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Genetic factors associated with risk of metabolic syndrome and hepatocellular carcinoma.
Authors: Tang R, Liu H, Yuan Y, Xie K, Xu P, Liu X, Wen J Abstract Although the metabolic syndrome is a commonplace topic, its potential threats to public health is a problem that cannot be neglected. As the living conditions improved significantly over the past few years, the morbidity of metabolic syndrome has also steadily risen, and the onset age is becoming younger. The hepatocellular carcinoma (HCC), is one of the most prevalent life-threatening human cancers worldwide, incidence of which is also on the rise, gradually occupied the top of the list associated with metabolic syndrome related complication. Despi...
Source: Oncotarget - May 20, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

An update on the animal models in hyperuricaemia research.
Authors: Zhu Y, Peng X, Ling G Abstract Hyperuricaemia is a metabolic disease caused by purine metabolic abnormalities, mainly due to the increased formation or reduced excretion of uric acid. In recent years, it has been proved that hyperuricaemia is an important risk factor for chronic kidney disease (CKD) and cardiovascular disease, and it also takes part in the pathophysiology of metabolic syndrome. In addition, more attention has been concentrated on the pathogenesis or treatment of hyperuricaemia. Since establishing an animal model on hyperuricaemia is the foundation for further researches, several methods to...
Source: Clinical and Experimental Rheumatology - May 20, 2017 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

A survey of the incidence of dyslipidemia and its components in people over 20 years old in Ahvaz: A cohort study 2009 –2014
Conclusion Age, educational level and daily intake of fruits and vegetables were effective variables on incidence of dyslipidemia. According to various studies, LDL and HDL levels in different regions of Iran, seems to be influenced by factors such as climate, nutrition and activity levels. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - May 20, 2017 Category: Endocrinology Source Type: research

NAFLD as a Sexual Dimorphic Disease: Role of Gender and Reproductive Status in the Development and Progression of Nonalcoholic Fatty Liver Disease and Inherent Cardiovascular Risk
AbstractNonalcoholic fatty liver disease (NAFLD) spans steatosis through nonalcoholic steatohepatis, cirrhosis, and hepatocellular carcinoma (HCC) associated with striking systemic features and excess cardiovascular and liver-related mortality. The pathogenesis of NAFLD is complex and multifactorial. Endocrine derangements are closely linked with dysmetabolic traits. For example, in animal and human studies, female sex is protected from dysmetabolism thanks to young individuals ’ ability to partition fatty acids towards ketone body production rather than very low density lipoprotein (VLDL)-triacylglycerol, and to sex...
Source: Advances in Therapy - May 19, 2017 Category: Drugs & Pharmacology Source Type: research

Basal hyperinsulinemia beyond a threshold predicts major adverse cardiac events at 1 year after coronary angiogram in type 2 diabetes mellitus: a retrospective cohort study
There is a substantial reduction in cardiovascular related morbidity and mortality in the general population attributed to improved treatment of cardiac risk factors and disease, the same magnitude of benefit ... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - May 19, 2017 Category: Endocrinology Authors: Mukund Srinivasan, Padmanabh Kamath, Narayan Bhat, Narasimha Pai, Rajesh Bhat, Tejas Shah, Poornima Manjrekar and Chakrapani Mahabala Source Type: research

Association of the polymorphism in NUCB2 gene and the risk of type 2 diabetes
Nesfatin-1, originating from its precursor protein called nucleobindin 2 (NUCB2), plays an important role in glucose metabolism and diabetes. The aim of this study is to examine the association of the c.1012C>... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - May 19, 2017 Category: Endocrinology Authors: Chunyu Wang, Yulun Wang and Wenchao Hu Source Type: research

Histological Subtypes of Hepatocellular Carcinoma Are Related To Gene Mutations and Molecular Tumour Classification
Malignant primary liver tumours are the second leading cause of cancer-related death worldwide, with an increasing incidence in almost all countries [1]. They are mainly represented by hepatocellular carcinoma (HCC) that results from the malignant transformation of hepatocytes. The most frequent risk factors of HCC comprise alcohol intake, infection by hepatitis B (HBV) or hepatitis C (HCV) viruses, and metabolic syndrome [2]. Although surveillance protocols of patients at-risk to develop HCC have significantly improved, clinical outcome remains poor with a majority of patients presenting with advanced disease not eligible...
Source: Journal of Hepatology - May 19, 2017 Category: Gastroenterology Authors: Julien Calderaro, Gabrielle Couchy, Sandrine Imbeaud, Giuliana Amaddeo, Eric Letouz é, Jean-Frédéric Blanc, Christophe Laurent, Yacine Hajji, Daniel Azoulay, Paulette Bioulac-Sage, Jean-Charles Nault, Jessica Zucman-Rossi Source Type: research

