Quality of life in pediatric chronic kidney disease: expectations and responsibilities
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - July 6, 2023 Category: Urology & Nephrology Source Type: research

Pediatric peritoneal dialysis training program and  its relationship to peritonitis: a study of the International Pediatric Peritoneal Dialysis Network
ConclusionsAn association between training duration and the number of training tools represent potentially modifiable risk factors to reduce peritonitis rates within the pediatric PD population.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - July 5, 2023 Category: Urology & Nephrology Source Type: research

Correction: A child with chronic kidney disease and hepatic dysfunction: Answers
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - July 5, 2023 Category: Urology & Nephrology Source Type: research

Correction: A child with chronic kidney disease and hepatic dysfunction: Questions
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - July 5, 2023 Category: Urology & Nephrology Source Type: research

Plasma leucine-rich α-2-glycoprotein 1 – a novel marker of diabetic kidney disease in children and adolescents with type 1 diabetes mellitus?
ConclusionsOur study supports the relationship between plasma LRG1 and eGFR decline and suggests LRG1 may be an early marker of DKD progression in children with T1DM.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - July 4, 2023 Category: Urology & Nephrology Source Type: research

Advances and potential of regenerative medicine in pediatric nephrology
AbstractThe endogenous capacity of the kidney to repair is limited, and generation of new nephrons after injury for adequate function recovery remains a need. Discovery of factors that promote the endogenous regenerative capacity of the injured kidney or generation of transplantable kidney tissue represent promising therapeutic strategies. While several encouraging results are obtained after administration of stem or progenitor cells, stem cell secretome, or extracellular vesicles in experimental kidney injury models, very little data exist in the clinical setting to make conclusions about their efficacy. In this review, w...
Source: Pediatric Nephrology - July 3, 2023 Category: Urology & Nephrology Source Type: research

Correction to: Outcomes based on induction regimens in pediatric kidney transplantation: a NAPRTCS and PHIS collaborative study
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - July 3, 2023 Category: Urology & Nephrology Source Type: research

Evaluation of lung ultrasound to detect volume overload in children undergoing dialysis
ConclusionsA simplified 8-zone ultrasound protocol can assess fluid volume change in real time and correlates with hematocrit levels obtained throughout dialysis. This provides a valuable method for monitoring fluid status in volume overloaded patient populations.Graphical abstractA higher resolution version of the Graphical abstract is available as  Supplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - June 2, 2023 Category: Urology & Nephrology Source Type: research

Kidney support for babies: building a comprehensive and integrated neonatal kidney support therapy program
AbstractKidney support therapy (KST), previously referred to as Renal Replacement Therapy, is utilized to treat children and adults with severe acute kidney injury (AKI), fluid overload, inborn errors of metabolism, and kidney failure. Several forms of KST are available including peritoneal dialysis (PD), intermittent hemodialysis (iHD), and continuous kidney support therapy (CKST). Traditionally, extracorporeal KST (CKST and iHD) in neonates has had unique challenges related to small patient size, lack of neonatal-specific devices, and risk of hemodynamic instability due to large extracorporeal circuit volume relative to ...
Source: Pediatric Nephrology - June 2, 2023 Category: Urology & Nephrology Source Type: research

Predictors of successful discontinuation of continuous kidney replacement therapy in a pediatric cohort
ConclusionsDetermining the predictors of sustained CKRT discontinuation is critical. Urine output greater than 0.5  mL/kg/h in this pediatric cohort predicted successful discontinuation. Future studies are needed to validate this threshold in disease- and age-specific cohorts and evaluate additional biomarkers of kidney injury.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - June 2, 2023 Category: Urology & Nephrology Source Type: research

Research progress of fibroblast growth factor 23 in acute kidney injury
AbstractFibroblast growth factor 23 (FGF23) is primarily produced in bones and mainly regulates calcium and phosphorus metabolism. The level of circulating FGF23 increases rapidly in the early stage of acute kidney injury (AKI). Recent studies have shown that FGF23 may serve as a biomarker for the diagnosis and poor prognosis of AKI. The mechanism of increased FGF23 in AKI may include increased production of FGF23, decreased renal clearance of FGF23, and some new regulatory factors, such as inflammation and glycerol 3-phosphate. However, the biological effects of elevated FGF23 in AKI are still unclear. It is also not know...
Source: Pediatric Nephrology - June 2, 2023 Category: Urology & Nephrology Source Type: research

Post-transplant education for kidney recipients and their caregivers
AbstractSuccessful outcomes in pediatric kidney transplantation require the involvement of the transplant team as well as recipients and their caregivers. Enhancing patient and family understanding of the disease and of post-transplant care can result in improved adherence and outcomes. Educational strategies should aim to be broad, understandable, innovative, and inclusive while maintaining a tailored approach to individualized care. Teaching should not be viewed as a one-time event but rather as an ongoing conversation throughout the duration of care, emphasizing different aspects throughout the patient ’s various deve...
Source: Pediatric Nephrology - June 2, 2023 Category: Urology & Nephrology Source Type: research

Treatment of idiopathic nephrotic syndrome at onset: a comparison between 8- and 12-week regimens in everyday clinical practice
ConclusionsDespite the limitations of a retrospective study with limited follow-up, our data indicate that switching treatment from a shorter to a longer scheme did not improve the clinical outcome at 24  months of observation.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - June 2, 2023 Category: Urology & Nephrology Source Type: research

Plasma FGF23 is associated with left atrial remodeling in children on hemodialysis
ConclusionsIn children on HD and preserved left ventricular  ejection fraction, greater FGF23 is associated with lower LA GLS (indicative of impaired atrial performance).Graphical AbstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - June 2, 2023 Category: Urology & Nephrology Source Type: research

Language barriers and kidney transplantation in children
ConclusionsPediatric kidney transplant recipients requiring interpreter services for healthcare delivery demonstrate fewer post-transplant interactions with their healthcare team (fewer hospitalizations and more no-show visits) and lower 5-year patient survival compared with recipients not requiring interpreters.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - June 2, 2023 Category: Urology & Nephrology Source Type: research