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Liver Transplantation in the Obese Cirrhotic Patient
Abstract: Despite the rapidly increasing prevalence of obesity in the transplant population, the optimal management of obese liver transplant candidates remains undefined. Setting strict body mass index cutoffs for transplant candidacy remains controversial, with limited data to guide this practice. Body mass index is an imperfect measure of surgical risk in this population, partly due to volume overload and variable visceral adiposity. Weight loss before transplantation may be beneficial, but it remains important to avoid protein calorie malnutrition and sarcopenia. Intensive lifestyle modifications appear to be successfu...
Source: Transplantation - September 21, 2017 Category: Transplant Surgery Tags: Reviews Source Type: research

Chronic obstructive pulmonary disease (COPD) exacerbation: impact of comorbidities on length and costs during hospitalization.
CONCLUSIONS: Comorbidities play an important role in the hospital management of COPD exacerbation, increasing health care costs related to this disease. PMID: 28925473 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - September 21, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Complex phenotype linked to a mutation in exon 11 of the lamin A/C gene: Hypertrophic cardiomyopathy, atrioventricular block, severe dyslipidemia and diabetes
In conclusion, the association between LMNA mutations and different phenotypes is complex and not fully understood, and can present with a broad spectrum of severity. (Source: Revista Portuguesa de Cardiologia)
Source: Revista Portuguesa de Cardiologia - September 21, 2017 Category: Cardiology Source Type: research

Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study
Conclusions: We observed little or no evidence of associations between low prenatal PFAS exposures and outcomes related to cardiometabolic risk in a cohort of Spanish children followed from birth until 7 y. https://doi.org/10.1289/EHP1330 Received: 07 November 2016 Revised: 13 July 2017 Accepted: 21 July 2017 Published: 20 September 2017 Address correspondence to C. B. Manzano-Salgado, ISGlobal–Centre for Research in Environmental Epidemiology (CREAL), Doctor Aiguader, 8808003 Barcelona, Catalonia, Spain. Phone: +34 932 147 314. Email: cyntia.manzano@isglobal.org Supplemental Material is available online (https...
Source: EHP Research - September 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Clinical and metabolic characteristics of Turkish adolescents with polycystic ovary syndrome.
Authors: Ates S, Aydın S, Ozcan P, Soyman Z, Gokmen Karasu AF, Sevket O Abstract The aim of this study was to investigate the clinical, endocrine, metabolic features and prevalence of metabolic syndrome (MBS) in Turkish adolescents with polycystic ovary syndrome (PCOS) and the differences in metabolic parameters between adolescent PCOS with or without the presence of polycystic ovaries (PCO) on ultrasound. Subjects (n = 77) were classified into two groups: oligomenorrhea (O) and clinical and/or biochemical hyperandrogenism (HA) (n = 38), without PCO and O + HA with PCO (n&...
Source: Journal of Obstetrics and Gynaecology - September 20, 2017 Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

Fasting Spot-urine pH is Associated with Metabolic Syndrome in the Japanese Population
Objective: To investigate the relationship between urine pH and metabolic syndrome (MetS) and its components while controlling for covariates. Subjects and Methods: This cross-sectional study was conducted on 5,430 Japanese subjects (4691 without MetS; 739 with MetS) undergoing health assessments. Partial correlation analysis and analysis of covariance were used for controlling confounding parameters (age, gender, serum uric acid (UA) levels, high sensitivity C-reactive protein, estimated glomerular filtration rate, and smoking and drinking statuses). Using multiple logistic regression analyses, adjusted odds ratios (ORs) ...
Source: Medical Principles and Practice - September 20, 2017 Category: Internal Medicine Source Type: research

The risk of metabolic syndrome in polycystic ovary syndrome: A systematic review and meta ‐analysis
ConclusionThese findings provide some information on the real features and a broader view of this syndrome that also help clarify conflicting results documented in literature. Accordingly, in prevention strategies, routine screening for metabolic syndrome are suggested for adolescents with PCOS.This article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - September 20, 2017 Category: Endocrinology Authors: Samira Behboudi ‐Gandevani, Mina Amiri, Raziyeh Bidhendi Yarandi, Mahsa Noroozzadeh, Maryam Farahmand, Marziyeh Rostami Dovom, Fahimeh Ramezani Tehrani Tags: Review Source Type: research

