Effect of melatonin on reproductive function in propylthiouracil induced hypothyroidism in adult male rats
CONCLUSIONS: Based on the study findings, melatonin could mitigate gonadal dysfunction induced by hypothyroidism by improving several components of semen analysis, such as sperm motility and sperm viability, as well as by enhancing testosterone production focusing on oxidative and inflammatory stress as the underlying mechanisms.PMID:38497875 | DOI:10.26355/eurrev_202403_35606 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: W Ezzat W K Abdelbasset R S Hussien A R Azab A Sulieman S Yousry Source Type: research
Analysis of orthostatic intolerance symptoms in patients with premature ejaculation
CONCLUSIONS: The orthostatic intolerance symptoms of patients with PE were higher than those of the control group. There was a correlation between the severity of PE and the severity of orthostatic intolerance. This is the first study in the literature to reveal a relationship between orthostatic intolerance and PE.PMID:38497876 | DOI:10.26355/eurrev_202403_35607 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: M O Ozilhan E Bulbul F Y Ilki E Uzun Source Type: research
Asprosin improved neuronal survival by suppressing apoptosis and enhancing the activity of the autophagy pathway in the MCAO model in rats
CONCLUSIONS: Asp has protective and therapeutic effects against CI/R damage. While applying Asp before ischemia activates the autophagy pathway more, applying it after ischemia protects the neuronal death/survival balance by activating the apoptosis pathway more.PMID:38497877 | DOI:10.26355/eurrev_202403_35608 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: K Tanbek F Yuksel S Tekin C Tekin S Sandal Source Type: research
Causal role of gut microbiota in intracranial aneurysm: evidence from a Mendelian randomization study
CONCLUSIONS: MR analyses identified several gut microbiota taxa that have a causal relationship with IA. Future research should prioritize understanding the mechanisms underlying this causal relationship, as it is expected to contribute to the development of new methods for predicting and treating IA.PMID:38497878 | DOI:10.26355/eurrev_202403_35609 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: J-W Sun Y-B Yu Source Type: research
Inflammatory factors mediated the effect of air pollution on ischemic stroke: a two-step, mediation Mendelian randomization study
CONCLUSIONS: A positive correlation between genetically predicted PM2.5 levels and elevated ischemic stroke risk is mediated by IL-1β, IL-6, and IL-17.PMID:38497879 | DOI:10.26355/eurrev_202403_35610 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: Z-L Huang Z-H Huang Y Xie Y-D Li Z-D Pi C Jiang A-M Chen X-Y Gao J Wen J-M Zhu Source Type: research
