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Plasma Isoagglutinin Depletion for Blood Group Independent Plasma Transfusion
We described a method for the production of anti-A- and anti-B-depleted plasma in a closed system that uses standard equipment. The resulting isoagglutinin-depleted plasma may allow for blood group independent plasma transfusion.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - February 4, 2022 Category: Hematology Source Type: research

Therapeutic Leukapheresis: Experience of a Single Oncologic Centre
Conclusion: Despite the reduced number of patients, we conclude that therapeutic leukapheresis is a safe and effective option that may still have a therapeutic role in some cases.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - February 1, 2022 Category: Hematology Source Type: research

PharmaNews
Transfus Med Hemother 2022;49:65 –66 (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - February 1, 2022 Category: Hematology Source Type: research

Non-Invasive Fetal K Status Prediction: 7 Years of Experience
Conclusion: We have developed an NGS-based method for the non-invasive prediction of fetal K status. This approach requires special considerations in terms of primer design, stringent preanalytical sample handling, and careful analytical procedures. We analyzed samples starting at GA 10 weeks and demonstrated the correct prediction of fetal K status. This assay enables timely clinical intervention in pregnancies at risk of hemolytic disease of the fetus and newborn caused by maternal anti-K IgG antibodies.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - January 31, 2022 Category: Hematology Source Type: research

XK-Associated McLeod Syndrome: Nonhematological Manifestations and Relation to VPS13A Disease
Background: McLeod syndrome (MLS) is an X-linked multisystemic progressive disorder caused by loss of function mutations in theXK gene. The rare blood group phenotype of MLS patients with absent Kx antigen requires the support of specialized transfusion institutions because of the risk of transfusion complications. Acanthocytosis of red blood cells occurs in almost all patients. Nonhematological manifestations of MLS are very similar to those of VPS13A disease (chorea-acanthocytosis), an autosomal-recessive condition. Their shared phenotype apart from acanthocytosis includes movement disorders such as chorea and dystonia, ...
Source: Transfusion Medicine and Hemotherapy - January 25, 2022 Category: Hematology Source Type: research

Closer to Nature: The Role of MSCs in Recreating the Microenvironment of the Hematopoietic Stem Cell Niche in vitro
Conclusion: Advanced 3D model systems using MSCs as niche cells and applying microbioreactor-based technology are capable of simulating the natural properties of the bone marrow niche more closely than ever before.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - January 14, 2022 Category: Hematology Source Type: research

Association of Blood Group Antigen CD59 with Disease
In 2014, the membrane-bound protein CD59 became a blood group antigen. CD59 has been known for decades as an inhibitor of the complement system, located on erythrocytes and on many other cell types. In paroxysmal nocturnal haemoglobinuria (PNH), a stem cell clone with acquired deficiency to express GPI-anchored molecules, including the complement inhibitor CD59, causes severe and life-threatening disease. The lack of CD59, which is the only membrane-bound inhibitor of the membrane attack complex, contributes a major part of the intravascular haemolysis observed in PNH patients. This crucial effect of CD59 in PNH disease pr...
Source: Transfusion Medicine and Hemotherapy - January 13, 2022 Category: Hematology Source Type: research

Blood Groups and Their Correlation with Hereditary Disease
Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - January 4, 2022 Category: Hematology Source Type: research

High-Resolution Melting Curve Analysis to Predict Extended Blood Group Phenotypes among Thai Donors and Patients
Conclusions: We developed and implemented the HRM analysis assay for red cell genotyping to predict extended blood group antigens in Thai donor and patient populations. The data from this study may help inform about and support transfusion care of Thai patients to reduce the risk of alloimmunisation.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - December 22, 2021 Category: Hematology Source Type: research

Application of Saliva Inhibition to Detect Underlying Alloantibodies in Bombay Blood Group
Conclusion: Tube IS appears more sensitive to anti-H. Saliva inhibition appears to be a promising method to detect underlying alloantibody in the plasma of Bombay phenotype individuals.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - December 10, 2021 Category: Hematology Source Type: research

Safety of Uncrossmatched ABO-Compatible RBCs in Alloimmunized Patients with Bleeding: Data from Two Decades: Results of a Systematic Analysis in 6,109 Patients
Conclusion: Transfusion of uncrossmatched ABO-compatible RBCs against alloantibodies is highly safe in patients with life-threatening hemorrhage.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - December 8, 2021 Category: Hematology Source Type: research

Augustine Blood Group System and Equilibrative Nucleoside Transporter 1
Augustine (AUG) is a blood group system comprising four antigens: AUG1, AUG2 (Ata), and AUG4 are of very high frequency; AUG3 is of very low frequency. These antigens are located on ENT1, an equilibrative nucleoside transporter encoded bySLC19A1. AUG antibodies are of clinical relevance in blood transfusion and pregnancy: anti-AUG2 have caused haemolytic transfusion reactions; the only anti-AUG3 was associated with severe haemolytic disease of the fetus and newborn. ENT1 is present in almost all human tissues. It facilitates the transfer of purine and pyrimidine nucleosides and is responsible for the majority of adenosine ...
Source: Transfusion Medicine and Hemotherapy - December 7, 2021 Category: Hematology Source Type: research

Contents Vol. 48, 2021
Transfus Med Hemother 2021;48:I –VI (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - December 3, 2021 Category: Hematology Source Type: research

Acknowledgement to Reviewers
Transfus Med Hemother 2021;48:381 –382 (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - December 3, 2021 Category: Hematology Source Type: research

News
Transfus Med Hemother 2021;48:383 –384 (Source: Transfusion Medicine and Hemotherapy)
Source: Transfusion Medicine and Hemotherapy - December 3, 2021 Category: Hematology Source Type: research