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Melittin alleviates sepsis-induced acute kidney injury by promoting GPX4 expression to inhibit ferroptosis
CONCLUSIONS: Our study reveals the protective mechanism of melittin in septic kidney injury and provides a new therapeutic direction for Sepsis-AKI.PMID:38149613 | DOI:10.1080/13510002.2023.2290864 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - December 27, 2023 Category: Biochemistry Authors: Hongyan Zan Jizheng Liu Meixia Yang Honghui Zhao Chunyan Gao Yunyan Dai Zhiming Wang Hongxuan Liu Yunfei Zhang Source Type: research

Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy
Redox Rep. 2024 Dec;29(1):2289740. doi: 10.1080/13510002.2023.2289740. Epub 2023 Dec 18.ABSTRACTIncreased life expectancy, attributed to improved access to healthcare and drug development, has led to an increase in multimorbidity, a key contributor to polypharmacy. Polypharmacy is characterised by its association with a variety of adverse events in the older persons. The mechanisms involved in the development of age-related chronic diseases are largely unknown; however, altered redox homeostasis due to ageing is one of the main theories. In this context, the present review explores the development and interaction between d...
Source: Redox Report : communications in free radical research - December 18, 2023 Category: Biochemistry Authors: Catalina Rojas-Sol é V íctor Pinilla-González Jos é Lillo-Moya Tommy Gonz ález-Fernández Luciano Saso Ram ón Rodrigo Source Type: research

Investigation of serum ischemic-modified albumin, galectin-3, paraoxonase-1, and myeloperoxidase activity levels in patients with acute brucellosis
Conclusion, it was found that serum gal-3, IMA levels and MPO activity increased, while PON-1 activity decreased. These results showed that the oxidant-anti-oxidant balance is impaired in acute brucellosis infection. In addition, these results indicate that brucella infection may be increase the risk of atherosclerosis. Further studies are needed to support our findings.PMID:38054459 | DOI:10.1080/13510002.2023.2289727 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - December 6, 2023 Category: Biochemistry Authors: Ahmet D ündar Source Type: research