The Relevance of Integrating CYP2C19 Phenoconversion Effects into
Clinical Pharmacogenetics
Discussion PC of CYP2C19 changes phenotypes but does not improve
correlations with serum concentrations. However, only a limited number of
patients received perturbators of CYP2C19. Studies with large numbers of
patients are still lacking, and thus, it cannot be decided if there are minor
differences and which method of correction to use. For the time being, PC is
relevant in individual patients treated with CYP2C19-affecting drugs, for
example, esomeprazole. To ensure adequate serum concentrations in these
patients, this study suggests the use of therap...
Source: Pharmacopsychiatry - February 14, 2024 Category: Psychiatry Authors: Scherf-Clavel, Maike Weber, Heike Unterecker, Stefan Frantz, Amelie Eckert, Andreas Reif, Andreas Deckert, J ürgen Hahn, Martina Tags: Original Paper Source Type: research
Pharmacogenetic Factors Influence Escitalopram Pharmacokinetics and Adverse Events in Youth with a Family History of Bipolar Disorder: A Preliminary Study
Journal of Child and Adolescent Psychopharmacology,Volume 34, Issue 1, Page 42-51, February 2024. (Source: Journal of Child and Adolescent Psychopharmacology)
Source: Journal of Child and Adolescent Psychopharmacology - February 14, 2024 Category: Pediatrics Authors: Duncan C. Honeycutt Thomas J. Blom Laura B. Ramsey Jeffrey R. Strawn Kaitlyn M. Bruns Jeffrey A. Welge Luis R. Patino Manpreet K. Singh Melissa P. DelBello Source Type: research
Letter to the Editor: The Impact of Adherence and CYP2C19 Phenotype on Escitalopram Exposure in Adolescents
Journal of Child and Adolescent Psychopharmacology,Volume 34, Issue 1, Page 67-69, February 2024. (Source: Journal of Child and Adolescent Psychopharmacology)
Source: Journal of Child and Adolescent Psychopharmacology - February 14, 2024 Category: Pediatrics Authors: W. Thomas Baumel Ethan A. Poweleit Zoe Neptune Heidi K. Schroeder Laura B. Ramsey Jeffrey Mills Jeffrey R. Strawn Source Type: research
The place of selective serotonin reuptake inhibitors (SSRIs) in the treatment of depressive disorders in children and adolescents. Recommendations of the Main Board of the Polish Psychiatric Association. Part 1 - Clinical efficacy and areas of application
Psychiatr Pol. 2023 Oct 31;57(5):899-916. doi: 10.12740/PP/171463. Epub 2023 Oct 31.ABSTRACTIn the adult population of patients with major depression, both psychotherapeutic and pharmacological interventions are effective, but antidepressants remain the mainstay of treatment. In the case of child and adolescent psychiatry, there is still controversy over whether to use pharmacological interventions and which drug to prefer. Although psychotherapeutic treatment is still considered a first-line treatment, antidepressants are widely used to treat depression in children and adolescents, and the number of medications prescribed...
Source: Psychiatria Polska - February 12, 2024 Category: Psychiatry Authors: Ma łgorzata Honorata Janas-Kozik Agnieszka S łopień Barbara Remberk Marcin Siwek Source Type: research
Microdosing ketamine in Drosophila does not block serotonin reuptake, but causes complex behavioral changes mediated by glutamate and serotonin receptors
Microdosing ketamine is a novel depression treatment, but it is not clear how it changes serotonin.Drosophila melanogaster (fruit fly) is a good model to study depressive behaviors. We used fast-scan cyclic voltammetry, video tracking, and feeding assays to measure serotonin and behavior after feeding ketamine and SSRIs to larvae. At microdoses, ketamine did not affect serotonin, which was different from SSRIs. However, higher doses inhibited dSERT. Locomotion and feeding changes were also dose-dependent, and we saw separate effects with NMDA and serotonin receptor drugs in a dSERT mutant. This work facilitates future beha...
Source: Journal of Neurochemistry - February 7, 2024 Category: Neuroscience Authors: Kelly E. Dunham,
Kani H. Khaled,
Leah Weizman,
B. Jill Venton Tags: ORIGINAL ARTICLE Source Type: research
Forensic investigation on a combined death by food aspiration and acute escitalopram intoxication occurred to a psychiatric subject in a nursing home
AbstractFood aspiration is one of the major health risks for elderly people in nursing homes which could lead to death. Moreover, misconducts in pharmacotherapy may represent a potential risk of adverse drug reactions. It is reported here the toxicological evaluation of a combined death by food aspiration and acute escitalopram intoxication of a psychiatric subject, occurred in a nursing home. An 89-year-old man, suffering from dysphagia and Alzheimer ’s, was resident in a nursing home. He was fed with a liquid diet administered directly in mouth using a syringe. The man was also being treated with escitalopram 10 mg ta...
Source: International Journal of Legal Medicine - February 6, 2024 Category: Medical Law Source Type: research
