NTCP modelling of xerostomia after radiotherapy for oropharyngeal cancer using the PRO-CTCAE and CTCAE scoring systems at different time-points post-RT

Head and neck cancer accounts for 3 –4 % of all cancers and the vast majority of them is oropharyngeal squamous cell carcinoma (OPSCC) [1,2]. Since 2000, the rate of diagnosed OPSCC has increased by about 66 % [3]. There is an increasing incidence of OPSCC with human papillomavirus (HPV) infection of the oropharyngeal mucosa [4– 6]. The 5-year survival rate for OPSCC has been steadily increasing over time (55 % to over 72 % since 1992) [3]. Although the cancer control and survival is excellent in HPV-associated OPSCC, standard CRT regimens produce substantial toxicity [7].

Source: Physica Medica: European Journal of Medical Physics - November 20, 2023 Category: General Medicine Authors: Athanasios Tzikas, Eleftherios Lavdas, Dimitrios Kehagias, Robert Amdur, William Mendenhall, Nathan Sheets, Rebecca Green, Bhishamjit Chera, Panayiotis Mavroidis Source Type: research