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Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.METHODS: A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.RESULTS: LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to...
Source: Redox Report : communications in free radical research - August 31, 2023 Category: Biochemistry Authors: Zhi-Qiang Ouyang Li-Shi Shao Wei-Peng Wang Teng-Fei Ke Dong Chen Guang-Rong Zheng Xi-Rui Duan Ji-Xiang Chu Yu Zhu Lu Yang Hai-Yan Shan Lin Huang Cheng-de Liao Source Type: research

Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.METHODS: A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.RESULTS: LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to...
Source: Redox Report : communications in free radical research - August 31, 2023 Category: Biochemistry Authors: Zhi-Qiang Ouyang Li-Shi Shao Wei-Peng Wang Teng-Fei Ke Dong Chen Guang-Rong Zheng Xi-Rui Duan Ji-Xiang Chu Yu Zhu Lu Yang Hai-Yan Shan Lin Huang Cheng-de Liao Source Type: research

Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.METHODS: A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.RESULTS: LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to...
Source: Redox Report : communications in free radical research - August 31, 2023 Category: Biochemistry Authors: Zhi-Qiang Ouyang Li-Shi Shao Wei-Peng Wang Teng-Fei Ke Dong Chen Guang-Rong Zheng Xi-Rui Duan Ji-Xiang Chu Yu Zhu Lu Yang Hai-Yan Shan Lin Huang Cheng-de Liao Source Type: research

Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect
CONCLUSIONS: In conclusion, our results indicate that MLT treatment reverses the Warburg effect and promotes intracellular ROS production, which leads to the suppression of Akt/mTOR/S6K signaling pathway, induction of cell apoptosis, and synergistically inhibition of cell growth with sunitinib in RCC cells. Overall, this study provides new insights into the mechanisms underlying anti-tumor effect of MLT in RCC cells, and suggests that MLT might be a promising therapeutic for RCC.PMID:37642220 | DOI:10.1080/13510002.2023.2251234 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - August 29, 2023 Category: Biochemistry Authors: Kai-Hua Xue Yi-Fan Jiang Ji-Yu Bai Di-Ze Zhang Yu-Hang Chen Jian-Bin Ma Zhi-Jing Zhu Xinyang Wang Peng Guo Source Type: research

Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect
CONCLUSIONS: In conclusion, our results indicate that MLT treatment reverses the Warburg effect and promotes intracellular ROS production, which leads to the suppression of Akt/mTOR/S6K signaling pathway, induction of cell apoptosis, and synergistically inhibition of cell growth with sunitinib in RCC cells. Overall, this study provides new insights into the mechanisms underlying anti-tumor effect of MLT in RCC cells, and suggests that MLT might be a promising therapeutic for RCC.PMID:37642220 | DOI:10.1080/13510002.2023.2251234 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - August 29, 2023 Category: Biochemistry Authors: Kai-Hua Xue Yi-Fan Jiang Ji-Yu Bai Di-Ze Zhang Yu-Hang Chen Jian-Bin Ma Zhi-Jing Zhu Xinyang Wang Peng Guo Source Type: research

Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect
CONCLUSIONS: In conclusion, our results indicate that MLT treatment reverses the Warburg effect and promotes intracellular ROS production, which leads to the suppression of Akt/mTOR/S6K signaling pathway, induction of cell apoptosis, and synergistically inhibition of cell growth with sunitinib in RCC cells. Overall, this study provides new insights into the mechanisms underlying anti-tumor effect of MLT in RCC cells, and suggests that MLT might be a promising therapeutic for RCC.PMID:37642220 | DOI:10.1080/13510002.2023.2251234 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - August 29, 2023 Category: Biochemistry Authors: Kai-Hua Xue Yi-Fan Jiang Ji-Yu Bai Di-Ze Zhang Yu-Hang Chen Jian-Bin Ma Zhi-Jing Zhu Xinyang Wang Peng Guo Source Type: research

