Retraction Note: The potential preventive role of a dietary supplement containing hydroxytyrosol in COVID-19: a multi-center study
This article has been retracted. The Publisher apologizes for any inconvenience this may cause.PMID:38708488 | DOI:10.26355/eurrev_202404_36067 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 6, 2024 Category: Drugs & Pharmacology Authors: K Dhuli C Micheletti M C Medori G Madeo G Bonetti K Donato F Gaffuri G M Tartaglia S Michelini A Fiorentino D Cesarz S T Connelly N Capodicasa M Bertelli Source Type: research
A Short Review on Obeticholic Acid: An Effective Modulator of Farnesoid X Receptor
Curr Rev Clin Exp Pharmacol. 2024;19(3):225-233. doi: 10.2174/0127724328239536230919070001.ABSTRACTFarnesoid X receptor (FXR) was identified as an orphan nuclear receptor resembling the steroid receptor in the late '90s. Activation of FXR is a crucial step in many physiological functions of the liver. A vital role of FXR is impacting the amount of bile acids in the hepatocytes, which it performs by reducing bile acid synthesis, stimulating the bile salt export pump, and inhibiting its enterohepatic circulation, thus protecting the hepatocytes against the toxic accumulation of bile acids. Furthermore, FXR mediates bile acid...
Source: Pharmacological Reviews - May 6, 2024 Category: Drugs & Pharmacology Authors: Anila Kutty Narayanan Sudhindran Surendran Dinesh Balakrishnan Unnikrishnan Gopalakrishnan Shweta Malick Arun Valsan Cyriac Abby Philips Christopher John Edward Watson Source Type: research
Current Pharmacotherapies for Smoking Cessation and Promising Emerging Drugs
CONCLUSION: Strategies to successfully quit smoking vary between individuals and may extend beyond pharmacotherapy and involve complex psychosocial factors and pathways.PMID:38708918 | DOI:10.2174/0127724328274939231121114142 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 6, 2024 Category: Drugs & Pharmacology Authors: Seetal Dodd Jodie Harper Michael Berk Source Type: research
A Chance to Grow and Excel as an Associate Editor of < em > Pharmacological Reviews < /em > -Editorial
Pharmacol Rev. 2024 May 2;76(3):321-322. doi: 10.1124/pharmrev.124.001101.NO ABSTRACTPMID:38697853 | DOI:10.1124/pharmrev.124.001101 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Ali H Eid Source Type: research
MDM2 Inhibitors for Cancer Therapy: The Past, Present, and Future
In conclusion, targeting MDM2 remains a promising treatment approach, and targeting MDM2 for protein degradation represents a novel strategy to downregulate MDM2 without the side effects of the existing agents blocking p53-MDM2 binding. Additional preclinical and clinical investigations are needed to finally realize the full potential of MDM2 inhibition in treating cancer and other chronic diseases where MDM2 has been implicated. SIGNIFICANCE STATEMENT: Overexpression/amplification of the MDM2 oncogene has been detected in various human cancers and is associated with disease progression, treatment resistance, and poor pati...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Wei Wang Najah Albadari Yi Du Josef F Fowler Hannah T Sang Wa Xian Frank McKeon Wei Li Jia Zhou Ruiwen Zhang Source Type: research
Steatotic Liver Disease: Pathophysiology and Emerging Pharmacotherapies
Pharmacol Rev. 2024 May 2;76(3):454-499. doi: 10.1124/pharmrev.123.001087.ABSTRACTSteatotic liver disease (SLD) displays a dynamic and complex disease phenotype. Consequently, the metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH) therapeutic pipeline is expanding rapidly and in multiple directions. In parallel, noninvasive tools for diagnosing and monitoring responses to therapeutic interventions are being studied, and clinically feasible findings are being explored as primary outcomes in interventional trials. The realization that distinct subgroups ex...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Michail Kokkorakis Emir Muzurovi ć Špela Volčanšek Marlene Chakhtoura Michael A Hill Dimitri P Mikhailidis Christos S Mantzoros Source Type: research
Molecular Pathways Governing the Termination of Liver Regeneration
Pharmacol Rev. 2024 May 2;76(3):500-558. doi: 10.1124/pharmrev.123.000955.ABSTRACTThe liver has the unique capacity to regenerate, and up to 70% of the liver can be removed without detrimental consequences to the organism. Liver regeneration is a complex process involving multiple signaling networks and organs. Liver regeneration proceeds through three phases: the initiation phase, the growth phase, and the termination phase. Termination of liver regeneration occurs when the liver reaches a liver-to-body weight that is required for homeostasis, the so-called "hepatostat." The initiation and growth phases have been the subj...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Lianne R de Haan Rowan F van Golen Michal Heger Source Type: research
Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4
Pharmacol Rev. 2024 May 2;76(3):388-413. doi: 10.1124/pharmrev.123.000901.ABSTRACTThe involvement of the prostaglandin E2 (PGE2) system in cancer progression has long been recognized. PGE2 functions as an autocrine and paracrine signaling molecule with pleiotropic effects in the human body. High levels of intratumoral PGE2 and overexpression of the key metabolic enzymes of PGE2 have been observed and suggested to contribute to tumor progression. This has been claimed for different types of solid tumors, including, but not limited to, lung, breast, and colon cancer. PGE2 has direct effects on tumor cells and angiogenesis th...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Ana Santiso Akos Heinemann Julia Kargl Source Type: research
