Measurement of Free Plasma Concentrations of Beta-Lactam Antibiotics: An Applicability Study in Intensive Care Unit Patients: Erratum
No abstract available (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2021 Category: Drugs & Pharmacology Tags: Erratum Source Type: research
The Question of Accuracy Versus Interlaboratory Agreement for Monitoring the Immunosuppressants Everolimus and Sirolimus
No abstract available (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2021 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
Stability of Vancomycin in Whole Blood
No abstract available (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2021 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
Plasma Concentrations and Cardiovascular Effects of Citalopram Enantiomers After Oral Versus Infusion Citalopram Therapy in Dextromethorphan-Mephenytoin-Phenotyped Patients With Major Depression
Conclusions:
Owing to CIT's high bioavailability, the plasma concentrations of its enantiomers remained largely independent on the administration route. CYP2C19 preferentially demethylated S-CIT after CIT therapy. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Impact of CYP2D6, CYP3A5, and ABCB1 Polymorphisms on Plasma Concentrations of Donepezil and Its Metabolite in Patients With Alzheimer Disease
Conclusions:
Results indicate that the mean plasma concentration ratio of donepezil to 6ODD is associated with CYP2D6 polymorphism and the concomitant use of psychotropics in patients with Alzheimer disease. In intermediate metabolizers, CYP3A5 may play a significant role in the metabolism of donepezil. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Simple Liquid Chromatography–Tandem Mass Spectrometry Method for Quantitation of Total and Free Aprepitant and Its Active N-Dealkylated Metabolites in Human Plasma
Conclusions:
The present developed method showed an acceptable analytical performance and can be used to evaluate total and free aprepitant and its N-dealkylated metabolites in patient plasma. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Development of a High-Throughput Quantification Method for Pazopanib Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry and Its Clinical Application in Patients With Soft Tissue Tumors
Conclusions:
The authors succeeded in developing a novel high-throughput UHPLC-MS/MS method for quantifying pazopanib in human plasma. This method can be applied to TDM of patients receiving pazopanib in clinical settings. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Body Surface Area Dosing of High-Dose Methotrexate Should Be Reconsidered, Particularly in Overweight, Adult Patients
Conclusions:
The results from this study provide additional information on the relationship between MTX concentration and nephrotoxicity. Patients with a plasma MTX concentration>6 µM at 36 hours were more likely to manifest AKI. In addition, the results suggest that overweight patients have a high AKI risk and that BSA-based adjustment of MTX dose is not appropriate. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Etiologies and Outcomes Associated With Tacrolimus Levels Out of a Typical Range That Lead to High Variability in Kidney Transplant Recipients
Conclusions:
Although high tac IPV has many causes, only high tac IPV caused by nonadherence is consistently associated with poor allograft outcomes. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Therapeutic Drug Monitoring of Lamotrigine, Lacosamide, and Levetiracetam in Dried Capillary Blood—Determination of Conversion Factors for Serum-Based Reference Ranges
Conclusions:
The estimation of serum concentrations from measured capillary blood concentrations is feasible for LCM, LTG, and LEV. A simple ratio approach using the mean ratio and Passing–Bablok regression showed the best results for all 3 AEDs. The volumetric absorptive microsampling technique facilitates the quantitative sample collection of capillary blood and overcomes the drawbacks associated with the classical dried blood spot technique. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2021 Category: Drugs & Pharmacology Tags: Focus Series: Alternative Sampling Strategies Source Type: research
Simultaneous Quantification of BCR-ABL and Bruton Tyrosine Kinase Inhibitors in Dried Plasma Spots and Its Application to Clinical Sample Analysis
Conclusions:
An LC-MS/MS method for the simultaneous quantification of 6 TKIs in DPS was developed and validated. Further large-scale studies should be conducted to assess the consistency of concentration measurements obtained from plasma and DPS. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2021 Category: Drugs & Pharmacology Tags: Focus Series: Alternative Sampling Strategies Source Type: research
Dried Plasma Spots and Oral Fluid as Alternative Matrices for Therapeutic Drug Monitoring of Busulfan: Analytical Method Development and Clinical Evaluation
Conclusions:
We developed and validated a simple and fast ultra–high-performance liquid chromatography–MS/MS assay to measure BU in oral fluid and DPS. The results do not support the use of oral fluid as a matrix for routine therapeutic drug monitoring of BU. The AUC estimated from BU measurements in DPS was comparable to that in plasma, supporting the use of DPS in BU therapeutic drug monitoring as an alternative matrix, with adequate short-term stability and logistic advantages. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2021 Category: Drugs & Pharmacology Tags: Focus Series: Alternative Sampling Strategies Source Type: research
Tacrolimus Measured in Capillary Volumetric Microsamples in Pediatric Patients—A Cross-Validation Study
Conclusions:
Tac concentrations can be accurately measured using VAMS technology in pediatric SOT recipients. This makes home-based Tac monitoring feasible in the pediatric population. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2021 Category: Drugs & Pharmacology Tags: Focus Series: Alternative Sampling Strategies Source Type: research
Quantitation of Tacrolimus in Human Whole Blood Samples Using the MITRA Microsampling Device
Conclusions:
The bioanalytical method validated in this study is appropriate and practical for the quantitation of tacrolimus in human whole blood samples collected using the MITRA microsampling device. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2021 Category: Drugs & Pharmacology Tags: Focus Series: Alternative Sampling Strategies Source Type: research
Validation of a Capillary Dry Blood Sample MITRA-Based Assay for the Quantitative Determination of Systemic Tacrolimus Concentrations in Transplant Recipients
Conclusions:
MITRA finger prick sampling provides a convenient alternative to venipuncture for therapeutic drug monitoring in transplant recipients maintained on prolonged-release tacrolimus. When using the finger prick MITRA method, the positive bias in tacrolimus concentrations observed with this technique, when compared with venipuncture, needs to be taken into consideration. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - May 20, 2021 Category: Drugs & Pharmacology Tags: Focus Series: Alternative Sampling Strategies Source Type: research
