Serum apolipoproteins (apoA-1, apoB, and apoB/apoA-1 ratio) for early identification of dyslipidemia in children with CKD
ConclusionsThe prevalence (78.9%) of dyslipidemia was high in patients with CKD especially in those with later stages. The ratio of apoB/apoA-1 was altered early and appears to be promising for early detection.Graphical AbstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - January 27, 2024 Category: Urology & Nephrology Source Type: research
Acute kidney injury in children with moderate-severe COVID-19 and multisystem inflammatory syndrome in children: a referral center experience
ConclusionsIndependent risk factors for AKI were need for vasoactive/inotropic agents and vomiting/diarrhea in moderate, severe or critical COVID-19 patients; and need for vasoactive/inotropic agents and severe inflammation in MIS-C patients. Our findings suggest that inflammation and cardiac dysfunction are associated with AKI in MIS-C patients; and the association with age in this group merits further studies in larger groups. Early outcome is favorable; long-term follow-up for kidney functions is needed.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Sour...
Source: Pediatric Nephrology - January 27, 2024 Category: Urology & Nephrology Source Type: research
Self-concept and academic achievement in children with chronic kidney disease
ConclusionsDespite the presence of a chronic disease, children with CKD endorse a positive self-concept. Positive self-concept may predict academic success in this population.Graphical Abstract A higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - January 27, 2024 Category: Urology & Nephrology Source Type: research
Genetics of kidney disorders in Phelan-McDermid syndrome: evidence from 357 registry participants
ConclusionsThe candidate genes for kidney disorders includeFBLN1,WNT7B,UPK3A,CELSR1, andPLXNB2. This study demonstrates the utility of patient registries for uncovering genetic contributions to rare diseases. Future work should focus on functional studies for these genes to assess their potential pathogenic contribution to the different subsets of kidney disorders.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - January 27, 2024 Category: Urology & Nephrology Source Type: research
Associations between anemia and FGF23 in the CKiD study
ConclusionsIn this cohort of pediatric patients with CKD, anemia was associated with increased total FGF23 levels but was not independently associated with elevated intact FGF23, suggesting possible effects on both FGF23 production and cleavage. Further studies are warranted to investigate non-mineral factors affecting FGF23 production and metabolism in CKD.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - January 27, 2024 Category: Urology & Nephrology Source Type: research
Compassionate use of roxadustat for treatment of refractory renal anemia in an infant
ConclusionThe successful experience in this case may inform the clinical utility of roxadustat for refractory renal anemia in children, which should be further confirmed by well-designed prospective clinical trials. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - January 27, 2024 Category: Urology & Nephrology Source Type: research
Programs and processes for advancing pediatric acute kidney support therapy in hospitalized and critically ill children: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference
AbstractPediatric acute kidney support therapy (paKST) programs aim to reliably provide safe, effective, and timely extracorporeal supportive care for acutely and critically ill pediatric patients with acute kidney injury (AKI), fluid and electrolyte derangements, and/or toxin accumulation with a goal of improving both hospital-based and lifelong outcomes. Little is known about optimal ways to configure paKST teams and programs, pediatric-specific aspects of delivering high-quality paKST, strategies for transitioning from acute continuous modes of paKST to facilitate rehabilitation, or providing effective short- and long-t...
Source: Pediatric Nephrology - January 27, 2024 Category: Urology & Nephrology Source Type: research
Impact of the first 24 h of continuous kidney replacement therapy on hemodynamics, ventilation, and analgo-sedation in critically ill children
ConclusionsCKRT showed a significant impact on hemodynamics and ventilation in the first 24 h of treatment. We observed a significant rise in the inotropic/vasoactive support required after 1 h of treatment in the overall population, and an improvement in the ventilation parameters at 24 h only in survivors.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - January 27, 2024 Category: Urology & Nephrology Source Type: research
Nutcracker syndrome in pediatrics: initial findings and long-term follow-up results
ConclusionsIn unexplained proteinuria and/or hematuria, NCS should be considered, especially in asthenic adolescents. Our results support conservative management in children as the first-line treatment approach.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - January 27, 2024 Category: Urology & Nephrology Source Type: research
Mother –child correlation of kidney function: data from the Yamanashi Adjunct Study of Japan Environment and Children’s Study (JECS)
ConclusionsWe directly confirmed mother –child correlations in both serum creatinine levels and eGFR values, particularly in girls.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - January 27, 2024 Category: Urology & Nephrology Source Type: research
Emerging progressive atypical acute kidney injury in young children linked to ethylene glycol and diethylene glycol intoxication
ConclusionCareful history taking of patient ’s clinical course, including consumption of syrup-based medications and laboratory findings, might aid clinicians to establish a working diagnosis of D(EG) intoxication without needing to wait for blood toxicology test. Early diagnosis and therapy are crucial to prevent substantial mortality.Graphical abstract A higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - January 27, 2024 Category: Urology & Nephrology Source Type: research
Efficacy and safety of long-term repeated use of rituximab in pediatric patients with nephrotic syndrome
ConclusionsLong-term repeated use of RTX may be effective and safe in pediatric NS patients. Furthermore, the redosing of RTX could be chosen by considering predictive factors for relapse-free and B-cell depletion periods.Graphical AbstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - January 27, 2024 Category: Urology & Nephrology Source Type: research
Epidemiology of acute kidney injury in children: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference
AbstractThe nephrology and critical care communities have seen an increase in studies exploring acute kidney injury (AKI) epidemiology in children. As a result, we now know that AKI is highly prevalent in critically ill neonates, children, and young adults. Furthermore, children who develop AKI experience greater morbidity and higher mortality. Yet knowledge gaps still exist that suggest a more comprehensive understanding of AKI will form the foundation for future efforts designed to improve outcomes. In particular, the areas of community acquired AKI, AKI in non-critically ill children, and cohorts from low-middle income ...
Source: Pediatric Nephrology - January 27, 2024 Category: Urology & Nephrology Source Type: research
The twenty-sixth Acute Disease Quality Initiative: the Pediatric ADQI (pADQI) —a dream realized
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - January 27, 2024 Category: Urology & Nephrology Source Type: research
C3 glomerulopathy in a patient with a history of post-infectious glomerulonephritis
AbstractPost-infectious glomerulonephritis (PIGN) is an immune complex mediated glomerular injury occurring because of an infection, most commonly with group A beta-hemolytic streptococcus in children. C3 glomerulopathy (C3G) is a distinct clinicopathological entity occurring secondary to dysregulation of alternate complement pathway encompassing both C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). While most patients with PIGN attain complete remission with normalized complement levels by 6 –8 weeks after presentation, patients with C3G continue to have hypocomplementemia with high rates of progressive ki...
Source: Pediatric Nephrology - January 27, 2024 Category: Urology & Nephrology Source Type: research
