Real-World Study on Effectiveness of Insulin Glargine U300 After Oral Antidiabetic Drug Failure in Patients with Type 2 Diabetes in the Gulf Region
ConclusionsIn the Gulf, Gla-300 in patients with T2DM uncontrolled on OADs improved glycemic control, with low rates of hypoglycemia and improved PROs. Gla-300 dose up-titration from baseline to month 6 did not, however, result in a vast proportion of patients achieving their pre-determined HbA1c targets.Trial RegistrationClinicalTrials.gov identifier: NCT03703869. (Source: Diabetes Therapy)
Source: Diabetes Therapy - February 15, 2024 Category: Endocrinology Source Type: research
Cardiovascular Outcomes in GRADE (Glycemia Reduction Approaches in Type 2 Diabetes: A Comparative Effectiveness Study)
CONCLUSIONS: This comparative effectiveness study of a contemporary cohort of adults with type 2 diabetes, largely without established cardiovascular disease, suggests that liraglutide treatment may reduce the risk of cardiovascular events in patients at relatively low risk compared with other commonly used glucose-lowering medications.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01794143.PMID:38344820 | DOI:10.1161/CIRCULATIONAHA.123.066604 (Source: Circulation)
Source: Circulation - February 12, 2024 Category: Cardiology Authors: Jennifer B Green Brendan M Everett Alokananda Ghosh Naji Younes Heidi Krause-Steinrauf Joshua Barzilay Cyrus Desouza Silvio E Inzucchi Yashashwi Pokharel David Schade Alexandra Scrymgeour Meng H Tan Kristina M Utzschneider Sunder Mudaliar GRADE Study Rese Source Type: research
Effectiveness and safety of insulin glargine U-300 as compared to insulin glargine U-100 in oral antidiabetic (OAD) failure cases —record-based observational study
ConclusionThe results suggest that insulin glargine U-300 is an effective and safer treatment option than insulin glargine U-100 for Indian patients with OAD failure. These findings have the potential to improve the management of type 2 diabetes patients with OAD failure globally. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 7, 2024 Category: Endocrinology Source Type: research
Comparative Analysis of PEG ‐Free and PEG‐Based Self‐Emulsifying Drug Delivery Systems for Enhanced Oral Bioavailability of Therapeutic (Poly) Peptides
This study presents a novel strategy to boost oral bioavailability of insulin glargine (IG) using polyglycerol/zwitterion-based self-emulsifying drug delivery systems (PG/ZW-SEDDS) as an alternative to polyethylene glycol-based SEDDS (PEG-SEDDS). Research focuses on optimizing hydrophobic ion pairing (HIP) complexation, developing a PEG-free SEDDS, and evaluating its oral IG bioavailability versus PEG-based SEDDS in rats, advancing diabetes therapeutics. AbstractThis study aims to compare the potential of Polyethylene glycol (PEG-free and PEG-based self-emulsifying drug delivery systems (SEDDS) for the oral administration ...
Source: Small - February 3, 2024 Category: Nanotechnology Authors: Soheil Haddadzadegan,
Dennis To,
Arne Matteo J örgensen,
Richard Wibel,
Flavia Laffleur,
Andreas Bernkop‐Schnürch Tags: Research Article Source Type: research
Comparison of efficacy and safety of insulin degludec/liraglutide and insulin glargine U ‐100/lixisenatide in individuals with type 2 diabetes mellitus using professional continuous glucose monitoring
ConclusionsA TIR of>70% was achieved for both fixed-ratio combinations without significant differences. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 23, 2024 Category: Endocrinology Authors: Yuji Kawaguchi,
Yuriko Hajika,
Maho Rinka,
Koji Masumoto,
Jun Sawa,
Kenji Hamazaki,
Yasuro Kumeda Tags: Original Article Source Type: research
Efficacy and safety of insulin glargine 300 units/mL vs insulin degludec in patients with type 1 and type 2 diabetes: a systematic review and meta-analysis
ConclusionThere is no evidence of a difference between IDeg and IGla-300 in the mean change in HbA1c and the risk of anytime, nocturnal, and severe hypoglycemia. IDeg appeared to cause a higher reduction in FPG compared to IGla-300. However, this finding should be interpreted with caution due to the small number of trials included and their high risk of bias.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022364891, identifier CRD42022364891. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 19, 2024 Category: Endocrinology Source Type: research
Se-Glargine : Chemical Synthesis of a Basal Insulin Analogue Stabilized by an Internal Diselenide Bridge
We describe the chemical synthesis of a basal insulin analogue stabilized by substitution of an internal cystine (A6-A11) by a diselenide bridge. The studies focused on insulin glargine (formulated as Lantus® and Toujeo®; Sanofi). Prepared at pH 4 in the presence of zinc ions, glargine exhibits a shifted isoelectric point due to a basic B chain extension (ArgB31-ArgB32). Subcutaneous injection leads to pH-dependent precipitation of a long-lived depot. Pairwise substitution of CysA6 and CysA11 by selenocysteine was effected by solid-phase peptide synthesis; the modified A chain also contained substitution of AsnA21 by Gly...
