Rethinking headache as a global public health case model for reaching the SDG 3 HEALTH by 2030
AbstractThe 2030 Agenda for Sustainable Development sets out, through 17 Sustainable Development Goals (SDGs), a path for the prosperity of people and the planet. SDG 3 in particular aims to ensure healthy lives and promote well-being for all at all ages and includes several targets to enhance health. This review presents a “headache-tailored” perspective on how to achieve SDG 3 by focusing on six specific actions: targeting chronic headaches; reducing the overuse of acute pain-relieving medications; promoting the education of healthcare professionals; granting access to medication in low- and middle-income countri es ...
Source: The Journal of Headache and Pain - October 27, 2023 Category: Neurology Source Type: research
BMP7 alleviates trigeminal neuralgia by reducing oligodendrocyte apoptosis and demyelination
ConclusionBMP7 can alleviate TN by reducing OLs apoptosis and subsequent demyelination. The mechanism behind this protection could be BMP7-mediated activation of the STAT3 and NF- κB/p65 signaling pathway and subsequent decrease in OL apoptosis. Importantly, our study presents clear evidence in support of BMP7 as a possible therapeutic target for the treatment of TN. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 24, 2023 Category: Neurology Source Type: research
Correction: Preventive treatment patterns and treatment satisfaction in migraine: results of the OVERCOME (EU) study
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 20, 2023 Category: Neurology Source Type: research
The potent analgesia of intrathecal 2R, 6R-HNK via TRPA1 inhibition in LF-PENS-induced chronic primary pain model
ConclusionsIn the newly designed CPP model, our findings highlighted the potential utility of intrathecal 2R, 6R-HNK for preventing and therapeutic modality of CPP. TRPA1-mediated uprgulation of CGRP and neuronal hyperexcitability in nociceptive pathways may undertake both unique characteristics and solving process of CPP. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 19, 2023 Category: Neurology Source Type: research
Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study
ConclusionHyperperfusion of bilateral amygdala might provide potential hemodynamics evidence in the neurolimbic pain network of CM. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 18, 2023 Category: Neurology Source Type: research
Characteristic oscillatory brain networks for predicting patients with chronic migraine
In conclusion, oscillatory synchrony within the pain-related network and default mode network corresponded to altered neurophysiological processes in patients with chronic migraine. Thus, these networks can serve as pivotal signatures in the model for identifying patients with chronic migra ine, providing reliable and generalisable results. This approach may facilitate the objective and individualised diagnosis of migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 18, 2023 Category: Neurology Source Type: research
GFAP-NpHR mediated optogenetic inhibition of trigeminal nucleus caudalis attenuates hypersensitive behaviors and thalamic discharge attributed to infraorbital nerve constriction injury
AbstractThe significance of hyperactive astrocytes in neuropathic pain is crucial. However, the association between medullary astrocytes and trigeminal neuralgia (TN)-related pain processing is unclear. Here, we examined how optogenetic inhibition of medullary astrocytes in the trigeminal nucleus caudalis (TNC) regulates pain hypersensitivity in an infraorbital nerve (ION) constricted TN model. We used adult Sprague Dawley rats subjected to infraorbital nerve (ION) constriction to mimic TN symptoms, with naive and sham rats serving as controls. For in vivo optogenetic manipulations, rats stereotaxically received AAV8-GFAP-...
Source: The Journal of Headache and Pain - October 11, 2023 Category: Neurology Source Type: research
Preventive therapy with galcanezumab for two consecutive cluster bouts in patients with episodic cluster headache: an observational multicenter study
ConclusionsThis exploratory analysis suggests that galcanezumab may be effective as a preventive therapy in subsequent cluster bouts. Patients with episodic cluster headaches who underwent galcanezumab therapy tended to receive a second round of treatment in the early stages of their next cluster bout without transitional therapy. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 10, 2023 Category: Neurology Source Type: research
European Headache Federation (EHF) critical reappraisal and meta-analysis of oral drugs in migraine prevention – part 3: topiramate
ConclusionsThere is high-quality evidence of the efficacy of topiramate in the prophylaxis of migraine, albeit its use poses a risk of adverse events that may lead to treatment discontinuation, with a negative effect on patient satisfaction and adherence to care. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 10, 2023 Category: Neurology Source Type: research
Triptan non-response in specialized headache care: cross-sectional data from the DMKG Headache Registry
ConclusionIn the present setting (specialized headache care in Germany), 13.1% of the patients had failed ≥ 2 triptans. Triptan failure was associated with increased migraine severity and disability, emphasizing the importance of establishing an effective and tolerable acute migraine medication. Acute treatment optimization might include switching to one of the triptans with the highest responder rates and/or to a different acute medication class.Trial registrationThe DMKG Headache Registry is registered with the German Clinical Trials Register (DRKS 00021081). (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 10, 2023 Category: Neurology Source Type: research
Increased MRI-based Brain Age in chronic migraine patients
ConclusionThe brain-predicted age has shown to be a sensitive biomarker of CM patients and can help reveal distinct aging patterns in migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 6, 2023 Category: Neurology Source Type: research
COVID-19 vaccination-related headache showed two different clusters in the long-term course: a prospective multicenter follow-up study (COVA-Head Study)
ConclusionThe identification of two distinct phenotypes of prolonged or worsened headaches related to COVID-19 vaccination can provide valuable clinical insights. Having an awareness of the potential worsening of headaches following COVID-19 vaccination, particularly in patients with a primary headache disorder such as migraine, can help clinicians and headache experts anticipate and adjust their treatment strategies accordingly. This knowledge can aid in preplanning treatment modifications and optimize patient care. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - September 29, 2023 Category: Neurology Source Type: research
Menstrual migraine is caused by estrogen withdrawal: revisiting the evidence
ConclusionFurther research is thus needed to ascertain the involvement of estrogen withdrawal in menstrual migraine and advance the development of effective management strategies to address unmet treatment needs. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - September 21, 2023 Category: Neurology Source Type: research
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention —part 2: flunarizine
ConclusionsPublished flunarizine trials predate the recommended endpoints for evaluating migraine prophylaxis drugs, hence the lack of an adequate assessment for these endpoints. Further, modern-day, large ‐scale studies would be valuable in re-evaluating the efficacy of flunarizine for the treatment of migraines, offering additional insights into its potential benefits. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - September 19, 2023 Category: Neurology Source Type: research
Serum tau protein elevation in migraine: a cross-sectional case –control study
DiscussionMigraine is associated with t-tau elevation in serum but not in the CSF. Our clinical study identifies t-tau as a new target for migraine research. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - September 19, 2023 Category: Neurology Source Type: research
