Redox Report : communications in free radical research 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Implication of endoplasmic reticulum stress and mitochondrial perturbations in remote liver injury after renal ischemia/reperfusion in rats: potential protective role of azilsartan
This study aimed to elucidate the cross-talk of endoplasmic reticulum (ER) stress and mitochondrial perturbations in renal I/R-induced liver injury, and the potential hepatoprotective effect of azilsartan (AZL).Methods: Male albino Wister rats were pre-treated with AZL (3 mg/kg/day, PO) for 7 days then a bilateral renal I/R or sham procedure was performed. Activities of liver enzymes were assessed in plasma. The structure and ultra-structure of hepatocytes were assessed by light and electron microscopy. Markers of ER stress, mitochondrial biogenesis and apoptosis were analyzed in livers of rats.Results: Renal ischemic rats...
Source: Redox Report : communications in free radical research - February 27, 2024 Category: Biochemistry Authors: Rania A Elrashidy Esraa M Zakaria Rehab A Hasan Asmaa M Elmaghraby Dina A Hassan Ranya M Abdelgalil Shaimaa R Abdelmohsen Amira M Negm Azza S Khalil Ayat M S Eraque Reem M Ahmed Walaa S Sabbah Ahmed A Ahmed Samah E Ibrahim Source Type: research
Implication of endoplasmic reticulum stress and mitochondrial perturbations in remote liver injury after renal ischemia/reperfusion in rats: potential protective role of azilsartan
This study aimed to elucidate the cross-talk of endoplasmic reticulum (ER) stress and mitochondrial perturbations in renal I/R-induced liver injury, and the potential hepatoprotective effect of azilsartan (AZL).Methods: Male albino Wister rats were pre-treated with AZL (3 mg/kg/day, PO) for 7 days then a bilateral renal I/R or sham procedure was performed. Activities of liver enzymes were assessed in plasma. The structure and ultra-structure of hepatocytes were assessed by light and electron microscopy. Markers of ER stress, mitochondrial biogenesis and apoptosis were analyzed in livers of rats.Results: Renal ischemic rats...
Source: Redox Report : communications in free radical research - February 27, 2024 Category: Biochemistry Authors: Rania A Elrashidy Esraa M Zakaria Rehab A Hasan Asmaa M Elmaghraby Dina A Hassan Ranya M Abdelgalil Shaimaa R Abdelmohsen Amira M Negm Azza S Khalil Ayat M S Eraque Reem M Ahmed Walaa S Sabbah Ahmed A Ahmed Samah E Ibrahim Source Type: research
Implication of endoplasmic reticulum stress and mitochondrial perturbations in remote liver injury after renal ischemia/reperfusion in rats: potential protective role of azilsartan
This study aimed to elucidate the cross-talk of endoplasmic reticulum (ER) stress and mitochondrial perturbations in renal I/R-induced liver injury, and the potential hepatoprotective effect of azilsartan (AZL).Methods: Male albino Wister rats were pre-treated with AZL (3 mg/kg/day, PO) for 7 days then a bilateral renal I/R or sham procedure was performed. Activities of liver enzymes were assessed in plasma. The structure and ultra-structure of hepatocytes were assessed by light and electron microscopy. Markers of ER stress, mitochondrial biogenesis and apoptosis were analyzed in livers of rats.Results: Renal ischemic rats...
Source: Redox Report : communications in free radical research - February 27, 2024 Category: Biochemistry Authors: Rania A Elrashidy Esraa M Zakaria Rehab A Hasan Asmaa M Elmaghraby Dina A Hassan Ranya M Abdelgalil Shaimaa R Abdelmohsen Amira M Negm Azza S Khalil Ayat M S Eraque Reem M Ahmed Walaa S Sabbah Ahmed A Ahmed Samah E Ibrahim Source Type: research
Implication of endoplasmic reticulum stress and mitochondrial perturbations in remote liver injury after renal ischemia/reperfusion in rats: potential protective role of azilsartan
This study aimed to elucidate the cross-talk of endoplasmic reticulum (ER) stress and mitochondrial perturbations in renal I/R-induced liver injury, and the potential hepatoprotective effect of azilsartan (AZL).Methods: Male albino Wister rats were pre-treated with AZL (3 mg/kg/day, PO) for 7 days then a bilateral renal I/R or sham procedure was performed. Activities of liver enzymes were assessed in plasma. The structure and ultra-structure of hepatocytes were assessed by light and electron microscopy. Markers of ER stress, mitochondrial biogenesis and apoptosis were analyzed in livers of rats.Results: Renal ischemic rats...
