Fight Aging! Newsletter, July 20th 2020
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons.
Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. This...
Source: Fight Aging! - July 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Metabolic syndrome is on the rise: What it is and why it matters
Metabolic syndrome may be the most common and serious condition you’ve never heard of. (At least that’s what I found out when I asked friends and relatives about it.) Worse, a study published recently in JAMA shows that it’s on the rise.
Let’s start with the name, according to Merriam-Webster:
Metabolic: Relating to the chemical changes in living cells by which energy is provided for vital processes and activities and new material is assimilated
Syndrome: A group of signs and symptoms that occur together and characterize a particular abnormality or condition.
So now you know what metabolic syndrome is, right? Perha...
Source: Harvard Health Blog - July 17, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Coronavirus and COVID-19 Diabetes Health Health care disparities Heart Health Hypertension and Stroke Source Type: blogs
Lipocalin 2 as a Link Between Metabolic Syndrome and Neuroinflammation
Obesity and its immediate consequences, such as non-alcoholic fatty liver disease and type 2 diabetes, are associated with greater neuroinflammation and risk of dementia. Excess visceral fat tissue does its part to produce chronic inflammation throughout the body, but here researchers focus on a specific metabolic dysregulation in the liver that produces inflammation in the brain. That inflammation in turn drives a faster progression towards neurodegenerative conditions. The lesson here, as in so much of this research: don't get fat, don't stay fat. You won't like the consequences.
Researchers have revealed the ca...
Source: Fight Aging! - July 14, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Everyday Drink That Doubles Weight Loss
The drink may also be protective against type 2 diabetes and metabolic syndrome.
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Source: PsyBlog | Psychology Blog - July 5, 2020 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss Source Type: blogs
Fight Aging! Newsletter, May 18th 2020
This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function.
On Nutraceutical Senolytics
https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/
Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therap...
Source: Fight Aging! - May 17, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Early Life Epigenetic Changes can Set the Stage for Later Life Metabolic Dysfunction
Epigenetic markers on DNA determine the pace and timing of protein production, and are thus one of the important influences on cell and tissue function. Cells adjust their epigenetic programs in response to the surrounding environment, but alterations can be lasting. It is thought that environmental influences on epigenetic programming of cellular behavior that occur in childhood set the stage for faster or slower onset of metabolic dysfunction in later life, once cell and tissue damage starts to accumulate. Researchers here provide a proof of principle of this process in rats.
Environmental exposures during early...
Source: Fight Aging! - May 15, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Physical Activity Slows the Consequences of Aging
We live in a world in which most people do not undertake anywhere near the level of physical activity that is optimal. Thus adding greater physical activity as a lifestyle choice appears very beneficial. There is a great deficiency, one that has serious consequences to health, and fixing that deficiency is touted as a successful intervention. But in reality, the situation is one in which most people harm their long term health through a form of self-neglect. This era of cheap calories and comfort is a time of vast benefits for humanity - but it has a few downsides, and this is one of them.
This meta-analysis showe...
Source: Fight Aging! - May 12, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Are sugar substitutes too sweet to be true?
About 40% of adults use low-calorie sweeteners, and most of those people do so at least once daily. While these sugar substitutes are most commonly consumed in beverages, they’re also eaten in foods and used in place of sugar to stir into coffee or sprinkle over cereal.
The presence of such sweeteners in our foods isn’t always apparent, though phrases like “light,” “no sugar added,” “sugar-free,” or “low-calorie” mean there’s a good chance they contain a sugar substitute. People are often unsure about whether to consume these items, and for good reason.
An alphabet soup of sugar substitutes
There are ...
