A Prospective Open-Label Study to Assess the Efficacy and Safety of a Herbal Medicinal Product (Sinupret) in Patients with Acute Rhinosinusitis
Conclusions: The results of this study suggest that this phytomedicinal preparation has a significant level of efficacy in acute rhinosinusitis and that treatment is safe.ORL 2015;77:27-32 (Source: ORL)
Source: ORL - January 30, 2015 Category: ENT & OMF Source Type: research

Active Bone Conduction System: Outcomes with the Bonebridge Transcutaneous Device
Conclusions: The BB device is a safe and effective solution for individuals with pathologies such as chronic otitis media, atresia auris and otosclerosis with inadequate benefit from conventional surgery or bone conduction hearing aids.ORL 2015;77:17-26 (Source: ORL)
Source: ORL - January 30, 2015 Category: ENT & OMF Source Type: research

Allergogenic Profile in Patients with Different Subtypes of Chronic Rhinosinusitis with Nasal Polyps
Conclusion: Patients with ENP showed significantly higher IgE levels when compared with patients with nENP based on allergy.ORL 2015;77:10-16 (Source: ORL)
Source: ORL - January 30, 2015 Category: ENT & OMF Source Type: research

Eosinophilic Otitis Media Is Associated with Asthma Severity and Smoking History
Conclusion: There was a close relationship between EOM and asthma severity in asthma patients with chronic rhinosinusitis. Cessation of smoking might help prevent EOM by reducing airway wall thickness.ORL 2015;77:1-9 (Source: ORL)
Source: ORL - January 28, 2015 Category: ENT & OMF Source Type: research

Transoral Videolaryngoscopic Surgery with a Navigation System for Excision of a Metastatic Retropharyngeal Lymph Node
Conclusions: A transoral approach may be a viable choice for surgery of a metastatic RPLN. Surgical indications for a transoral approach to the RPS include that (1) the location of the RPLN is below the level of the hard palate and the pterygoid hamulus and (2) there is only a single lesion, without adhesion to the surrounding tissue.ORL 2014;76:357-363 (Source: ORL)
Source: ORL - January 26, 2015 Category: ENT & OMF Source Type: research

Bisphosphonate-Related Osteonecrosis of the Palatal Torus
Conclusions: Although osteonecrosis of the palatal torus associated with bisphosphonate use is a rare condition, otolaryngologists should consider this condition in the differential diagnosis of intractable ulceration of the hard palate.ORL 2014;76:353-356 (Source: ORL)
Source: ORL - January 24, 2015 Category: ENT & OMF Source Type: research

The University of Pennsylvania Curriculum for Training Otorhinolaryngology Residents in Transoral Robotic Surgery
Conclusion: A structured curriculum for training residents in transoral robotic surgery was developed. This training is important for otorhinolaryngology residents to acquire the knowledge and skills to perform robotic surgery safely.ORL 2014;76:342-352 (Source: ORL)
Source: ORL - January 15, 2015 Category: ENT & OMF Source Type: research

Eyelid Lifting for Ectropion and Scleral Show in Facial Palsy Disease
Conclusion: Noninvasive surgery yielded good clinical results in 100% of the cases without any risk or subsequent reoccurrence.ORL 2014;76:329-335 (Source: ORL)
Source: ORL - January 8, 2015 Category: ENT & OMF Source Type: research

Bilateral Cervical Fistulas from Heterotopic Salivary Gland Tissues
A 24-year-old male was referred to our department with intermittent clear drainage in both sides of the middle neck that did not increase while eating. On physical examination, there were fistulas in both sides of the neck, anterior to the sternocleidomastoid muscles. Fistulography revealed a 9-mm-long sinus from the left fistula, extending in the medial-caudal direction. On the right side, cannulation was not possible. Surgical excision of the lesion was performed on both sides, and the pathological examination revealed heterotopic salivary gland tissue (HSGT). From a literature review of reports of bilateral neck HSGT, w...
Source: ORL - January 8, 2015 Category: ENT & OMF Source Type: research

