Redox Report : communications in free radical research 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Analysis of an antioxidative defence system of hydrogen peroxide-treated pancreatic islet-derived 1.1B4 cells and siRNA targeting NR4A3-treated cells by microarray
In this study, human pancreatic islet-derived 1.1B4 cells were exposed to H2O2 and analysed using a human microarray, which revealed that heme oxygenase 1 (HMOX1), glutamate-cysteine ligase, early growth response 1, nuclear receptor subfamily 4 group A member 3 (NR4A3) and jun B proto-oncogene were upregulated, whereas superoxide dismutase 1 and catalase were not. Expression of NR4A3 rapidly increased after H2O2 addition, and the 1.1B4 cells treated with siRNA targeting NR4A3 became sensitive to H2O2; further, HMOX1 expression was strongly inhibited, suggesting that NR4A3 is an oxidative stress-responsive transcription fac...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Motoko Nakayama Etsuko Ueta Mitsuru Yoshida Yuri Shimizu Atsuko Tokuda Yasuko Sone Yuri Nomi Y Otsuka Source Type: research
Tolerable treatment of glioblastoma with redox-cycling 'mitocans': a comparative study in vivo
Discussion: Q0/A differentiated cancer cells and tissues, particularly glioblastoma, from normal ones by redox targeting, causing a severe oxidative stress in the tumor but not in non-cancerous tissues. Q0/A had a pronounced anticancer activity and could be considered safe for the organism within certain concentration limits. The results suggest that the rate of tumor resorption and metabolism of toxic residues must be controlled and maintained within tolerable limits to achieve longer survival, especially at intracranial drug administration.PMID:37581329 | PMC:PMC10435007 | DOI:10.1080/13510002.2023.2220531 (Source: Redox...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Akira Sumiyoshi Sayaka Shibata Dessislava Lazarova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Source Type: research
Analysis of an antioxidative defence system of hydrogen peroxide-treated pancreatic islet-derived 1.1B4 cells and siRNA targeting NR4A3-treated cells by microarray
In this study, human pancreatic islet-derived 1.1B4 cells were exposed to H2O2 and analysed using a human microarray, which revealed that heme oxygenase 1 (HMOX1), glutamate-cysteine ligase, early growth response 1, nuclear receptor subfamily 4 group A member 3 (NR4A3) and jun B proto-oncogene were upregulated, whereas superoxide dismutase 1 and catalase were not. Expression of NR4A3 rapidly increased after H2O2 addition, and the 1.1B4 cells treated with siRNA targeting NR4A3 became sensitive to H2O2; further, HMOX1 expression was strongly inhibited, suggesting that NR4A3 is an oxidative stress-responsive transcription fac...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Motoko Nakayama Etsuko Ueta Mitsuru Yoshida Yuri Shimizu Atsuko Tokuda Yasuko Sone Yuri Nomi Y Otsuka Source Type: research
Tolerable treatment of glioblastoma with redox-cycling 'mitocans': a comparative study in vivo
Discussion: Q0/A differentiated cancer cells and tissues, particularly glioblastoma, from normal ones by redox targeting, causing a severe oxidative stress in the tumor but not in non-cancerous tissues. Q0/A had a pronounced anticancer activity and could be considered safe for the organism within certain concentration limits. The results suggest that the rate of tumor resorption and metabolism of toxic residues must be controlled and maintained within tolerable limits to achieve longer survival, especially at intracranial drug administration.PMID:37581329 | PMC:PMC10435007 | DOI:10.1080/13510002.2023.2220531 (Source: Redox...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Akira Sumiyoshi Sayaka Shibata Dessislava Lazarova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Source Type: research
Analysis of an antioxidative defence system of hydrogen peroxide-treated pancreatic islet-derived 1.1B4 cells and siRNA targeting NR4A3-treated cells by microarray
In this study, human pancreatic islet-derived 1.1B4 cells were exposed to H2O2 and analysed using a human microarray, which revealed that heme oxygenase 1 (HMOX1), glutamate-cysteine ligase, early growth response 1, nuclear receptor subfamily 4 group A member 3 (NR4A3) and jun B proto-oncogene were upregulated, whereas superoxide dismutase 1 and catalase were not. Expression of NR4A3 rapidly increased after H2O2 addition, and the 1.1B4 cells treated with siRNA targeting NR4A3 became sensitive to H2O2; further, HMOX1 expression was strongly inhibited, suggesting that NR4A3 is an oxidative stress-responsive transcription fac...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Motoko Nakayama Etsuko Ueta Mitsuru Yoshida Yuri Shimizu Atsuko Tokuda Yasuko Sone Yuri Nomi Y Otsuka Source Type: research