Source: Harvard Health Blog - May 4, 2020 Category: Consumer Health News Authors: Emily Gelsomin, MLA, RD, LDN Tags: Diet and Weight Loss Health Healthy Eating Source Type: blogs
Weight loss can help head off lasting damage caused by fatty liver
Non-alcoholic fatty liver disease is the most common cause of liver disease in the United States, and is estimated to affect up to a quarter of adults in the world. It is defined by excess fat accumulating in the liver and usually occurs in people with obesity, high blood sugars (diabetes), abnormal cholesterol or triglyceride levels, or high blood pressure. These disorders often run together and as a group are called metabolic syndrome. The “non-alcoholic” part of “non-alcoholic fatty liver disease” is important to distinguish it from alcohol-related liver disease, which can also cause excess liver fat.
How fat ca...
Source: Harvard Health Blog - April 30, 2020 Category: Consumer Health News Authors: Irun Bhan, MD Tags: Diet and Weight Loss Digestive Disorders Source Type: blogs
Role of aldosterone in obesity
Role of aldosterone in obesity: Excessive aldosterone is produced by adrenal glands and adipose tissue in obesity. This explains the sensitivity of heart failure (HF) in obesity to mineralocorticoid receptor antagonists (MRA) [1].
Epicardial fat thickness has been shown to be increased in primary hyperaldosteronism [2]. So aldosterone secretion enhances fat deposition and fat deposits enhance aldosterone secretion. Primary hyperaldosteronism is associated with increased left ventricular mass and cardiovascular risk. Transition of epicardial fat from a nourishing tissue to proinflammatory tissue is mediated by aldosterone....
Source: Cardiophile MD - April 29, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
In Rats, Calorie Restriction Started in Later Life Prevents Many Age-Related Changes in Gene Expression
Researchers here apply modern genomics approaches to assessing the ability of calorie restriction to slow the progression of aging. As is usually the case, beyond greater understanding of the complexities of the metabolic response to calorie restriction, the goal is to find potential points of intervention that have as yet gone unremarked. Single genes where expression might be changed in order to mimic some fraction of the response to a lower calorie intake. Taken more broadly, exploration that might lead to the development of novel calorie restriction mimetics represents a sizable fraction of all present work on interven...
Source: Fight Aging! - March 5, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Deacetylation of the NLRP3 Inflammasome as a Way to Control Chronic Inflammation
Chronic inflammation is an important component of degenerative aging. Excessive inflammatory signaling and activation of the immune system arises due to a combination of many factors, of which some are more important than others, such as the presence of lingering senescent cells. Most of the research focused on controlling inflammation is more interested in sabotaging the mechanisms of control than in removing root causes, however. The work here is an example of the type, in which scientists identify an important feature of the regulatory system controlling inflammation. Forcing a sizable reduction of inflammation via this...
Source: Fight Aging! - February 13, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 13th 2020
In this study, we investigated the link between AF and senescence markers through the assessment of protein expression in the tissue lysates of human appendages from patients in AF, including paroxysmal (PAF) or permanent AF (PmAF), and in sinus rhythm (SR). The major findings of the study indicated that the progression of AF is strongly related to the human atrial senescence burden as determined by p53 and p16 expression. The stepwise increase of senescence (p53, p16), prothrombotic (TF), and proremodeling (MMP-9) markers observed in the right atrial appendages of patients in SR, PAF, and PmAF points toward multiple inter...
Source: Fight Aging! - January 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrially Targeted Antioxidant SS-31 Reduces Mitochondrial Proton Leak and Dysfunction in a Mouse Model of Heart Failure
In this report we investigated the effect and underlying mechanism of action of SS-31 on aged cardiomyocytes, especially on the mitochondrial proton leak. Using the naturally aged rodent model we provided direct evidence of increased proton leak as the primary energetic change in aged mitochondria. We further show that the inner membrane protein ANT1 mediates the augmented proton entry in the old mitochondria. Most significantly, we demonstrate that SS-31 prevents the proton entry and rejuvenates mitochondrial function through direct association with ANT1 and stabilization of the ATP synthasome. (Source: Fight Aging!)
Source: Fight Aging! - January 10, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
