A Novel Quantitative Method for Analyzing Desmopressin in Human Plasma Using Liquid Chromatography–Tandem Mass Spectrometry
Conclusions:
The LC-MS/MS method presented enables quantification of desmopressin in human plasma, and it is sensitive, specific, efficient, accurate, and precise. This analytical technique is a valuable and useful tool to study the interpatient variability of pharmacokinetics. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - November 23, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Population Pharmacokinetics of Voriconazole in Patients With Invasive Aspergillosis: Serum Albumin Level as a Novel Marker for Clearance and Dosage Optimization
Conclusions:
SA level was identified as a novel marker associated with VRCZ clearance. This marker may be a practical choice for physicians to perform therapeutic drug monitoring and optimize VRCZ dosage. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - November 23, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Factors Associated With Voriconazole Concentration in Pediatric Patients
Conclusions:
Considering the variability of voriconazole concentrations in pediatric patients, monitoring certain parameters and considering the route of administration could help determine the therapeutic range of voriconazole and subsequently avoid unwanted effects. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - November 23, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Population Pharmacokinetic Modeling of Vancomycin in Thai Patients With Heterogeneous and Unstable Renal Function
Background:
Vancomycin is widely used to treat gram-positive bacterial infections. However, given significant interpatient variability in its pharmacokinetics, maintaining plasma concentrations is difficult within its characteristically narrow therapeutic window. This is especially challenging in patients with unstable renal function. Thus, the aim of this study was to develop a population pharmacokinetic model for vancomycin that is suitable for Thai patients with variable renal functions, including those with unstable renal function.
Methods:
Data from 213 patients, including 564 blood samples, were retrospect...
Source: Therapeutic Drug Monitoring - November 23, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Effect of Cystatin C on Vancomycin Clearance Estimation in Critically Ill Children Using a Population Pharmacokinetic Modeling Approach
Conclusions:
CysC-based equations help better estimate vancomycin CL than bedside Schwartz in critically ill children. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - November 23, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Impact of Therapeutic Drug Monitoring on Once-Daily Regimen of Amikacin in Patients With Urinary Tract Infection: A Prospective Observational Study
Conclusions:
In patients receiving short-term amikacin therapy, Cmax/MIC value can be used to predict the time required for a clinical cure. Ctrough can be used to predict the occurrence of nephrotoxicity in patients receiving amikacin therapy. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - November 23, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Safety and Efficacy of Tigecycline in Intensive Care Unit Patients Based on Therapeutic Drug Monitoring
Conclusions:
There was considerable variability in the Cmin of tigecycline among the ICU patients in this study and it is at risk of high exposure in women. Cmin can be a useful predictor of hepatotoxicity with a cut-off of 474.8 ng/mL. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - November 23, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Differences in Theophylline Clearance Between Patients With Chronic Hepatitis and Those With Liver Cirrhosis
Conclusions:
Differences exist in theophylline clearance between CH and LC patients as per the PPK analysis. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - November 23, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Comparative Evaluation of 4 Commercially Available ELISA Kits for Measuring Adalimumab and Anti-adalimumab Antibodies
Conclusions:
All ADM kits tested were dose responsive within the therapeutic range and correlated well. The significance of observed low-range false positives and cross reactivity with infliximab in LISA-Tracker and Shikari kits is dependent on the indications received for testing in the laboratory. Anti-ADM ELISA kits produced varied results for spiked sera; however, they showed good precision. Inter-kit variability suggested that anti-ADM levels should be compared only when using the same method. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - November 23, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Immunosuppressive Drug-Associated Adverse Event Profiles in De Novo Kidney Transplant Recipients Receiving Everolimus and Reduced Tacrolimus Doses
Background:
The safety of immunosuppressive regimens is influenced by the induction agent, maintenance drug combination, and prophylactic strategy for cytomegalovirus (CMV) infection. Herein, this safety analysis compares rabbit antithymocyte globulin (r-ATG) or basiliximab (BAS) combined with everolimus (EVR) versus BAS combined with mycophenolate sodium (MPS) in kidney transplant recipients receiving tacrolimus, prednisone, and preemptive CMV therapy.
Methods:
In this single-center, prospective, randomized study, adverse events (AEs), serious AEs (SAEs), viral infections, laboratory abnormalities, dose reducti...
Source: Therapeutic Drug Monitoring - November 23, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Clinical Factors Affecting the Dose Conversion Ratio from Intravenous to Oral Tacrolimus Formulation among Pediatric Hematopoietic Stem Cell Transplantation Recipients
Conclusions:
After switching of tacrolimus formulation, pediatric HCT recipients might need oral tacrolimus dose that is 5–6 and 3.5–4.5 times the intravenous dose to maintain tacrolimus blood concentrations and area under the concentration–time curve, respectively. With the concomitant use of voriconazole or itraconazole, an oral tacrolimus dose of 4–5 times the intravenous dose seemed appropriate to maintain blood tacrolimus concentration. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - November 23, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Pharmacokinetic–Pharmacogenomic Model for Chinese Children Treated With Lamotrigine Also Applies for Mexican Children
No abstract available (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 25, 2020 Category: Drugs & Pharmacology Tags: Letter to the Editor Source Type: research
Oral Fluid to Blood Concentration Ratios of Different Psychoactive Drugs in Samples from Suspected Drugged Drivers
Conclusions:
High OF/B ratios were found for amphetamines and opioids, reflecting a high degree of drug transfer from blood to oral fluid and a longer detection window in oral fluid than in blood. For benzodiazepines, low OF/B ratios were found. Results of the concentration measurements in oral fluid from both sides of the mouth could indicate that some remnants of THC and buprenorphine were present in the oral cavity. The large variations among individuals and between the 2 sides of the mouth suggest that drug concentrations in oral fluid do not accurately reflect drug concentrations in the blood. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 25, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Screening for Opioid and Stimulant Exposure In Utero Through Targeted and Untargeted Metabolomics Analysis of Umbilical Cords
Conclusions:
Our research is a prospective method development study using untargeted and targeted approaches to characterize steady-state drug metabolite levels in the umbilical cord matrix at the time of delivery. By characterizing drug type and concentration, this methodology can be used to develop a reliable complementary testing method for meconium toxicology screens. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 25, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Model-Informed Bayesian Estimation Improves the Prediction of Morphine Exposure in Neonates and Infants
Conclusions:
Model-informed Bayesian estimation is a better predictor of morphine exposure than PK models alone in critically ill neonates and infants. A large variability was also identified in morphine clearance. A further study is warranted to elucidate the predictive covariates and precision dosing strategies that use morphine concentration and pain scores as feedbacks. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 25, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
