Combined radiomics of primary tumour and bone metastasis improve the prediction of EGFR mutation status and response to EGFR-TKI therapy for NSCLC

Lung cancer represents the deadliest cancer with the highest incidence [1]. Non-small cell lung cancer (NSCLC) is the largest subgroup of lung cancer and occurs at a frequency of 80  % [2]. Many NSCLC patients suffer from distant metastases at the first time diagnosis, which remains a significant challenge for clinical treatment [3–5]. Approximately 30–––40 % of patients may develop spinal metastasis [6,7], which often leads to poor prognosis due to spinal cord compre ssion and hypercalcaemia [8].

Source: Physica Medica: European Journal of Medical Physics - November 23, 2023 Category: General Medicine Authors: Yuan Cheng, Huan Wang, Wendi Yuan, Haotian Wang, Yuheng Zhu, Huanhuan Chen, Wenyan Jiang Tags: Original paper Source Type: research