Extramedullary relapsed acute lymphoblastic leukemia presenting as asymptomatic acute kidney injury after hematopoietic stem cell transplantation
AbstractAcute kidney injury (AKI) is a common complication in children with hematological malignancies. Although AKI due to infiltration of tumor cells in children is rare, it negatively impacts treatment outcomes and increases the risk of mortality. We introduce a case of a child with acute lymphoblastic leukemia (ALL) who experienced kidney relapse resulting in asymptomatic AKI after remission from treatment, to remind clinicians not to overlook the primary disease in clinical judgment. In cases of unexplained AKI, kidney biopsy should be performed when feasible to get an accurate diagnosis and scientific treatment. In b...
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Eculizumab in STEC-HUS with severe neurological involvement: a New Zealand perspective
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Use of a donor kidney with known autosomal dominant polycystic kidney disease in a highly sensitised paediatric recipient
We report the use of an autosomal-dominant polycystic kidney disease (ADPKD) donor kidney in a paediatric recipient. A 14-year-old boy on haemodialysis for 4 years following loss of a first kidney transplant, highly sensitised, and with limited vascular options for ongoing dialysis access, was offered a deceased brain death donor transplant from a mid-30s donor with known ADPKD but normal kidney function and negligible proteinuria. After extensive discussion with the patient and family, discussing all alternative options and review of available literature, the kidney was accepted and implanted. Graft function was immediate...
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Susceptibility to diabetic nephropathy
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Response to “Susceptibility to diabetic nephropathy”
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Water-soluble vitamins and trace elements in children with chronic kidney disease stage 5d
AbstractChildren receiving maintenance dialysis (chronic kidney disease (CKD) stage 5d) have unique risk factors for micronutrient deficiency or toxicity. Children receiving chronic dialysis often require specialized diet plans that may provide more than the recommended daily allowance (RDA) of water-soluble vitamins and micronutrients, with or without the addition of a kidney-friendly vitamin. The following is a comprehensive review of current literature on disorders of micronutrients in this population including those of water-soluble vitamins (vitamin C and vitamin B complexes) and trace elements (copper, selenium, and ...
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research
Complement gene mutations in children with C3 glomerulopathy: do they affect the response to mycophenolate mofetil?
ConclusionsThis study is the largest pediatric C3G study examining the relationship between genotype and phenotype. We showed that the mutation group often presented with asymptomatic urinary abnormalities, was diagnosed relatively late but was not different from the without mutation group in terms of MMF treatment response and kidney survival.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research
Characteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort study
ConclusionMMC-related CKD is common in childhood in Turkey. A proactive approach to neurogenic bladder management and early protective surgery in selected cases where conservative treatment has failed should be implemented to prevent progressive kidney failure in the pediatric MMC population in our country.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research
Non-contrast-enhanced magnetic resonance urography for measuring split kidney function in pediatric patients with hydronephrosis: comparison with renal scintigraphy
ConclusionsNCE-MRU can be used as an alternative method for estimating SKF in pediatric patients with hydronephrosis when comparing with RS. Specifically, SKPV proves to be a simple and universally applicable indicator for predicting SKF.Graphical AbstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research
Insight into prevalence, etiology, and modalities of pediatric chronic dialysis: a comprehensive nationwide analysis
ConclusionsThis first nationwide study of pediatric chronic dialysis in Saudi Arabia sheds light on the prevalence of children undergoing chronic dialysis and underlying causes of their KF, thereby contributing to our understanding of clinical management considerations. This research serves as a stepping stone for the development of national registries.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research
Caffeine and neonatal acute kidney injury
AbstractAcute kidney injury is one of the most threatening diseases in neonates, with complex pathogenesis and limited treatment options. Caffeine is a commonly used central nervous system stimulant for treating apnea in preterm infants. There is compelling evidence that caffeine may have potential benefits for preventing neonatal acute kidney injury, but comprehensive reports are lacking in this area. Hence, this review aims to provide a summary of clinical data on the potential benefits of caffeine in improving neonatal acute kidney injury. Additionally, it delves into the molecular mechanisms underlying caffeine ’s ef...
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research
Predictors of augmented renal clearance based on iohexol plasma clearance in critically ill children
ConclusionsOur findings raise PICU clinician awareness about increased risk for ARC after major surgery and in patients with eGFR above age-specific thresholds. This knowledge enables identification of patients with an ARC risk profile who would potentially benefit from a dose increase at initiation of treatment to avoid underexposure.Trial registrationClinicalTrials.gov NCT05179564, registered retrospectively on January 5, 2022.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research
Effect of peritoneal dialysate on bioelectrical impedance analysis variability in pediatric patients receiving peritoneal dialysis
ConclusionsA total of 94.1% of BIA parameters exhibited excellent correlations between D + and D- measurements, especially patients older than 10 years. We recommend that BIA measurements be collected from children regardless of the presence of peritoneal dialysate. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research
Beyond the kidney: extra-renal manifestations of monogenic nephrolithiasis and their significance
ConclusionRecognizing the extra-renal manifestations associated with monogenic causes of kidney stones is critical for earlier diagnosis and optimal care in patients.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research
Persistent acute kidney injury and fluid accumulation with outcomes after the Norwood procedure: report from NEPHRON
ConclusionsThe combination of persistent CS-AKI and peak CFB > 10% after the Norwood procedure is associated with mortality and hospital resource utilization. Prospective studies targeting intra- and postoperative CS-AKI risk factors and reducing CFB have the potential to improve outcomes.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research
