Identifying causal genes for migraine by integrating the proteome and transcriptome
ConclusionsOur proteomic and transcriptome findings have identified disease-associated genes that may give new insights into the pathogenesis and potential therapeutic targets for migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 17, 2023 Category: Neurology Source Type: research

Phenotype of new daily persistent headache: subtypes and comparison to transformed chronic daily headache
ConclusionsWhilst there is overlap in the phenotype of NDPH and T-CDH, the differences in migrainous, cranial autonomic symptoms, and vulnerability to medication overuse suggest that they are not the same disorder. NDPH may be fractionated into three sub-phenotypes, which require further investigation. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 16, 2023 Category: Neurology Source Type: research

Trajectory of blood pressure after initiating anti-calcitonin gene-related peptide treatment of migraine: a target trial emulation from the veterans health administration
ConclusionsOur findings suggest that anti-CGRP treatment is safe regarding blood pressure in patients without hypertension. However, for those with baseline hypertension, anti-CGRP treatment resulted in a small but persistent increase in the number of antihypertensives, indicating an exacerbation of hypertension. Future studies are needed to evaluate the cardio-cerebrovascular safety of anti-CGRP treatment beyond the first four years. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 15, 2023 Category: Neurology Source Type: research

Correction: Changes of migraine aura with advancing age of patients
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 14, 2023 Category: Neurology Source Type: research

Neuroimaging in the pre-ictal or premonitory phase of migraine: a narrative review
ConclusionAdvances in human migraine research, including the use of functional imaging techniques lacking radiation or radio-isotope exposure, have led to an exciting opportunity to study the premonitory phase using repeated measures imaging designs. These studies have provided novel insights into attack initiation, migraine neurochemistry and therapeutic targets. Emerging migraine-specific therapies, such as those targeting calcitonin gene-related peptide (CGRP), are showing promise acutely when taken during premonitory phase to reduce symptoms and prevent subsequent headache. Therapeutic research in this area using PS fo...
Source: The Journal of Headache and Pain - August 11, 2023 Category: Neurology Source Type: research

Mechanisms of initiation of cortical spreading depression
ConclusionsBoth NMDARs and CaV channels are necessary for CSD initiation, which is not determined by the extracellular K+ or neuronal depolarization levels per se, but requires the CaV-dependent activation of a threshold level of NMDARs. This occurs with a delay of several seconds relative to the rapid depolarization produced by the KCl stimulus. Our data give insights into potential mechanisms of CSD initiation in migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 8, 2023 Category: Neurology Source Type: research

Exploring sensory sensitivity, cortical excitability, and habituation in episodic migraine, as a function of age and disease severity, using the pattern-reversal task
ConclusionsThe results of this study yielded evidence for significant hypersensitivity in patients but no significant differences in either habituation or cortical excitability, as compared to headache-free controls. Although the alterations in patients may be less pronounced than originally anticipated they demonstrate the need for the definition and standardization of optimal methodological parameters. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 7, 2023 Category: Neurology Source Type: research

Galcanezumab in patients with episodic migraine: results from the open-label period of the phase 3 PERSIST study
ConclusionsGalcanezumab was efficacious and well-tolerated in patients with episodic migraine from China, India and Russia, for up to 6  months.Trial registrationClinicalTrisABSTRACT_pals.gov NCT03963232, registered May 24, 2019. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 4, 2023 Category: Neurology Source Type: research

Real-world effectiveness, satisfaction, and optimization of ubrogepant for the acute treatment of migraine in combination with onabotulinumtoxinA: results from the COURAGE Study
ConclusionsIn this prospective real-world effectiveness study, ubrogepant treatment in onabotulinumtoxinA users with self-identified migraine was associated with high rates of MPR and RNF at 2 and 4  h as well as satisfaction and acute treatment optimization. Although the lack of a contemporaneous control group limits causal inference, these findings demonstrate the feasibility of using a novel, app-based design to evaluate the real-world effectiveness and satisfaction of treatments.Graphical Abstract (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 3, 2023 Category: Neurology Source Type: research

Persistence to anti-CGRP monoclonal antibodies and onabotulinumtoxinA among patients with migraine: a retrospective cohort study
ConclusionPatients treated with eptinezumab demonstrated persistency that was higher than subcutaneous anti-CGRP mAbs and similar to onabotulinumtoxinA.Graphical Abstract (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 2, 2023 Category: Neurology Source Type: research

Changes of migraine aura with advancing age of patients
ConclusionThe frequency of typical characteristics of migraine aura and migraine headache including photophobia and phonophobia decreases with advancing patient age. This might have potentially difficult implications for the diagnosis of MA in the elderly. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 1, 2023 Category: Neurology Source Type: research

Ten open questions in migraine prophylaxis  with monoclonal antibodies blocking the calcitonin-gene related peptide pathway: a narrative review
AbstractThe monoclonal antibodies (mAbs) blocking the calcitonin-gene related peptide (CGRP) pathway, collectively called here “anti-CGRP/rec mAbs”, have dramatically improved preventive migraine treatment. Although their efficacy and tolerability were proven in a number of randomized controlled trials (RCTs) and, maybe even more convincingly, in real world settings, a number of open questions remain. In this narrative review, we will analyze published data allowing insight in some of the uncertainties related to the use of anti-CGRP/rec mAbs in clinical practice: their differential efficacy in migraine subtypes, outco...
Source: The Journal of Headache and Pain - August 1, 2023 Category: Neurology Source Type: research

A higher probability of subsequent stroke and ischemic heart disease in migraine patients: a longitudinal follow-up study in Korea
ConclusionsOur longitudinal follow-up study demonstrated a significant association between the presence of migraine and the development of stroke and ischemic heart disease in Korea, even after adjusting for cardiovascular risk factors. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 31, 2023 Category: Neurology Source Type: research

MRI features of idiopathic intracranial hypertension are not prognostic of visual and headache outcome
ConclusionsMRI features of IIH are neither prognostic of visual nor headache outcome. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 28, 2023 Category: Neurology Source Type: research

2:1 ketogenic diet and low-glycemic-index diet for the treatment of chronic and episodic migraine: a single-center real-life retrospective study
ConclusionsBoth diets are effective in reducing migraine symptoms and migraine-related disability. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 28, 2023 Category: Neurology Source Type: research