The rationale for nephron-sparing surgery in unilateral non-syndromic Wilms tumour
AbstractThe central question of nephron-sparing surgery in unilateral non-syndromic Wilms tumour sits at a crossroads between surgery, oncology, and nephrology. There has been a significant paradigm shift in paediatric oncology towards reducing toxicity and addressing long-term treatment-related sequalae amongst childhood cancer survivors. After paediatric nephrectomy and 30 –50 years of follow-up, 40% of patients will have chronic kidney disease, including 22% with hypertension and 23% with albuminuria. It is difficult to predict which patients will progress to develop hypertension, reduced glomerular filtration rate, ...
Source: Pediatric Nephrology - February 28, 2024 Category: Urology & Nephrology Source Type: research
Eu- or hypoglycemic ketosis and ketoacidosis in children: a review
In conclusion, the role of ketone bodies is increasingly recognized in several clinical conditions. In the co ntext of acid–base balance evaluation, it is advisable to routinely integrate both the assessment of lactic acid and β-hydroxybutyrate. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - February 28, 2024 Category: Urology & Nephrology Source Type: research
School attendance and sport participation amongst children with chronic kidney disease: a cross-sectional analysis from the Kids with CKD (KCAD) study
ConclusionsChildren receiving dialysis and with a kidney transplant had greater school absences and played fewer sports compared to children with CKD stages 1 –2. Innovative strategies to improve school attendance and sport participation are needed to improve life participation of children with CKD.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - February 28, 2024 Category: Urology & Nephrology Source Type: research
Acute kidney injury in infants with hypoxic-ischemic encephalopathy
ConclusionsHIE is associated with an increased prevalence of AKI. Infants with severe HIE had the highest prevalence of AKI and associated mortality. The study highlights the need for close monitoring and early detection of AKI in infants with HIE, particularly those with severe HIE, to ameliorate the associated adverse outcomes. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - February 28, 2024 Category: Urology & Nephrology Source Type: research
Long-term kidney outcomes in pediatric continuous-flow ventricular assist device patients
ConclusionsIn the first multicenter study to focus on kidney outcomes for pediatric long-term CF-VAD patients, preimplantation CKD and peri-implantation AKI were common. Both de novo CKD and worsening CKD can happen on prolonged CF-VAD support. Proactive kidney function monitoring and targeted follow-up are important to optimize outcomes.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - February 28, 2024 Category: Urology & Nephrology Source Type: research
Worldwide disparities in access to treatment and investigations for nephropathic cystinosis: a 2023 perspective
ConclusionsOver the last decade, access to investigations (namely genetics and IL-CL) and to cysteamine have improved in DEing and TrE. However, discrepancies remain with DEed: access to delayed released cysteamine is limited, and reimbursement is still profoundly insufficient, therefore limiting their current use.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - February 28, 2024 Category: Urology & Nephrology Source Type: research
Hypertension in children with congenital anomalies of the kidney and urinary tract
ConclusionHypertension is common in children with CAKUT and increases the risk of CKD. These findings will aid in the development of a standardized clinical pathway for the care of hypertensive children with CAKUT.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - February 28, 2024 Category: Urology & Nephrology Source Type: research
Kidney sequelae in 281 Shiga toxin –producing Escherichia coli-hemolytic uremic syndrome patients after a median follow-up of 12 years
ConclusionsFifty-one percent of patients evolved to CKD after 12 years of follow-up and 14% to CKD2–5. Ten days of dialysis was the best cutoff to recognize outcomes. In some cases, kidney damage was evident after 15 years of surveillance, highlighting the need for follow-up until adulthood in all STEC-HUS patients.Graphical AbstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - February 28, 2024 Category: Urology & Nephrology Source Type: research
A previously healthy 3-year-old female with hypertension, proteinuria, and hypercalciuria
AbstractA 3-year-old female patient with no significant medical history presented to her pediatrician with foamy urine. Initial testing revealed moderate proteinuria on qualitative testing, although she was incidentally noted to have severe hypertension (240/200 mmHg). Physical examination of the carotid and femoral areas revealed significant systolic vascular murmurs. Labs showed elevated serum creatinine, hypokalemia, metabolic alkalosis, elevated renin and aldosterone and hypercalciuria. Echocardiography identified ventricular hypertrophy. Computed tom ography (CT) of the abdomen and magnetic resonance angiography of ...
Source: Pediatric Nephrology - February 28, 2024 Category: Urology & Nephrology Source Type: research
Rurality of patient residence and access to transplantation among children with kidney failure in the United States
ConclusionsIn children with kidney failure, residence in rural and micropolitan areas was associated with better access to living donor transplantation and similar access to deceased donor transplantation compared with residence in metropolitan areas.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - February 28, 2024 Category: Urology & Nephrology Source Type: research
Safety and efficacy of sodium zirconium cyclosilicate for the management of acute and chronic hyperkalemia in children with chronic kidney disease 4 –5 and on dialysis
ConclusionsSZC was safe and effective for the management of acute and chronic hyperkalemia in children with CKD4-5/5D. Its use was associated with relaxation of dietary potassium restriction. Studies to examine its routine use to improve diet and nutritional status in children with CKD are required.Graphical Abstract A higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - February 28, 2024 Category: Urology & Nephrology Source Type: research
Multifocal lesions in a kidney allograft
ConclusionsEven without a clear source, serious infections may develop in kidney transplant patients who otherwise have concern for malignancy. Chlamydial infections may lead to serious intra-abdominal infections in immunocompromised patients. The inadequately treated chlamydia likely led to polymicrobial ascension of the genitourinary tract that seeded the transplanted kidney. A high index of suspicion for infection is essential in immunosuppressed patients. Biopsy is crucial for a timely diagnosis. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - February 28, 2024 Category: Urology & Nephrology Source Type: research
Renal water handling in urinary tract infections
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - February 28, 2024 Category: Urology & Nephrology Source Type: research
Blasting off: persistent hypertension in a child with neuroblastoma
In this report, we h ighlight the importance of careful, multidisciplinary management to avoid peri-operative complications in patients with catecholamine-producing tumors. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - February 28, 2024 Category: Urology & Nephrology Source Type: research
Renal water handling in urinary tract infections
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - February 28, 2024 Category: Urology & Nephrology Source Type: research
