Passage of Venlafaxine in Human Milk During 12 Months of Lactation: A Case Report
No abstract available (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 16, 2022 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
Impact of Heat Inactivation of Blood Samples on Therapeutic Drug Monitoring of 5 Second-Generation Antipsychotics and Their Metabolites
Background:
The severe acute respiratory syndrome coronavirus 2 outbreak has been classified as a pandemic. Because many coronaviruses are heat sensitive, heat inactivation of patient samples at 56°C before testing reduces the risk of transmission. The aim of this study is to assess the impact of heat inactivation of patient blood samples on plasma concentrations of 5 second-generation antipsychotics and their metabolites.
Methods:
Blood samples were collected during routine clinical therapeutic drug monitoring examination between April 3, 2021, and April 19, 2021. Samples were divided into 2 groups: group A, n...
Source: Therapeutic Drug Monitoring - September 16, 2022 Category: Drugs & Pharmacology Tags: Short Communication Source Type: research
Best Practices to Implement Dried Blood Spot Sampling for Therapeutic Drug Monitoring in Clinical Practice
Background:
Sampling of blood at home to determine the concentration of drugs or other compounds can be effective in limiting hospital-based sampling. This could lower hospital visits and patient burden, improve the quality of life, and reduce health care costs. Dried blood spot (DBS) microsampling is often used for this purpose, wherein capillary blood, obtained by pricking the heel or finger, is used to measure different analytes. Although DBS has several advantages over venous blood sampling, it is not routinely implemented in clinical practice. To facilitate the bench to bedside transition, it is important to be aw...
Source: Therapeutic Drug Monitoring - September 16, 2022 Category: Drugs & Pharmacology Tags: Short Communication Source Type: research
Evaluation of a Highly Efficient Multidrug Biochip Array Technology for a Simultaneous and High-Throughput Urine Drug Screening in Clinical and Toxicological Settings
Background:
A high-throughput and highly efficient analytical platform for urine drug screening is critical in both clinical and forensic settings. Mass spectrometry (MS) has better sensitivity and specificity than conventional immunoassays (IA); however, not all laboratories have the necessary resources and workforce to operate MS. The goal of this study was to evaluate a multidrug biochip with 20 discrete testing regions (DTRs) for high-throughput urine drug screening (UDS).
Methods:
The Randox DOA Ultra Urine (DOAULT URN) biochip employs chemiluminescent IA to detect various analytes, including stimulants, ha...
Source: Therapeutic Drug Monitoring - September 16, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Towards Precision Dosing of Clozapine in Schizophrenia: External Evaluation of Population Pharmacokinetic Models and Bayesian Forecasting
Conclusions:
Our study showed that upon external evaluation, clozapine models provide limited predictive performance, especially in subpopulations such as nonsmokers. From the perspective of model-informed prediction dosing, model predictability should be improved using updating or metamodeling methods. Moreover, BF substantially improved model predictability and could be used for clozapine treatment optimization. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 16, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Dosing for Personalized Prophylaxis in Hemophilia A Highly Varies on the Underlying Population Pharmacokinetic Models
Conclusions:
One model performed best across the population (bias: −3.8 hours a priori, −1.0 hours a posteriori, and 0.6 hours general model fit) and acceptably predicted 44% (a priori) to 90% (general model fit) of the patients. To allow the community-based evaluation of patient–individual FVIII dosing, this model was implemented in the open-access model-informed precision dosing software “TDMx.” (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 16, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Correlation Between Ultrasonographic Response and Anti–Tumor Necrosis Factor Drug Levels in Crohn's disease
Background:
Ultrasound is valuable in tight control algorithms for Crohn's disease (CD). However, the correlation between ultrasonographic response and anti–tumor necrosis factor (TNF) drug levels remains unknown. Elucidating this correlation would be helpful in optimizing the use of anti-TNF drugs. Thus, the authors aimed to investigate this correlation.
Methods:
Between June 2020 and June 2021, all patients with CD who completed anti-TNF induction therapy were retrospectively included. Ultrasound was performed at week 0 and week 14, and proactive therapeutic drug monitoring of anti-TNF drugs was performed at...
