Transformation from Sinonasal Seromucinous Hamartoma to Adenocarcinoma: A Case Report
Conclusion: We report the first case of malignant transformation of SMH. Patients with SMH must be counseled that there is an extremely rare and potentially unrecognized risk of malignancy that may influence treatment and postoperative monitoring.ORL (Source: ORL)
Source: ORL - July 8, 2021 Category: ENT & OMF Source Type: research
Eosinophils Correlate with Epithelial-Mesenchymal Transition in Chronic Rhinosinusitis with Nasal Polyps
Conclusion: E-cadherin was downregulated, and vimentin was upregulated in epithelial tissue from the ECRSwNP group, compared with that from the control group and the other groups. The number of vimentin-expressing epithelial cells correlated with sinus CT imaging Lund-Mackay scores (r = 0.560,p #x3c; 0.001). Moreover, expression levels of vimentin in the epithelium were associated with numbers of infiltrating EOS in tissues (r = 0.710,p #x3c; 0.001) and the peripheral blood EOS ratio (r = 0.594,p #x3c; 0.001). EMT occurred in patients with CRSwNP, especially in those with ECRSwNP. Epithelial reprogramming correlates with e...
Source: ORL - July 6, 2021 Category: ENT & OMF Source Type: research
Alteration of Histopathology in Recurrent Nasal Polyps
Conclusion: NP recurrence is associated with higher inflammatory grade (especially in eosinophilia and neutrophilia). Surgical and corticoid treatments may have an impact on mucosal histopathologic changes but need further certification.ORL (Source: ORL)
Source: ORL - July 1, 2021 Category: ENT & OMF Source Type: research
In vitro Inhibition of Biofilm Formation on Silicon Rubber Voice Prosthesis: Α Systematic Review and Meta-Analysis
Conclusions: The meta-analysis on biofilm inhibition demonstrated significant differences in favor of yeast biofilm inhibition compared to bacteria. A stronger inhibition with the application of passive or combined active and passive surface modification techniques was reported.ORL (Source: ORL)
Source: ORL - June 28, 2021 Category: ENT & OMF Source Type: research
Intranasal Steroid Use and Satisfaction in Allergic Rhinitis: A Cross-Sectional Study from an Asian Perspective
Conclusions: Identifying risk factors for noncompliance to INS can help health-care providers address difficulties faced by patients and hence increase compliance, allowing better control of AR symptoms.ORL (Source: ORL)
Source: ORL - June 24, 2021 Category: ENT & OMF Source Type: research
A Randomized, Placebo-Controlled Study to Evaluate the Effect of Bio-Enhanced Turmeric Formulation on Radiation-Induced Oral Mucositis
Conclusion: BTF (BCM-95 ®) can significantly reduce chemoradiotherapy-induced severe oral mucositis, dysphagia, oral pain, and dermatitis in oral cancer patients.Trial Registration: Clinical Trials Registry, India (Registration No. CTRI) (CTRI/2015/12/006413 dated December 4, 2015).ORL (Source: ORL)
Source: ORL - June 23, 2021 Category: ENT & OMF Source Type: research
The First Report on Incidence of Nasopharyngeal Carcinoma in Sabah, Borneo
Conclusion: This is the first report on the incidence of NPC in Sabah, Borneo. The data suggest high ASRs among the population, especially in male Dusun and Chinese ethnic groups. Further research looking into NPC in this state, especially on risk factors and ways to improve diagnosis and prevention among the population, is recommended.ORL (Source: ORL)
Source: ORL - June 18, 2021 Category: ENT & OMF Source Type: research
Human Neutrophil Elastase Mediates MUC5AC Hypersecretion via the Tumour Necrosis Factor- α Converting Enzyme-Epidermal Growth Factor Receptor Signalling Pathway in vivo
Conclusion: Using a newly developed, stable experimental model of nasal hypersecretion in mice, we showed that TAPI-2 or AG1478 inhibited HNE-induced MUC5AC production. This suggests that MUC5AC mucin expression in vivo is mediated by a cascade involving the HNE-TACE-EGFR signalling pathway.ORL (Source: ORL)
Source: ORL - June 15, 2021 Category: ENT & OMF Source Type: research
Postinfectious Olfactory Dysfunction: Oral Steroids and Olfactory Training versus Olfactory Training Alone: Is There any Benefit from Steroids?
Conclusions: The percentage of improved patients after oral methylprednisolone was relatively low to suggest it as first-line treatment. Half of the improved patients had an underlying upper airway inflammatory condition not related to the infection that caused the acute loss of olfactory function.ORL (Source: ORL)
Source: ORL - June 9, 2021 Category: ENT & OMF Source Type: research
Postural Control in Subjects with Incomplete Partition Inner Ear Malformations: A Comparison of Incomplete Partition Types
Conclusion: This study demonstrated that subjects with the same IP type on both sides and with early implantation may differ in terms of their postural control abilities depending on their IP type. Subjects with IP should be regularly followed up by the vestibular assessment and supported by their postural control ability by vestibular rehabilitation.ORL (Source: ORL)
Source: ORL - June 7, 2021 Category: ENT & OMF Source Type: research
Nuclear Factor Erythroid 2-Related Factor 2-Histone Deacetylase 2 Pathway in the Pathogenesis of Refractory Sudden Sensorineural Hearing Loss and Glucocorticoid Resistance
Conclusion: Low response of NRF2/HDAC2 proteins is associated with GC insensitivity in SSNHL. We speculate that the NRF2-HDAC2 pathway affects GC sensitivity in SSNHL patients.ORL (Source: ORL)
Source: ORL - June 4, 2021 Category: ENT & OMF Source Type: research
Increased Expression of Activation-Induced Cytidine Deaminase in Sinus Mucosa from IgG4-Related Disease Patients with Comorbid Chronic Rhinosinusitis
Conclusion: Ethmoid sinus mucosa from IgG4-RD-associated CRS patients showed clearly increased AID production, suggesting AID involvement in class-switching to IgG4 in those local sites. This implies the existence of a distinct form of CRS that is an IgG4-RD.ORL (Source: ORL)
Source: ORL - June 2, 2021 Category: ENT & OMF Source Type: research
Aerodynamics Analysis of the Impact of Nasal Surgery on Patients with Obstructive Sleep Apnea and Nasal Obstruction
Conclusion: Nasal surgery can decrease the total resistance of the upper airway and increase the nasal airflow volume and subjective sleep quality in patients with OSA and nasal obstruction. The altered airflow characteristics might contribute to the postoperative reduction of pharyngeal collapse in a subset of OSA patients.ORL (Source: ORL)
Source: ORL - May 31, 2021 Category: ENT & OMF Source Type: research
Oral Squamous Cell Carcinoma Bone Invasion: Possible Roles of E-Cadherin in Osteoclastogenesis and Bone Infiltration
Conclusion: Our results suggest that the tumor cells that interact with the bone tissue could gain molecular changes, like partial EMT and osteoclastogenesis induction, which facilitate their migration and increase the bone resorption, resulting in a worse patient ’s prognosis.ORL (Source: ORL)
Source: ORL - May 25, 2021 Category: ENT & OMF Source Type: research
Complications after Functional Neck Dissection in Head and Neck Cancer Patients: An Observational, Retrospective, Single-Centre Study
Conclusion: FND represents a useful technique. In this study, 40.5% of the patients suffer a complication in the postoperative period, being the SAN injury the most common complication. However, these data contribute to increasing our knowledge about surgical complications related to FND.ORL (Source: ORL)
Source: ORL - May 19, 2021 Category: ENT & OMF Source Type: research
