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A generalised method for calculating repopulation-corrected tumour EQD2 values in a wide range of clinical situations, including interrupted treatments
The use of EQD2 (equivalent dose in 2  Gy fractions) as an iso-effective descriptor of any radiotherapy treatment schedule is well-established [1]. The EQD2 metric allows, in principle at least, any schedule to be expressed in terms of the iso-effective total dose required if it were to be delivered using conventional 2 Gy fractionati on. Such an approach has been recommended as it is useful for clinicians seeking an appreciation of the likely effectiveness of relatively novel treatment patterns [2]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - January 9, 2024 Category: General Medicine Authors: Roger Dale, Georgios Plataniotis, Bleddyn Jones Source Type: research

Dosimetric effect of rotational setup errors in volumetric modulated arc therapy and field-in-field treatment of left-sided breast cancer
In this study, we investigated how rotational setup errors influence the dose distribution in volumetric modulated arc therapy (VMAT) and tangential field-in-field (FiF) treatment of left-sided breast cancer with supraclavicular lymph node involvement in deep inspiration breath hold. Treatment planning computed tomography images and radiotherapy plans of 20 patients were collected retrospectively for the study. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - January 2, 2024 Category: General Medicine Authors: Annele Heikkil ä, Eeva Boman, Maija Rossi, Antti Vanhanen, Mikko Mankinen, Michiel Postema, Tuomas Koivumäki Tags: Technical note Source Type: research

Aims & Scope & Editorial Board
(Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - January 1, 2024 Category: General Medicine Source Type: research

Ct-based subregional radiomics using hand-crafted and deep learning features for prediction of therapeutic response to anti-PD1 therapy in NSCLC
Lung cancer has been a major worldwide health problem, and the leading cause of cancer death, with non-small cell lung cancer (NSCLC) as the most common form [1,2]. In the past decades, immune checkpoint inhibitors (ICIs) and the specifically targeting programmed cell death 1 (PD-1) receptor have drawn many attractions as the effective immunotherapeutic strategy in NSCLC [3]. Many PD-1 inhibitors for advanced NSCLC have been proposed and approved by FDA because of great clinical benefits [4]. Previous studies have shown that 20 –50 % of patients with advanced solid tumors were responders to clinical immune treatments [5...
Source: Physica Medica: European Journal of Medical Physics - December 30, 2023 Category: General Medicine Authors: Yue Hu, Tao Jiang, Huan Wang, Jiangdian Song, Zhiguang Yang, Yan Wang, Juan Su, Meiqi Jin, Shijie Chang, Kexue Deng, Wenyan Jiang Tags: Original paper Source Type: research

Homogenous dose prescription in Gamma Knife Radiotherapy: Combining the best of both worlds
Stereotactic radiosurgery (SRS) is an effective option for non-surgical management of intracranial lesions. SRS may be delivered using linear accelerators (LINACs) or specific devices such as the Leksell Gamma Knife ® (LGK, Elekta Instruments AB, Sweden) [1–4]. The latter is known for high accuracy yielding clinical outcomes that are similar to surgery depending on the target size [5,6]. Specifically for small lesions, LGK treatment achieves high local control (LC) and limited toxicity due to high prescripti on doses with sharp gradients [7,8]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 29, 2023 Category: General Medicine Authors: Manon Spaniol, Yasser Abo-Madyan, Arne M. Ruder, Jens Fleckenstein, Frank A. Giordano, Florian Stieler Tags: Original paper Source Type: research

Machine learning-based ensemble prediction model for the gamma passing rate of VMAT-SBRT plan
Intensity-modulated radiotherapy (IMRT) techniques, including volume-modulated arc therapy (VMAT), provide highly conformal dose distribution with sharp dose falloffs to complex target volume and minimum dose to normal tissues surrounding targets. Owing to the complexity of planning and delivery, pretreatment plan verification plays a vital role in patient-specific quality assurance (QA) to assure the delivery accuracy of treatment plans. The American Association of Physicists in Medicine Task Groups 119 and 218 recommend that each treatment plan should be verified by using measurement-based methods with gamma analysis pri...
Source: Physica Medica: European Journal of Medical Physics - December 27, 2023 Category: General Medicine Authors: Wenzhao Sun, Zijie Mo, Yongbao Li, Jifeng Xiao, Lecheng Jia, Sijuan Huang, Can Liao, Jinlong Du, Shumeng He, Li Chen, Wei Zhang, Xin Yang Tags: Original paper Source Type: research

Gamma-ray sources imaging and test-beam results with MACACO III Compton camera
Hadron therapy is a radiotherapy modality which offers a precise energy deposition to the tumors and a dose reduction to healthy tissue as compared to conventional methods. However, methods for real-time monitoring are required to ensure that the radiation dose is deposited on the target. The IRIS group of IFIC-Valencia developed a Compton camera prototype for this purpose, intending to image the Prompt Gammas emitted by the tissue during irradiation. The system detectors are composed of Lanthanum (III) bromide scintillator crystals coupled to silicon photomultipliers. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 23, 2023 Category: General Medicine Authors: L. Barrientos, M. Borja-Lloret, J.V. Casa ña, P. Dendooven, J. García López, F. Hueso-González, M.C. Jiménez-Ramos, J. Pérez-Curbelo, A. Ros, J. Roser, C. Senra, R. Viegas, G. Llosá Tags: Original paper Source Type: research

Incoming President of the European Federation of Organizations for Medical Physics editorial
Since the onset of the federation, EFOMP has a mission to improve and harmonize the educational and professional status of its 10,000 members in 36 National Member Organisations (NMOs), having as core objectives Communication, Intergration and Education [1]. Working together, we accomplished tackling critical challenges, the greatest being during the 2020 –2023, the coronavirus pandemic, the war in Ukraine and rising inflation across the Eurozone. They affected the provision of Medical Physics services, education and training opportunities, cross border mobility. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 21, 2023 Category: General Medicine Authors: Efi Koutsouveli Source Type: research