Adrenoceptor Desensitization: Current Understanding of Mechanisms
Pharmacol Rev. 2024 May 2;76(3):358-387. doi: 10.1124/pharmrev.123.000831.ABSTRACTG-protein coupled receptors (GPCRs) transduce a wide range of extracellular signals. They are key players in the majority of biologic functions including vision, olfaction, chemotaxis, and immunity. However, as essential as most of them are to body function and homeostasis, overactivation of GPCRs has been implicated in many pathologic diseases such as cancer, asthma, and heart failure (HF). Therefore, an important feature of G protein signaling systems is the ability to control GPCR responsiveness, and one key process to control overstimulat...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Dina Maaliki Aneese A Jaffa Suzanne Nasser Amirhossein Sahebkar Ali H Eid Source Type: research
New Advances in the Pharmacology and Toxicology of Lithium: A Neurobiologically Oriented Overview
Pharmacol Rev. 2024 May 2;76(3):323-357. doi: 10.1124/pharmrev.120.000007.ABSTRACTOver the last six decades, lithium has been considered the gold standard treatment for the long-term management of bipolar disorder due to its efficacy in preventing both manic and depressive episodes as well as suicidal behaviors. Nevertheless, despite numerous observed effects on various cellular pathways and biologic systems, the precise mechanism through which lithium stabilizes mood remains elusive. Furthermore, there is recent support for the therapeutic potential of lithium in other brain diseases. This review offers a comprehensive ex...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Analia Bortolozzi Giovanna Fico Michael Berk Marco Solmi Michele Fornaro Joao Quevedo Carlos A Zarate Lars V Kessing Eduard Vieta Andre F Carvalho Source Type: research
A Chance to Grow and Excel as an Associate Editor of < em > Pharmacological Reviews < /em > -Editorial
Pharmacol Rev. 2024 May 2;76(3):321-322. doi: 10.1124/pharmrev.124.001101.NO ABSTRACTPMID:38697853 | DOI:10.1124/pharmrev.124.001101 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Ali H Eid Source Type: research
MDM2 Inhibitors for Cancer Therapy: The Past, Present, and Future
In conclusion, targeting MDM2 remains a promising treatment approach, and targeting MDM2 for protein degradation represents a novel strategy to downregulate MDM2 without the side effects of the existing agents blocking p53-MDM2 binding. Additional preclinical and clinical investigations are needed to finally realize the full potential of MDM2 inhibition in treating cancer and other chronic diseases where MDM2 has been implicated. SIGNIFICANCE STATEMENT: Overexpression/amplification of the MDM2 oncogene has been detected in various human cancers and is associated with disease progression, treatment resistance, and poor pati...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Wei Wang Najah Albadari Yi Du Josef F Fowler Hannah T Sang Wa Xian Frank McKeon Wei Li Jia Zhou Ruiwen Zhang Source Type: research
Steatotic Liver Disease: Pathophysiology and Emerging Pharmacotherapies
Pharmacol Rev. 2024 May 2;76(3):454-499. doi: 10.1124/pharmrev.123.001087.ABSTRACTSteatotic liver disease (SLD) displays a dynamic and complex disease phenotype. Consequently, the metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH) therapeutic pipeline is expanding rapidly and in multiple directions. In parallel, noninvasive tools for diagnosing and monitoring responses to therapeutic interventions are being studied, and clinically feasible findings are being explored as primary outcomes in interventional trials. The realization that distinct subgroups ex...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Michail Kokkorakis Emir Muzurovi ć Špela Volčanšek Marlene Chakhtoura Michael A Hill Dimitri P Mikhailidis Christos S Mantzoros Source Type: research
Molecular Pathways Governing the Termination of Liver Regeneration
Pharmacol Rev. 2024 May 2;76(3):500-558. doi: 10.1124/pharmrev.123.000955.ABSTRACTThe liver has the unique capacity to regenerate, and up to 70% of the liver can be removed without detrimental consequences to the organism. Liver regeneration is a complex process involving multiple signaling networks and organs. Liver regeneration proceeds through three phases: the initiation phase, the growth phase, and the termination phase. Termination of liver regeneration occurs when the liver reaches a liver-to-body weight that is required for homeostasis, the so-called "hepatostat." The initiation and growth phases have been the subj...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Lianne R de Haan Rowan F van Golen Michal Heger Source Type: research
Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4
Pharmacol Rev. 2024 May 2;76(3):388-413. doi: 10.1124/pharmrev.123.000901.ABSTRACTThe involvement of the prostaglandin E2 (PGE2) system in cancer progression has long been recognized. PGE2 functions as an autocrine and paracrine signaling molecule with pleiotropic effects in the human body. High levels of intratumoral PGE2 and overexpression of the key metabolic enzymes of PGE2 have been observed and suggested to contribute to tumor progression. This has been claimed for different types of solid tumors, including, but not limited to, lung, breast, and colon cancer. PGE2 has direct effects on tumor cells and angiogenesis th...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Ana Santiso Akos Heinemann Julia Kargl Source Type: research