Different Relationship Between Physical Activity, Arterial Stiffness and Metabolic Status in Obese Subjects.
Authors: Joo HJ, Cho SA, Cho JY, Lee S, Park JH, Yu CW, Hong SJ, Lim DS Abstract BACKGROUND: Although the relationship between physical activity and arterial stiffness has been shown in healthy persons, it remains controversial in obese persons. METHODS: From January to September 2014, we evaluated 795 obese subjects from 25 public health centers in Seoul. We compared physical activity and brachial-ankle pulse wave velocity (baPWV) between obese subjects with metabolic syndrome (MetS) (MO) and obese subjects without MetS (NMO). RESULTS: The MO group had more men, higher body mass index (BMI), higher fasting...
Source: Journal of Physical Activity and Health - May 18, 2017 Category: Sports Medicine Tags: J Phys Act Health Source Type: research

Impact of risk-reducing salpingo-oophorectomy in premenopausal women.
CONCLUSIONS: The conclusions of this systematic review are limited by the absence of randomized, controlled trials. There is growing evidence from observational studies that RRSO may impact negatively on all-cause non-survival endpoints. PMID: 28509627 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - May 18, 2017 Category: Geriatrics Authors: Vermeulen RFM, Beurden MV, Korse CM, Kenter GG Tags: Climacteric Source Type: research

Comparing indices of median nerve among diabetic patients with or without metabolic syndrome
Conclusion Components of metabolic syndrome had more influence on sensory indices than motor indices and primary control of these components might prevent dysfunction of sensory neurons and also motor neurons in advanced stages among diabetic patients. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - May 18, 2017 Category: Endocrinology Source Type: research

Are inflammatory cytokines and angiogenic factors a predictive biomarker of diabetes retinopathy?
Publication date: Available online 17 May 2017 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): Alexander E. Berezin (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - May 18, 2017 Category: Endocrinology Source Type: research

Disease management programs for patients with type 2 diabetes mellitus in Germany: a longitudinal population-based descriptive study
The primary aim of the disease management program (DMP) for patients with diabetes mellitus type 2 is to improve the quality of health care and the treatment process. 12  years after its introduction in Germany... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - May 18, 2017 Category: Endocrinology Authors: Michael Mehring, Ewan Donnachie, Florian Cornelius Bonke, Christoph Werner and Antonius Schneider Source Type: research

Prevalence and Predictors of Significant Fibrosis Among Subjects with Transient Elastography-Defined Nonalcoholic Fatty Liver Disease
AbstractBackground/AimsTransient elastography (TE) can be used to assess the degree of liver fibrosis and steatosis. We investigated the prevalence and predictors of nonalcoholic fatty liver disease (NAFLD) with or without significant liver fibrosis in the general population.MethodsA total of 3033 subjects without alcoholic or chronic viral liver diseases who underwent a medical health check-up including TE were recruited from April 2013 to August 2014. TE-defined NAFLD was defined as a controlled attenuation parameter of ≥250 dB/m, and significant liver fibrosis was defined as a liver stiffness (LS) value of ≥8...
Source: Digestive Diseases and Sciences - May 18, 2017 Category: Gastroenterology Source Type: research

Serum Alanine Aminotransferase Trends and Their Relationship with Obesity and Metabolic Syndrome in United States Adolescents, 1999 –2014
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - May 18, 2017 Category: Endocrinology Source Type: research

PC214 In Vivo Evaluation of Ischemia-Reperfusion Injury of Skeletal Muscle, Using 3-Carbamoyl-PROXYL-Enhanced MRI
Myonephropathic metabolic syndrome is caused by ischemia-reperfusion injury to skeletal muscle, following revascularization of an acute arterial occlusion in an extremity. Although ongoing research into ischemia-reperfusion injury has revealed that off-balance of the redox status plays an important role in this pathologic condition, detection of a free radical reaction at the injury site has been difficult. The purpose of this study was to evaluate a redox reaction at ischemia-reperfusion injury sites. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - May 17, 2017 Category: Surgery Authors: Yoshinori Kuroda, Tetsuro Uchida, Hitoshi Togashi, Kazuyuki Haga, Ai Takahashi, Kimihiro Kobayashi, Shingo Nakai, Mitsuaki Sadahiro Tags: C10: Poster Competition Source Type: research

