Alterations in regional homogeneity and multiple frequency amplitudes of low-frequency fluctuation in patients with new daily persistent headache: a resting-state functional magnetic resonance imaging study
ConclusionsPatients with NDPH may have abnormal activation of the visual system. Abnormal visual activation may occur mainly in higher frequency band of the classical band. No sex differences in brain activity were found in patients with NDPH. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - February 23, 2023 Category: Neurology Source Type: research
Alteration of the cortical morphology in classical trigeminal neuralgia: voxel-, deformation-, and surface-based analysis
ConclusionsThe gray matter volume and cortical morphology of pain-related brain regions were correlated with clinical and trigeminal nerve parameters. voxel-based morphometry, deformation-based morphometry, and surface-based morphometry complemented each other in analyzing the brain structures of patients with classical trigeminal neuralgia and provided a basis for studying the pathophysiology of classical trigeminal neuralgia.Graphical Abstract (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - February 21, 2023 Category: Neurology Source Type: research
Genetics of migraine: where are we now?
AbstractMigraine is a complex brain disorder explained by the interaction of genetic and environmental factors. In monogenic migraines, including familial hemiplegic migraine and migraine with aura associated with hereditary small-vessel disorders, the identified genes code for proteins expressed in neurons, glial cells, or vessels, all of which increase susceptibility to cortical spreading depression. The study of monogenic migraines has shown that the neurovascular unit plays a prominent role in migraine. Genome-wide association studies have identified numerous susceptibility variants that each result in only a small inc...
Source: The Journal of Headache and Pain - February 20, 2023 Category: Neurology Source Type: research
Spatio-temporal dynamics of resting-state brain networks are associated with migraine disability
ConclusionsOur study confirmed the notion that altered spatio-temporal dynamics exist in migraine patients during resting-state. And the temporal dynamics, the spatial changes and the clinical traits such as migraine disability interact with each other. The spatio-temporal dynamics obtained from EEG microstate and fMRI FC analyses may be potential biomarkers for migraine and with a huge potential to change future clinical practice in migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - February 20, 2023 Category: Neurology Source Type: research
A study of differential microRNA expression profile in migraine: the microMIG exploratory study
ConclusionsA 3-miRNA (miR-342-3p, miR-532-3p and miR-758-5p) novel signature has been found differentially expressed between controls and patients with migraine. Enrichment analysis showed that these pathways are closely associated with known migraine pathophysiology, which could lead to the first reliable epigenetic biomarker set. Further studies should be performed to validate these findings in a larger and more heterogeneous sample. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - February 17, 2023 Category: Neurology Source Type: research
The sense of stopping migraine prophylaxis
ConclusionTranslational and basic studies are warranted to investigate the long-term effects of a preventive drug after its discontinuation, starting from what is known about the biology of migraine. In addition, observational studies and, eventually, clinical trials focusing on the effect of discontinuation of migraine prophylactic therapies, are essential to substantiate evidence-based recommendations on stopping rules for both oral preventives and CGRP(-receptor) targeted therapies in migraine.Graphical Abstract (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - February 16, 2023 Category: Neurology Source Type: research
Causal relationships between migraine and microstructural white matter: a Mendelian randomization study
ConclusionsOur findings provided genetic evidence for the causal relationships between migraine and microstructural WM, bringing new insights into brain structure for the development and experience of migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - February 16, 2023 Category: Neurology Source Type: research
The relationship between headache-attributed disability and lost productivity: 3 Attack frequency is the dominating variable
ConclusionIn the relationship between migraine-attributed impairment (symptom burden) and lost productivity,frequency (migraine days/month) is the dominating variable – more important than headache intensity and far more important than episode duration. This has major implications for current practice in headache care and for health policy and health-resource investment. Preventative drugs, grossly underutilized in current practice, offer a high prospect of eco nomic benefit (cost-saving), but new preventative drugs are needed with better efficacy and/or tolerability. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - February 14, 2023 Category: Neurology Source Type: research
Primary headache epidemiology in children and adolescents: a systematic review and meta-analysis
ConclusionWe found an overall remarkably high prevalence of primary headaches in children and adolescents, even if flawed by a high degree of heterogeneity. Further up-to-date studies are warranted to complete the picture of pediatric headache-related burden to enhance specific public interventions. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - February 14, 2023 Category: Neurology Source Type: research
A multicenter, longitudinal survey of headaches and concussions among youth athletes in the United States from 2009 to 2019
ConclusionA history of concussions was a significant contributor to headache burden among American adolescents and young adults. However, those with chronic headaches were not more likely to be diagnosed with a concussion, despite presenting with more severe concussions that had protracted recovery. Our findings not only suggest the need for conservative management among youth athletes with chronic headaches, they also indicate a potential health care gap in this population, in that those with chronic headaches may be referred for concussion diagnosis and management at lower rates than those with no such comorbidity. (Sour...
Source: The Journal of Headache and Pain - February 8, 2023 Category: Neurology Source Type: research
Medium-term real-world data for erenumab in 177 treatment resistant or difficult to treat chronic migraine patients: persistence and patient reported outcome measures after 17 –30 months
ConclusionApproximately 55% of treatment resistant or difficult to treat CM patients who trialled erenumab in our clinics reported a subjective benefit and were still on treatment after 17 –30 months. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - January 16, 2023 Category: Neurology Source Type: research
MARS1 mutations linked to familial trigeminal neuralgia via the integrated stress response
ConclusionMARS1 mutations may cause chronic activation of ISR, contribute to ISR pathophysiological changes in FTN, and cause/accelerate peripheral nerve degeneration. The findings of this study can enrich our knowledge of the role of molecular genetics in TN in humans. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - January 14, 2023 Category: Neurology Source Type: research
Migraine attacks are of peripheral origin: the debate goes on
ConclusionsBoth peripheral and central mechanisms are likely involved in a migraine attack, e.g., peripheral nociceptive input is necessary for pain transmission and cortical activity is necessary for pain perception. Yet, the debate of whether migraine attacks are initiated a peripheral or central site remains unresolved. The increased focus on prodromal symptoms and on the development of a human model of migraine aura will possibly provide key arguments needed to answer this question in the near future. Until then, we cannot draw firm conclusions and the debate goes on.Video linkVideo recording of the debate held at the ...
Source: The Journal of Headache and Pain - January 10, 2023 Category: Neurology Source Type: research
Role of ATP in migraine mechanisms: focus on P2X3 receptors
AbstractMigraine is a major health burden worldwide with complex pathophysiology and multifarious underlying mechanisms. One poorly understood issue concerns the early steps in the generation of migraine pain. To elucidate the basic process of migraine pain further, it seems useful to consider key molecular players that may operate synergistically to evoke headache. While the neuropeptide CGRP is an important contributor, we propose that extracellular ATP (that generally plays a powerful nociceptive role) is also a major component of migraine headache, acting in concert with CGRP to stimulate trigeminal nociceptive neurons...
Source: The Journal of Headache and Pain - January 3, 2023 Category: Neurology Source Type: research
Sphenopalatine ganglion volumetry in episodic cluster headache: from symptom laterality to cranial autonomic symptoms
ConclusionsThis proof-of-concept study successfully measured the SPG volume and demonstrated its associations with symptomatology in patients with episodic CH. The direct measurement of SPG provide insights into studies on peripheral mechanism of CH. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - January 3, 2023 Category: Neurology Source Type: research
