Quality Control of Busulfan Plasma Quantitation, Modeling, and Dosing: An Interlaboratory Proficiency Testing Program
Conclusions:
A proficiency testing program by which laboratories are alerted to inaccuracies in their quantitation, pharmacokinetic modeling, and dose recommendations for busulfan in hematopoietic cell transplant recipients was developed. These rounds of proficiency testing suggests that additional educational efforts and proficiency rounds are needed to ensure appropriate busulfan dosing. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 19, 2021 Category: Drugs & Pharmacology Tags: Original Manuscript Source Type: research
Initial Serum C-reactive Protein Level as a Predictor of Increasing Serum Vancomycin Concentration During Treatment
Conclusions:
A high serum CRP level on the initial day of TDM is an independent predictor of increasing vancomycin concentration-to-dose ratio in patients receiving intravenous vancomycin treatment, even if eGFR remains unchanged. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 19, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Adalimumab Concentration Changes After Dose Escalation in Inflammatory Bowel Disease
Background:
Dose escalation of adalimumab (ADA) for loss or response in inflammatory bowel disease (IBD) is a common practice. Recent data suggest improved outcomes with an ADA concentration of 12 mcg/mL, but limited data are available on the ability to achieve a target concentration. The aim of this study was to determine the expected change in serum ADA concentration after a dose escalation performed every 7 days in patients with IBD.
Methods:
A retrospective cohort of patients with IBD receiving ADA was divided into every fourteen-day dosing, every 7-day dosing, and dose escalation (ie, q14 to q7 day dosing)....
Source: Therapeutic Drug Monitoring - September 19, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Apixaban Level and Its Influence on Immunosuppression and Graft Outcome in Kidney Transplant Recipients With Atrial Fibrillation
Conclusions:
Similar to nontransplant patients, KT patients administered the standard 5-mg bid dosage had apixaban levels that were well within the recommended manufacturers' expected ranges. In addition, this dosage had minimal influence on immunosuppression and no effect on graft function. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 19, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Comparison of a Point-of-Care Testing with Enzyme-Multiplied Immunoassay Technique and Liquid Chromatography Combined With Tandem Mass Spectrometry Methods for Therapeutic Drug Monitoring of Mycophenolic Acid: A Preliminary Study
Conclusions:
The consistency of the new FICA using a point-of-care testing device with LC-MS/MS and EMIT was inadequate, and the accuracy of EMIT and LC-MS/MS was inappropriate. Clinicians should be informed when switching MPA detection methods to avoid misleading results. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 19, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
High Intrapatient Variability in Tacrolimus Exposure Calculated Over a Long Period Is Associated With De Novo Donor-Specific Antibody Development and/or Late Rejection in Thai Kidney Transplant Patients Receiving Concomitant CYP3A4/5 Inhibitors
Conclusions:
Tac IPV6–24 was higher and more significantly associated with DSA development and/or late rejection than Tac IPV6–12, independent of Tac trough level. This is the first study to demonstrate the impact of high IPV on DSA development in Asian patients, and that Tac IPV is comparable between patients with and without CYPinh. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 19, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine
In this study, the authors aimed to investigate the role of 6-thioguanine nucleotide (TGN) measurements, geno/phenotyping of thiopurine S-methyltransferase (TPMT), and their mutual relationship with TG therapy in IBD.
Methods:
An international retrospective, multicenter cohort study was performed at 4 centers in the Netherlands (Máxima Medical Centre) and the United Kingdom (Guy's and St. Thomas' Hospital, Queen Elizabeth Hospital, and East Surrey Hospital).
Results:
Overall, 526 6-TGN measurements were performed in 316 patients with IBD. The median daily dosage of TG was 20 mg/d (range 10–40 mg/d), and th...