Tolerable treatment of glioblastoma with redox-cycling 'mitocans': a comparative study in vivo
Discussion: Q0/A differentiated cancer cells and tissues, particularly glioblastoma, from normal ones by redox targeting, causing a severe oxidative stress in the tumor but not in non-cancerous tissues. Q0/A had a pronounced anticancer activity and could be considered safe for the organism within certain concentration limits. The results suggest that the rate of tumor resorption and metabolism of toxic residues must be controlled and maintained within tolerable limits to achieve longer survival, especially at intracranial drug administration.PMID:37581329 | PMC:PMC10435007 | DOI:10.1080/13510002.2023.2220531 (Source: Redox...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Akira Sumiyoshi Sayaka Shibata Dessislava Lazarova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Source Type: research
Analysis of an antioxidative defence system of hydrogen peroxide-treated pancreatic islet-derived 1.1B4 cells and siRNA targeting NR4A3-treated cells by microarray
In this study, human pancreatic islet-derived 1.1B4 cells were exposed to H2O2 and analysed using a human microarray, which revealed that heme oxygenase 1 (HMOX1), glutamate-cysteine ligase, early growth response 1, nuclear receptor subfamily 4 group A member 3 (NR4A3) and jun B proto-oncogene were upregulated, whereas superoxide dismutase 1 and catalase were not. Expression of NR4A3 rapidly increased after H2O2 addition, and the 1.1B4 cells treated with siRNA targeting NR4A3 became sensitive to H2O2; further, HMOX1 expression was strongly inhibited, suggesting that NR4A3 is an oxidative stress-responsive transcription fac...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Motoko Nakayama Etsuko Ueta Mitsuru Yoshida Yuri Shimizu Atsuko Tokuda Yasuko Sone Yuri Nomi Y Otsuka Source Type: research
Tolerable treatment of glioblastoma with redox-cycling 'mitocans': a comparative study in vivo
Discussion: Q0/A differentiated cancer cells and tissues, particularly glioblastoma, from normal ones by redox targeting, causing a severe oxidative stress in the tumor but not in non-cancerous tissues. Q0/A had a pronounced anticancer activity and could be considered safe for the organism within certain concentration limits. The results suggest that the rate of tumor resorption and metabolism of toxic residues must be controlled and maintained within tolerable limits to achieve longer survival, especially at intracranial drug administration.PMID:37581329 | PMC:PMC10435007 | DOI:10.1080/13510002.2023.2220531 (Source: Redox...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Akira Sumiyoshi Sayaka Shibata Dessislava Lazarova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Source Type: research
Analysis of an antioxidative defence system of hydrogen peroxide-treated pancreatic islet-derived 1.1B4 cells and siRNA targeting NR4A3-treated cells by microarray
In this study, human pancreatic islet-derived 1.1B4 cells were exposed to H2O2 and analysed using a human microarray, which revealed that heme oxygenase 1 (HMOX1), glutamate-cysteine ligase, early growth response 1, nuclear receptor subfamily 4 group A member 3 (NR4A3) and jun B proto-oncogene were upregulated, whereas superoxide dismutase 1 and catalase were not. Expression of NR4A3 rapidly increased after H2O2 addition, and the 1.1B4 cells treated with siRNA targeting NR4A3 became sensitive to H2O2; further, HMOX1 expression was strongly inhibited, suggesting that NR4A3 is an oxidative stress-responsive transcription fac...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Motoko Nakayama Etsuko Ueta Mitsuru Yoshida Yuri Shimizu Atsuko Tokuda Yasuko Sone Yuri Nomi Y Otsuka Source Type: research
Tolerable treatment of glioblastoma with redox-cycling 'mitocans': a comparative study in vivo
