Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes
Redox Rep. 2023 Dec;28(1):2260646. doi: 10.1080/13510002.2023.2260646. Epub 2023 Sep 26.ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metabolism is the major compromised metabolic process in isolated primary hepatocytes, along with drastically decreased GSH and ROS content, while lipid peroxidation is increased. Gain- and loss-of-function studies revealed that Slc7a11 expression is critical in maintaining fatty acid metabolism ...
Source: Redox Report : communications in free radical research - September 26, 2023 Category: Biochemistry Authors: Yifan Liu Kaimin Wu Yinkun Fu Wenyan Li Xu-Yun Zhao Source Type: research

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes
Redox Rep. 2023 Dec;28(1):2260646. doi: 10.1080/13510002.2023.2260646. Epub 2023 Sep 26.ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metabolism is the major compromised metabolic process in isolated primary hepatocytes, along with drastically decreased GSH and ROS content, while lipid peroxidation is increased. Gain- and loss-of-function studies revealed that Slc7a11 expression is critical in maintaining fatty acid metabolism ...
Source: Redox Report : communications in free radical research - September 26, 2023 Category: Biochemistry Authors: Yifan Liu Kaimin Wu Yinkun Fu Wenyan Li Xu-Yun Zhao Source Type: research

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes
Redox Rep. 2023 Dec;28(1):2260646. doi: 10.1080/13510002.2023.2260646. Epub 2023 Sep 26.ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metabolism is the major compromised metabolic process in isolated primary hepatocytes, along with drastically decreased GSH and ROS content, while lipid peroxidation is increased. Gain- and loss-of-function studies revealed that Slc7a11 expression is critical in maintaining fatty acid metabolism ...
Source: Redox Report : communications in free radical research - September 26, 2023 Category: Biochemistry Authors: Yifan Liu Kaimin Wu Yinkun Fu Wenyan Li Xu-Yun Zhao Source Type: research

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes
Redox Rep. 2023 Dec;28(1):2260646. doi: 10.1080/13510002.2023.2260646. Epub 2023 Sep 26.ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metabolism is the major compromised metabolic process in isolated primary hepatocytes, along with drastically decreased GSH and ROS content, while lipid peroxidation is increased. Gain- and loss-of-function studies revealed that Slc7a11 expression is critical in maintaining fatty acid metabolism ...
Source: Redox Report : communications in free radical research - September 26, 2023 Category: Biochemistry Authors: Yifan Liu Kaimin Wu Yinkun Fu Wenyan Li Xu-Yun Zhao Source Type: research

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes
Redox Rep. 2023 Dec;28(1):2260646. doi: 10.1080/13510002.2023.2260646. Epub 2023 Sep 26.ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metabolism is the major compromised metabolic process in isolated primary hepatocytes, along with drastically decreased GSH and ROS content, while lipid peroxidation is increased. Gain- and loss-of-function studies revealed that Slc7a11 expression is critical in maintaining fatty acid metabolism ...
Source: Redox Report : communications in free radical research - September 26, 2023 Category: Biochemistry Authors: Yifan Liu Kaimin Wu Yinkun Fu Wenyan Li Xu-Yun Zhao Source Type: research

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes
Redox Rep. 2023 Dec;28(1):2260646. doi: 10.1080/13510002.2023.2260646. Epub 2023 Sep 26.ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metabolism is the major compromised metabolic process in isolated primary hepatocytes, along with drastically decreased GSH and ROS content, while lipid peroxidation is increased. Gain- and loss-of-function studies revealed that Slc7a11 expression is critical in maintaining fatty acid metabolism ...
Source: Redox Report : communications in free radical research - September 26, 2023 Category: Biochemistry Authors: Yifan Liu Kaimin Wu Yinkun Fu Wenyan Li Xu-Yun Zhao Source Type: research

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes
Redox Rep. 2023 Dec;28(1):2260646. doi: 10.1080/13510002.2023.2260646. Epub 2023 Sep 26.ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metabolism is the major compromised metabolic process in isolated primary hepatocytes, along with drastically decreased GSH and ROS content, while lipid peroxidation is increased. Gain- and loss-of-function studies revealed that Slc7a11 expression is critical in maintaining fatty acid metabolism ...
Source: Redox Report : communications in free radical research - September 26, 2023 Category: Biochemistry Authors: Yifan Liu Kaimin Wu Yinkun Fu Wenyan Li Xu-Yun Zhao Source Type: research

