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A novel approach to predict acute radiation dermatitis in patients with head and neck cancer using a model based on Bayesian probability
Radiation therapy for head and neck cancer preserves their function and shape and reduces impairments in speech, chewing, and swallowing functions [1 –3]. Approximately 50 % of patients with head and neck cancer are treated with a combination of radiation therapy and chemoradiation [4–6]. Volumetric Modulated Arc Therapy (VMAT) for head and neck cancer delivers approximately 70 Gy of irradiation to the planned target volume of the tumor [7– 9]. Severe acute radiation dermatitis (ARD) [10], such as erythema and desquamation, frequently occurs as an adverse effect, which interrupts the treatment schedules [11,12]. (S...
Source: Physica Medica: European Journal of Medical Physics - November 24, 2023 Category: General Medicine Authors: Keisuke Hamada, Toshioh Fujibuchi, Hiroyuki Arakawa, Yuichi Yokoyama, Naoki Yoshida, Hiroki Ohura, Naonobu Kunitake, Muneyuki Masuda, Takeo Honda, Satoru Tokuda, Makoto Sasaki Source Type: research

A novel model-based equation for size dependent mean recovery coefficients for spheres and other shapes
Due to limited spatial resolution of imaging systems in nuclear medicine (NM) such as SPECT (Single Photon Emission Computed Tomography) and PET (Positron Emission Tomography) images are blurred resulting in spatial broadening of especially small objects, constituting the so-called partial volume effect (PVE). The total measured signal inside an object originates from both the radioactivity inside and outside of the object. The signal originating from within the object will be partly located outside the object due the limited spatial resolution causing a spill-out of signal. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - November 24, 2023 Category: General Medicine Authors: Robin de Nijs Source Type: research

Combined radiomics of primary tumour and bone metastasis improve the prediction of EGFR mutation status and response to EGFR-TKI therapy for NSCLC
Lung cancer represents the deadliest cancer with the highest incidence [1]. Non-small cell lung cancer (NSCLC) is the largest subgroup of lung cancer and occurs at a frequency of 80  % [2]. Many NSCLC patients suffer from distant metastases at the first time diagnosis, which remains a significant challenge for clinical treatment [3–5]. Approximately 30–––40 % of patients may develop spinal metastasis [6,7], which often leads to poor prognosis due to spinal cord compre ssion and hypercalcaemia [8]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - November 23, 2023 Category: General Medicine Authors: Yuan Cheng, Huan Wang, Wendi Yuan, Haotian Wang, Yuheng Zhu, Huanhuan Chen, Wenyan Jiang Tags: Original paper Source Type: research

Comparison of Ethos template-based planning and AI-based dose prediction: General performance, patient optimality, and limitations
In the field of radiation therapy (RT), adaptive RT (ART) has been a major research topic for many years [1 –3]. Unlike conventional radiation therapy that relies on single computed tomography scans (CT) acquired prior to treatment, ART aims at accounting for anatomical changes that can occur in the tumor (shrinkage, progression) and organs at risk (OAR) (weight loss, air cavity filling, organs deformat ion, …), over the course of a treatment. In practice, ART requires repeated image acquisitions to capture the daily anatomy, to delineate the updated patient volumes, and to re-optimize the dose based on the current sna...
Source: Physica Medica: European Journal of Medical Physics - November 23, 2023 Category: General Medicine Authors: Benjamin Roberfroid, Ana M. Barrag án-Montero, David Dechambre, Edmond Sterpin, John A. Lee, Xavier Geets Source Type: research

IS2aR, a computational tool to transform voxelized reference phantoms into patient-specific whole-body virtual CTs for peripheral dose estimation
It is well known that radiotherapy (RT) is a very effective treatment applied in more than 50  % of all cancer patients. One crucial part of its development has been making RT as personalized as possible (e.g., image-guided and biology-guided adapted RT). However, despite the non-negligible proportion of second cancers related to RT and an increasing number of RT patients showing long-term survival ([1] and references therein), the minimization of second cancer induction risk has not been usually considered in the personalization process. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - November 23, 2023 Category: General Medicine Authors: Isidora Sof ía Muñoz-Hernández, Ignacio Espinoza, Ignacio N. López-Martínez, Beatriz Sánchez-Nieto Tags: Technical Note Source Type: research

A single centre intercomparison between commercial treatment planning systems for 90Y radioembolization using virtual and experimental phantoms
The transarterial radioembolization (TARE) with 90Y-loaded microspheres is a well-established targeted radiotherapy procedure for the treatment of primary or secondary liver cancer based on the intra-arterial injection of radioactive compounds. Currently, two types of medical devices have been registered for this purpose, including 90Y-loaded glass (TheraSphereTM, Boston Scientific) and resin (Sir-Spheres, Sirtex) microspheres, that differ in terms of physical properties such as microsphere-specific activity, number of microspheres per injection, and microspheres size, and pre-injection compound preparation [1]. (Source: P...
Source: Physica Medica: European Journal of Medical Physics - November 23, 2023 Category: General Medicine Authors: Giuseppe Della Gala, Miriam Santoro, Garoson Albertine Rasoatsaratanany, Giulia Paolani, Silvia Strolin, Lidia Strigari Tags: Original paper Source Type: research