Tolerable treatment of glioblastoma with redox-cycling 'mitocans': a comparative study in vivo
Discussion: Q0/A differentiated cancer cells and tissues, particularly glioblastoma, from normal ones by redox targeting, causing a severe oxidative stress in the tumor but not in non-cancerous tissues. Q0/A had a pronounced anticancer activity and could be considered safe for the organism within certain concentration limits. The results suggest that the rate of tumor resorption and metabolism of toxic residues must be controlled and maintained within tolerable limits to achieve longer survival, especially at intracranial drug administration.PMID:37581329 | PMC:PMC10435007 | DOI:10.1080/13510002.2023.2220531 (Source: Redox...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Akira Sumiyoshi Sayaka Shibata Dessislava Lazarova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Source Type: research

Analysis of an antioxidative defence system of hydrogen peroxide-treated pancreatic islet-derived 1.1B4 cells and siRNA targeting NR4A3-treated cells by microarray
In this study, human pancreatic islet-derived 1.1B4 cells were exposed to H2O2 and analysed using a human microarray, which revealed that heme oxygenase 1 (HMOX1), glutamate-cysteine ligase, early growth response 1, nuclear receptor subfamily 4 group A member 3 (NR4A3) and jun B proto-oncogene were upregulated, whereas superoxide dismutase 1 and catalase were not. Expression of NR4A3 rapidly increased after H2O2 addition, and the 1.1B4 cells treated with siRNA targeting NR4A3 became sensitive to H2O2; further, HMOX1 expression was strongly inhibited, suggesting that NR4A3 is an oxidative stress-responsive transcription fac...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Motoko Nakayama Etsuko Ueta Mitsuru Yoshida Yuri Shimizu Atsuko Tokuda Yasuko Sone Yuri Nomi Y Otsuka Source Type: research

Tolerable treatment of glioblastoma with redox-cycling 'mitocans': a comparative study in vivo
Discussion: Q0/A differentiated cancer cells and tissues, particularly glioblastoma, from normal ones by redox targeting, causing a severe oxidative stress in the tumor but not in non-cancerous tissues. Q0/A had a pronounced anticancer activity and could be considered safe for the organism within certain concentration limits. The results suggest that the rate of tumor resorption and metabolism of toxic residues must be controlled and maintained within tolerable limits to achieve longer survival, especially at intracranial drug administration.PMID:37581329 | PMC:PMC10435007 | DOI:10.1080/13510002.2023.2220531 (Source: Redox...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Akira Sumiyoshi Sayaka Shibata Dessislava Lazarova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Source Type: research

Analysis of an antioxidative defence system of hydrogen peroxide-treated pancreatic islet-derived 1.1B4 cells and siRNA targeting NR4A3-treated cells by microarray
In this study, human pancreatic islet-derived 1.1B4 cells were exposed to H2O2 and analysed using a human microarray, which revealed that heme oxygenase 1 (HMOX1), glutamate-cysteine ligase, early growth response 1, nuclear receptor subfamily 4 group A member 3 (NR4A3) and jun B proto-oncogene were upregulated, whereas superoxide dismutase 1 and catalase were not. Expression of NR4A3 rapidly increased after H2O2 addition, and the 1.1B4 cells treated with siRNA targeting NR4A3 became sensitive to H2O2; further, HMOX1 expression was strongly inhibited, suggesting that NR4A3 is an oxidative stress-responsive transcription fac...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Motoko Nakayama Etsuko Ueta Mitsuru Yoshida Yuri Shimizu Atsuko Tokuda Yasuko Sone Yuri Nomi Y Otsuka Source Type: research

Tolerable treatment of glioblastoma with redox-cycling 'mitocans': a comparative study in vivo
Discussion: Q0/A differentiated cancer cells and tissues, particularly glioblastoma, from normal ones by redox targeting, causing a severe oxidative stress in the tumor but not in non-cancerous tissues. Q0/A had a pronounced anticancer activity and could be considered safe for the organism within certain concentration limits. The results suggest that the rate of tumor resorption and metabolism of toxic residues must be controlled and maintained within tolerable limits to achieve longer survival, especially at intracranial drug administration.PMID:37581329 | PMC:PMC10435007 | DOI:10.1080/13510002.2023.2220531 (Source: Redox...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Akira Sumiyoshi Sayaka Shibata Dessislava Lazarova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Source Type: research

