Comparative Efficacy of Augmenting Escitalopram with Modified Electroconvulsive Therapy or High-Frequency Repetitive Transcranial Magnetic Stimulation on Depressive Symptoms, Quality of Life, and Cognitive Function in Treatment-Resistant Depression
Tohoku J Exp Med. 2023 Dec 28. doi: 10.1620/tjem.2023.J103. Online ahead of print.NO ABSTRACTPMID:38171724 | DOI:10.1620/tjem.2023.J103 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - January 3, 2024 Category: Research Authors: Bo-Wen Yin Liu Yang Source Type: research
Comparative Efficacy of Augmenting Escitalopram with Modified Electroconvulsive Therapy or High-Frequency Repetitive Transcranial Magnetic Stimulation on Depressive Symptoms, Quality of Life, and Cognitive Function in Treatment-Resistant Depression
Tohoku J Exp Med. 2023 Dec 28. doi: 10.1620/tjem.2023.J103. Online ahead of print.NO ABSTRACTPMID:38171724 | DOI:10.1620/tjem.2023.J103 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - January 3, 2024 Category: Research Authors: Bo-Wen Yin Liu Yang Source Type: research
Comparative Efficacy of Augmenting Escitalopram with Modified Electroconvulsive Therapy or High-Frequency Repetitive Transcranial Magnetic Stimulation on Depressive Symptoms, Quality of Life, and Cognitive Function in Treatment-Resistant Depression
Tohoku J Exp Med. 2023 Dec 28. doi: 10.1620/tjem.2023.J103. Online ahead of print.NO ABSTRACTPMID:38171724 | DOI:10.1620/tjem.2023.J103 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - January 3, 2024 Category: Research Authors: Bo-Wen Yin Liu Yang Source Type: research
Efficacy and safety of repeated transcranial magnetic stimulation combined with escitalopram in the treatment of major depressive disorder: a meta-analysis
ConclusionOur findings suggest that rTMS combined with escitalopram can benefit patients with MDD in a safe manner, which may help in guiding clinical practice.Systematic review registrationDOI number: 10.37766/inplasy2023.11.0114, INPLASY2023110114. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - January 3, 2024 Category: Psychiatry Source Type: research
36-Year-Old Woman With Progressive Dyspnea, Cough, and Chills
A 36-year-old woman presented to the hospital for evaluation of progressively worsening dyspnea on exertion. She had a pertinent medical history of anxiety, polycystic ovary syndrome, and rheumatoid arthritis work-up with her primary care provider. Her home medications included escitalopram, gabapentin, glucosamine-chondroitin, loratadine, multivitamin, acetaminophen, and ibuprofen. She reported 2 weeks of progressively worsening dyspnea on exertion with associated nonproductive cough, chills, sore throat, and palpitations. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - January 1, 2024 Category: Internal Medicine Authors: Megan M. Ellis, Nayla Ahmed, Eva M. Carmona Tags: Residents ’ clinic Source Type: research
Adverse drug events associated with nortriptyline compared with paroxetine and alternative medications in an older adult population: a retrospective cohort study in Southern California
Conclusions
Compared with therapeutic alternatives, nortriptyline was found to represent a lower risk for falls, fractures and syncope, versus comparator medications, except for a few instances that had equivalent risk. The risk for these adverse events from paroxetine was comparable to the alternative medications. (Source: BMJ Open)
Source: BMJ Open - December 28, 2023 Category: General Medicine Authors: George, M. M., Deamer, R. L., Do, D. Tags: Open access, Geriatric medicine Source Type: research
Drug-induced QT prolongation and torsade de pointes: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System database
Conclusion: Our study provided a real-world overview of QT prolongation and TdP to drugs, and the presentation of the potential culprit-drug list, the proportion of reports, the detection results of ADR signals, and the distribution characteristics of ADR signals may help understand the safety profile of drugs and optimize clinical practice. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 21, 2023 Category: Drugs & Pharmacology Source Type: research
Saikosaponin-d alleviates depression by promoting NLRP3 ubiquitination and inhibiting inflammasome activation
This study's objective was to ascertain how SSd may reduce depression in depressed mice subjected to chronic unpredictable animal stress (CUMS) and to investigate the mechanisms underlying these effects. Models of CUMS depression were established and different groups were treated with SSd and escitalopram. After the last day of administration of the treatment, behavioral tests were performed. ELISA was used to measure the expression of IL-1β, TNF-α, and IL-18, and western blot was used to measure the presence of proteins associated with NLRP3. Hippocampal neuronal damage was observed using Nissl staining, and NLRP3 ubiqu...
Source: International Immunopharmacology - December 9, 2023 Category: Allergy & Immunology Authors: Tiantian Gao Tao Wang Lili Wu Yue Tong Jinlong Tian Keke Zhao Hanqing Wang Source Type: research
Saikosaponin-d alleviates depression by promoting NLRP3 ubiquitination and inhibiting inflammasome activation
This study's objective was to ascertain how SSd may reduce depression in depressed mice subjected to chronic unpredictable animal stress (CUMS) and to investigate the mechanisms underlying these effects. Models of CUMS depression were established and different groups were treated with SSd and escitalopram. After the last day of administration of the treatment, behavioral tests were performed. ELISA was used to measure the expression of IL-1β, TNF-α, and IL-18, and western blot was used to measure the presence of proteins associated with NLRP3. Hippocampal neuronal damage was observed using Nissl staining, and NLRP3 ubiqu...
