The Everyday Drink That Doubles Weight Loss
The drink may also be protective against type 2 diabetes and metabolic syndrome. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - July 14, 2022 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss Source Type: blogs
Fight Aging! Newsletter, June 6th 2022
This study examines evidence suggesting that mitochondrial dysfunction plays a significant early impact on AD pathology.
Although mitochondrial dysfunction is a typical indication of Alzheimer's disease, it is unclear whether the cellular systems that maintain mitochondrial integrity malfunction, aggravating mitochondrial pathology. Different levels of vigilance and preventive methods are used to reduce mitochondrial damage and efficiently destroy faulty mitochondria to maintain the mitochondrial equilibrium. The form and function of mitochondria are regulated by mitochondrial fusion and fission. In contrast, mitoch...
Source: Fight Aging! - June 5, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Type 2 Diabetes Accelerates Brain Aging
The metabolic dysfunction of type 2 diabetes is known to accelerate the pathologies of aging. A range of mechanisms are involved, the most prominent of which is elevated chronic inflammation. Type 2 diabetes is a lifestyle condition caused, in the vast majority of cases, by being very overweight. Excess visceral fat tissue, required to produce the metabolic syndrome that leads into type 2 diabetes, accelerates the production of pro-inflammatory and generally disruptive senescent cells, but also produces inflammation via other mechanisms, such as the release of DNA debris from dying fat cells. Diabetes also features increas...
Source: Fight Aging! - June 1, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, May 2nd 2022
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - May 1, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Control of Inflammation as an Important Goal in the Treatment of Aging
Today I'll point out a review article that laments the present state of progress towards the control of inflammation in the human body. While acknowledging that great strides have been made in ways to interfere in inflammatory signaling, benefiting many patients, present tools are crude in comparison to the technologies that will most likely be needed in order to truly control unresolved, chronic inflammation and eliminate its contribution to age-related disease. True control of inflammation would imply the ability to (a) trigger resolution mechanisms with specificity, avoiding impairment of the operation of inflammation w...
Source: Fight Aging! - April 25, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Best Way To Lose Stomach Fat
Belly fat is linked to developing heart disease, diabetes and metabolic syndrome. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 5, 2022 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss Source Type: blogs
The Everyday Drink That Doubles Weight Loss
The drink may also be protective against type 2 diabetes and metabolic syndrome. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 19, 2022 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss Source Type: blogs
Progress in adulting
Progress in adultingWhen asked to do something he doesn ' t want to do #1 rants for shorter and shorter periods of time and often then just does it. (Assuming he sees the point of it.) Or he comes up with a reasonable compromise.#2 has a line on a reasonable government job that he can do well and that is well suited to him. (Government jobs have lots of accommodations and support for neuroatypical.)#1 hasn ' t gotten a handle on his diet (he ' s classic ' metabolic syndrome ' ) but he understands the need and sometimes he tries. He cheerfully does his 300 calorie a day bike trainer routine. Every day.#1 has done a go...
Source: Be the Best You can Be - February 12, 2022 Category: Disability Tags: ADHD adult autism cognitive impairment Source Type: blogs
The Everyday Drink That Doubles Weight Loss
The drink may also be protective against type 2 diabetes and metabolic syndrome. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - November 27, 2021 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss Source Type: blogs
Fight Aging! Newsletter, November 1st 2021
In conclusion, mitophagy pathways play an important role in maintaining physiological homeostasis, are involved in the mechanisms of aging and neurodegenerative disorders, and represent promising targets for the development of potential therapeutic agents aimed at regulating mitochondria quality control in neurons and glial cells. A significant number of molecules that induce or inhibit mitophagy are currently under consideration, which may be useful for testing hypotheses or developing drugs for the treatment of neurodegenerative diseases. The validation of promising drugs in animal and cell models, including neurons and ...
Source: Fight Aging! - October 31, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Calorie Restriction Mimetics in the Context of Cardiovascular Disease
The practice of calorie restriction produces a beneficial upregulation of cellular stress responses. In short-lived species such as mice this can produce a dramatic slowing of aging, improvement in health, and extension of life span. The same mechanisms produce similar short-term benefits to health, but not a significant lengthening of life, in species as long-lived a our own, however. Nonetheless, there is considerable interest in calorie restriction mimetics, compounds that can trigger at least some of the same regulatory mechanisms governing cellular stress responses, particularly the operation of autophagy.
Re...
Source: Fight Aging! - October 29, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 13th 2021
In this study, mature DCs (mDCs), generated from the GM-CSF and IL-4 induced bone marrow cells, were intravenously injected into wild-type mice. Three days later, assays showed that the mDCs were indeed able to return to the thymus. Homing DCs have been mainly reported to deplete thymocytes and induce tolerance. However, medullary TECs (mTECs) play a crucial role in inducing immune tolerance. Thus, we evaluated whether the mDCs homing into the thymus led to TECs depletion. We cocultured mDCs with mTEC1 cells and found that the mDCs induced the apoptosis and inhibited the proliferation of mTEC1 cells. These effects were onl...
Source: Fight Aging! - September 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Quantifying the Effects of a Five Day Fast for Comparison with Fasting Mimicking and Calorie Restriction
One of the more interesting developments of recent years in work on the beneficial effects of calorie restriction in humans is the establishment of an optimal boundary of reduced calorie intake. Can one obtain near all the benefits of fasting by eating a little, and how much is "a little" in this context? That question led to the fasting mimicking diet, supported by evidence for "a little" to be something like 750 calories per day for an averagely sized human, when considering a five day fast or low-calorie diet. As researchers note here, improvements in many metabolic parameters are not very different when considering fas...
Source: Fight Aging! - September 9, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 6th 2021
In conclusion, patients over 90 years of age had an overall low prevalence of fractures and relative preservation of bone health, suggesting a preserved bone molecular profile in these individuals. Epigenetic factors and activity levels might also have favorably affected bone health. The low percentage of osteoporosis and fractures likely reduced the morbidity and mortality in this population, potentially contributing to their overall longevity.
Building a Therapy for Aging Based on SIRT6 Upregulation
https://www.fightaging.org/archives/2021/08/building-a-therapy-for-aging-based-on-sirt6-upregulation/
G...
Source: Fight Aging! - September 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fecal Microbiota Transplant as a Treatment for Neurodegenerative Conditions
It is thought that an appreciable fraction of the chronic inflammation of aging is caused by changes in the gut microbiome. There is a bidirectional interaction between the immune system and the microbial populations of the intestinal tract. The immune system gardens these populations, destroying problematic microbes. Microbes secrete metabolites and other molecules that can either benefit or harm the function of the immune system, the harms caused particularly by those microbes capable of provoking a sustained inflammatory response. The immune system declines with age for a range of reasons, and reduced efficacy in immune...
Source: Fight Aging! - September 3, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