A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress
Publication date: 19 September 2017 Source:Cell Reports, Volume 20, Issue 12 Author(s): Shashi Kant, Claire L. Standen, Caroline Morel, Dae Young Jung, Jason K. Kim, Wojciech Swat, Richard A. Flavell, Roger J. Davis Obesity is a major risk factor for the development of metabolic syndrome and type 2 diabetes. How obesity contributes to metabolic syndrome is unclear. Free fatty acid (FFA) activation of a non-receptor tyrosine kinase (SRC)-dependent cJun NH2-terminal kinase (JNK) signaling pathway is implicated in this process. However, the mechanism that mediates SRC-dependent JNK activation is unclear. Here, we identi...
Source: Cell Reports - September 20, 2017 Category: Cytology Source Type: research

Cancers, Vol. 9, Pages 127: Liver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells
Testa Liver cancer is the second most common cause of cancer-related death. The major forms of primary liver cancer are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). Both these tumors develop against a background of cirrhotic liver, non-alcoholic fatty liver disease, chronic liver damage and fibrosis. HCC is a heterogeneous disease which usually develops within liver cirrhosis related to various etiologies: hepatitis B virus (HBV) infection (frequent in Asia and Africa), hepatitis C virus (HCV), chronic alcohol abuse, or metabolic syndrome (frequent in Western countries). In cirrhosis, hepa...
Source: Cancers - September 20, 2017 Category: Cancer & Oncology Authors: Germana Castelli Elvira Pelosi Ugo Testa Tags: Review Source Type: research

Clinical, Diagnostic, and Therapeutic Implications in Psoriasis Associated With Cardiovascular Disease
Publication date: Available online 19 September 2017 Source:Actas Dermo-Sifiliográficas (English Edition) Author(s): C. Bonanad, E. González-Parra, R. Rivera, J.M. Carrascosa, E. Daudén, A. Olveira, R. Botella-Estrada In recent years the concept of psoriasis as a systemic disease has gained acceptance due to its association with numerous comorbid conditions, particularly atherosclerosis and cardiovascular disease. Several studies have shown that patients with psoriasis, especially younger patients and those with more severe forms of psoriasis or with psoriatic arthritis, have a higher prevalence of ri...
Source: Actas Dermo-Sifiliograficas - September 20, 2017 Category: Dermatology Source Type: research

PGBR extract ameliorates TNF- α induced insulin resistance in hepatocytes
In conclusion, this study found that TNF-α inhibited insulin stimulated glucose uptake and aggravated related proteins expressions, suggesting that it might cause insulin resistance. PGBR extract was found to ameliorate this TNF-α induced insulin resistance, suggesting that it might be used in the future to help control insulin resistance. (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - September 20, 2017 Category: Universities & Medical Training Source Type: research

Drugs for metabolic conditions and prostate cancer death in men on GnRH agonists
ConclusionWe did not find evidence for a better or worse response to GnRH agonists in men with PCa who were also on drugs for hypertension, dyslipidaemia, or hyperglycaemia.This article is protected by copyright. All rights reserved. (Source: BJU International)
Source: BJU International - September 20, 2017 Category: Urology & Nephrology Authors: Cecilia Bosco, Chloe Wong, Hans Garmo, Danielle Crawley, Lars Holmberg,, Niklas Hammar, Jan Adolfsson, P är Stattin, Mieke Van Hemelrijck Tags: Original Article Source Type: research

Vitamin D and type 2 diabetes
Publication date: October 2017 Source:The Journal of Steroid Biochemistry and Molecular Biology, Volume 173 Author(s): Paul Lips, Marelise Eekhoff, Natasja van Schoor, Mirjam Oosterwerff, Renate de Jongh, Yvonne Krul-Poel, Suat Simsek Vitamin D deficiency is associated with a decreased insulin release, insulin resistance and type 2 diabetes in experimental and epidemiological studies. Animal studies show that 1α,25–dihydroxyvitamin D3 (1,25(OH)2D3) stimulates the pancreatic β-cell to secrete insulin. The relationship between vitamin D deficiency and insulin resistance could develop through inflammation, a...
Source: The Journal of Steroid Biochemistry and Molecular Biology - September 20, 2017 Category: Biochemistry Source Type: research