Implementation of dosimetry for molecular radiotherapy; results from a European survey
Treatments with radioactive nuclides, also known as molecular radiotherapies (MRTs), have been rapidly increasing over the last years. The aim is to deliver an absorbed dose to the region of disease, leading to a therapeutic effect, while minimising absorbed doses to non-target tissues. While some treatments, including radioactive iodine (Na[131I]I), have been in routine use since the 1940s [1,2], many new carriers and radionuclides have been developed for MRTs in the last decade. A recent review found that 72 radionuclides have been investigated for molecular radiotherapy [3]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 16, 2023 Category: General Medicine Authors: Steffie Peters, Johannes Tran-Gia, Sam Agius, Oleksandra V. Ivashchenko, Jean No ël Badel, Marta Cremonesi, Jens Kurth, Pablo Minguez Gabiña, Elisa Richetta, Katarina Sjögreen Gleisner, Jill Tipping, Manuel Bardiès, Caroline Stokke Tags: Original paper Source Type: research

Cone-beam computed-tomography-based delta-radiomic analysis for investigating prognostic power for esophageal squamous cell cancer patients undergoing concurrent chemoradiotherapy
Esophageal cancer is a malignant neoplasm developed in the esophagus; it is the tenth most common type of cancer and sixth most common cause of cancer mortality worldwide [1]. In addition, squamous cell cancer is the most frequently diagnosed histological subtype, and it is related to risk factors such as smoking and alcohol consumption [2 –4]. Surgery resection, endoscopic resection, radiotherapy, chemotherapy, and concurrent chemoradiotherapy (CCRT) are treatments selected depending on the clinical stage, tumor location, and patient’s condition [3,5,6]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 11, 2023 Category: General Medicine Authors: Takahiro Nakamoto, Hideomi Yamashita, Haruka Jinnouchi, Kanabu Nawa, Toshikazu Imae, Shigeharu Takenaka, Atsushi Aoki, Takeshi Ohta, Sho Ozaki, Yuki Nozawa, Keiichi Nakagawa Source Type: research

Deep learning for classification of late gadolinium enhancement lesions based on the 16-segment left ventricular model
Radiologic diagnosis of cardiac magnetic resonance imaging (MRI) or computed tomography (CT) data is performed based on the 16-segment left ventricular (LV) model [1] for the regional detection and characterization of the LV myocardium. This is true when myocardial function, wall motion, ischemia, and viability are assessed by cardiac radiologists, using cine, dynamic contrast-enhanced stress perfusion, and late gadolinium enhancement (LGE) image data [2,3]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 5, 2023 Category: General Medicine Authors: Yoon-Chul Kim, Younjoon Chung, Yeon Hyeon Choe Source Type: research

Time-Activity data fitting in molecular Radiotherapy: Methodology and pitfalls
Akaike information criterion (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 5, 2023 Category: General Medicine Authors: Oleksandra V. Ivashchenko, Jim O'Doherty, Deni Hardiansyah, Marta Cremonesi, Johannes Tran-Gia, Eero Hippel äinen, Caroline Stokke, Elisa Grassi, Mattias Sandström, Gerhard Glatting Tags: Original paper Source Type: research

A fully automated machine learning-based methodology for personalized radiation dose assessment in thoracic and abdomen CT
Computed tomography (CT) constitutes one of the most frequently used medical imaging modalities. It is a powerful diagnostic tool for many different clinical indications. Therefore, the rising trend in CT utilization comes as no surprise [1 –4]. CT comprises the largest source of medical exposure and CT scans make up over half of the collective dose from imaging procedures [5]. In many cases, patients undergo multiple CT examinations within short time intervals [6]. To minimize the radiation burden, institutions should evaluate the i mplemented techniques and develop optimized examination protocols. (Source: Physica Medi...
Source: Physica Medica: European Journal of Medical Physics - December 4, 2023 Category: General Medicine Authors: Eleftherios Tzanis, John Stratakis, Marios Myronakis, John Damilakis Source Type: research

MRI compatibility testing of commercial high intensity focused ultrasound transducers
High Intensity Focused Ultrasound (HIFU) has emerged in the oncological sector as a non-invasive modality to ablate tissue [1]. By combining HIFU with Magnetic Resonance Imaging (MRI), physicians can precisely guide and monitor the therapeutic procedure [2]. There are though numerous challenges in safely integrating and operating a HIFU system in the MRI environment due to the potential interference caused by the strong magnetic fields [3]. Ensuring MRI compatibility of HIFU transducers thus constitutes a critical step in the evaluation process of MRI-guided HIFU systems. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 3, 2023 Category: General Medicine Authors: Nikolas Evripidou, Anastasia Antoniou, Leonidas Georgiou, Cleanthis Ioannides, Kyriakos Spanoudes, Christakis Damianou Source Type: research

Comparison of quantitative [11C]PE2I brain PET studies between an integrated PET/MR and a stand-alone PET system
Hybrid positron emission tomography/magnetic resonance (PET/MR) systems have opened up many new neuroimaging opportunities, potentially providing a great tool for a broad range of research and clinical applications in neurology [1,2]. Initially, clinical neuroimaging applications for PET/MR have been hampered partially due to the lack of a widely accepted subject-specific attenuation correction (AC) method for the PET data [3]. The main reason is that MRI provides no direct information on electron density that can be used for photon AC [4,5]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 2, 2023 Category: General Medicine Authors: Jo ão M. Sousa, Lieuwe Appel, Mathias Engström, Dag Nyholm, Håkan Ahlström, Mark Lubberink Source Type: research