Impact of ABCB1 Polymorphisms on Lacosamide Serum Concentrations in Uygur Pediatric Patients With Epilepsy in China
Background:
P-glycoprotein, encoded by ABCB1 (or MDR1), may contribute to drug resistance in epilepsy by limiting gastrointestinal absorption and brain access to antiseizure medications. The study aimed to evaluate the impact of ABCB1 polymorphisms on lacosamide (LCM) serum concentrations in Uygur pediatric patients with epilepsy.
Methods:
The serum concentrations of LCM were determined by ultrahigh performance liquid chromatography, and the ABCB1 polymorphism was analyzed through polymerase chain reaction–fluorescence staining in situ hybridization. The χ2 test and the Fisher exact test were used to analyze ...
Source: Therapeutic Drug Monitoring - May 13, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Interindividual Variability in the Bioavailability of Gabapentin Enacarbil Extended Release in Healthy Adults: An Analysis of Data From 6 Phase I Studies
Conclusions:
Gabapentin PK after gabapentin enacarbil administration was consistent across studies, with low interindividual variability in bioavailability. Gabapentin enacarbil may provide more consistent and predictable exposure to gabapentin than oral gabapentin formulations. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 13, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Longitudinal Monitoring of Hair Cortisol Using Liquid Chromatography–Mass Spectrometry to Prevent Hypercortisolism in Patients Undergoing Glucocorticoid Replacement Therapy
Objective:
Currently available methods for endogenous cortisol monitoring in patients with hormonal insufficiency rely on measurements of plasma levels only at a single time point; thus, any kind of chronic exposure to cortisol is challenging to evaluate because it requires collecting samples at different time points. Hair cortisol levels acquired longitudinally better reflected chronic exposure (both cortisol synthesis and deposition) and may significantly contribute to better outcomes in glucocorticoid replacement therapies.
Design:
Twenty-two patients on cortisol substitution therapy were monitored for plasma...
Source: Therapeutic Drug Monitoring - May 13, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Validation and Clinical Application of a Liquid Chromatography–Ultraviolet Detection Method to Quantify Dolutegravir in Dried Blood Spots
Conclusions:
The application of this simple, accurate, and precise method will expand opportunities for clinical assessment of dolutegravir in resource-limited settings. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 13, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Development of a Sensitive and High-Throughput Assay for Simultaneous Quantification of 5 Tyrosine Kinase Inhibitors and 2 Active Metabolites in Human Plasma Using Ultra-high Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry
Conclusions:
The method allows assessment of trough concentrations of TKIs and active metabolites in patients with CML, and hence can be used to assess blood samples in routine clinical settings. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 13, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Decreased Systemic Busulfan Exposure After Oral Dosing With Concomitant Levetiracetam Compared With Phenytoin
This study was a retrospective cohort study in adults undergoing myoablative conditioning with oral Bu between August 2018 and August 2020. Bu pharmacokinetic parameters (AUC0-6, C0, Cmax, and Tmax) were compared in patients treated with phenytoin comedication (during the year before the change in policy) and levetiracetam comedication (during the year after the change). Potential confounders were accounted for including age, azole comedication, and body weight.
Results:
There were no significant differences in demographic and clinical parameters or weight-corrected Bu dose between the phenytoin group (n = 28) and t...
Source: Therapeutic Drug Monitoring - May 13, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Optimal Teicoplanin Dosing Regimen in Neonates and Children Developed by Leveraging Real-World Clinical Information
Conclusions:
This study leverages real-world clinical information and proposes new optimal dosing regimens for teicoplanin in neonates and children through PK modeling and simulation analyses, taking into account the age, including PMA, and renal function of patients. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 13, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Optimal Sampling Strategy and Threshold of Serum Vancomycin Concentration in Elderly Japanese Patients Undergoing High-Flux Hemodialysis
Background:
The optimal sampling points and thresholds for initial serum vancomycin (VCM) concentrations have not been determined in hemodialysis (HD) patients. To clarify this, multiple blood tests were performed, and the correlations between VCM concentrations at several sampling points and the area under the concentration–time curve for 24 hours (AUC24h) were analyzed.
Methods:
A single-center, prospective observational study was conducted. Patients with end-stage renal failure who received VCM treatment while undergoing chronic maintenance HD were enrolled in this study. HD was performed using a high-flux ...
Source: Therapeutic Drug Monitoring - May 13, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Inosine Triphosphate Pyrophosphatase and NUDT15 are Good Predictors of Clinical Outcomes in Thiopurine-Treated Chinese Patients with Inflammatory Bowel Disease
Conclusions:
In summary, it is recommended that both ITPA and NUDT15 genotyping should be performed before azathioprine initiation. Moreover, the 6-TGN concentration should be routinely monitored during the later period of treatment. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 13, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Drug–Drug Interactions Between Mycophenolic Acid and Proton Pump Inhibitors: A Systematic Review and Meta-Analysis
Conclusions:
Coadministration of PPIs and mycophenolate mofetil significantly altered the pharmacokinetics of MPA, particularly by decreasing MPA absorption. However, PPI-MPA interactions did not impact pharmacodynamic outcomes of MPA. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 13, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Drug–Drug Interactions With Cyclosporine in the Anti-Hepatitis C Viral PrOD Combination Regimen of Paritaprevir/Ritonavir–Ombitasvir and Dasabuvir in Organ Transplant Recipients With Severe Hepatic Fibrosis or Cirrhosis
Conclusions
Although the combination with PrOD significantly affects the pharmacokinetics of CsA, it is effective and safe with regular monitoring of the CsA blood concentrations and appropriate CsA dose adjustment. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 13, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
High Tacrolimus Intrapatient Variability and Subtherapeutic Immunosuppression are Associated With Adverse Kidney Transplant Outcomes
Conclusions:
This study verifies the relationship between high tacrolimus IPV and impaired kidney allograft survival in long-term follow-up. DSA was also found to be more prevalent in patients with subtherapeutic concentrations of tacrolimus and MPA. An increased prevalence of donor-specific alloreactivity is yet to be demonstrated in patients with high IPV. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 13, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
A Patient With Sepsis-Induced Multiorgan Failure and Increasing Serum Methadone Concentration: A Case Study
Abstract:
The authors describe a patient with substance use disorder admitted to the hospital with septic shock and multiorgan failure, in whom the serum concentration of methadone kept increasing despite discontinuation of the drug. Therapeutic drug monitoring was performed to monitor the methadone serum concentration during treatment of the underlying diseases. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 13, 2022 Category: Drugs & Pharmacology Tags: Grand Rounds Source Type: research
What Is the Therapeutic Reference Range for Levetiracetam? Grand Round/A Case Study
In this study, the authors agree with the range to 10–40 mg/L but discuss to what extent a wider interval may be proposed for certain patients. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 13, 2022 Category: Drugs & Pharmacology Tags: Case Report Source Type: research
Meropenem to Treat Valproic Acid Intoxication
Abstract:
This therapeutic drug monitoring (TDM) grand round describes a patient with serious valproic acid intoxication. A total valproic acid level of 844 mg/L and an unbound valproic acid level of 604 mg/L were observed. Meropenem was administered to enhance the clearance of valproic acid. This off-label usage of meropenem is based on the drug–drug interaction between carbapenems and valproic acid, which reduced the level of valproic acid within 24 hours after administration. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 13, 2022 Category: Drugs & Pharmacology Tags: Case Report Source Type: research