Prevalence and severity of syndrome Z in women with metabolic syndrome on waiting list for bariatric surgery: a cross-sectional study
In recent years, obesity has become one of the most important public health problems in the world, with a growing prevalence in both developed and developing countries. Recent studies show that sleep disturban... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - September 20, 2017 Category: Endocrinology Authors: Eduardo Araujo Perez, Luis Vicente Franco Oliveira, Wilson Rodrigues Freitas Jr., Carlos Alberto Malheiros, Elias Jirjoss Ilias, Anderson Soares Silva, Jessica Julioti Urbano, Patricia Clemente Oliveira, Felipe X. Cepeda, Luciana M. M. Sampaio, Ivani C. T Tags: Research Source Type: research

Anthocyanins from Purple Corn Ameliorated Tumor Necrosis Factor ‐α‐Induced Inflammation and Insulin Resistance in 3T3‐L1 Adipocytes via Activation of Insulin Signaling and Enhanced GLUT4 Translocation
ConclusionAnthocyanins from colored corn prevented adipocyte differentiation, lipid accumulation, and reduced PPAR‐γ transcriptional activity on adipocytes in basal conditions. Ameliorated TNF‐α‐induced inflammation and insulin resistance in adipocytes via activation of insulin signaling and enhanced GLUT4 translocation suggesting a reduced hyperglycemia associated with the metabolic syndrome. Abstract Obesity and diabetes are becoming more and more prevalent around the world. Obese individuals have far more adipose tissue than a healthy individual. Highly colored fruits and vegetables contain flavonoid ...
Source: Molecular Nutrition and Food Research - September 19, 2017 Category: Food Science Authors: Diego Luna ‐Vital, Matthew Weiss, Elvira Gonzalez de Mejia Tags: RESEARCH ARTICLE Source Type: research

Retraction Note to: Metabolic syndrome factors and risk of postoperative depression in high-grade glioma patients in a 1.5-year prospective study
(Source: Medical Oncology)
Source: Medical Oncology - September 19, 2017 Category: Cancer & Oncology Source Type: research

Erratum to: Proton pump inhibitors as risk factor for metabolic syndrome and hepatic steatosis in coeliac disease patients on gluten-free diet
Abstract Erratum to: J Gastroenterol DOI 10.1007/s00535-017-1381-7. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - September 19, 2017 Category: Gastroenterology Source Type: research

Links between lower urinary tract symptoms, intermittent hypoxia and diabetes: Causes or cures?
Publication date: Available online 17 September 2017 Source:Respiratory Physiology & Neurobiology Author(s): Lisa L. Abler, Chad M. Vezina Bothersome lower urinary tract symptoms (LUTS) manifest as urinary frequency, urgency, incontinence and incomplete bladder emptying. Existing treatments ameliorate but do not eliminate most symptoms, leading to financial and personal burdens attributable to sustained medical therapies that may last a lifetime. The purpose of this review is to highlight evidence of causal associations between LUTS and several common comorbidities, including intermittent hypoxia (IH) concomitant ...
Source: Respiratory Physiology and Neurobiology - September 19, 2017 Category: Respiratory Medicine Source Type: research

Moderate- to high-intensity statins for secondary prevention in patients with type 2 diabetes mellitus on dialysis after acute myocardial infarction
This study... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - September 19, 2017 Category: Endocrinology Authors: Yan-Rong Li, Sung-Sheng Tsai, Yu-Sheng Lin, Chang-Min Chung, Szu-Tah Chen, Jui-Hung Sun, Miaw-Jene Liou and Tien-Hsing Chen Tags: Research Source Type: research

Erratum to: Cardiovascular risk assessment in patients with diabetes
Upon publication of the original article [1], it was noticed that the Ref. [32] was incorrectly given as [32]: Allan GM, Nouri F, Korownyk C, Kolber MR, Vandermeer B, McCormack J. Agreement among cardiovascular d... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - September 19, 2017 Category: Endocrinology Authors: Marcello Casaccia Bertoluci and Viviane Zorzanelli Rocha Tags: Erratum Source Type: research