Source: Therapeutic Drug Monitoring - September 16, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
An Audit to Evaluate Vancomycin Therapeutic Drug Monitoring in a Neonatal Intensive Care Unit
Conclusions:
This study showed that there is a need for an increase in dose to improve target attainment. There is also a need to explore more effective TDM strategies to increase the proportion of neonatal patients attaining vancomycin target trough concentrations. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 16, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Real-World Comparison of Isavuconazole and Voriconazole in Terms of the Need for Dosage Adjustments Guided by Clinical Pharmacological Advice During Primary Prophylaxis of Invasive Fungal Infections in Pediatric Patients with Hemato-Oncological Malignancies
Background:
Limited evidence concerning optimal azole dosing regimens currently exists for antifungal prophylaxis in hemato-oncological pediatric patients.
Methods:
Hemato-oncological children receiving intravenous or oral isavuconazole or voriconazole for primary antifungal prophylaxis at IRCCS Azienda Ospedaliero–Universitaria of Bologna during November 2020 to October 2021 and undergoing CPA programs based on real-time therapeutic drug monitoring (TDM) were retrospectively analyzed. CPAs for isavuconazole and voriconazole and the number of dosage adjustments were collected. Normalized trough concentrations ...
Source: Therapeutic Drug Monitoring - September 16, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
High-Sensitivity and High-Throughput Quantification of Everolimus in Human Whole Blood Using Ultrahigh-Performance Liquid Chromatography Coupled With Tandem Mass Spectrometry
Conclusions:
Therefore, the authors succeeded in developing a novel high-sensitivity and high-throughput method for measuring blood EVR concentration by UHPLC-MS/MS using a µElution plate for sample pretreatment. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 16, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Association Between the Intracellular Tacrolimus Concentration in CD3+ T Lymphocytes and CD14+ Monocytes and Acute Kidney Transplant Rejection
Background:
Intracellular tacrolimus concentration in peripheral blood mononuclear cells (PBMCs) (TAC[PBMC]) has been proposed to better represent its active concentration than its whole blood concentration. As tacrolimus acts on T lymphocytes and other white blood cells, including monocytes, we investigated the association of tacrolimus concentration in CD3+ T lymphocytes (TAC[CD3]) and CD14+ monocytes (TAC[CD14]) with acute rejection after kidney transplantation.
Methods:
From a total of 61 samples in this case–control study, 28 samples were obtained during biopsy-proven acute rejection (rejection group), an...
Source: Therapeutic Drug Monitoring - September 16, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Tacrolimus Population Pharmacokinetic Model in Adult Chinese Patients with Nephrotic Syndrome and Dosing Regimen Identification Using Monte Carlo Simulations
Conclusions:
An improved tacrolimus PPK model for patients with nephrotic syndrome was established, and the most suitable combination of Wuzhi capsule and tacrolimus doses was identified, thus, facilitating the selection of a more economical and safe administration regimen. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 16, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Model-Based Tacrolimus Follow-up Dosing in Adult Renal Transplant Recipients: A Simulation Trial
Conclusions:
The combination of an algorithm-based tacrolimus starting dose with model-based follow-up dosing has the potential to minimize under- and overexposure to tacrolimus in the early posttransplant phase, although the additional effect of model-based follow-up dosing on initial algorithm-based dosing seems small. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 16, 2022 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
New Psychoactive Substances: Which Biological Matrix Is the Best for Clinical Toxicology Screening?
Conclusions:
Blood and urine represent the most common biological matrices used in a CT setting; however, reports concerning NPSs detection in alternative matrices are also available. Noteworthy, the selection of the biological matrix must depend on the clinician's enquiry because the individual advantages and disadvantages must be considered. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 16, 2022 Category: Drugs & Pharmacology Tags: Review Article Source Type: research
Longitudinal Monitoring of Hair Cortisol Using Liquid Chromatography–Mass Spectrometry to Prevent Hypercortisolism in Patients Undergoing Glucocorticoid Replacement Therapy: Erratum
No abstract available (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - July 20, 2022 Category: Drugs & Pharmacology Tags: Errata Source Type: research
