MARS1 mutations linked to familial trigeminal neuralgia via the integrated stress response

ConclusionMARS1 mutations may cause chronic activation of ISR, contribute to ISR pathophysiological changes in FTN, and cause/accelerate peripheral nerve degeneration. The findings of this study can enrich our knowledge of the role of molecular genetics in TN in humans.

http://link.springer.com/10.1186/s10194-022-01537-2

Source: The Journal of Headache and Pain - January 14, 2023 Category: Neurology Source Type: research