Diagnosis and Molecular Profiling of Lung Cancer by Percutaneous Ultrasound-Guided Biopsy of Superficial Metastatic Sites Is Safe and Highly Effective
Conclusion: US-NAB of “superficial” metastasis of lung cancer is safe and is associated with high success for diagnosis and molecular profiling. In this clinical setting, using US-NAB as a first-step technique would significantly limit the use of more invasive and costly diagnostic procedures.Respiration (Source: Respiration)
Source: Respiration - April 7, 2021 Category: Respiratory Medicine Source Type: research
Pre-Procedural COVID-19 Nasopharyngeal Swab Has Good Concordance with Bronchoalveolar Lavage in Patients at Low Risk for Viral Infection
Conclusions: These results are promising and suggest that preoperative nasopharyngeal SARS-CoV-2 testing provides adequate screening to rule out active COVID-19 infection prior to OR cases in a population characterized as low risk by negative symptom screening. This information can be used for both pre-procedural screening and when reintroducing trainees into the workforce.Respiration (Source: Respiration)
Source: Respiration - March 30, 2021 Category: Respiratory Medicine Source Type: research
A Note on USS-Guided Biopsies
Respiration (Source: Respiration)
Source: Respiration - March 30, 2021 Category: Respiratory Medicine Source Type: research
Intrapleural Fibrinolytics and Deoxyribonuclease for Treatment of Indwelling Pleural Catheter-Related Pleural Infection: A Multi-Center Observational Study
Conclusion: Treatment of IPC-related pleural infection with intrapleural tPA/DNase instillations via the IPC appears feasible and safe, usually without additional drainage procedures or surgery. Pleurodesis post-infection is common.Respiration (Source: Respiration)
Source: Respiration - March 30, 2021 Category: Respiratory Medicine Source Type: research
Diagnosis and Management of Severe Asthma in Switzerland: Analysis of Survey Results Conducted with Specialists and General Practitioners
Conclusions: Oral corticosteroids (OCSs) are considered as background therapy for severe asthma by GPs and specialists. In order to reduce the OCS burden, there is a need to improve the awareness for other add-on therapies. A joint collaboration between GPs and specialists is the key to leverage therapeutic strategies together.Respiration (Source: Respiration)
Source: Respiration - March 30, 2021 Category: Respiratory Medicine Source Type: research
Exertional Desaturation in Idiopathic Pulmonary Fibrosis: The Role of Oxygen Supplementation in Modifying Cerebral-Skeletal Muscle Oxygenation and Systemic Hemodynamics
Conclusions: IPF patients with isolated exertional hypoxemia exhibit an inability to increase/maintain cerebral oxygenation during submaximal exercise. Correcting desaturation with O2 supplementation prevented the decline in brain oxygenation, improved muscle oxygenation, and lessened dyspnea, suggesting an efficacy of acute oxygen supplementation during exercise training in protecting brain hypoxia in these IPF patients.Respiration (Source: Respiration)
Source: Respiration - March 30, 2021 Category: Respiratory Medicine Source Type: research
The Short- and Long-Term Impact of Pulmonary Rehabilitation in Subjects with Sarcoidosis: A Prospective Study and Review of the Literature
Conclusion: PR is a promising complementary therapeutic intervention for subjects with sarcoidosis. Further study is needed to validate these findings.Respiration (Source: Respiration)
Source: Respiration - March 30, 2021 Category: Respiratory Medicine Source Type: research
Pulmonary Rehabilitation in Patients Recovering from COVID-19
Conclusions: Pulmonary rehabilitation is possible and effective in patients recovering from COVID-19. Our findings may be useful to guide clinicians taking care of patients surviving COVID-19 infection.Respiration (Source: Respiration)
Source: Respiration - March 30, 2021 Category: Respiratory Medicine Source Type: research
Ventilation Heterogeneity in Asthma and COPD: The Value of the Poorly Communicating Fraction as the Ratio of Total Lung Capacity to Alveolar Volume
Conclusions: These results showed that PCF, a readily measure derived from routine pulmonary function testing, can provide a comprehensive measure of both global and acinar VH in asthma and in COPD patients and can be considered as a comparable tool to the well-established MBNW technique.Respiration (Source: Respiration)
Source: Respiration - March 30, 2021 Category: Respiratory Medicine Source Type: research
Use of Ventilation-Perfusion Single-Photon Emission Computed Tomography to Select the Target Lobe for Endobronchial Valve Lung Volume Reduction
Conclusion: In this study of treatment responders, EBV-LVR target lobe selection using VQDI concurs with qCT and thus supports its value for this purpose. It complements qCT and may potentially be of synergistic value especially in homogenous emphysema.Respiration (Source: Respiration)
Source: Respiration - March 26, 2021 Category: Respiratory Medicine Source Type: research
Management of Significant Airway Bleeding during Robotic Assisted Bronchoscopy: A Tailored Approach
We present a case report that exemplifies our approach and management strategy using a combined and simultaneous flexible/robotic bronchoscopy if this complication is encountered.Respiration (Source: Respiration)
Source: Respiration - March 26, 2021 Category: Respiratory Medicine Source Type: research
Effect of Supervised Training Therapy on Pulmonary Arterial Compliance and Stroke Volume in Severe Pulmonary Arterial Hypertension and Inoperable or Persistent Chronic Thromboembolic Pulmonary Hypertension
Conclusions: Our findings suggest that supervised exercise training may improve right ventricular function and PAC at the same time. Further prospective studies are needed to evaluate these findings.Respiration (Source: Respiration)
Source: Respiration - March 25, 2021 Category: Respiratory Medicine Source Type: research
Identifying Responders and Exploring Mechanisms of Action of the Endobronchial Coil Treatment for Emphysema
Conclusions: Our results confirm that emphysema patients benefit from endobronchial coil treatment. The primary mechanism of action is decreasing static hyperinflation with improvement of airway resistance which consequently changes dynamic lung mechanics. However, the right patient population needs to be selected for the treatment to be beneficial which should include patients with severe lung hyperinflation, severe air trapping, and significant emphysema in target lobes.Respiration (Source: Respiration)
Source: Respiration - March 19, 2021 Category: Respiratory Medicine Source Type: research
Bronchoscopic Thermal Vapour Ablation for Localized Cancer Lesions of the Lung: A Clinical Feasibility Treat-and-Resect Study
Conclusion: BTVA of lung tumours is feasible and well tolerated, with preliminary evidence suggesting high potential for effective ablation of tumours. Thermal injury is well demarcated, and uniform tissue necrosis is observed within ablation zones receiving sufficient thermal dose per volume of lung. Treatment of smaller volumes and ensuring adequate thermal dose may be important for ablative efficacy.Respiration (Source: Respiration)
Source: Respiration - March 17, 2021 Category: Respiratory Medicine Source Type: research
Covid-19 Interstitial Pneumonia: Histological and Immunohistochemical Features on Cryobiopsies
Conclusions: Morphologically distinct features were identified in early stages of Covid-19 pneumonia, with epithelial and endothelial cell abnormalities different from either classical interstitial lung diseases or diffuse alveolar damage. Alveolar type II cell hyperplasia was a prominent event in the majority of cases. Inflammatory cells expressed peculiar phenotypes. No evidence of hyaline membranes and endothelial changes characterized by IDO expression might in part explain the compliance and the characteristic pulmonary vasoplegia observed in less-advanced Covid-19 pneumonia.Respiration (Source: Respiration)
Source: Respiration - March 16, 2021 Category: Respiratory Medicine Source Type: research