Analysis of an antioxidative defence system of hydrogen peroxide-treated pancreatic islet-derived 1.1B4 cells and siRNA targeting NR4A3-treated cells by microarray
In this study, human pancreatic islet-derived 1.1B4 cells were exposed to H2O2 and analysed using a human microarray, which revealed that heme oxygenase 1 (HMOX1), glutamate-cysteine ligase, early growth response 1, nuclear receptor subfamily 4 group A member 3 (NR4A3) and jun B proto-oncogene were upregulated, whereas superoxide dismutase 1 and catalase were not. Expression of NR4A3 rapidly increased after H2O2 addition, and the 1.1B4 cells treated with siRNA targeting NR4A3 became sensitive to H2O2; further, HMOX1 expression was strongly inhibited, suggesting that NR4A3 is an oxidative stress-responsive transcription fac...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Motoko Nakayama Etsuko Ueta Mitsuru Yoshida Yuri Shimizu Atsuko Tokuda Yasuko Sone Yuri Nomi Y Otsuka Source Type: research

Tolerable treatment of glioblastoma with redox-cycling 'mitocans': a comparative study in vivo
Discussion: Q0/A differentiated cancer cells and tissues, particularly glioblastoma, from normal ones by redox targeting, causing a severe oxidative stress in the tumor but not in non-cancerous tissues. Q0/A had a pronounced anticancer activity and could be considered safe for the organism within certain concentration limits. The results suggest that the rate of tumor resorption and metabolism of toxic residues must be controlled and maintained within tolerable limits to achieve longer survival, especially at intracranial drug administration.PMID:37581329 | PMC:PMC10435007 | DOI:10.1080/13510002.2023.2220531 (Source: Redox...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Akira Sumiyoshi Sayaka Shibata Dessislava Lazarova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Source Type: research

Analysis of an antioxidative defence system of hydrogen peroxide-treated pancreatic islet-derived 1.1B4 cells and siRNA targeting NR4A3-treated cells by microarray
In this study, human pancreatic islet-derived 1.1B4 cells were exposed to H2O2 and analysed using a human microarray, which revealed that heme oxygenase 1 (HMOX1), glutamate-cysteine ligase, early growth response 1, nuclear receptor subfamily 4 group A member 3 (NR4A3) and jun B proto-oncogene were upregulated, whereas superoxide dismutase 1 and catalase were not. Expression of NR4A3 rapidly increased after H2O2 addition, and the 1.1B4 cells treated with siRNA targeting NR4A3 became sensitive to H2O2; further, HMOX1 expression was strongly inhibited, suggesting that NR4A3 is an oxidative stress-responsive transcription fac...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Motoko Nakayama Etsuko Ueta Mitsuru Yoshida Yuri Shimizu Atsuko Tokuda Yasuko Sone Yuri Nomi Y Otsuka Source Type: research

Tolerable treatment of glioblastoma with redox-cycling 'mitocans': a comparative study in vivo
Discussion: Q0/A differentiated cancer cells and tissues, particularly glioblastoma, from normal ones by redox targeting, causing a severe oxidative stress in the tumor but not in non-cancerous tissues. Q0/A had a pronounced anticancer activity and could be considered safe for the organism within certain concentration limits. The results suggest that the rate of tumor resorption and metabolism of toxic residues must be controlled and maintained within tolerable limits to achieve longer survival, especially at intracranial drug administration.PMID:37581329 | PMC:PMC10435007 | DOI:10.1080/13510002.2023.2220531 (Source: Redox...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Akira Sumiyoshi Sayaka Shibata Dessislava Lazarova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Source Type: research