Source: Chembiochem - December 27, 2023 Category: Biochemistry Authors: Orit Weil-Ktorza Balamurugan Dhayalan Yen-Shan Chen Michael A Weiss Norman Metanis Source Type: research
Se-Glargine : Chemical Synthesis of a Basal Insulin Analogue Stabilized by an Internal Diselenide Bridge
We describe the chemical synthesis of a basal insulin analogue stabilized by substitution of an internal cystine (A6-A11) by a diselenide bridge. The studies focused on insulin glargine (formulated as Lantus® and Toujeo®; Sanofi). Prepared at pH 4 in the presence of zinc ions, glargine exhibits a shifted isoelectric point due to a basic B chain extension (ArgB31-ArgB32). Subcutaneous injection leads to pH-dependent precipitation of a long-lived depot. Pairwise substitution of CysA6 and CysA11 by selenocysteine was effected by solid-phase peptide synthesis; the modified A chain also contained substitution of AsnA21 by Gly...
Source: Chembiochem - December 27, 2023 Category: Biochemistry Authors: Orit Weil-Ktorza Balamurugan Dhayalan Yen-Shan Chen Michael A Weiss Norman Metanis Source Type: research
A retrospective electronic medical record-based study of insulin usage and outcomes in insulin-naive Indian adults with T2DM: The REALITY study
ConclusionThe REALITY study in India demonstrated that initiating basal insulin treatment in insulin-naive individuals with T2DM led to improved glycemic parameters over a 12-month period. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - December 15, 2023 Category: Endocrinology Source Type: research
EE628 Cost of Basal Insulin Therapy in France: An Observational Longitudinal Study
Second-generation basal insulins like insulin glargine 300 U/mL (Gla-300) have a longer duration of action and less intra-day fluctuation and inter-day variability than first-generation ones, such as glargine 100 U/mL (Gla-100). The EF-BI study, a nationwide observational, retrospective study, was designed to compare the total costs of care associated with the initiation of such basal insulins (BI) in real-life setting in France. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: C. Emery, I. Bureau, N. Allali, A. Bahloul, A. Mahieu, B. Detournay Source Type: research
EE318 Cost-Effectiveness Analysis for Soliqua in the Treatment of T2DM in Turkiye
Diabetes causes high health expenditures due to its high prevalence and comorbidities. The aim of this study is to evaluate the pharmacoeconomic evaluation of Soliqua (fixed doses combination insulin glargine + lixisenatide) versus premixed insulin treatment in type 2 diabetes mellitus (T2DM) in Turkiye. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: K. Atikeler, M. Kurnaz, S. Ileri, M. Cansever, S. Kahveci, B. Kader, C. Duran, E.E. Akbay, G. Karacar, F. Öztürk, S. Okcun, G. Kockaya Source Type: research
Charitable medication distribution improves care for uninsured patients with diabetes
CONCLUSIONS: Our results showed a significant improvement in glycemic control among participants, demonstrating the substantial impact that pharmacies partnered with charitable medication distributors such as the Dispensary of Hope can have on individuals with insulin-treated T2D.PMID:37948644 | DOI:10.37765/ajmc.2023.89453 (Source: The American Journal of Managed Care)
Source: The American Journal of Managed Care - November 10, 2023 Category: Health Management Authors: Jonathan Hughes Abby Sparkman Priscilla Smith Tim McCormack Tavajay Campbell Hillary Blackburn Source Type: research
Charitable medication distribution improves care for uninsured patients with diabetes
CONCLUSIONS: Our results showed a significant improvement in glycemic control among participants, demonstrating the substantial impact that pharmacies partnered with charitable medication distributors such as the Dispensary of Hope can have on individuals with insulin-treated T2D.PMID:37948644 | DOI:10.37765/ajmc.2023.89453 (Source: The American Journal of Managed Care)
Source: The American Journal of Managed Care - November 10, 2023 Category: Health Management Authors: Jonathan Hughes Abby Sparkman Priscilla Smith Tim McCormack Tavajay Campbell Hillary Blackburn Source Type: research
Charitable medication distribution improves care for uninsured patients with diabetes
CONCLUSIONS: Our results showed a significant improvement in glycemic control among participants, demonstrating the substantial impact that pharmacies partnered with charitable medication distributors such as the Dispensary of Hope can have on individuals with insulin-treated T2D.PMID:37948644 | DOI:10.37765/ajmc.2023.89453 (Source: The American Journal of Managed Care)
Source: The American Journal of Managed Care - November 10, 2023 Category: Health Management Authors: Jonathan Hughes Abby Sparkman Priscilla Smith Tim McCormack Tavajay Campbell Hillary Blackburn Source Type: research
