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Assessment of Time-Dependent Platelet Activation Using Extracellular Vesicles, CD62P Exposure, and Soluble Glycoprotein V Content of Platelet Concentrates with Two Different Platelet Additive Solutions
Novel analytical measures are needed to accurately monitor the properties of platelet concentrates (PCs). Since activated platelets produce platelet-derived extracellular vesicles (EVs), analyzing EVs of PCs may provide additional information about the condition of platelets. The prospect of using EVs as an auxiliary measure of platelet activation state was investigated by examining the effect of platelet additive solutions (PASs) on EV formation and platelet activation during PC storage. The time-dependent activation of platelets in PCs with PAS-B or with the further developed PAS-E was compared by measuring the exposure ...
Source: Transfusion Medicine and Hemotherapy - May 7, 2019 Category: Hematology Source Type: research

Science First: Cool Is Beautiful
Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - May 6, 2019 Category: Hematology Source Type: research

Aberrant ABO B Phenotype with Irregular Anti-B Caused by a Para-Bombay < b > < i > FUT1 < /i > < /b > Mutation
Conclusion: While a functionalB allele was found, analysis ofFUT1 andFUT2 genes revealed the presence of a rare para-Bombay genotype OhB. Interestingly, no anti-H but irregular anti-B was found in the patient ’s plasma, responsible for the positive cross-match with group B RBCs. Even though very rare and not reported for the European population, the presence of an H-deficient phenotype should be considered when investigating individuals with an unusual ABO blood group type.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - May 5, 2019 Category: Hematology Source Type: research

Potential of Parameters of Iron Metabolism for the Diagnosis of Anemia of Inflammation in the Critically Ill
Conclusions: In this explorative study on the use of different parameters of iron metabolism for diagnosing AI during an ICU stay, low levels of commonly measured markers such as plasma iron, transferrin, and transferrin saturation have the highest sensitivity and specificity and outperform ferritin and hepcidin.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - May 5, 2019 Category: Hematology Source Type: research

Impact of Regular Whole-Blood Donation on Body Iron Stores
Conclusion: The present study demonstrates iron depletion in regular voluntary blood donors. In 11.2% of the donors, iron deficiency erythropoiesis was noted. A ferritin screening after the first donation followed up at the tenth donation might help detect iron-deficient individuals. Iron supplementation for all regular blood donors and female donors in particular will help prevent the shrinking donor pool due to iron deficiency.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - May 5, 2019 Category: Hematology Source Type: research

Organ Preservation into the 2020s: The Era of Dynamic Intervention
Organ preservation has been of major importance ever since transplantation developed into a global clinical activity. The relatively simple procedures were developed on a basic comprehension of low-temperature biology as related to organs outside the body. In the past decade, there has been a significant increase in knowledge of the sequelae of effects in preserved organs, and how dynamic intervention by perfusion can be used to mitigate injury and improve the quality of the donated organs. The present review focuses on (1) new information about the cell and molecular events impacting on ischemia/reperfusion injury during ...
Source: Transfusion Medicine and Hemotherapy - May 5, 2019 Category: Hematology Source Type: research

Cryopreservation of Human Ovarian Tissue: A Review
Background: Cryopreservation of human ovarian tissue has been increasingly applied worldwide to safeguard fertility in cancer patients, notably in young girls and women who cannot delay the onset of their treatment. Moreover, it has been proposed to patients with benign pathologies with a risk of premature ovarian insufficiency. So far, more than 130 live births have been reported after transplantation of cryopreserved ovarian tissue, and almost all patients recovered their ovarian function after tissue reimplantation.Summary: This review aims to summarize the recent results described in the literature regarding human ovar...
Source: Transfusion Medicine and Hemotherapy - April 15, 2019 Category: Hematology Source Type: research

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Transfus Med Hemother 2019;46:124 –127 (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - April 15, 2019 Category: Hematology Source Type: research

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Transfus Med Hemother 2019;46:129 –130 (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - April 15, 2019 Category: Hematology Source Type: research

Comprehensive Molecular Analysis of Serologically D-Negative and Weak/Partial D Phenotype in Thai Blood Donors
Discussion: For the first time, a comprehensive overview of the nature and distribution of variantRHD alleles in Thailand is reported. It is a milestone to pave the way towards improvement of the current screening strategy to identify DEL donors accurately. The next step will be the design and implementation of a simple molecular test for screening the most frequent alleles, specifically in this population.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - April 3, 2019 Category: Hematology Source Type: research

Risk Factors for Transfusion after Orthotopic Liver Transplantation
Conclusion: Our study demonstrated an association between intraoperative transfusion and warm ischemia time with postoperative transfusion requirements. The identification of risk factors for transfusion in the postoperative period may improve management of these patients by increasing awareness to bleeding complications in this high-risk population and by expanding hemostasis monitoring to the postoperative period.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - April 3, 2019 Category: Hematology Source Type: research

Evaluation for Perioperative Blood Transfusion during Major Abdominal Procedures in a Pediatric Population: A Retrospective Observation Cohort Study
Conclusions: Overtransfusion was common in hepatic resection and younger age, but to definitely prove this hypothesis, a prospective randomized trial needs to be performed.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - March 31, 2019 Category: Hematology Source Type: research

The Near Future of Vitrification of Oocytes and Embryos: Looking into Past Experience and Planning into the Future
Currently vitrification is the method of choice for low-temperature preservation of oocytes and embryos. However, that was not the case until about 10 years ago when freezing methods were used relatively successfully for embryos and investigated (unsuccessfully) for oocyte preservation. In this paper we will review the history of oocyte and embryo cryopreservation and look into ways and methods for overcoming and improving the vitrification method since it suffers from inherent disadvantages since it is a cumbersome, time-consuming and costly procedure.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - March 31, 2019 Category: Hematology Source Type: research

Age of Red Cells for Transfusion and Outcomes in Critically Ill Patients: A Meta-Analysis
Conclusions: The study concluded that age of red cells for transfusion did not affect the outcomes in critically ill patients.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - March 31, 2019 Category: Hematology Source Type: research

Technical Considerations in the Freezing, Low-Temperature Storage and Thawing of Stem Cells for Cellular Therapies
The commercial and clinical development of cellular therapy products will invariably require cryopreservation and frozen storage of cellular starting materials, intermediates and/or final product. Optimising cryopreservation is as important as optimisation of the cell culture process in obtaining maximum yield and a consistent end-product. Suboptimal cryopreservation can lead not only to batch-to-batch variation, lowered cellular functionality and reduced cell yield, but also to the potential selection of subpopulations with genetic or epigenetic characteristics divergent from the original cell line. Regulatory requirement...
Source: Transfusion Medicine and Hemotherapy - March 31, 2019 Category: Hematology Source Type: research