The Experience, Prerequisites, and the Barriers in Organizing a Specialized Rehabilitation Program for Patients with Pulmonary Hypertension
Conclusions: Despite a number of challenges and barriers, the implementation of a specialized rehabilitation program should be encouraged in a few dedicated PH expert centers per country, who are capable to fulfill all prerequisites and organizational aspects. Local PH experts, supervision by an experienced center, in-patient rehabilitation facilities, dedicated personnel, equipment, and patient motivation are essential.Respiration (Source: Respiration)
Source: Respiration - May 27, 2021 Category: Respiratory Medicine Source Type: research
Relative Sparing of the Left Upper Zone on Chest Radiography in Severe COVID-19 Pneumonia
The radiological findings of COVID-19 are well-described, including its evolution. In an earlier report of admission chest radiographs of patients with COVID-19, we anecdotally noted relative sparing of the left upper zone (LUZ). We subsequently aimed to describe the main chest radiograph findings in another cohort, focusing on zonal predominance. The admission chest radiographs of 111 patients with CO VID-19 pneumonia requiring intensive care admission were reviewed by 2 thoracic radiologists and categorized according to the predominant pattern into either ground-glass opacities (GGOs), alveolar infiltrates and/or conso...
Source: Respiration - May 27, 2021 Category: Respiratory Medicine Source Type: research
Tuberculosis: The Past, the Present and the Future
Respiration (Source: Respiration)
Source: Respiration - May 25, 2021 Category: Respiratory Medicine Source Type: research
Sleep Duration and Its Associations with Mortality and Quality of Life in Chronic Obstructive Pulmonary Disease: Results from the 2007 –2015 KNAHNES
Conclusions: In patients with COPD, sleep duration was not associated with all-cause mortality. However, short sleep duration was significantly associated with worse HRQOL.Respiration (Source: Respiration)
Source: Respiration - May 21, 2021 Category: Respiratory Medicine Source Type: research
Role of Intermediate Care Unit Admission and Noninvasive Respiratory Support during the COVID-19 Pandemic: A Retrospective Cohort Study
Conclusions: IMCU admission including standardized triage criteria, self-proning, and noninvasive respiratory support prevents ICU admission for a large proportion of patients with COVID-19 hypoxemic respiratory failure. In the context of the COVID-19 pandemic, IMCUs may play an important role in preserving ICU capacity by avoiding ICU admission for patients with worsening respiratory failure and allowing early discharge of ICU patients.Respiration (Source: Respiration)
Source: Respiration - May 21, 2021 Category: Respiratory Medicine Source Type: research
Bronchoscopic Diagnosis of Peripheral Lung Lesions
Respiration (Source: Respiration)
Source: Respiration - May 18, 2021 Category: Respiratory Medicine Source Type: research
Postdischarge Recovery after Acute Pediatric Lung Disease Can Be Quantified with Digital Biomarkers
Conclusions: The digital biomarkers, physical activity, and HR obtained via smartwatch show promise for quantifying postdischarge recovery in a noninvasive manner, which can be useful in pediatric clinical trials and clinical care.Respiration (Source: Respiration)
Source: Respiration - May 18, 2021 Category: Respiratory Medicine Source Type: research
Comparisons of Efficacy and Safety between Triple (Inhaled Corticosteroid/Long-Acting Muscarinic Antagonist/Long-Acting Beta-Agonist) Therapies in Chronic Obstructive Pulmonary Disease: Systematic Review and Bayesian Network Meta-Analysis
Conclusion: There were no significant differences in clinical outcomes, including acute exacerbation and all-cause mortality among various ICS/LAMA/LABA combinations in patients with moderate to very severe COPD.Respiration (Source: Respiration)
Source: Respiration - May 10, 2021 Category: Respiratory Medicine Source Type: research
Endobronchial Coil System versus Standard-of-Care Medical Management in the Treatment of Subjects with Severe Emphysema
Conclusion: Despite early study termination, coil treatment compared to control results in a significant improvement in the lung function and quality of life benefits for up to 6 months in patients with emphysema and severe hyperinflation. These improvements were of clinical importance but were associated with a higher likelihood of serious adverse events.Respiration (Source: Respiration)
Source: Respiration - May 7, 2021 Category: Respiratory Medicine Source Type: research
Noninvasive Home Mechanical Ventilation in Adult Myotonic Dystrophy Type 1: A Systematic Review
Conclusion: This review shows that HMV can improve gas exchange and relieve symptoms with a possible survival benefit in DM1 patients with chronic hypercapnic respiratory failure. Future studies should focus on developing strategies to optimize the timing of HMV initiation and to promote compliance.Respiration (Source: Respiration)
Source: Respiration - May 7, 2021 Category: Respiratory Medicine Source Type: research
Technical Innovations in Pneumology: E-Health, Screening, Diagnostics, and Therapy
This article weighs the pros and cons of technical innovations in specific subspecialties of pneumology based on the lively exch ange of ideas among various pneumological experts.Respiration (Source: Respiration)
Source: Respiration - May 7, 2021 Category: Respiratory Medicine Source Type: research
Antifibrotic Therapy: Is There a Role in Myositis-Interstitial Lung Disease?
Interstitial lung disease (ILD) is a cause of substantial morbidity and mortality amongst autoimmune diseases, including myositis. Despite first-line therapy with immunosuppression, many inflammatory ILDs advance to a fibrotic stage. In such patients, progressive fibrosis may be amenable to treatment with antifibrotic medications, which were initially studied and approved for the treatment of idiopathic pulmonary fibrosis. We here review the available data that support the use of antifibrotics in connective tissue diseases and progressive fibrosing ILDs. There is now a growing body of evidence in both large randomized clin...
Source: Respiration - May 5, 2021 Category: Respiratory Medicine Source Type: research
Assessment of Extensive Airway Obstruction Using Point-by-Point Lateral Pressure Measurements during Bronchoscopy
Conclusions: Point-by-pointPlat measurement could be used to detect the site of maximal obstruction physiologically. Furthermore,Plat measurement could assess the need for additional procedures in real time in patients with extensive airway obstruction.Respiration (Source: Respiration)
Source: Respiration - May 4, 2021 Category: Respiratory Medicine Source Type: research
Sleep-Disordered Breathing and Nocturnal Hypoxemia in Precapillary Pulmonary Hypertension: Prevalence, Pathophysiological Determinants, and Clinical Consequences
Conclusion: OSA, but not CSA, is highly prevalent in patients with PH, and OSA severity is not associated with nighttime SpO2, clinical and functional status. Nocturnal hypoxemia is a frequent finding and (in contrast to OSA) relates to structural RV remodeling in PH.Respiration (Source: Respiration)
Source: Respiration - April 28, 2021 Category: Respiratory Medicine Source Type: research
Low-Blood Lymphocyte Number and Lymphocyte Decline as Key Factors in COPD Outcomes: A Longitudinal Cohort Study
Conclusion: BL count and BL decline are related to worse outcomes in smokers with and without COPD, which suggests that BL count and decline might play a mechanistic role in outcomes deterioration. Insights into mechanisms inducing the fall in BL count could improve the understanding of COPD pathogenesis and point toward new therapeutic measures.Respiration (Source: Respiration)
Source: Respiration - April 26, 2021 Category: Respiratory Medicine Source Type: research
