Severe anemia and massive proteinuria in a boy with diabetes mellitus: Questions
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - August 16, 2023 Category: Urology & Nephrology Source Type: research
Acute kidney injury in an allogeneic hematopoietic cell transplant recipient: Questions
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - August 16, 2023 Category: Urology & Nephrology Source Type: research
Use of furosemide in preterm neonates with acute kidney injury is associated with increased mortality: results from the TINKER registry
ConclusionsIn preterm neonates with AKI, mortality was independently associated with furosemide treatment. The furosemide usage rates were higher in neonates with associated co-morbidities, i.e. significant cardiac diseases or surgical interventions. Sicker babies needed more resuscitation at birth, and died early, and hence needed shorter furosemide courses. Thus, survival probability was higher in neonates treated with long furosemide courses vs. short courses.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - August 15, 2023 Category: Urology & Nephrology Source Type: research
Ocular manifestations of the genetic causes of focal and segmental glomerulosclerosis
This study examined FSGS-associated genes from the Genomics England Renal proteinuria panel for reported and likely ocular features. Thirty-two of the 55 genes (58%) were associated with ocular abnormalities in human disease, and a further 12 (22%) were expressed in the retina or had an eye phenotype in mouse models. The commonest genes affected in congenital nephrotic syndrome (NPHS1,NPHS2,WT1,LAMB2,PAX2 but notPLCE1) may have ocular manifestations . Many genes affected in childhood–adolescent onset FSGS (NPHS1,NPHS2,WT1,LAMB2,SMARCAL1,NUP107 but notTRPC6 orPLCE1) have ocular features. The commonest genes affected ...
Source: Pediatric Nephrology - August 14, 2023 Category: Urology & Nephrology Source Type: research
Prophylactic bilateral nephrectomy and preemptive kidney transplantation for Denys –Drash syndrome prior to development of kidney failure
ConclusionWe performed prophylactic bilateral nephrectomy with KTX on a DDS patient who had not developed kidney failure or Wilms tumor by the age of 7 years. Although the risk of development of Wilms tumor in such a patient is unclear, this treatment may be an optimal approach for patients who are physically able to undergo KTX, considering the potentially lethal nature of Wilms tumor in CKD patients. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - August 12, 2023 Category: Urology & Nephrology Source Type: research
Multinucleated podocytes as a clue to diagnosis of juvenile nephropathic cystinosis
ConclusionEarly diagnosis is crucial to improve the prognosis of patients with cystinosis. This report emphasizes the importance of recognizing the unique pathological feature of multinucleated podocytes as an essential clue to the diagnosis of cystinosis. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - August 12, 2023 Category: Urology & Nephrology Source Type: research
Sex differences in fetal kidney reprogramming: the case in the renin-angiotensin system
AbstractDuring the early stages of the development of the living multiorgan systems, genome modifications other than sequence variation occur that guide cell differentiation and organogenesis. These modifications are known to operate as a fetal programming code during this period, and recent research indicates that there are some tissue-specific codes in organogenesis whose effects may persist after birth until adulthood. Consequently, the events that disrupt the pre-established epigenetic pattern could induce shifts in organ physiology, with implications on health from birth or later in adult life. Chronic kidney disease ...
Source: Pediatric Nephrology - August 12, 2023 Category: Urology & Nephrology Source Type: research
Real-world evidence on the dosing and safety of C.E.R.A. in pediatric dialysis patients: findings from the International Pediatric Dialysis Network registries
ConclusionsC.E.R.A. was associated with efficient maintenance of hemoglobin concentrations in pediatric patients with CKD on dialysis, and appeared to have a favorable safety profile. The current analysis revealed no safety signals.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - August 11, 2023 Category: Urology & Nephrology Source Type: research
Should we consider sarcopenia in pediatric patients with chronic kidney disease? A preliminary cross-sectional analysis
ConclusionAmong pediatric patients with CKD, the prevalence of sarcopenia and its related traits was high. Nephrology professionals should consider the assessment of sarcopenia in this population, while more evidence is needed to determine its prognostic value.Graphical AbstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - August 11, 2023 Category: Urology & Nephrology Source Type: research
Hospital admissions associated with dehydration in childhood kidney transplantation
ConclusionsDehydration admissions in the 12 months following childhood kidney transplantation are common. Highlighted admission risk factors should prompt further study into optimal fluid intake prescription and hydration advice given to children, teenagers, and their carers following kidney transplantation. Use of an enteric feeding tube m ay not protect patients from admission with dehydration associated with contributing illness.Graphical abstractA highger resolution version of the Graphical abstract is available as Supplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - August 9, 2023 Category: Urology & Nephrology Source Type: research
Meta-analyses: how can we ensure that the hole is not greater than the sum of the parts?
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - August 9, 2023 Category: Urology & Nephrology Source Type: research
Urinary biomarkers associated with acute kidney injury in pediatric mechanical circulatory support patients
ConclusionsEarly increase in urine osteoactivin is associated with AKI development within 7 days of MCS initiation in pediatric patients. Contrary, an increased urine EGF is associated with kidney protection.Graphical AbstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - August 8, 2023 Category: Urology & Nephrology Source Type: research
Lipid abnormalities in pediatric kidney transplant recipients on steroid withdrawal maintenance immunosuppression
ConclusionsLipid abnormalities are highly prevalent in pKTR, but therapeutic intervention is infrequent. Calcineurin inhibition without corticosteroids may not be protective; however, higher eGFR is associated with a lower prevalence of lipid abnormalities.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - August 3, 2023 Category: Urology & Nephrology Source Type: research
Effects of aminophylline therapy on urine output and kidney function in children with acute kidney injury
ConclusionsAminophylline increases urine output in critically ill children with AKI.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - August 3, 2023 Category: Urology & Nephrology Source Type: research
Urine biomarker score captures response to induction therapy with lupus nephritis
ConclusionsThe RAIL biomarkers differentiate LN patients based on activity of kidney disease, with decreases of ≥ 1 in pRAIL scores indicating complete response to induction therapy. Significantly lower RAIL scores in healthy controls and in SLE patients without known LN raise the possibility of subclinical kidney disease.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - August 1, 2023 Category: Urology & Nephrology Source Type: research