Association between Exposure to p,p ′-DDT and Its Metabolite p,p′-DDE with Obesity: Integrated Systematic Review and Meta-Analysis
Conclusions: We classified p,p′-DDT and p,p′-DDE as “presumed” to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies. https://doi.org/10.1289/EHP527 Received: 17 May 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 18 September 2017 Please address correspondence to M.A. La Merrill, Dept. of Environmental Toxicology, University of California, Davis, 1 Shields Ave., 4245 Meyer Hall, Davis, CA 95616-5270 USA. Telephone: (530) 754-7254. E...
Source: EHP Research - September 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellular vesicles
Summary Obesity, metabolic syndrome, and hyperleptinemia are associated with aging and age‐associated diseases including prostate cancer. One experimental approach to inhibit tumor growth is to reduce dietary protein intake and hence levels of circulating amino acids. Dietary protein restriction (PR) increases insulin sensitivity and suppresses prostate cancer cell tumor growth in animal models, providing a rationale for clinical trials. We sought to demonstrate that biomarkers derived from plasma extracellular vesicles (EVs) reflect systemic leptin and insulin signaling and respond to dietary interventions. We studied p...
Source: Aging Cell - September 18, 2017 Category: Cytology Authors: Erez Eitan, Valeria Tosti, Caitlin N. Suire, Edda Cava, Sean Berkowitz, Beatrice Bertozzi, Sophia M. Raefsky, Nicola Veronese, Ryan Spangler, Francesco Spelta, Maja Mustapic, Dimitrios Kapogiannis, Mark P. Mattson, Luigi Fontana Tags: Short Take Source Type: research

Molecules, Vol. 22, Pages 1565: The Native Fruit Geoffroea decorticans from Arid Northern Chile: Phenolic Composition, Antioxidant Activities and In Vitro Inhibition of Pro-Inflammatory and Metabolic Syndrome-Associated Enzymes
rmo Schmeda-Hirschmann The native tree Geoffroea decorticans (chañar) grows in the arid lands of northern Chile. It has been used as a food plant since prehistoric times. Phenolic-enriched extracts (PEEs) of Chilean chañar fruits were assessed for their chemical composition, antioxidant properties and inhibition of pro-inflammatory and metabolic syndrome-associated enzymes. Phenolic profiles were determined by HPLC-DAD-MS/MS. The PEEs of G. decorticans showed a strong effect towards the enzymes COX-1/COX-2, with inhibition percentages ranging from inactive to 92.1% and inactive to 76.0% at 50 µg PEE...
Source: Molecules - September 18, 2017 Category: Chemistry Authors: Felipe Jim énez-Aspee Cristina Theoduloz Maria Soriano Maider Ugalde-Arbizu Maria Alberto Iris Zampini Maria Isla Mario Simirigiotis Guillermo Schmeda-Hirschmann Tags: Article Source Type: research

Alanine Aminotransferase and Total Bilirubin Are Synergistically Associated with Metabolic Syndrome Among Middle-Aged and Elderly Japanese Women
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - September 18, 2017 Category: Endocrinology Authors: Ryuichi Kawamoto Daisuke Ninomiya Kensuke Senzaki Teru Kumagi Source Type: research

The Currency of Science
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - September 18, 2017 Category: Endocrinology Authors: Adrian Vella Source Type: research

Re: Changes in Weight and Metabolic Syndrome Are Associated with Prostate Growth Rate over a 5-Year Period
Y. S. Kyung, D. You, I. G. Jeong, S. Han, H. K. Kim and C. S. Kim (Source: The Journal of Urology)
Source: The Journal of Urology - September 18, 2017 Category: Urology & Nephrology Authors: Steven A. Kaplan Tags: Urological Survey Source Type: research