Cardiovascular Drift during Training for Fitness in Metabolic Syndrome Patients—Erratum
No abstract available (Source: Medicine and Science in Sports and Exercise)
Source: Medicine and Science in Sports and Exercise - May 17, 2017 Category: Sports Medicine Tags: SPECIAL COMMUNICATIONS: Erratum Source Type: research

The predictors of metabolic syndrome based on Walker Health-Promoting lifestyle in Iran 2016
Conclusion Considering the results of this study, the greater emphasis in planning and interventions to reduce the risk of metabolic syndrome should be spotted on physical activity and stress management in patients with the metabolic syndrome. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - May 17, 2017 Category: Endocrinology Source Type: research

Assessment of Framingham Risk Score and Systemic Coronary Risk Evaluation in Rosacea Patients
Conclusion Rosacea patients did not have an increased risk of cardiovascular disease, as estimated by the two validated models. However, further studies are needed with the four subtypes of rosacea to evaluate cardiovascular risk factors separately. (Source: Dermatologica Sinica)
Source: Dermatologica Sinica - May 17, 2017 Category: Dermatology Source Type: research

Plasma Trans-fatty Acids Concentrations Continue to Be Associated with Metabolic Syndrome Among U.S. Adults after Reductions in Trans-fatty Acid Intake
No study examined and compared the association between intake of trans-fatty acids (TFAs) and risk of metabolic syndrome before and after significant reduction of TFA intakes in the U.S. population. We hypothesized that the relationship might remain significant after substantial reduction of TFA intakes in the population. We used data on 1442 and 2233 adults aged ≥20years from NHANES 1999–2000 and 2009–2010, respectively. Multivariable logistic regression analysis was used to assess the association between plasma TFA concentrations and metabolic syndrome, including each of its 5 components. (Source: Nutrition Research)
Source: Nutrition Research - May 17, 2017 Category: Nutrition Authors: Zefeng Zhang, Cathleen Gillespie, Quanhe Yang Source Type: research

Reducing health inequalities for people with serious mental illness.
This article discusses four areas of health that commonly affect people with SMI: metabolic syndrome, smoking, oral health and sexual health. Metabolic syndrome is a cluster of risk factors that increase an individual's risk of cardiovascular disease, stroke and type 2 diabetes mellitus. Smoking is increasingly prevalent in people with SMI, with rates remaining steady despite a decline in smoking rates nationally. Oral health and sexual health can negatively affect the physical health and well-being of people with SMI; however, these aspects of health are often neglected. This article identifies ways that nurses in all pra...
Source: Nursing Standard - May 17, 2017 Category: Nursing Authors: Hallett N, Rees H Tags: Nurs Stand Source Type: research

The Role of Diet in Patients with Metabolic Syndrome.
ute;nchez N Abstract Metabolic syndrome is a frequent metabolic disorder characterized by obesity and insulin resistance seems to be the main pathophysiological alteration. The goal of treating metabolic syndrome is to reduce the risk of coronary heart disease and the development of type 2 diabetes. The lifestyle modification therapy combines specific recommendations on diet alone or combined with other strategies. In this review, we address the following topics: 1) the importance of the high prevalence of metabolic syndrome and obesity, and 2) the role of lifestyle modification focusing on dietary fat intake in t...
Source: Current Medicinal Chemistry - May 17, 2017 Category: Chemistry Authors: Almeda-Valdes P, Herrera-Mercadillo RJ, Aguilar-Salinas CA, Uribe M, Méndez-Sánchez N Tags: Curr Med Chem Source Type: research

Diet after cholecystectomy.
Abstract Patients with gallstones are often affected by alimentary disorders contributing to the onset of gallstones disease. Cholecystectomy can have nutritional and metabolic consequences in the short-term (diarrhea, abdominal pain and bloating) and in the long-term (increased Body Mass Index with metabolic syndrome, gastritis, liposoluble vitamin deficiency). Pathogenic mechanisms behind these disturbances are reviewed and the need for an early post-operative nutritional intervention based on low-lipid, high-fibers diet, is highlighted. PMID: 28521679 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 17, 2017 Category: Chemistry Authors: Altomare DF, Rotelli MT, Palasciano N Tags: Curr Med Chem Source Type: research

