Trends in migraine incidence among women of childbearing age from 1990 to 2019 and the prediction for 2030: an analysis of national data in China
ConclusionMigraine incidence remained an increasing trend from 1990 to 2019 and is projected to continually increase till 2030 among women of childbearing age in China. This study has important public health implication for population-level migraine prevention in China. Precision intervention strategies and approaches shall be considered in campaigns initiated for migraine prevention among Chinese women of childbearing age. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 27, 2023 Category: Neurology Source Type: research
Long-term effectiveness and tolerability of galcanezumab in patients with migraine excluded from clinical trials: real world evidence of 1055 patients with 1 year follow-up from the Galca-Only registry
ConclusionThis study provides class III evidence of effectiveness and tolerability of galcanezumab in patients with HFEM and CM with comorbidities that would result in exclusion of the pivotal RCTs. Nonetheless, the clinical results over a 12-month period were similar to the efficacy observed in randomized controlled trials. Few patients discontinued the drug due to inadequate tolerability. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 22, 2023 Category: Neurology Source Type: research
Correction: Global, regional, and national epidemiology of migraine and tension-type headache in youths and young adults aged 15 –39 years from 1990 to 2019: findings from the global burden of disease study 2019
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 22, 2023 Category: Neurology Source Type: research
Long-term effectiveness of eptinezumab in patients with migraine and prior preventive treatment failures: extension of a randomized controlled trial
ConclusionsThe long-term effectiveness and safety/tolerability of eptinezumab in patients with migraine and 2 –4 prior preventive treatment failures was demonstrated by high completion rates and migraine-preventive benefits sustained for up to 18 months, implying that eptinezumab is a viable long-term treatment option for patients still seeking successful migraine treatments.Trial registrationClinicalTrials.gov (Identifier: NCT04418765; URL:https://www.clinicaltrials.gov/ct2/show/NCT04418765); EudraCT (Identifier: 2019-004497-25; URL:https://www.clinicaltrialsregister.eu/ctr-search/search?query=2019-004497-25).Graphical ...
Source: The Journal of Headache and Pain - November 20, 2023 Category: Neurology Source Type: research
Progesterone distribution in the trigeminal system and its role to modulate sensory neurotransmission: influence of sex
ConclusionsIn conclusion, these results highlight the potential for progesterone to modulate sensory neurotransmission and vascular responses in a complex manner, with effects varying by sex, tissue type, and the nature of the stimulus. Further investigations are needed to elucidate the underlying mechanisms and physiological implications of these findings.Graphical Abstract (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 14, 2023 Category: Neurology Source Type: research
Treatment patterns for patients initiating novel acute migraine specific medications (nAMSMs) in the context of monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway
ConclusionsMost patients initiating nAMSMs had prior treatment with acute and preventive medications. Approximately one-third of patients had prior treatment with anti-CGRP pathway mAbs. After starting nAMSMs, more than one-third of patients discontinued at least one traditional acute medication and one-third of patients discontinued at least one traditional preventive medication.Despite nAMSM initiation, most patients with prior anti-CGRP pathway mAb use continued mAb use. Around 15% of patients without a prior mAb newly started a mAb. These results provide insight into how nAMSMs and mAbs have been integrated into clinic...
Source: The Journal of Headache and Pain - November 9, 2023 Category: Neurology Source Type: research
Pre- and post-headache phases of migraine: multi-country results from the CaMEO – International Study
ConclusionsPre- and post-headache phases of migraine are common, carry unrecognized burden, and may be a target for treatment.Graphical Abstract (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 8, 2023 Category: Neurology Source Type: research
One-year prospective real-world assessment of effectiveness and safety of erenumab in migraine prevention: results of the French FHU INOVPAIN registry study
ConclusionThis first French real-world study related to migraine prevention with CGRP-mAbs confirms effectiveness and safety of erenumab in patients with extreme unmet needs. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 8, 2023 Category: Neurology Source Type: research
Medication overuse headache is associated with elevated lipopolysaccharide binding protein and pro-inflammatory molecules in the bloodstream
ConclusionElevated serum LBP, VE-cadherin and occludin levels indicating disrupted intestinal barrier function and leakage of LPS into the systemic circulation were shown in female rats with MOH. LPS induced low-grade inflammation and elevated nociceptive and/or pro-inflammatory molecules such as HMGB1, IL-6, IL-17 and CGRP may play a role in the development and maintenance of MOH. Interference with leaky gut and pro-inflammatory nociceptive molecules could also be a target for sustained management of MOH. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 8, 2023 Category: Neurology Source Type: research
Increased glymphatic system activity in migraine chronification by diffusion tensor image analysis along the perivascular space
ConclusionsGlymphatic system activity is shown to be increased instead of impaired during migraine chronification. The mechanism behind this observation suggests that increased glymphatic activity is more likely to be a concomitant phenomenon of altered vascular reactivity associated with migraine pathophysiology rather than a risk factor of migraine chronification. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 6, 2023 Category: Neurology Source Type: research
Development and validation of non-invasive prediction models for migraine in Chinese adults
ConclusionsThis study developed and validated a series of convenient and novel non-invasive prediction models for migraine, which have good predictive ability for migraine in Chinese adults of different genders and ages. It is of great significance for the early prevention, screening, and diagnosis of migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 6, 2023 Category: Neurology Source Type: research
Serum neurofilament light chain levels in migraine patients: a monocentric case –control study in China
ConclusionsThis is the first study to evaluate sNfL levels in migraine patients. The sNfL levels significantly increased in patients with a migraine course ≥ 10 years. More attention to nerve damage in young patients with a long course of migraine is required. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 6, 2023 Category: Neurology Source Type: research
Effects of Introvision, a self-regulation method with a mindfulness-based perception technique in migraine prevention: a monocentric randomized waiting-list controlled study (IntroMig Study)
ConclusionAlthough the study did not reach its primary endpoint, several secondary outcome parameters in the pooled (non-controlled) pre-post analysis showed an improvement with a decrease in monthly headache days by 1.9 days/ month. A larger randomized controlled trial has to corroborate these preliminary findings.Trial registrationNCT03507400, Registration date 09.03.2018. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 3, 2023 Category: Neurology Source Type: research
Sex differences in the clinical manifestations related to dependence behaviors in medication-overuse headache
ConclusionsThe current study identified an association between smoking and MOH in men, as well as sex-specific cutoffs of the LDQ and the SDS, for MOH. MOH was characterized by a shorter latency between migraine onset and CM onset in men and a more severe phenotype in women. Sex should be considered as an important factor in the evaluation of MOH. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 1, 2023 Category: Neurology Source Type: research
Impact of a reimbursement policy change on treatment with erenumab in migraine – a real-world experience from Germany
ConclusionsStarting erenumab earlier in the course of migraine progression in a real-world setting may lead to a better response than starting after multiple failed prophylactic attempts. Continually gathering real-world evidence may help policymakers in deciding how readily to cover CGRP-targeted therapies in migraine prevention. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 30, 2023 Category: Neurology Source Type: research
