Preoperative BMI and Hb levels are important predictors of massive bleeding in liver transplant patients
CONCLUSIONS: Preoperative BMI and Hb levels are critical predictors of massive bleeding during liver transplantation, emphasizing the importance of proactive management based on these indicators for improved patient outcomes.PMID:38497862 | DOI:10.26355/eurrev_202403_35593 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: K-D Chen W Chen B Hu Z-S Zhao Source Type: research
Effect of Esketamine on perioperative anxiety and depression in women with systemic tumors based on big data medical background
CONCLUSIONS: Significant differences were observed in the brain EEG signals between individuals with depression and those without depression. The improved SVM-KNN algorithm developed in this study demonstrates good predictive capability for anxiety and depression.PMID:38497863 | DOI:10.26355/eurrev_202403_35594 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: C-H Wang C-Y Lv Y-F Lin W-H Zhang X-L Tang L-X Zhao Source Type: research
Independent predictors of true positivity of positive myocardial perfusion imaging
CONCLUSIONS: The true positivity rate of SPECT-MPI is low. Moreover, this rate is much lower for women. The PPVs of different stress methods are similar. Age, presence of diabetes, and MHR ratio are independent predictors for true positive results of SPECT-MPI.GRAPHICAL ABSTRACT: https://www.europeanreview.org/wp/wp-content/uploads/Graphical-abstract-9.jpg.PMID:38497864 | DOI:10.26355/eurrev_202403_35595 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: F Koca G Özmen Source Type: research
Therapeutic potential of ramipril, losartan, and spironolactone against sepsis-associated liver tissue injury induced by cecal ligation and puncture in rats
CONCLUSIONS: Administration of ramipril, losartan, or spironolactone after CLP produced a hepatoprotective effect in rats, possibly by reducing oxidative stress, inflammation, and apoptosis.PMID:38497865 | DOI:10.26355/eurrev_202403_35596 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: A Al-Kadi M El-Daly N F G El-Tahawy O Fahmi A B Abdel-Naim M M A Khalifa A F Ahmed Source Type: research
The efficacy and safety of venetoclax combined with demethylating agents in elderly patients with acute myeloid leukemia: a systematic review and meta-analysis
CONCLUSIONS: The combination of venetoclax and demethylating drugs has a good therapeutic effect on elderly patients with acute myeloid leukemia, but it also induces some adverse events. Although this therapy has a small impact on the quality of life, further attention is still needed to reduce the occurrence of such adverse events.PMID:38497866 | DOI:10.26355/eurrev_202403_35597 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: M-Y Wei J Yin Y Liao J-Y Liu Y Zhao X-M Chen Y Liu X-M Wang C-L Huang Source Type: research
High expression of angiotensin-converting enzyme 2 receptor (ACE-2), transmembrane protease serine (TMPRSS), and P-selectin in platelets lead to thrombosis formation in COVID-19 patients
CONCLUSIONS: In summary, the interaction of ACE-2, TMPRSS, and P-selectin in platelets appears to be a key element contributing to COVID-19 severity via their impact on thrombus development. Further investigation into these pathways may provide possible treatment targets for reducing the severe consequences of the COVID-19 infection.PMID:38497867 | DOI:10.26355/eurrev_202403_35598 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: H A Waggiallah M M Eltayeb A M Hjazi Y M Elmosaad Source Type: research
Simplified clinical frailty scale design, validation, and adaptation in older patients
CONCLUSIONS: The sCFS can be used to assess frailty with high sensitivity and specificity.PMID:38497868 | DOI:10.26355/eurrev_202403_35599 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: T-V Nguyen G-M Tran T-T-T Nguyen H-T-H Le B-L-T Tran T-H Ngo H-H Nguyen K-T Nguyen Source Type: research
Prospects of targeting JAK/STAT signal transduction pathways for vasculitis
Eur Rev Med Pharmacol Sci. 2024 Mar;28(5):1864-1872. doi: 10.26355/eurrev_202403_35600.ABSTRACTVasculitis is the inflammation of blood vessels caused by autoimmunity and/or autoinflammation, and its etiology and pathogenesis remain largely unknown. The Janus kinase (JAK) and Signal transduction Transcription Activator (STAT) signal transduction pathways are a group of molecules involved in the major pathways by which many cytokines exert and integrate their functions, and their dysregulation has been implicated in the pathogenesis of a variety of autoimmune diseases. However, current data supporting the role of the JAK/STA...