Prevalence of abdominal obesity and its association with cardio metabolic risk factors among older adults in Ecuador
Conclusions the prevalence of abdominal obesity is high among older adults in Ecuador. Moreover, abdominal obesity is significantly associated with cardio metabolic risk factors. Therefore, further research is needed to evaluate sociodemographic and nutritional determinants of this emerging public health burden among older Ecuadorians. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - May 16, 2017 Category: Endocrinology Source Type: research

The effects of vitamin D supplementation on proatherogenic inflammatory markers and carotid intima media thickness in subjects with metabolic syndrome: a randomized double-blind placebo-controlled clinical trial
AbstractPurposeMetabolic syndrome may predispose to cardiovascular diseases. Since, in recent studies, vitamin D is advocated for cardioprotective roles, this study was designed to investigate the effects of vitamin D supplementation on proatherogenic inflammatory markers and common carotid intima media thickness in subjects with metabolic syndrome.MethodsThis randomized double blind clinical trial was conducted in Tabriz, Iran. Eligible subjects (n = 80) with metabolic syndrome were recruited thorough advertisement and randomized to receive either vitamin D (50,000 IU/week) or matching placebo for 16 ...
Source: Endocrine - May 16, 2017 Category: Endocrinology Source Type: research

Simple anthropometric indices are useful for predicting Non-alcoholic fatty liver disease [NAFLD] in Asian Indians
Conclusions The simple anthropometric parameters, such as BMI, waist circumference, waist-hip ratio and waist-height ratio are useful for predicting NAFLD in Indian adults. The anthropometry cut offs would be very useful in setting target points of life style modification and weight reduction. Besides, our study also clearly demonstrated that a simple assessment of BMI, is as efficacious as other anthropometry parameters in predicting NAFLD. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - May 16, 2017 Category: Gastroenterology Source Type: research

Influence of a home-based exercise program on the urine pH in elderly female subjects: a secondary analysis of a randomized controlled trial
AbstractBackgroundA low urine pH is a characteristic metabolic feature of metabolic syndrome and type 2 diabetes. The purpose of the current study was to investigate the effects of a 12-week home-based bench step exercise on the urine pH status of elderly female subjects.MethodsThe current study is a secondary analysis of a randomized controlled trial (RCT) in which 59 postmenopausal female subjects were randomized to either the exercise group (n = 29) or the control group (n = 30). The subjects in the exercise group were instructed to perform home-based exercises using a bench step at the anaer...
Source: European Review of Aging and Physical Activity - May 16, 2017 Category: Geriatrics Source Type: research

Impact of dietary intake, lifestyle and biochemical factors on metabolic health in obese adolescents
Conclusions In obese adolescents metabolic health was related to anthropometric and biochemical parameters and only weak associations were found with most of the studied lifestyle factors. Uric acid concentration associated with metabolic health when abdominal obesity was excluded. (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Source: Nutrition, Metabolism and Cardiovascular Diseases - May 16, 2017 Category: Nutrition Source Type: research

Absolute and relative accelerometer thresholds for determining the association between physical activity and metabolic syndrome in the older adults: The Generation-100 study
When assessing population adherence to physical activity (PA) recommendation using accelerometers, absolute intensity threshold definition is applied despite having limited validity in those with low cardiores... (Source: BMC Geriatrics)
Source: BMC Geriatrics - May 16, 2017 Category: Geriatrics Authors: Nina Zisko, Javaid Nauman, Silvana Bucher Sandbakk, Nils Petter Aspvik, Øyvind Salvesen, Trude Carlsen, Hallgeir Viken, Jan Erik Ingebrigtsen, Ulrik Wisløff and Dorthe Stensvold Source Type: research