Source: Redox Report : communications in free radical research - February 27, 2024 Category: Biochemistry Authors: Rania A Elrashidy Esraa M Zakaria Rehab A Hasan Asmaa M Elmaghraby Dina A Hassan Ranya M Abdelgalil Shaimaa R Abdelmohsen Amira M Negm Azza S Khalil Ayat M S Eraque Reem M Ahmed Walaa S Sabbah Ahmed A Ahmed Samah E Ibrahim Source Type: research
< em > Angelica keiskei < /em > water extract Mitigates Age-Associated Physiological Decline in Mice
CONCLUSIONS: Our findings indicated the potential of Angelica keiskei as a safe and effective dietary supplement to combat aging and revealed the broad prospects of medicinal and edible plants for addressing aging and age-related chronic diseases.PMID:38390941 | PMC:PMC10896161 | DOI:10.1080/13510002.2024.2305036 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - February 23, 2024 Category: Biochemistry Authors: Huan Liu Gang Wei Tongxing Wang Yunlong Hou Bin Hou Xiaoyan Li Chao Wang Mingzhe Sun Min Su Zhifang Guo Lu Wang Ning Kang Mengnan Li Zhenhua Jia Source Type: research
< em > Angelica keiskei < /em > water extract Mitigates Age-Associated Physiological Decline in Mice
CONCLUSIONS: Our findings indicated the potential of Angelica keiskei as a safe and effective dietary supplement to combat aging and revealed the broad prospects of medicinal and edible plants for addressing aging and age-related chronic diseases.PMID:38390941 | DOI:10.1080/13510002.2024.2305036 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - February 23, 2024 Category: Biochemistry Authors: Huan Liu Gang Wei Tongxing Wang Yunlong Hou Bin Hou Xiaoyan Li Chao Wang Mingzhe Sun Min Su Zhifang Guo Lu Wang Ning Kang Mengnan Li Zhenhua Jia Source Type: research
Glutamine sustains energy metabolism and alleviates liver injury in burn sepsis by promoting the assembly of mitochondrial HSP60-HSP10 complex via SIRT4 dependent protein deacetylation
In this study, we demonstrated that Gln alleviated liver injury by sustaining energy supply and restoring redox balance. Meanwhile, Gln also rescued the dysfunctional mitochondrial electron transport chain (ETC) complexes, improved ATP production, reduced oxidative stress, and protected hepatocytes from burn sepsis injury. Mechanistically, we revealed that Gln could activate SIRT4 by upregulating its protein synthesis and increasing the level of Nicotinamide adenine dinucleotide (NAD+), a co-enzyme that sustains the activity of SIRT4. This, in turn, reduced the acetylation of shock protein (HSP) 60 to facilitate the assemb...
Source: Redox Report : communications in free radical research - February 8, 2024 Category: Biochemistry Authors: Yongjun Yang Qian Chen Shijun Fan Yongling Lu Qianyin Huang Xin Liu Xi Peng Source Type: research
Glutamine sustains energy metabolism and alleviates liver injury in burn sepsis by promoting the assembly of mitochondrial HSP60-HSP10 complex via SIRT4 dependent protein deacetylation
In this study, we demonstrated that Gln alleviated liver injury by sustaining energy supply and restoring redox balance. Meanwhile, Gln also rescued the dysfunctional mitochondrial electron transport chain (ETC) complexes, improved ATP production, reduced oxidative stress, and protected hepatocytes from burn sepsis injury. Mechanistically, we revealed that Gln could activate SIRT4 by upregulating its protein synthesis and increasing the level of Nicotinamide adenine dinucleotide (NAD+), a co-enzyme that sustains the activity of SIRT4. This, in turn, reduced the acetylation of shock protein (HSP) 60 to facilitate the assemb...
Source: Redox Report : communications in free radical research - February 8, 2024 Category: Biochemistry Authors: Yongjun Yang Qian Chen Shijun Fan Yongling Lu Qianyin Huang Xin Liu Xi Peng Source Type: research
Glutamine sustains energy metabolism and alleviates liver injury in burn sepsis by promoting the assembly of mitochondrial HSP60-HSP10 complex via SIRT4 dependent protein deacetylation
In this study, we demonstrated that Gln alleviated liver injury by sustaining energy supply and restoring redox balance. Meanwhile, Gln also rescued the dysfunctional mitochondrial electron transport chain (ETC) complexes, improved ATP production, reduced oxidative stress, and protected hepatocytes from burn sepsis injury. Mechanistically, we revealed that Gln could activate SIRT4 by upregulating its protein synthesis and increasing the level of Nicotinamide adenine dinucleotide (NAD+), a co-enzyme that sustains the activity of SIRT4. This, in turn, reduced the acetylation of shock protein (HSP) 60 to facilitate the assemb...
Source: Redox Report : communications in free radical research - February 8, 2024 Category: Biochemistry Authors: Yongjun Yang Qian Chen Shijun Fan Yongling Lu Qianyin Huang Xin Liu Xi Peng Source Type: research
Glutamine sustains energy metabolism and alleviates liver injury in burn sepsis by promoting the assembly of mitochondrial HSP60-HSP10 complex via SIRT4 dependent protein deacetylation
In this study, we demonstrated that Gln alleviated liver injury by sustaining energy supply and restoring redox balance. Meanwhile, Gln also rescued the dysfunctional mitochondrial electron transport chain (ETC) complexes, improved ATP production, reduced oxidative stress, and protected hepatocytes from burn sepsis injury. Mechanistically, we revealed that Gln could activate SIRT4 by upregulating its protein synthesis and increasing the level of Nicotinamide adenine dinucleotide (NAD+), a co-enzyme that sustains the activity of SIRT4. This, in turn, reduced the acetylation of shock protein (HSP) 60 to facilitate the assemb...