Usefulness of the 2MACE Score to Predicts Adverse Cardiovascular Events in Patients with Atrial Fibrillation.
We investigated the incidence of non-embolic adverse events in 2 cohorts of AF patients and validated the 2MACE score [(metabolic syndrome, age ≥75) [doubled]; (myocardial infarction (MI)/revascularization, congestive heart failure (HF) and stroke/TIA/thromboembolism)] as predictor of major adverse cardiovascular events (MACEs). We recruited 2630 AF patients from two different cohorts (Murcia AF and FANTASIIA). The 2MACE score was calcula ted and during a median of 7.2 years (Murcia AF cohort) and 1.01 years (FANTASIIA) of follow-up we recorded all non-embolic adverse events and MACEs (composite of non-fatal MI/revascul...
Source: The American Journal of Cardiology - September 18, 2017 Category: Cardiology Authors: Jos é Miguel Rivera-Caravaca, Francisco Marín, María Asunción Esteve-Pastor, Paula Raña-Míguez, Manuel Anguita, Javier Muñiz, Ángel Cequier, Vicente Bertomeu-Martínez, Mariano Valdés, Vicente Vicente, Gregory Yoke Hong Lip, Vanessa Roldán Source Type: research

"Metabolically Healthy" Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes: 5-year Japanese Cohort Study.
"Metabolically Healthy" Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes: 5-year Japanese Cohort Study. Obesity (Silver Spring). 2017 Sep 18;: Authors: Kuwabara M, Kuwabara R, Hisatome I, Niwa K, Roncal-Jimenez CA, Bjornstad P, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Ohno M, Hill JO, Lanaspa MA, Johnson RJ Abstract OBJECTIVE: Whether obesity without metabolic syndrome (i.e., "metabolically healthy" obesity) confers similar or less metabolic risk remains controversial. METHODS: A retrospective 5-year cohort study of 9,721 Japanese subjects (48.5&thin...
Source: Obesity - September 18, 2017 Category: Eating Disorders & Weight Management Authors: Kuwabara M, Kuwabara R, Hisatome I, Niwa K, Roncal-Jimenez CA, Bjornstad P, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Ohno M, Hill JO, Lanaspa MA, Johnson RJ Tags: Obesity (Silver Spring) Source Type: research

Natural active compounds from plant food and Chinese herbal medicine for nonalcoholic fatty liver disease.
This study aimed to summarize the use and mechanism of action of natural active compounds in the treatment of NAFLD in the recent 10 years. An updated search was conducted on the PubMed, Web of Science, and Google Scholar databases from 2006 (for studies on silibinin, resveratrol, curcumin, and berberine compounds since 2010). Fifty-nine active compounds for NAFLD treatment were presented in detail in textual form and tabular form according to their chemical classification. PMID: 28925892 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 18, 2017 Category: Drugs & Pharmacology Authors: Liu Q, Zhu L, Cheng C, Hu Y, Feng Q Tags: Curr Pharm Des Source Type: research

Impact of Adrenal Steroids on Regulation of Adipose Tissue.
Authors: Infante M, Armani A, Mammi C, Fabbri A, Caprio M Abstract Corticosteroids are secreted by the adrenal glands and control the functions of adipose tissue via the activation of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR). In turn, adipocytes release a large variety of adipokines into the bloodstream, regulating the function of several organs and tissues, including the adrenal glands, hereby controlling corticosteroid production. In adipose tissue, the activation of the MR by glucocorticoids (GC) and aldosterone affects important processes such as adipocyte differentiation, oxidative stre...
Source: Comprehensive Physiology - September 17, 2017 Category: Physiology Tags: Compr Physiol Source Type: research

Adaptive Immunity and Metabolic Health: Harmony Becomes Dissonant in Obesity and Aging.
Authors: Bharath LP, Ip BC, Nikolajczyk BS Abstract Adipose tissue (AT) is the primary energy reservoir organ, and thereby plays a critical role in energy homeostasis and regulation of metabolism. AT expands in response to chronic overnutrition or aging and becomes a major source of inflammation that has marked influence on systemic metabolism. The chronic, sterile inflammation that occurs in the AT during the development of obesity or in aging contributes to onset of devastating diseases such as insulin resistance, diabetes, and cardiovascular pathologies. Numerous studies have shown that inflammation in the visce...
Source: Comprehensive Physiology - September 17, 2017 Category: Physiology Tags: Compr Physiol Source Type: research