Traceable calibration with 177Lu and comparison of activity meters at hospitals in Norway and Sweden
The field of therapeutic nuclear medicine continues to grow around the world, in terms of number of radiopharmaceuticals, number of patients and treatments. A central measurement instrument in radionuclide therapy is the activity meter, also known as dose calibrator, which is used to determine the activity administered to patients. Furthermore, the activity meter is the central instrument when calibration of gamma-camera systems for image-based dosimetry is performed. As such, the activity meter can be considered the reference instrument for radionuclide therapy. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - November 21, 2023 Category: General Medicine Authors: Cecilia Hindorf, Lovisa Jessen, Selma Curkic Kapidzic, Johan Blakkisrud, Johanna Dalmo, Ola Engelsen, Johan Gustafsson, Mattias Sandstr öm, Jostein Sæterstøl, Katarina Sjögreen Gleisner Source Type: research

Noise reduction by multiple path neural network using Attention mechanisms with an emphasis on robustness against Errors: A pilot study on brain Diffusion-Weighted images
Improving the signal-to-noise ratio has always been a major challenge in the history of magnetic resonance imaging (MRI). Recently, deep learning-based image noise reduction has attracted attention as a promising technique for this purpose [1 –3]. The methods found a relationship between noisy images and noise-free images by combining the high approximation ability of neural networks and the high optimisation ability of deep learning in the ‘training’ process. This relationship, incorporated in the trained model, is used to reduce image noise. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - November 21, 2023 Category: General Medicine Authors: Yasuhiko Tachibana, Yujiro Otsuka, Hayato Nozaki, Koji Kamagata, Shinichiro Mori, Yuya Saito, Shigeki Aoki Tags: Technical Note Source Type: research

NTCP modelling of xerostomia after radiotherapy for oropharyngeal cancer using the PRO-CTCAE and CTCAE scoring systems at different time-points post-RT
Head and neck cancer accounts for 3 –4 % of all cancers and the vast majority of them is oropharyngeal squamous cell carcinoma (OPSCC) [1,2]. Since 2000, the rate of diagnosed OPSCC has increased by about 66 % [3]. There is an increasing incidence of OPSCC with human papillomavirus (HPV) infection of the oropharyngeal mucosa [4– 6]. The 5-year survival rate for OPSCC has been steadily increasing over time (55 % to over 72 % since 1992) [3]. Although the cancer control and survival is excellent in HPV-associated OPSCC, standard CRT regimens produce substantial toxicity [7]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - November 20, 2023 Category: General Medicine Authors: Athanasios Tzikas, Eleftherios Lavdas, Dimitrios Kehagias, Robert Amdur, William Mendenhall, Nathan Sheets, Rebecca Green, Bhishamjit Chera, Panayiotis Mavroidis Source Type: research

Results of the IAEA supported national end-to-end audit of the IMRT technique in Poland
In the last decades intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) techniques have become widely used for radiotherapy patients in Poland. These high conformity techniques create optimal dose coverage while protecting organs at risk (OARs), even for very irregular target shapes. Such an advanced technique requires an adequate level of dosimetry verification. There is a wide range of quality assurance (QA) verification methods being used for pretreatment [1]. The sensitivity for the detecting of errors varies for every method, and only an independent dosimetry audit allows for the accura...
Source: Physica Medica: European Journal of Medical Physics - November 18, 2023 Category: General Medicine Authors: Paulina Wesolowska, Wioletta Slusarczyk-Kacprzyk, Marta Fillmann, Pavel Kazantsev, Wojciech Bulski Source Type: research

A Patient-Specific correspondence model to track tumor location in thorax during radiation therapy
The main goal of a radiation therapy treatment plan is to deliver the maximum radiation dose to the tumor while sparing the organs at risk. A precise measure of the tumor motion location is crucial for achieving this goal. For many treatment sites, respiratory-induced motion makes the measurement and tracking of the tumor location more difficult during radiation delivery. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - November 14, 2023 Category: General Medicine Authors: Sharareh Fakhraei, Eric Ehler, David Sterling, L. Chinsoo Cho, Parham Alaei Tags: Technical Note Source Type: research

EFOMP policy statement NO. 19: Dosimetry in nuclear medicine therapy – Molecular radiotherapy
Molecular radiotherapya refers to the use of radioactive drugs or radioactive medical devices for medical treatment. First introduced in the 1930  s [1], the field is now rapidly expanding with many new agents for a growing number of indications [2]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - November 3, 2023 Category: General Medicine Authors: Katarina Sj ögreen-Gleisner, Glenn Flux, Klaus Bacher, Carlo Chiesa, Robin de Nijs, George C. Kagadis, Thiago Lima, Maria Lyra Georgosopoulou, Pablo Minguez Gabiña, Stephan Nekolla, Steffie Peters, Joao Santos, Bernhard Sattler, Caroline Stokke, Johanne Source Type: research

Title Page
(Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - November 1, 2023 Category: General Medicine Source Type: research

Editorial Board
(Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - November 1, 2023 Category: General Medicine Source Type: research

Table of Contents
(Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - November 1, 2023 Category: General Medicine Source Type: research