Characterization of Upper Airway Obstruction by Fiber-Optic Nasolaryngoscopy and MRI in Preoperative OSAHS Patients
Objective: To investigate changes in the upper airway and its surrounding soft tissue and to characterize the extent and severity of upper airway obstruction in 136 obstructive sleep apnea/hypopnea syndrome (OSAHS) patients who were awake. Methods: OSAHS patients and healthy controls were evaluated by fiber-optic nasolaryngoscopy and MRI. The cross-sectional area and pharyngeal wall thickness of the retropalatal, retroglossal and epiglottic region were determined. Results: Ninety-five percent of the mild OSAHS subjects had single-plane obstruction (vs. severe OSAHS, p
Source: ORL - December 19, 2014 Category: ENT & OMF Source Type: research

Outcome and Safety of the Montgomery T-Tube for Laryngotracheal Stenosis: A Single-Center Retrospective Analysis of 546 Cases
Conclusion: This large clinical series demonstrated the safety and effectiveness of the T-tube for grade 1 and 2 stenosis with stenosed segments of 6 cm, tracheal end-to-end anastomosis is not appropriate and long-term placement of a T-tube is recommended. Our findings provide useful guidance for preoperatively selecting patients with laryngotracheal stenosis of various causes and differing severity.ORL 2014;76:314-320 (Source: ORL)
Source: ORL - December 19, 2014 Category: ENT & OMF Source Type: research

Phenotypic Characteristics of Nasal Mast Cells in a Mouse Model of Allergic Rhinitis
Background: Mast cells (MCs) in the nasal respiratory mucosa (NRM) play a triggering role in the pathogenesis of allergic rhinitis (AR). Recent research evidence in mouse models of AR suggests an underlying MC-related allergic response in mouse nasal olfactory mucosa (NOM). Objective: We sought to investigate the phenotypic characteristics of nasal MCs in a mouse model of AR. Methods: By MC-specific staining and immunohistochemistry, we analyzed the subset, protease and IgE-binding phenotypes of nasal MCs in ovalbumin (OVA)-sensitized unchallenged and challenged mice. Results: In OVA-sensitized challenged mice, increased s...
Source: ORL - December 17, 2014 Category: ENT & OMF Source Type: research

Surfactant Proteins A, B, C and D in the Human Nasal Airway: Associated with Mucosal Glands and Ciliated Epithelium but Absent in Fluid-Phase Secretions and Mucus
Conclusion: SP-A, -B, -C and -D exert their protective effect in the ductal epithelium of the submucosal glands rather than in nasal secretions and mucus. Further studies are required to clarify the functions of these proteins in nasal secretory pathways for understanding upper airway diseases.ORL 2014;76:288-301 (Source: ORL)
Source: ORL - December 9, 2014 Category: ENT & OMF Source Type: research

Retrospective Analysis of a Combined Endoscopic and Transcutaneous Technique for the Management of Parotid Salivary Gland Stones
Sialendoscopy is used in the diagnosis and treatment of various symptoms relating to the salivary gland, e.g. chronic swelling or obstruction and inflammation of the salivary duct. Small intraductal stones can be removed with various instruments during sialendoscopy, whereas larger ones can be fragmented with extracorporeal shockwave lithotripsy or laser. However, 5-10% of the patients with parotid stones cannot be treated with these methods. In patients with large impacted stones or stones in a hilus area, a combined endoscopic and transcutaneous technique can be employed. The stone is approached endoscopically, a skin fl...
Source: ORL - December 5, 2014 Category: ENT & OMF Source Type: research

Osteopontin Promotes EZH2 Expression and Tumor Progression in Nasopharyngeal Carcinoma
Objective: To evaluate the possible mechanism of osteopontin (OPN) in the tumor progression of nasopharyngeal carcinoma (NPC). Methods: Twenty NPC specimens and 10 normal biopsy specimens were analyzed, and the expression of OPN and enhancer of zeste homolog 2 (EZH2) was examined by immunohistochemical staining. Moreover, the expression of EZH2 in NPC cell lines was examined using quantitative reverse transcription polymerase chain reaction and Western blot analysis in the presence of recombinant human (rh) OPN and specific inhibitors. NPC cell migration and invasion were evaluated using a transwell chamber in the presence...
Source: ORL - November 27, 2014 Category: ENT & OMF Source Type: research