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: R-X Huo Y-T Yang Y Yang X-C Huo D-L Meng R-J Huang Y-J Huang J-Y Lin X Zhu C-C Wei X-X Huang Source Type: research
Clinical, biochemical, and genotypical characteristics in urea cycle mitochondrial transporter disorders
CONCLUSIONS: Increasing patients' caloric intake with HHH syndrome improves their ornithine levels. Our patients with citrin deficiency recovered clinically and biochemically before seven months.PMID:38497870 | DOI:10.26355/eurrev_202403_35601 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: H Bilgin S Bilge M Binici S Tekes Source Type: research
Dry eye disease pathogenesis and clinical signs: searching for correspondence in the clinical practice
CONCLUSIONS: Literature evidence and clinical experiences suggest that basic diagnostic approaches (assessment of hyperemia, MMP-9 levels, and staining of the ocular surface with Lissamine green or fluorescein) represent useful tools to assess the inflammatory component of DED in everyday practice, providing a guide to establish the correct therapeutic strategy.PMID:38497871 | DOI:10.26355/eurrev_202403_35602 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: S Barabino J M Ben ítez-Del-Castillo Source Type: research
In vitro inhibition of uterine contractions using electrospun nanofibers loaded with nifedipine and ML7
CONCLUSIONS: The results indicate that human uterine contractions can be inhibited using calcium channel blocker (nifedipine) and myosin light chain kinase inhibitor (ML7) loaded nanofibers in uterine tissue strips. These results strongly suggested the potential for the development of locally effective and safe controlled drug release systems to prevent premature birth.PMID:38497872 | DOI:10.26355/eurrev_202403_35603 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: Y Karasu M Demeli Ertu ş D Önal B Top çu H Ero ğlu B Pehlivano ğlu Source Type: research
Hepatitis E virus infection increases the risk of obstetric complications and perinatal adverse outcomes in pregnant women with chronic hepatitis B virus infection
CONCLUSIONS: HEV infection increases the risk of obstetric complications and perinatal adverse outcomes in pregnant women with chronic HBV infection.PMID:38497873 | DOI:10.26355/eurrev_202403_35604 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: C Chen M-L Wang W-X Li X Qi Q Li L Chen Source Type: research
Measures of health-related quality of life in PCOS women: a cross sectional study from Saudi Arabia
CONCLUSIONS: The findings revealed that PCOS-related conditions such as weight problems, menstrual irregularity, and infertility were associated with a reduction in quality of life.PMID:38497874 | DOI:10.26355/eurrev_202403_35605 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: L S M AlAhmari H S Alzahrani N Alzahrani S O AlDhafyan R H Al-Qahtani J A Al-Zaid M S AlShahrani L A Al-Ghamdi Source Type: research
Effect of melatonin on reproductive function in propylthiouracil induced hypothyroidism in adult male rats
CONCLUSIONS: Based on the study findings, melatonin could mitigate gonadal dysfunction induced by hypothyroidism by improving several components of semen analysis, such as sperm motility and sperm viability, as well as by enhancing testosterone production focusing on oxidative and inflammatory stress as the underlying mechanisms.PMID:38497875 | DOI:10.26355/eurrev_202403_35606 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: W Ezzat W K Abdelbasset R S Hussien A R Azab A Sulieman S Yousry Source Type: research
Analysis of orthostatic intolerance symptoms in patients with premature ejaculation
CONCLUSIONS: The orthostatic intolerance symptoms of patients with PE were higher than those of the control group. There was a correlation between the severity of PE and the severity of orthostatic intolerance. This is the first study in the literature to reveal a relationship between orthostatic intolerance and PE.PMID:38497876 | DOI:10.26355/eurrev_202403_35607 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: M O Ozilhan E Bulbul F Y Ilki E Uzun Source Type: research
