Population Pharmacokinetic Analysis of Meropenem in Critically Ill Patients With Acute Kidney Injury Treated With Continuous Hemodiafiltration
Conclusions:
A population PK model was developed for meropenem in critically ill patients with acute kidney injury receiving CHDF. Our results indicated that a meropenem dosage of 0.5 g every 8 hours or 1 g every 12 hours was suitable in this population and for susceptible bacteria. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - July 30, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Determination of Total and Unbound Meropenem, Imipenem/Cilastatin, and Cefoperazone/Sulbactam in Human Plasma: Application for Therapeutic Drug Monitoring in Critically Ill Patients
Conclusions:
The method was simple, rapid, and reliable and is currently being used to provide a TDM service to enhance the efficacious use of the 3 antibiotics. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - July 30, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Development of a Mass Spectrometry-Based Method for Quantification of Ustekinumab in Serum Specimens
Conclusions:
The newly developed LC/MS-based method was shown to be feasible for UST quantification. This analytical approach may lead to individualized dosing and improved patient care. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - July 30, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Is Salivary Busulfan the Cause of Oral Mucositis and the Changes in Salivary Antioxidant Enzymes After Hematopoietic Cell Transplantation?
Background:
To determine whether the busulfan (Bu) present in saliva during hematopoietic cell transplantation (HCT) conditioning correlates with oral mucositis and the changes in salivary antioxidant enzymes.
Methods:
Bu levels in the plasma and saliva of 19 patients who received HCTs were quantified. Salivary flow and salivary superoxide dismutase and catalase activities were measured during HCT. For the toxicity analysis of salivary Bu, an in vitro assay was conducted by exposing human keratinocytes to artificial saliva containing Bu.
Results:
Plasma and salivary Bu concentrations were very similar (rho = 0.92, ...
Source: Therapeutic Drug Monitoring - July 30, 2020 Category: Drugs & Pharmacology Tags: Focus Series: Therapeutic Drug Monitoring in Oncology Source Type: research
Evaluation of Imatinib Concentrations in Samples Submitted for BCR-ABL1 or Imatinib Testing—Evidence to Support Therapeutic Drug Monitoring for Dose Optimization?
Conclusions:
Therapeutic drug monitoring for imatinib may assist clinicians in the identification of patients who may not be adherent to therapy, display variable pharmacokinetics or pharmacodynamics, or may be experiencing toxicity or treatment failure. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - July 30, 2020 Category: Drugs & Pharmacology Tags: Focus Series: Therapeutic Drug Monitoring in Oncology Source Type: research
High-Performance Liquid Chromatography for Therapeutic Drug Monitoring of Serum Lenvatinib
Conclusions:
This sensitive high-performance liquid chromatography method can be used for lenvatinib therapeutic drug monitoring when liquid chromatography–tandem mass spectrometry facilities are unavailable. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - July 30, 2020 Category: Drugs & Pharmacology Tags: Focus Series: Therapeutic Drug Monitoring in Oncology Source Type: research
Quantification of 3-Hydroxypropyl Mercapturic Acid in the Urine of Patients with Breast Cancer to Monitor Cyclophosphamide Toxicity
Conclusions:
The method was applicable for the quantification of 3-HPMA in human urine. Large variations in 3-HPMA concentrations were found in 40 patients with breast cancer treated with cyclophosphamide, with a significant difference (P (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - July 30, 2020 Category: Drugs & Pharmacology Tags: Focus Series: Therapeutic Drug Monitoring in Oncology Source Type: research
Phenotyping of Uracil and 5-Fluorouracil Metabolism Using LC-MS/MS for Prevention of Toxicity and Dose Adjustment of Fluoropyrimidines
This study aimed to develop a quick and easy bioanalytical method for the simultaneous determination of endogenous uracil (U), exogenous 5-fluorouracil (5-FU), and their respective 5,6-dihydro-metabolite in human plasma using Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Methods:
After protein precipitation, the compounds were purified using liquid–liquid extraction. Chromatographic separation was conducted using a Cortecs T3 column and binary gradient elution. Detection and quantification were performed in the positive electrospray ionization and selected the reaction monitoring mode after 2 t...
Source: Therapeutic Drug Monitoring - July 30, 2020 Category: Drugs & Pharmacology Tags: Focus Series: Therapeutic Drug Monitoring in Oncology Source Type: research
Evaluation of Extrapolation Methods to Predict Trough Concentrations to Guide Therapeutic Drug Monitoring of Oral Anticancer Drugs
Conclusions:
Both method 1 and 2 provided accurate and precise individual Cmin,pred values. However, method 2 was easier to implement than method 1 to guide individual dose adjustments in TDM programs. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - July 30, 2020 Category: Drugs & Pharmacology Tags: Focus Series: Therapeutic Drug Monitoring in Oncology Source Type: research
Usage of Tacrolimus and Mycophenolic Acid During Conception, Pregnancy, and Lactation, and Its Implications for Therapeutic Drug Monitoring: A Systematic Critical Review
Conclusions:
Tac treatment during conception, pregnancy and lactation seems to be relatively safe. Due to pharmacokinetic changes during pregnancy, a higher Tac dose might be indicated to maintain target concentrations. However, more evidence is needed to make recommendations on both Tac dose adjustments and alternative matrices than whole-blood for TDM of Tac during pregnancy. MPA treatment in men during conception seems to have no adverse effect on pregnancy outcomes, whereas MPA use in women during conception and pregnancy is strongly discouraged. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - July 30, 2020 Category: Drugs & Pharmacology Tags: Review Article Source Type: research
Subtherapeutic Linezolid Concentration in a Patient With Bullous Pemphigoid Complicated by Methicillin-Resistant Staphylococcus aureus Infection: A Case Study
We presented a case of subtherapeutic linezolid concentration in a patient with bullous pemphigoid characterized by large area skin anabrosis complicated by methicillin-resistant Staphylococcus aureus infections. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - July 30, 2020 Category: Drugs & Pharmacology Tags: Case Report Source Type: research
Finger-Prick Blood Sampling for Therapeutic Drug Monitoring: Be Aware of Skin Contamination by Nebulized Drugs
No abstract available (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2020 Category: Drugs & Pharmacology Tags: Letter to the Editor Source Type: research
A Reversed-Phase Mode LC-MS/MS Method Using a Polysaccharide Chiral Selector for Simultaneous Quantitation of Each Enantiomer of Tramadol and its Metabolites in Human Plasma and Evaluation of CYP-Mediated Stereoselective Demethylation
Conclusions:
The present method can be useful in the enantiomeric evaluation of tramadol and its metabolites in human plasma. Although CYP2D6 contributed to the stereoselective demethylation of tramadol, remarkable differences between (+)- and (−)-ODT were not observed in the plasma of the cancer patients. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Population Pharmacokinetics of Levobupivacaine During Transversus Abdominis Plane Block in Children
Conclusions:
For improved efficiency in the pediatric population, the dose of levobupivacaine should be greater than 0.4 mg/kg. Children's weight should be considered to anticipate any risk of toxicity. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Clozapine and Norclozapine Plasma Levels in Patients Switched Between Different Liquid Formulations
Conclusions:
No significant difference in clozapine plasma levels was observed after switching from Denzapine suspension to a recently introduced clozapine solution. This study also highlights the significance of medicinal characteristics such as taste for patient acceptability and compliance. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2020 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