GSE103929 Epigenomic and lipidomic changes in Multiple Sclerosis patients with high Body Mass Index enhance the neurotoxic function of monocytes
Contributors : Yunjiao Zhu ; Corey T Watson ; Jimmy Huynh ; Patrizia CasacciaSeries Type : Methylation profiling by arrayOrganism : Homo sapiensThe growing obesity “epidemic” has shed light on its negative impact on overall health status, not only in relation to cardiovascular disorders and metabolic syndrome, but also in regard to its influence on a variety of other health conditions, including autoimmune diseases, such as Multiple Sclerosis (MS). High Bo dy Mass index (BMI) is a risk factor for MS, however, it is not known whether and how it could impact disease course. Several studies, including those on the...
Source: GEO: Gene Expression Omnibus - September 17, 2017 Category: Genetics & Stem Cells Tags: Methylation profiling by array Homo sapiens Source Type: research

Physical Exercise Prescription in Metabolic Chronic Disease.
Authors: Stefani L, Galanti G Abstract Metabolic syndrome as a consequence of the association to overweight, hypertension, and diabetes is at high risk of coronary events. Regular physical training has been recently promoted to reduce cardiovascular risks factors, by the improved lifestyle and also by the "anti-inflammatory effectiveness." A positive impact has been shown in case of cancer survived patients either with or without comorbidities and especially in those subjects where the inflammatory process is globally represented. The American College of Sports Medicine (ACSM) guidelines and more recently...
Source: Advances in Experimental Medicine and Biology - September 17, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Glucose intolerance as the key risk factor for metabolic syndrome
(Source: The Journal of Clinical Hypertension)
Source: The Journal of Clinical Hypertension - September 17, 2017 Category: Cardiology Authors: Guido Grassi Tags: Commentary Source Type: research

Irisin is a biomarker for metabolic syndrome in prepubertal children.
Authors: Suk Shim Y, Jae Kang M, Yang S, Tae Hwang I Abstract The aim of the present study was to evaluate the association of irisin with obesity and metabolic syndrome (MetS) in Korean prepubertal children. A total of 96 children and adolescents aged 6 to 10 years (56 males) were included in this study. Subjects were divided into 3 groups: normal weight (n = 54), overweight (n = 16), and obese (n = 26). In the subgroup analyses, overweight/obese children were further divided based on their MetS status (with MetS vs. without MetS). Children with obesity tended to exhibit a lower mean irisin concentration compared t...
Source: Endocrine Journal - September 16, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Decreased plasma neuregulin 4 concentration is associated with increased high-sensitivity C-reactive protein in newly diagnosed type 2 diabetes mellitus patients: a cross-sectional study
AbstractAims Inflammation has been reported to be involved in the pathogenesis of atherosclerosis. This principal objective of this study was to investigate if the secretion of neuregulin 4 (Nrg4), a soluble protein associated with metabolic syndrome and subclinical cardiovascular disease, is correlated with the inflammation marker high-sensitivity C-reactive protein (hs-CRP) in patients with newly diagnosed type 2 diabetes mellitus (nT2DM).MethodsA study group of 311 nT2DM patients was divided into three subgroups based on hs-CRP tertiles. Multiple linear regression was conducted to explore the association between plasm...
Source: Acta Diabetologica - September 16, 2017 Category: Endocrinology Source Type: research

The (FTO) gene polymorphism is associated with metabolic syndrome risk in Egyptian females: a case- control study
This study was designed to investigate FTO rs9939609 association with metabolic... (Source: BMC Medical Genetics)
Source: BMC Medical Genetics - September 16, 2017 Category: Genetics & Stem Cells Authors: Mina S. Khella, Nadia M. Hamdy, Ashraf I. Amin and Hala O. El-Mesallamy Tags: Research article Source Type: research

EP29.06: Metabolic syndrome and risk of endometrial carcinoma among asymptomatic, postmenopausal, urban Sri Lankan females: a community cohort follow ‐up study
(Source: Ultrasound in Obstetrics and Gynecology)
Source: Ultrasound in Obstetrics and Gynecology - September 16, 2017 Category: Radiology Authors: T. Dias, M. Niriella, S. de Silva, C. Motha, T.S. Palihawadana, D. Ediiweera, J. de Silva Tags: Abstracts Source Type: research

