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Effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in APP695V717I transgenic mice
Redox Rep. 2023 Dec;28(1):2259246. doi: 10.1080/13510002.2023.2259246. Epub 2023 Sep 20.ABSTRACTMitochondrial dysfunction leading to overproduction of oxygen free radicals is an important event in the development of Alzheimer's disease. Tetrahydroxy stilbene glycoside (TSG) is one of the main effective components of Polygonum multiflorum and has a certain free radical scavenging effect. We synthesized tetrahydroxy stilbene glycoside derivatives (Mito-TSGs) that can cross the mitochondrial membrane and may provide effective protection against Alzheimer's disease. This experiment investigates the protective mechanism of tetr...
Source: Redox Report : communications in free radical research - September 20, 2023 Category: Biochemistry Authors: Jun Qian Yun Li Yanyun Wang Qunying Ye Hongbo Luo Source Type: research

Effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in APP695V717I transgenic mice
Redox Rep. 2023 Dec;28(1):2259246. doi: 10.1080/13510002.2023.2259246. Epub 2023 Sep 20.ABSTRACTMitochondrial dysfunction leading to overproduction of oxygen free radicals is an important event in the development of Alzheimer's disease. Tetrahydroxy stilbene glycoside (TSG) is one of the main effective components of Polygonum multiflorum and has a certain free radical scavenging effect. We synthesized tetrahydroxy stilbene glycoside derivatives (Mito-TSGs) that can cross the mitochondrial membrane and may provide effective protection against Alzheimer's disease. This experiment investigates the protective mechanism of tetr...
Source: Redox Report : communications in free radical research - September 20, 2023 Category: Biochemistry Authors: Jun Qian Yun Li Yanyun Wang Qunying Ye Hongbo Luo Source Type: research

Effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in APP695V717I transgenic mice
Redox Rep. 2023 Dec;28(1):2259246. doi: 10.1080/13510002.2023.2259246. Epub 2023 Sep 20.ABSTRACTMitochondrial dysfunction leading to overproduction of oxygen free radicals is an important event in the development of Alzheimer's disease. Tetrahydroxy stilbene glycoside (TSG) is one of the main effective components of Polygonum multiflorum and has a certain free radical scavenging effect. We synthesized tetrahydroxy stilbene glycoside derivatives (Mito-TSGs) that can cross the mitochondrial membrane and may provide effective protection against Alzheimer's disease. This experiment investigates the protective mechanism of tetr...
Source: Redox Report : communications in free radical research - September 20, 2023 Category: Biochemistry Authors: Jun Qian Yun Li Yanyun Wang Qunying Ye Hongbo Luo Source Type: research

Effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in APP695V717I transgenic mice
Redox Rep. 2023 Dec;28(1):2259246. doi: 10.1080/13510002.2023.2259246. Epub 2023 Sep 20.ABSTRACTMitochondrial dysfunction leading to overproduction of oxygen free radicals is an important event in the development of Alzheimer's disease. Tetrahydroxy stilbene glycoside (TSG) is one of the main effective components of Polygonum multiflorum and has a certain free radical scavenging effect. We synthesized tetrahydroxy stilbene glycoside derivatives (Mito-TSGs) that can cross the mitochondrial membrane and may provide effective protection against Alzheimer's disease. This experiment investigates the protective mechanism of tetr...
Source: Redox Report : communications in free radical research - September 20, 2023 Category: Biochemistry Authors: Jun Qian Yun Li Yanyun Wang Qunying Ye Hongbo Luo Source Type: research

Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.METHODS: A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.RESULTS: LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to...
Source: Redox Report : communications in free radical research - August 31, 2023 Category: Biochemistry Authors: Zhi-Qiang Ouyang Li-Shi Shao Wei-Peng Wang Teng-Fei Ke Dong Chen Guang-Rong Zheng Xi-Rui Duan Ji-Xiang Chu Yu Zhu Lu Yang Hai-Yan Shan Lin Huang Cheng-de Liao Source Type: research

Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.METHODS: A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.RESULTS: LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to...
Source: Redox Report : communications in free radical research - August 31, 2023 Category: Biochemistry Authors: Zhi-Qiang Ouyang Li-Shi Shao Wei-Peng Wang Teng-Fei Ke Dong Chen Guang-Rong Zheng Xi-Rui Duan Ji-Xiang Chu Yu Zhu Lu Yang Hai-Yan Shan Lin Huang Cheng-de Liao Source Type: research

Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.METHODS: A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.RESULTS: LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to...
Source: Redox Report : communications in free radical research - August 31, 2023 Category: Biochemistry Authors: Zhi-Qiang Ouyang Li-Shi Shao Wei-Peng Wang Teng-Fei Ke Dong Chen Guang-Rong Zheng Xi-Rui Duan Ji-Xiang Chu Yu Zhu Lu Yang Hai-Yan Shan Lin Huang Cheng-de Liao Source Type: research

Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.METHODS: A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.RESULTS: LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to...
Source: Redox Report : communications in free radical research - August 31, 2023 Category: Biochemistry Authors: Zhi-Qiang Ouyang Li-Shi Shao Wei-Peng Wang Teng-Fei Ke Dong Chen Guang-Rong Zheng Xi-Rui Duan Ji-Xiang Chu Yu Zhu Lu Yang Hai-Yan Shan Lin Huang Cheng-de Liao Source Type: research

Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.METHODS: A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.RESULTS: LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to...
Source: Redox Report : communications in free radical research - August 31, 2023 Category: Biochemistry Authors: Zhi-Qiang Ouyang Li-Shi Shao Wei-Peng Wang Teng-Fei Ke Dong Chen Guang-Rong Zheng Xi-Rui Duan Ji-Xiang Chu Yu Zhu Lu Yang Hai-Yan Shan Lin Huang Cheng-de Liao Source Type: research

Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.METHODS: A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.RESULTS: LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to...
Source: Redox Report : communications in free radical research - August 31, 2023 Category: Biochemistry Authors: Zhi-Qiang Ouyang Li-Shi Shao Wei-Peng Wang Teng-Fei Ke Dong Chen Guang-Rong Zheng Xi-Rui Duan Ji-Xiang Chu Yu Zhu Lu Yang Hai-Yan Shan Lin Huang Cheng-de Liao Source Type: research

Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.METHODS: A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.RESULTS: LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to...
Source: Redox Report : communications in free radical research - August 31, 2023 Category: Biochemistry Authors: Zhi-Qiang Ouyang Li-Shi Shao Wei-Peng Wang Teng-Fei Ke Dong Chen Guang-Rong Zheng Xi-Rui Duan Ji-Xiang Chu Yu Zhu Lu Yang Hai-Yan Shan Lin Huang Cheng-de Liao Source Type: research

Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.METHODS: A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.RESULTS: LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to...
Source: Redox Report : communications in free radical research - August 31, 2023 Category: Biochemistry Authors: Zhi-Qiang Ouyang Li-Shi Shao Wei-Peng Wang Teng-Fei Ke Dong Chen Guang-Rong Zheng Xi-Rui Duan Ji-Xiang Chu Yu Zhu Lu Yang Hai-Yan Shan Lin Huang Cheng-de Liao Source Type: research

Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.METHODS: A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.RESULTS: LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to...
Source: Redox Report : communications in free radical research - August 31, 2023 Category: Biochemistry Authors: Zhi-Qiang Ouyang Li-Shi Shao Wei-Peng Wang Teng-Fei Ke Dong Chen Guang-Rong Zheng Xi-Rui Duan Ji-Xiang Chu Yu Zhu Lu Yang Hai-Yan Shan Lin Huang Cheng-de Liao Source Type: research

Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.METHODS: A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.RESULTS: LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to...
Source: Redox Report : communications in free radical research - August 31, 2023 Category: Biochemistry Authors: Zhi-Qiang Ouyang Li-Shi Shao Wei-Peng Wang Teng-Fei Ke Dong Chen Guang-Rong Zheng Xi-Rui Duan Ji-Xiang Chu Yu Zhu Lu Yang Hai-Yan Shan Lin Huang Cheng-de Liao Source Type: research

Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.METHODS: A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.RESULTS: LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to...
Source: Redox Report : communications in free radical research - August 31, 2023 Category: Biochemistry Authors: Zhi-Qiang Ouyang Li-Shi Shao Wei-Peng Wang Teng-Fei Ke Dong Chen Guang-Rong Zheng Xi-Rui Duan Ji-Xiang Chu Yu Zhu Lu Yang Hai-Yan Shan Lin Huang Cheng-de Liao Source Type: research