Source: Therapeutic Drug Monitoring - September 19, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Systematic Review and Meta-Analysis of Thiopurine Metabolite Levels and Biochemical Remission in Autoimmune Hepatitis
Conclusions:
This meta-analysis suggests a link between 6-TGN levels and biochemical remission in AIH. Further high-quality studies are required to determine the therapeutic cutoff of 6-TGN. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 19, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Review of the Preanalytical Errors That Impact Therapeutic Drug Monitoring
Conclusions:
The identification of preanalytical factors that may negatively impact TDM is critical. Developing workflows that can standardize TDM practices, align appropriate timing and blood collection techniques, and specimen processing will eliminate errors. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 19, 2021 Category: Drugs & Pharmacology Tags: Review Article Source Type: research
Lithium Level in Cerebrospinal Fluid Cannot be a Reliable Indicator of Severity of Chronic Lithium Intoxication
No abstract available (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - July 24, 2021 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
Relationship of Prolactin Concentrations to Steady-State Plasma Concentrations of Aripiprazole in Patients With Schizophrenia
Background:
Aripiprazole is regarded as the first-line antipsychotic medication. Long-term aripiprazole therapy can cause hypoprolactinemia, which may result from its activity as a dopamine agonist. However, there is little information on hypoprolactinemia and steady-state aripiprazole concentrations.
Methods:
The subjects included 66 male and 177 female patients diagnosed with schizophrenia who were treated with aripiprazole. The plasma concentrations of aripiprazole and dehydroaripiprazole and the plasma concentration of prolactin were measured using high-performance liquid chromatography and enzyme immunoassa...
Source: Therapeutic Drug Monitoring - July 24, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Rapid Simultaneous Determination of 14 Antidepressants and 13 Antipsychotics in Human Plasma by Using High-Performance Liquid Chromatography–Tandem Mass Spectrometry With Dynamic Multiple Reaction Monitoring and Its Application to Therapeutic Drug Monitoring
Conclusions:
This dynamic method is comprehensive (includes most antidepressants and antipsychotics listed in China), reliable (stably used for almost 2 years), and efficient (convenient sample processing and short run time) and provides a large amount of meaningful data for optimized pharmacotherapy. Our experimental data from the plasma concentrations of supra–alert-level samples could serve as a reference for the interpretation of the pharmacokinetics of patients with a high risk of toxicity or loss of tolerability. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - July 24, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Development and Validation of a Simple and Rapid Ultrahigh-Performance Liquid Chromatography Tandem Spectrometry Method for the Quantification of Hydroxychloroquine in Plasma and Blood Samples in the Emergency Context of SARS-CoV-2 Pandemic
Abstract:
Therapeutic drug monitoring of hydroxychloroquine (HCQ) has been recommended to optimize the treatment of patients with COVID-19. The authors describe an ultrahigh-performance liquid chromatography tandem spectrometry method developed in a context of emergency, to analyze HCQ in both human plasma and blood samples. After adding the labeled internal standard and simple protein precipitation, plasma samples were analyzed using a C18 column. Blood samples required evaporation before analysis. The total chromatographic run time was 4 minutes (including 1.5 minutes of column equilibration). The assay was linear ov...
Source: Therapeutic Drug Monitoring - July 24, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Relationship Between Amphetamine Concentrations in Saliva and Serum in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder
In this study, 28 patient samples (mean age, 11.3 years; boys, 23; and girls, 5) treated with lisdexamfetamine were included. The active compound amphetamine was extracted and derivatized before quantification by high-performance liquid chromatography with fluorescence detection. Nonparametric Spearman rank correlations were used for correlation analyses; for clinical validation, Bland–Altman analysis was applied.
Results:
The median amphetamine concentrations in saliva were 2.7 times higher (range 0.7–23.6) than those in serum (257.8 ng/mL versus 77.2 ng/mL; z = −4.51, P (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - July 24, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Quantitative Method for the Analysis of Ivacaftor, Hydroxymethyl Ivacaftor, Ivacaftor Carboxylate, Lumacaftor, and Tezacaftor in Plasma and Sputum Using Liquid Chromatography With Tandem Mass Spectrometry and Its Clinical Applicability
Background:
The novel cystic fibrosis transmembrane conductance regulator (CFTR) modulators, ivacaftor, lumacaftor, and tezacaftor, are the first drugs directly targeting the underlying pathophysiological mechanism in cystic fibrosis (CF); however, independent studies describing their pharmacokinetics are lacking. The aim of this study was to develop a quantification method for ivacaftor and its 2 main metabolites, lumacaftor and tezacaftor, in plasma and sputum using liquid chromatography with tandem mass spectrometry.
Methods:
The developed method used a small sample volume (20 µL) and simple pretreatment met...
Source: Therapeutic Drug Monitoring - July 24, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