Source: Redox Report : communications in free radical research - February 8, 2024 Category: Biochemistry Authors: Yongjun Yang Qian Chen Shijun Fan Yongling Lu Qianyin Huang Xin Liu Xi Peng Source Type: research
Glutamine sustains energy metabolism and alleviates liver injury in burn sepsis by promoting the assembly of mitochondrial HSP60-HSP10 complex via SIRT4 dependent protein deacetylation
In this study, we demonstrated that Gln alleviated liver injury by sustaining energy supply and restoring redox balance. Meanwhile, Gln also rescued the dysfunctional mitochondrial electron transport chain (ETC) complexes, improved ATP production, reduced oxidative stress, and protected hepatocytes from burn sepsis injury. Mechanistically, we revealed that Gln could activate SIRT4 by upregulating its protein synthesis and increasing the level of Nicotinamide adenine dinucleotide (NAD+), a co-enzyme that sustains the activity of SIRT4. This, in turn, reduced the acetylation of shock protein (HSP) 60 to facilitate the assemb...
Source: Redox Report : communications in free radical research - February 8, 2024 Category: Biochemistry Authors: Yongjun Yang Qian Chen Shijun Fan Yongling Lu Qianyin Huang Xin Liu Xi Peng Source Type: research
Glutamine sustains energy metabolism and alleviates liver injury in burn sepsis by promoting the assembly of mitochondrial HSP60-HSP10 complex via SIRT4 dependent protein deacetylation
In this study, we demonstrated that Gln alleviated liver injury by sustaining energy supply and restoring redox balance. Meanwhile, Gln also rescued the dysfunctional mitochondrial electron transport chain (ETC) complexes, improved ATP production, reduced oxidative stress, and protected hepatocytes from burn sepsis injury. Mechanistically, we revealed that Gln could activate SIRT4 by upregulating its protein synthesis and increasing the level of Nicotinamide adenine dinucleotide (NAD+), a co-enzyme that sustains the activity of SIRT4. This, in turn, reduced the acetylation of shock protein (HSP) 60 to facilitate the assemb...
Source: Redox Report : communications in free radical research - February 8, 2024 Category: Biochemistry Authors: Yongjun Yang Qian Chen Shijun Fan Yongling Lu Qianyin Huang Xin Liu Xi Peng Source Type: research
Glutamine sustains energy metabolism and alleviates liver injury in burn sepsis by promoting the assembly of mitochondrial HSP60-HSP10 complex via SIRT4 dependent protein deacetylation
In this study, we demonstrated that Gln alleviated liver injury by sustaining energy supply and restoring redox balance. Meanwhile, Gln also rescued the dysfunctional mitochondrial electron transport chain (ETC) complexes, improved ATP production, reduced oxidative stress, and protected hepatocytes from burn sepsis injury. Mechanistically, we revealed that Gln could activate SIRT4 by upregulating its protein synthesis and increasing the level of Nicotinamide adenine dinucleotide (NAD+), a co-enzyme that sustains the activity of SIRT4. This, in turn, reduced the acetylation of shock protein (HSP) 60 to facilitate the assemb...
Source: Redox Report : communications in free radical research - February 8, 2024 Category: Biochemistry Authors: Yongjun Yang Qian Chen Shijun Fan Yongling Lu Qianyin Huang Xin Liu Xi Peng Source Type: research
Jaceosidin induces apoptosis and inhibits migration in AGS gastric cancer cells by regulating ROS-mediated signaling pathways
Redox Rep. 2024 Dec;29(1):2313366. doi: 10.1080/13510002.2024.2313366. Epub 2024 Feb 6.ABSTRACTJaceosidin (JAC) is a natural flavonoid with anti-oxidant and other pharmacological activities; however, its anti-cancer mechanism remains unclear. We investigated the mechanism of action of JAC in gastric cancer cells. Cytotoxicity and apoptosis assays showed that JAC effectively killed multiple gastric cancer cells and induced apoptosis in human gastric adenocarcinoma AGS cells via the mitochondrial pathway. Network pharmacological analysis suggested that its activity was linked to reactive oxygen species (ROS), AKT, and MAPK s...
Source: Redox Report : communications in free radical research - February 6, 2024 Category: Biochemistry Authors: Jian Liu Shu-Mei Li Yan-Jun Tang Jing-Long Cao Wen-Shuang Hou An-Qi Wang Chang Wang Cheng-Hao Jin Source Type: research
Melittin alleviates sepsis-induced acute kidney injury by promoting GPX4 expression to inhibit ferroptosis
CONCLUSIONS: Our study reveals the protective mechanism of melittin in septic kidney injury and provides a new therapeutic direction for Sepsis-AKI.PMID:38149613 | PMC:PMC10763831 | DOI:10.1080/13510002.2023.2290864 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - December 27, 2023 Category: Biochemistry Authors: Hongyan Zan Jizheng Liu Meixia Yang Honghui Zhao Chunyan Gao Yunyan Dai Zhiming Wang Hongxuan Liu Yunfei Zhang Source Type: research