Discussion: Q0/A differentiated cancer cells and tissues, particularly glioblastoma, from normal ones by redox targeting, causing a severe oxidative stress in the tumor but not in non-cancerous tissues. Q0/A had a pronounced anticancer activity and could be considered safe for the organism within certain concentration limits. The results suggest that the rate of tumor resorption and metabolism of toxic residues must be controlled and maintained within tolerable limits to achieve longer survival, especially at intracranial drug administration.PMID:37581329 | DOI:10.1080/13510002.2023.2220531 (Source: Redox Report : communic...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Akira Sumiyoshi Sayaka Shibata Dessislava Lazarova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Source Type: research
Analysis of an antioxidative defence system of hydrogen peroxide-treated pancreatic islet-derived 1.1B4 cells and siRNA targeting NR4A3-treated cells by microarray
In this study, human pancreatic islet-derived 1.1B4 cells were exposed to H2O2 and analysed using a human microarray, which revealed that heme oxygenase 1 (HMOX1), glutamate-cysteine ligase, early growth response 1, nuclear receptor subfamily 4 group A member 3 (NR4A3) and jun B proto-oncogene were upregulated, whereas superoxide dismutase 1 and catalase were not. Expression of NR4A3 rapidly increased after H2O2 addition, and the 1.1B4 cells treated with siRNA targeting NR4A3 became sensitive to H2O2; further, HMOX1 expression was strongly inhibited, suggesting that NR4A3 is an oxidative stress-responsive transcription fac...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Motoko Nakayama Etsuko Ueta Mitsuru Yoshida Yuri Shimizu Atsuko Tokuda Yasuko Sone Yuri Nomi Y Otsuka Source Type: research
Tolerable treatment of glioblastoma with redox-cycling 'mitocans': a comparative study in vivo
Discussion: Q0/A differentiated cancer cells and tissues, particularly glioblastoma, from normal ones by redox targeting, causing a severe oxidative stress in the tumor but not in non-cancerous tissues. Q0/A had a pronounced anticancer activity and could be considered safe for the organism within certain concentration limits. The results suggest that the rate of tumor resorption and metabolism of toxic residues must be controlled and maintained within tolerable limits to achieve longer survival, especially at intracranial drug administration.PMID:37581329 | DOI:10.1080/13510002.2023.2220531 (Source: Redox Report : communic...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Akira Sumiyoshi Sayaka Shibata Dessislava Lazarova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Source Type: research
Analysis of an antioxidative defence system of hydrogen peroxide-treated pancreatic islet-derived 1.1B4 cells and siRNA targeting NR4A3-treated cells by microarray
In this study, human pancreatic islet-derived 1.1B4 cells were exposed to H2O2 and analysed using a human microarray, which revealed that heme oxygenase 1 (HMOX1), glutamate-cysteine ligase, early growth response 1, nuclear receptor subfamily 4 group A member 3 (NR4A3) and jun B proto-oncogene were upregulated, whereas superoxide dismutase 1 and catalase were not. Expression of NR4A3 rapidly increased after H2O2 addition, and the 1.1B4 cells treated with siRNA targeting NR4A3 became sensitive to H2O2; further, HMOX1 expression was strongly inhibited, suggesting that NR4A3 is an oxidative stress-responsive transcription fac...
Source: Redox Report : communications in free radical research - August 15, 2023 Category: Biochemistry Authors: Motoko Nakayama Etsuko Ueta Mitsuru Yoshida Yuri Shimizu Atsuko Tokuda Yasuko Sone Yuri Nomi Y Otsuka Source Type: research
Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway
CONCLUSION: LCB protects against LPS-induced acute lung injury in cells and mice. The Keap1/Nrf2 pathway may be involved in its protective effects. LCB shows potential as a strategy to alleviate ALI caused by LPS.PMID:37565601 | PMC:PMC10424628 | DOI:10.1080/13510002.2023.2243423 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - August 11, 2023 Category: Biochemistry Authors: Ju Huang Yu Zhu Songtao Li Huanyu Jiang Nianzhi Chen Hang Xiao Jingwen Liu Dan Liang Qiao Zheng Jianyuan Tang Xiangrui Meng Source Type: research
Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway
CONCLUSION: LCB protects against LPS-induced acute lung injury in cells and mice. The Keap1/Nrf2 pathway may be involved in its protective effects. LCB shows potential as a strategy to alleviate ALI caused by LPS.PMID:37565601 | DOI:10.1080/13510002.2023.2243423 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - August 11, 2023 Category: Biochemistry Authors: Ju Huang Yu Zhu Songtao Li Huanyu Jiang Nianzhi Chen Hang Xiao Jingwen Liu Dan Liang Qiao Zheng Jianyuan Tang Xiangrui Meng Source Type: research