Adverse cardiovascular outcomes in atrial fibrillation: Validation of the new 2MACE risk score
In addition to thromboembolism, atrial fibrillation (AF) may also predispose to major adverse cardiovascular events (MACE) attributable to coronary artery disease (CAD), including myocardial infarction (MI). The 2MACE score (2 points - Metabolic syndrome and Age ≥75years, 1 point - MI/revascularization, Congestive heart failure/ejection-fraction (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 16, 2017 Category: Cardiology Authors: Marija Polovina, Dijana Đikić, Ana Vlajković, Matej Vilotijević, Ivan Milinković, Milika Ašanin, Miodrag Ostojić, Andrew J.S. Coats, Petar M. Seferović Source Type: research

Significant burden of nonalcoholic fatty liver disease with advanced fibrosis in the US: a cross ‐sectional analysis of 2011‐2014 National Health and Nutrition Examination Survey
ConclusionsNAFLD represents a major healthcare burden among US adults with as many as 5 million adults estimated to have NAFLD with ≥F3 fibrosis. Age and the components of the metabolic syndrome are independently associated with higher risk of fibrosis. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 15, 2017 Category: Drugs & Pharmacology Authors: R. J. Wong, B. Liu, T. Bhuket Tags: ORIGINAL ARTICLE Source Type: research

Systematic review and meta-analysis of the association between psoriasis and metabolic syndrome
Several studies have shown a relationship between psoriasis and metabolic syndrome (MS), but no meta-analysis has been restricted to studies that adjusted for confounders. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - September 15, 2017 Category: Dermatology Authors: Milton Jos é Max Rodríguez-Zúñiga, Herney Andrés García-Perdomo Tags: Original article Source Type: research

Insulin resistance, serum uric acid and metabolic syndrome are linked to cardiovascular dysfunction in pediatric obesity
Childhood obesity is associated with cardiovascular abnormalities but little is known on the potential correlation between early cardiovascular and metabolic alterations. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 15, 2017 Category: Cardiology Authors: Giulia Genoni, Veronica Menegon, Gioel Gabrio Secco, Michela Sonzini, Massimiliano Martelli, Matteo Castagno, Roberta Ricotti, Alice Monzani, Michele Aronici, Elena Grossini, Carlo Di Mario, Gianni Bona, Simonetta Bellone, Flavia Prodam Source Type: research

HDL ‐C / apoA‐I ] : a multi‐vessel cardiometabolic risk marker in women with T2DM
Abstract AimsAlthough women have higher HDL‐C than men, their HDL particles are also prone to become small, dense and dysfunctional in case of T2DM. To assess the vascular risk related to HDLs of different sizes/densities without direct measurement, we adjusted HDL‐C to its main apolipoprotein (apoA‐I), as [HDL‐C/apoA‐I]. This ratio estimates HDLs size and provides indices as to their number, cholesterol load, and density. MethodsWe stratified 280 Caucasian T2DM women according to [HDL‐C/apoA‐I] quartiles (Q), to determine how it segregates cardiometabolic risk, β‐cell function, glycemic control, and v...
Source: Diabetes/Metabolism Research and Reviews - September 15, 2017 Category: Endocrinology Authors: Michel P. Hermans, Paul Valensi, Sylvie A. Ahn, Michel F. Rousseau Tags: RESEARCH ARTICLE Source Type: research

Association among total serum isomers of perfluorinated chemicals, glucose homeostasis, lipid profiles, serum protein and metabolic syndrome in adults: NHANES, 2013-2014.
In conclusion, serum isomers of PFOA and PFOS were associated with glucose homeostasis, serum protein as well as lipid profiles; they were also indicators of MS. This may suggest that there is a distinct difference in the toxicokinetics of the isomers of PFOA and PFOS. Further clinical and animal studies are warranted to clarify the putative causal relationships between isomers and biochemical alterations. PMID: 28923343 [PubMed - as supplied by publisher] (Source: Environmental Pollution)
Source: Environmental Pollution - September 15, 2017 Category: Environmental Health Authors: Liu HS, Wen LL, Chu PL, Lin CY Tags: Environ Pollut Source Type: research