A Pilot Study of Physical Activity and Sedentary Behavior Distribution Patterns in Older Women
Physical inactivity is defined as a lack of regular moderate-to-vigorous physical activity (MVPA), whereas sedentary behavior (SB) is defined as sitting/reclining with low energy expenditure while awake. Physical inactivity and SB are recognized as two distinct and separate risk factors for metabolic syndrome and cardiovascular disease (CVD), in addition to not enough low-intensity physical activity (LPA) and sleep [1]. Understanding the health benefits of replacing sedentary time with LPA or sleep is of substantial public health interest, particularly for older adults as physical inactivity and metabolic syndrome prevalen...
Source: Gait and Posture - May 16, 2017 Category: Orthopaedics Authors: Emma Fortune, Benjamin Mundell, Shreyasee Amin, Kenton Kaufman Source Type: research

Spiritual well-being, religious activity, and the metabolic syndrome: results from the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study
AbstractSociocultural risk and protective factors for developing the metabolic syndrome (MetS), a risk factor for cardiovascular disease (CVD), have not been well studied in Hispanics/Latinos residing in the United States (U.S.). Religiosity and/or spirituality (R/S), important aspects of Hispanic/Latino culture, have been inversely associated with CVD and multiple CVD risk factors. Cross-sectional associations between dimensions of R/S and prevalent MetS, and its five individual components were examined using multiple logistic and linear regression, among 3278 U.S., middle-aged and older Hispanic/Latino adults from the Hi...
Source: Journal of Behavioral Medicine - May 15, 2017 Category: Psychiatry Source Type: research

Plasminogen Activator Inhibitor-1 and Pericardial Fat in Individuals with Type 2 Diabetes Mellitus
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - May 15, 2017 Category: Endocrinology Source Type: research

Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review
In recent years, metabolic syndromes (MetSs), including diabetes mellitus, dyslipidemia, and cardiovascular diseases, have become a common health problem in both developed and developing countries. Accumulating data have suggested that traditional herbs might be able to provide a wide range of remedies in prevention and treatment of MetSs. Ginger (Zingiber officinale Roscoe, Zingiberaceae) has been documented to ameliorate hyperlipidemia, hyperglycemia, oxidative stress, and inflammation. These beneficial effects are mediated by transcription factors, such as peroxisome proliferator–activated receptors, adenosine mon...
Source: Annals of the New York Academy of Sciences - May 15, 2017 Category: Science Authors: Jing Wang, Weixin Ke, Rui Bao, Xiaosong Hu, Fang Chen Tags: CONCISE REVIEW Source Type: research

Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis
ConclusionsSerum HBsAg positivity is inversely associated with the prevalence of MetS. Among the five components of MetS, elevated triglycerides had the strongest inverse relationship with HBsAg positivity. (Source: PLoS One)
Source: PLoS One - May 15, 2017 Category: Biomedical Science Authors: Yuanyuan Li Source Type: research

Increased adipose tissue expression of IL ‐18R and its ligand IL‐18 associates with inflammation and insulin resistance in obesity
Abstract IntroductionThe proinflammatory cytokine IL‐18 is involved in the pathogenesis of metabolic syndrome. While the changes in IL‐18 are known, IL‐18R expression and relationship with IL‐18 and other inflammatory markers in the adipose tissue in obesity/type‐2 diabetes (T2D) remain unclear. MethodsWe, therefore, determined the adipose tissue expression of IL‐18R and IL‐18 mRNA/protein in lean, overweight, and obese individuals with and without T2D, 15 each, using qRT‐PCR, immunohistochemistry, and confocal microscopy. Data (mean ± SEM) were analyzed using unpaired t‐test and Pear...
Source: Immunity, Inflammation and Disease - May 15, 2017 Category: Allergy & Immunology Authors: Rasheed Ahmad, Reeby Thomas, Shihab Kochumon, Sardar Sindhu Tags: Original Research Source Type: research

Vildagliptin has the same safety profile as a sulfonylurea on bone metabolism and bone mineral density in post-menopausal women with type 2 diabetes: a randomized controlled trial
The objective of this study is to compare the effects of vildagliptin and gliclazid... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - May 15, 2017 Category: Endocrinology Authors: Andre Gustavo Daher Vianna, Claudio Silva de Lacerda, Luciana Muniz Pechmann, Michelle Garcia Polesel, Emerson Cestari Marino, Victoria Zeghbi Cochenski Borba and Fellype de Carvalho Barreto Source Type: research