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes
Redox Rep. 2023 Dec;28(1):2260646. doi: 10.1080/13510002.2023.2260646. Epub 2023 Sep 26.ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metabolism is the major compromised metabolic process in isolated primary hepatocytes, along with drastically decreased GSH and ROS content, while lipid peroxidation is increased. Gain- and loss-of-function studies revealed that Slc7a11 expression is critical in maintaining fatty acid metabolism ...
Source: Redox Report : communications in free radical research - September 26, 2023 Category: Biochemistry Authors: Yifan Liu Kaimin Wu Yinkun Fu Wenyan Li Xu-Yun Zhao Source Type: research

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes
Redox Rep. 2023 Dec;28(1):2260646. doi: 10.1080/13510002.2023.2260646. Epub 2023 Sep 26.ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metabolism is the major compromised metabolic process in isolated primary hepatocytes, along with drastically decreased GSH and ROS content, while lipid peroxidation is increased. Gain- and loss-of-function studies revealed that Slc7a11 expression is critical in maintaining fatty acid metabolism ...
Source: Redox Report : communications in free radical research - September 26, 2023 Category: Biochemistry Authors: Yifan Liu Kaimin Wu Yinkun Fu Wenyan Li Xu-Yun Zhao Source Type: research

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes
Redox Rep. 2023 Dec;28(1):2260646. doi: 10.1080/13510002.2023.2260646. Epub 2023 Sep 26.ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metabolism is the major compromised metabolic process in isolated primary hepatocytes, along with drastically decreased GSH and ROS content, while lipid peroxidation is increased. Gain- and loss-of-function studies revealed that Slc7a11 expression is critical in maintaining fatty acid metabolism ...
Source: Redox Report : communications in free radical research - September 26, 2023 Category: Biochemistry Authors: Yifan Liu Kaimin Wu Yinkun Fu Wenyan Li Xu-Yun Zhao Source Type: research

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes
Redox Rep. 2023 Dec;28(1):2260646. doi: 10.1080/13510002.2023.2260646. Epub 2023 Sep 26.ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metabolism is the major compromised metabolic process in isolated primary hepatocytes, along with drastically decreased GSH and ROS content, while lipid peroxidation is increased. Gain- and loss-of-function studies revealed that Slc7a11 expression is critical in maintaining fatty acid metabolism ...
Source: Redox Report : communications in free radical research - September 26, 2023 Category: Biochemistry Authors: Yifan Liu Kaimin Wu Yinkun Fu Wenyan Li Xu-Yun Zhao Source Type: research

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes
Redox Rep. 2023 Dec;28(1):2260646. doi: 10.1080/13510002.2023.2260646. Epub 2023 Sep 26.ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metabolism is the major compromised metabolic process in isolated primary hepatocytes, along with drastically decreased GSH and ROS content, while lipid peroxidation is increased. Gain- and loss-of-function studies revealed that Slc7a11 expression is critical in maintaining fatty acid metabolism ...
Source: Redox Report : communications in free radical research - September 26, 2023 Category: Biochemistry Authors: Yifan Liu Kaimin Wu Yinkun Fu Wenyan Li Xu-Yun Zhao Source Type: research

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes
Redox Rep. 2023 Dec;28(1):2260646. doi: 10.1080/13510002.2023.2260646. Epub 2023 Sep 26.ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metabolism is the major compromised metabolic process in isolated primary hepatocytes, along with drastically decreased GSH and ROS content, while lipid peroxidation is increased. Gain- and loss-of-function studies revealed that Slc7a11 expression is critical in maintaining fatty acid metabolism ...
Source: Redox Report : communications in free radical research - September 26, 2023 Category: Biochemistry Authors: Yifan Liu Kaimin Wu Yinkun Fu Wenyan Li Xu-Yun Zhao Source Type: research

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes
Redox Rep. 2023 Dec;28(1):2260646. doi: 10.1080/13510002.2023.2260646. Epub 2023 Sep 26.ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metabolism is the major compromised metabolic process in isolated primary hepatocytes, along with drastically decreased GSH and ROS content, while lipid peroxidation is increased. Gain- and loss-of-function studies revealed that Slc7a11 expression is critical in maintaining fatty acid metabolism ...
Source: Redox Report : communications in free radical research - September 26, 2023 Category: Biochemistry Authors: Yifan Liu Kaimin Wu Yinkun Fu Wenyan Li Xu-Yun Zhao Source Type: research

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes
Redox Rep. 2023 Dec;28(1):2260646. doi: 10.1080/13510002.2023.2260646. Epub 2023 Sep 26.ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metabolism is the major compromised metabolic process in isolated primary hepatocytes, along with drastically decreased GSH and ROS content, while lipid peroxidation is increased. Gain- and loss-of-function studies revealed that Slc7a11 expression is critical in maintaining fatty acid metabolism ...
Source: Redox Report : communications in free radical research - September 26, 2023 Category: Biochemistry Authors: Yifan Liu Kaimin Wu Yinkun Fu Wenyan Li Xu-Yun Zhao Source Type: research