Phenolic acids alleviate high ‐fat and high‐fructose diet‐induced metabolic disorders in rats
Abstract Phenolic acids are naturally occurring compounds with meritorious physiological activities. The purpose of this study was to compare the ameliorative effects of six common phenolic acids on diet‐induced metabolic syndrome (MS) in rats. SD rats were fed with high‐fat and high‐fructose diet supplemented with equimolar concentration of individual phenolic acids for 13 weeks. Results showed that different phenolic acids ameliorated MS through different ways. Compared with other phenolic acids, caffeic acid exerted more comprehensive effect in alleviating MS, with significant effects in attenuating hyperlipidemia...
Source: Journal of Food Biochemistry - September 14, 2017 Category: Food Science Authors: Xiaoxuan Guo, Ou Wang, Yong Wang, Kai Wang, Baoping Ji, Feng Zhou Tags: FULL ARTICLE Source Type: research

Melatonin and Periodontal tissues: molecular and clinical perspectives.
Publication date: Available online 14 September 2017 Source:Pharmacological Research Author(s): Agata Rita Carpentieri, María Elena Peralta Lopez, Javier Aguilar, Verónica Mariana Solá Periodontal disease is a frequent chronic inflammatory pathology that implies the destruction of the tissues supporting the teeth, which represents a high sanitary cost. It usually appears associated with other systemic conditions such as diabetes, metabolic syndrome, depression and Alzheimer disease among others. The presence of melatonin and its receptors in the oral cavity supports the hypothesis that this hormone co...
Source: Pharmacological Research - September 14, 2017 Category: Drugs & Pharmacology Source Type: research

Elevated Neutrophil-to-Lymphocyte Ratio in Metabolic Syndrome Is Associated with Increased Risk of Colorectal Adenoma
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - September 14, 2017 Category: Endocrinology Authors: Jae Hyun Kim Kyoung Im Cho Young A. Kim Seun Ja Park Source Type: research

Superior reductions in hepatic steatosis and fibrosis with co-administration of a glucagon-like peptide-1 receptor agonist and obeticholic acid in mice
Conclusion Our data suggest a complementary or synergistic therapeutic effect of GLP-1R and FXR agonism in mouse models of metabolic disease and NASH. (Source: Molecular Metabolism)
Source: Molecular Metabolism - September 14, 2017 Category: Endocrinology Source Type: research

Chronic urticaria and the metabolic syndrome: a cross ‐sectional community‐based study of 11 261 patients
Abstract BackgroundEmerging evidence suggests that chronic urticaria (CU) is associated with chronic, low‐grade, inflammatory process. ObjectiveTo evaluate the association between CU and metabolic syndrome and its components in a large community‐based medical database. MethodsA cross‐sectional study of CU patients and matched controls was performed. CU was defined as eight urticaria diagnoses (with each two diagnoses registered within a period of 6 weeks) from 2002 to 2012. Data regarding the prevalence of metabolic syndrome, its components and possible complications were collected. ResultsThe study included 11 261 p...
Source: Journal of the European Academy of Dermatology and Venereology - September 14, 2017 Category: Dermatology Authors: G. Shalom, E. Magen, M. Babaev, S. Tiosano, D.A. Vardy, D. Linder, A. Horev, A. Saadia, D. Comaneshter, N. Agmon ‐Levin, A.D. Cohen Tags: Original Article Source Type: research

Sleep quality, chronotype and metabolic syndrome components in bipolar disorders during the remission period: Results from the FACE-BD cohort.
Abstract Data on sleep or circadian abnormalities and metabolic disturbances in euthymic bipolar disorders are scarce and based on small sample sizes. The aim of this study was to explore the associations between sleep disturbances, chronotype and metabolic components in a large sample of euthymic patients with bipolar disorders (BD). From 2009 to 2015, 752 individuals with bipolar disorders from the FACE-BD cohort were included and assessed for sleep quality, chronotype and metabolic components. The Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) was used to confirm the diagnosis of BD. Subjectiv...
Source: Chronobiology International - September 14, 2017 Category: Biology Authors: Godin O, Henry C, Leboyer M, Azorin JM, Aubin V, Bellivier F, Polosan M, Courtet P, Gard S, Kahn JP, Loftus J, Passerieux C, Costagliola D, Etain B Tags: Chronobiol Int Source Type: research