclusionsExtending metformin or statin usage by one year conferred breast cancer protection in women with T2DM. Enhanced protective effect of metformin was observed among those who also use statins. These results suggest the potential of combined metformin and statin therapy as promising breast cancer prevention strategies. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - April 12, 2024 Category: Cancer & Oncology Source Type: research
Safety vs price in the generic drug market: metformin
CONCLUSIONS: Recalls of metformin ER medications were effective in lowering NDMA levels below the FDA threshold; however, some samples of generic metformin still contained carcinogens even after FDA-announced recalls. The absence of any correlation with price indicates that potentially safer products are available on the market for the same price as poorer-quality products.PMID:38603530 | DOI:10.37765/ajmc.2024.89450 (Source: The American Journal of Managed Care)
Source: The American Journal of Managed Care - April 11, 2024 Category: Health Management Authors: Ben Teasdale Amber Hudspeth Kaury Kucera David Light Jill Nailor Shannon Williams Arnold Milstein Kevin A Schulman Source Type: research