Mesenchymal stem cell therapy in type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM), which is characterized by the combination of relative insulin deficiency and insulin resistance, cannot be reversed with existing therapeutic strategies. Transplantation of ins... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - May 15, 2017 Category: Endocrinology Authors: Li Zang, Haojie Hao, Jiejie Liu, Yijun Li, Weidong Han and Yiming Mu Source Type: research

Serum YKL-40 as a potential biomarker of inflammation in psoriasis.
Authors: Baran A, Myśliwiec H, Szterling-Jaworowska M, Kiluk P, Świderska M, Flisiak I Abstract OBJECTIVE: YKL-40 is an inflammatory glycoprotein associated with atherosclerosis, cardiovascular disease, diabetes or metabolic syndrome which are common comorbidities in psoriasis. The aim of the study was to assess serum YKL-40 level in psoriasis and elucidate possible associations with disease activity, inflammatory or metabolic parameters and treatment. METHODS: A total of 37 individuals with active plaque-type psoriasis and 15 healthy controls were enrolled. Blood samples were collected before and after two w...
Source: Journal of Dermatological Treatment - May 14, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

NASH Therapy: omega 3 supplementation, vitamin E, insulin sensitizers and statin drugs.
Authors: Caldwell S Abstract Non-alcoholic steatohepatitis (NASH) is the more aggressive form of non-alcoholic fatty liver disease (NAFLD). NASH can progress to hepatic fibrosis, cirrhosis, portal hypertension and primary liver cancer. Therapy is evolving with a substantial number of trials of promising new agents now in progress. In this article however, we will examine data for several older forms of therapy which have been fairly extensively studied over the years: Polyunsaturated Fatty Acid (PUFA) supplements, vitamin E, insulin sensitizing agents with a focus on pioglitazone and statin agents. Early interest i...
Source: Clinical and molecular hepatology - May 14, 2017 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Relationships Among Factors Relevant to Abdominal Fat and Age-Related Hearing Loss.
Conclusion: We found that FRAs were associated with hearing loss with frequency specific characteristics according to sex and reinforced that DM and VAT is particularly an important role for hearing. PMID: 28494527 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Otorhinolaryngology)
Source: Clinical and Experimental Otorhinolaryngology - May 14, 2017 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Metabolic Syndrome and Hypertension Resulting from Fructose Enriched Diet in Wistar Rats.
Abstract Increased sugar consumption, especially fructose, is strongly related to the development of type 2 diabetes (T2D) and metabolic syndrome. The aim of this study was to evaluate long term effects of fructose supplementation on Wistar rats. Three-week-old male rats were randomly divided into 2 groups: control (C; n = 14) and fructose fed (FF; n = 18), with a fructose enriched drink (20-25% w/v fructose in water) for 21 weeks. Systolic blood pressure, fasting glycemia, and bodyweight were regularly measured. Glucose tolerance was evaluated three times using an oral glucose tolerance test. Insulin levels were ...
Source: Biomed Res - May 14, 2017 Category: Research Authors: Dupas J, Feray A, Goanvec C, Guernec A, Samson N, Bougaran P, Guerrero F, Mansourati J Tags: Biomed Res Int Source Type: research

Correlation of Resistin Serum Level with Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism in Obese Women with Type 2 Diabetes
Conclusion There was no significant association between rs9939609 and resistin serum level in type 2 obese diabetic women while percentile ranges (25th, 50th and 75th) of resistin concentrations was high in diabetic group. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - May 14, 2017 Category: Endocrinology Source Type: research

Association between metabolic syndrome and chronic kidney disease in a Chinese urban population
Conclusions MetS was highly prevalent in the middle-aged and elderly Chinese population in the city of Jinan. There was a graded relationship between the number of MetS components and risk of CKD. High fasting blood glucose levels were the main risk factor of reduced renal function. High blood pressure, high fasting blood glucose levels and high triglycerides were main risk factors for proteinuria. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 14, 2017 Category: Laboratory Medicine Source Type: research

Erratum to 'Pleiotropic protective effects of vitamin D against high fat diet-induced metabolic syndrome in rats: One for all' [Eur. J. Pharmacol. 792 (2016) 38-47].
PMID: 28495015 [PubMed - in process] (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - May 13, 2017 Category: Drugs & Pharmacology Authors: Mostafa DK, Nasra RA, Zahran N, Ghoneim MT Tags: Eur J Pharmacol Source Type: research