Source: International Immunopharmacology - December 9, 2023 Category: Allergy & Immunology Authors: Tiantian Gao Tao Wang Lili Wu Yue Tong Jinlong Tian Keke Zhao Hanqing Wang Source Type: research
Efficacy of Preventing Relapse Evaluated by a Multicenter Randomized Double-Blind Placebo-Controlled Withdrawal Study of Escitalopram in Japanese Adolescents with Major Depressive Disorder
Journal of Child and Adolescent Psychopharmacology, Ahead of Print. (Source: Journal of Child and Adolescent Psychopharmacology)
Source: Journal of Child and Adolescent Psychopharmacology - December 7, 2023 Category: Pediatrics Authors: Takuya Saito Hidetoshi Takahashi Noa Tsujii Tsuyoshi Sasaki Yuta Yamaguchi Masahiro Takatsu Masaki Sato Source Type: research
Effects of electroacupuncture at Baihui (GV20) and Yintang (GV29) on endoplasmic reticulum stress in depressive rats caused by chronic unpredictable mild stress
ConclusionEA at Baihui (GV20) and Yintang (GV29) can significantly mitigate behavioral deficits of rats with CUMS-induced depression. The mechanism may be related to adjusting the ERS and inhibiting cell apoptosis. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - December 1, 2023 Category: Complementary Medicine Source Type: research
Pharmacological treatments in panic disorder in adults: a network meta-analysis
CONCLUSIONS: In terms of efficacy, SSRIs, SNRIs (venlafaxine), TCAs, MAOIs and BDZs may be effective, with little difference between classes. However, it is important to note that the reliability of these findings may be limited due to the overall low quality of the studies, with all having unclear or high risk of bias across multiple domains. Within classes, some differences emerged. For example, amongst the SSRIs paroxetine and fluoxetine seem to have stronger evidence of efficacy than sertraline. Benzodiazepines appear to have a small but significant advantage in terms of tolerability (incidence of dropouts) over other ...
Source: Cochrane Database of Systematic Reviews - November 28, 2023 Category: General Medicine Authors: Giuseppe Guaiana Nicholas Meader Corrado Barbui Simon Jc Davies Toshi A Furukawa Hissei Imai Sofia Dias Deborah M Caldwell Markus Koesters Aran Tajika Irene Bighelli Alessandro Pompoli Andrea Cipriani Sarah Dawson Lindsay Robertson Source Type: research
Pharmacological treatments in panic disorder in adults: a network meta-analysis
CONCLUSIONS: In terms of efficacy, SSRIs, SNRIs (venlafaxine), TCAs, MAOIs and BDZs may be effective, with little difference between classes. However, it is important to note that the reliability of these findings may be limited due to the overall low quality of the studies, with all having unclear or high risk of bias across multiple domains. Within classes, some differences emerged. For example, amongst the SSRIs paroxetine and fluoxetine seem to have stronger evidence of efficacy than sertraline. Benzodiazepines appear to have a small but significant advantage in terms of tolerability (incidence of dropouts) over other ...
Source: Cochrane Database of Systematic Reviews - November 28, 2023 Category: General Medicine Authors: Giuseppe Guaiana Nicholas Meader Corrado Barbui Simon Jc Davies Toshi A Furukawa Hissei Imai Sofia Dias Deborah M Caldwell Markus Koesters Aran Tajika Irene Bighelli Alessandro Pompoli Andrea Cipriani Sarah Dawson Lindsay Robertson Source Type: research
Escitalopram versus other antidepressive agents for major depressive disorder: a systematic review and meta-analysis
Escitalopram is selective serotonin reuptake inhibitors (SSRIs) and one of the most commonly prescribed newer antidepressants (ADs) worldwide. We aimed to explore the efficacy, acceptability and tolerability o... (Source: BMC Psychiatry)
Source: BMC Psychiatry - November 24, 2023 Category: Psychiatry Authors: Juntao Yin, Xiaoyong Song, Chaoyang Wang, Xuhong Lin and Mingsan Miao Tags: Research Source Type: research
Machine Learning Prediction of Quality of Life Improvement During Antidepressant Treatment of Patients With Major Depressive Disorder: A STAR*D and CAN-BIND-1 Report
Conclusions: Machine learning can predict normative QoL after antidepressant treatment with similar performance to that of prior work predicting depressive symptom response and remission. These results suggest that QoL outcomes in MDD patients can be predicted with simple patient-rated measures and provide a foundation to further improve performance and demonstrate clinical utility.Trial Registration: ClinicalTrials.gov identifiers NCT00021528 and NCT01655706.PMID:37967350 | DOI:10.4088/JCP.23m14864 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 15, 2023 Category: Psychiatry Authors: Tejas Phaterpekar John-Jose Nunez Emma Morton Yang S Liu Bo Cao Benicio N Frey Roumen V Milev Daniel J M üller Susan Rotzinger Claudio N Soares Valerie H Taylor Rudolf Uher Sidney H Kennedy Raymond W Lam Source Type: research
