For Whom the bugs toll: do uTLR4 levels have a role in screening for urinary tract infection?
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - December 19, 2023 Category: Urology & Nephrology Source Type: research
Publisher Correction: The urological evaluation and management of neurogenic bladder in children and adolescents —what every pediatric nephrologist needs to know
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - December 19, 2023 Category: Urology & Nephrology Source Type: research
Urinary TIMP-2*IGFBP-7 to diagnose acute kidney injury in children receiving cisplatin
ConclusionsTIMP-2*IGFBP-7 were poor to modest at detecting AKI post-cisplatin. Additional studies are needed to determine whether raw biomarker values or biomarker values normalized to urinary creatinine are more strongly associated with patient outcomes.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - November 25, 2023 Category: Urology & Nephrology Source Type: research
Incremental dialysis: review of the literature with pediatric perspective
AbstractDrivers towards initiation of kidney replacement therapy in advanced chronic kidney disease include metabolic and fluid derangements, growth, and nutritional status with focus on health optimization. Once initiated, prescription of dialysis is often uniform despite variability in patient characteristics and etiology of kidney failure. Preservation of residual kidney function has been associated with improved outcomes in patients with advanced chronic kidney disease on dialysis. Incremental dialysis is the approach of reducing the dialysis dose by reduction in treatment time, days, or efficiency of clearance. Increm...
Source: Pediatric Nephrology - November 25, 2023 Category: Urology & Nephrology Source Type: research
Referees for 2023
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - November 25, 2023 Category: Urology & Nephrology Source Type: research
Isotonic versus hypotonic intravenous maintenance fluid therapy: what ’s new?
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - November 25, 2023 Category: Urology & Nephrology Source Type: research
Changes at Pediatric Nephrology for 2024 and beyond
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - November 25, 2023 Category: Urology & Nephrology Source Type: research
Live attenuated vaccines in patients receiving immunosuppressive agents
AbstractThe use of live attenuated vaccines in patients with immunosuppressive agents is contraindicated in package inserts and guidelines in Japan and other countries. However, patients receiving immunosuppressants have a high risk of infectious disease becoming severe, and the necessity to prevent infectious disease is high. To date, 2,091 vaccinations have been reported in 25 reports of live attenuated vaccines in people receiving immunosuppressants. Twenty-three patients (1.1%) became infected with the virus strain used in the vaccine, which was varicella virus in 21 patients. No reports have described life-threatening...
Source: Pediatric Nephrology - October 18, 2023 Category: Urology & Nephrology Source Type: research
An unusual cause of diarrhea in a child with nephrotic syndrome: Answers
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - October 18, 2023 Category: Urology & Nephrology Source Type: research
Distress in parents of children with first-onset steroid-sensitive nephrotic syndrome
ConclusionsFour weeks after onset, SSNS mothers and fathers experience equal distress as reference parents. However, both parents endorsed significantly more everyday problems. Therefore, monitoring parental distress, even in the first weeks of the disease, could contribute to timely interventions and prevent worsening of problems.Clinical trial registryDutch Trial Register (https://onderzoekmetmensen.nl/en/trial/27331).Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - October 18, 2023 Category: Urology & Nephrology Source Type: research
Tidal continuous cycling peritoneal dialysis in children
AbstractAbout 10% of all home peritoneal dialysis regimens in children with chronic kidney disease stage 5 are reported to involve some form of a tidal peritoneal dialysis (TPD) prescription. Despite this, there remain several gaps in how pediatric nephrologists approach the use of TPD. This stems from a combination of factors such as the confusing technical terminology pertaining to TPD, seemingly conflicting data on the risks, benefits, and indications for TPD, and lastly, limited published guidelines on the practical aspects of how to write a TPD prescription, based on the indication, in children. Our educational review...
Source: Pediatric Nephrology - October 18, 2023 Category: Urology & Nephrology Source Type: research
Successful treatment with avacopan (CCX168) in a pediatric patient with C3 glomerulonephritis
ConclusionsIn this case, use of avacopan in a pediatric patient with C3GN was safe and well tolerated. On avacopan, the patient was able to discontinue mycophenolate mofetil (MMF) while maintaining remission. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - October 18, 2023 Category: Urology & Nephrology Source Type: research
Trajectories of eGFR after kidney transplantation according to trajectories of eGFR prior to kidney replacement therapies in children with chronic kidney disease
ConclusionseGFR decline substantially slows down after transplant even among children with rapidly progressing forms of CKD. Nonetheless, those who had albuminuria and high SBP before KRT might continue to show faster eGFR decline after transplant, specifically when both risk factors were present. This subgroup might benefit from intensive pre-transplant management for at least one of the two risk factors.Graphical abstractA higher resolution version of the Graphical abstract is available as Supplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - October 18, 2023 Category: Urology & Nephrology Source Type: research
Sodium handling in pediatric patients on maintenance dialysis
AbstractThe risk of cardiovascular disease remains exceedingly high in pediatric patients with chronic kidney disease stage 5 on dialysis (CKD 5D). Sodium (Na+) overload is a major cardiovascular risk factor in this population, both through volume-dependent and volume-independent toxicity. Given that compliance with a Na+-restricted diet is generally limited and urinary Na+ excretion impaired in CKD 5D, dialytic Na+ removal is critical to reduce Na+ overload. On the other hand, an excessive or too fast intradialytic Na+ removal may lead to volume depletion, hypotension, and organ hypoperfusion. This review presents current...
Source: Pediatric Nephrology - October 18, 2023 Category: Urology & Nephrology Source Type: research
Long-term outcomes with rituximab as add-on therapy in severe childhood-onset lupus nephritis
ConclusionAdd-on rituximab is an effective and safe rescue therapy for cLN patients with life-/organ-threatening manifestations or treatment-resistance.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - October 18, 2023 Category: Urology & Nephrology Source Type: research