The Association between Ghrelin Levels and Markers of Arterial Stiffness and Inflammatory Markers in Saudi Subjects with Metabolic Syndrome
Conclusions Depending on our outcomes showing the valuable properties of ghrelin in the cardiovascular system in patients with metabolic syndrome, it can be postulated that ghrelin may be associated with markers of atherosclerosis. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - May 13, 2017 Category: Endocrinology Source Type: research

Cardiovascular Risk Stratification in Patients with Metabolic Syndrome Without Diabetes or Cardiovascular Disease: Usefulness of Metabolic Syndrome Severity Score
ConclusionIn this population, the calculated cardiovascular risk was heterogenic. The prevalence of carotid plaque was high. The Metabolic Syndrome Severity Calculator showed a good predictive power to detect carotid plaque. (Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - May 13, 2017 Category: Cardiology Source Type: research

Nonalcoholic Fatty Liver Disease in Children
Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome and has become the most common form of chronic liver disease in children and adolescents. The histologic spectrum of NAFLD is broad ranging, from the relatively benign form of simple steatosis to the aggressive form of nonalcoholic steatohepatitis, eventually leading to fibrosis and cirrhosis. NAFLD has also been recognized as an independent risk factor for extrahepatic complications, such as cardiovascular disease, type 2 diabetes mellitus, sleep disorders, and osteoporosis. In this review, we discuss both the hepatic an...
Source: Pediatric Clinics of North America - May 12, 2017 Category: Pediatrics Authors: Praveen Kumar Conjeevaram Selvakumar, Mohammad Nasser Kabbany, Valerio Nobili, Naim Alkhouri Source Type: research

Nonalcoholic fatty liver disease: implications for cardiovascular risk
Nonalcoholic fatty liver disease (NAFLD) is a growing epidemic in the USA affecting ∼30% of the population. It has been closely linked to metabolic syndrome and type 2 diabetes, with strong implications for cardiovascular disease (CVD). This review focuses on the relationship between NAFLD and CVD and the proposed interactions interlinking these two diseases. This appraisal also discusses treatments targeting NAFLD in the context of CVD. NAFLD is a multisystem disease and ultimately the goals of therapy are to ameliorate CVD and prevent coronary artery disease morbidity and mortality. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - May 12, 2017 Category: Cardiology Tags: Review articles Source Type: research

Effects of testosterone replacement therapy on metabolic syndrome among Japanese hypogonadal men: A subanalysis of a prospective randomised controlled trial (EARTH study)
Summary We investigated the effects of testosterone replacement therapy (TRT) on metabolic factors among hypogonadal men with a metabolic syndrome. From the study population of the EARTH study, which was a randomised controlled study in Japan, 65 hypogonadal patients with a metabolic syndrome, comprising the TRT group (n = 32) and controls (n = 33), were included in this study analysis. The TRT group was administered 250 mg of testosterone enanthate as an intramuscular injection every 4 weeks for 12 months. Waist circumference, body mass index, body fat volume and blood pressure were me...
Source: Andrologia - May 12, 2017 Category: Urology & Nephrology Authors: K. Shigehara, H. Konaka, T. Nohara, K. Izumi, Y. Kitagawa, Y. Kadono, T. Iwamoto, E. Koh, A. Mizokami, M. Namiki Tags: ORIGINAL ARTICLE Source Type: research

Roles of fasting and postprandial blood glucose in the effect of type 2 diabetes on central arterial stiffness: a 5-year prospective community-based analysis
Cardiovascular disease constitutes a major challenge for the health of community-dwelling population, it is essential to delay the development of atherosclerosis. However, long-term prospective studies analyzi... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - May 12, 2017 Category: Endocrinology Authors: Shihui Fu, Wenji Chen, Leiming Luo and Ping Ye Source Type: research

Gene variants in the FTO gene are associated with adiponectin and TNF-alpha levels in gestational diabetes mellitus
Obesity may have a role in the development of gestational diabetes mellitus (GDM). Single-nucleotide-polymorphisms (SNPs) of the FTO (fat mass and obesity associated) gene have been associated with obesity. Th... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - May 12, 2017 Category: Endocrinology Authors: Renata Saucedo, Jorge Valencia, Claudia Gutierrez, Lourdes Basurto, Marcelino Hernandez, Edgardo Puello, Guadalupe Rico, Gloria Vega and Arturo Zarate Source Type: research