Corticosteroid Regulates Epithelial Occludin Expression in Nasal Polyps through a MKP-1-Dependent Pathway
Objective: To evaluate the regulatory effect of corticosteroid on occludin expression in polyp tissues of chronic rhinosinusitis with nasal polyps (CRSwNP) patients and in vitro. Methods: Twenty CRSwNP patients were enrolled and subjected to prednisone (30 mg/day for 14 days). The expression of occludin in polyp tissues was examined before and after treatment using immunohistochemical staining and quantitative reverse transcription polymerase chain reaction. Moreover, the expression of occludin in polyp-derived epithelial cells (PECs) and human bronchial epithelial cells (BECs) was examined using Western blot analysis in t...
Source: ORL - November 19, 2014 Category: ENT & OMF Source Type: research

Body Mass Index Predicts Success in Patients Undergoing Transoral Robotic Surgery for Obstructive Sleep Apnea
Objective: To determine the predictors of success in patients undergoing transoral robotic surgery (TORS) and multilevel procedures for the management of moderate-to-severe obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: A total of 121 patients (83 male, 38 female) underwent TORS between 2010 and 2013. All patients had robotic assisted lingual tonsillectomy, either as stand-alone surgery or in combination with palatal Z-plasty, lateral pharyngoplasty or uvulopalatopharyngoplasty. The apnea-hypopnea index (AHI) and body mass index (BMI) were measured preoperatively and 3 months postoperatively. Success was defin...
Source: ORL - November 19, 2014 Category: ENT & OMF Source Type: research

Plasma-Assisted Hydrophilization of Cochlear Implant Electrode Array Surfaces Enables Adhesion of Neurotrophin-Secreting Cells
Conclusion: Plasma treatment of CI electrode arrays enhances their biocompatibility and allows for the colonization with hASCs that are known to produce neurotrophic factors.ORL 2014;76:257-265 (Source: ORL)
Source: ORL - November 19, 2014 Category: ENT & OMF Source Type: research

Upregulation of Interleukin-35 Subunits in Regulatory T Cells in a Murine Model of Allergic Rhinitis
Conclusions: Decreased Ebi3 may have a crucial regulatory effect on the nasal mucosa in AR. The increased IL-35 subunit expression in CD4+CD25+ Treg cells may contribute to regulating the pathogenesis of AR.ORL 2014;76:237-247 (Source: ORL)
Source: ORL - November 19, 2014 Category: ENT & OMF Source Type: research

Temporal Bone Malignancies Involving the Jugular Foramen: Diagnosis and Management
Conclusions: Temporal bone malignancies involving the jugular foramen had a poor prognosis, especially in patients with squamous cell carcinoma. Misdiagnoses including glomus jugulare tumor, Bell's palsy and chronic otitis media were frequently encountered. Temporal bone malignancies involving the jugular foramen can be resected, and the choice of the surgical approach should be individualized.ORL 2014;76:227-235 (Source: ORL)
Source: ORL - November 13, 2014 Category: ENT & OMF Source Type: research

Malignant Minor Salivary Gland Carcinomas of the Larynx
Conclusion: Malignant minor salivary gland carcinoma of the larynx is a rare disease that showed male predominance in our study. The carcinomas were most often localised in the subglottic region, and the most common histological types were ACC and MEC. Wide-margin surgery with postoperative radiotherapy is advocated. The overall prognosis is poor compared to squamous cell carcinomas of the same location and tumour stage.ORL 2014;76:222-226 (Source: ORL)
Source: ORL - November 12, 2014 Category: ENT & OMF Source Type: research

Composite Hyoid Bone Graft Interposition for the Treatment of Laryngotracheal Stenosis
Conclusion: This technique allows vascularized stable graft survival with minimal donor site morbidity. Furthermore, it can be performed for thyroid, cricoid, and tracheal stenosis without fear of damage to the recurrent laryngeal nerves.ORL 2014;76:147-152 (Source: ORL)
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

Predictors of Postoperative Complications, Prolonged Length of Hospital Stay, and Short-Term Mortality in Elderly Patients with Malignant Head and Neck Neoplasm
Conclusions: Complications after head and neck cancer surgery in the elderly are common and related to the prolonged length of hospital stay, both being influenced by previous radiotherapy, smoking, functional dependence in instrumental activities of daily living, and nutritional conditions. Such predictors should be considered in a preoperative assessment of elderly patients as these are modifiable risk factors.ORL 2014;76:153-164 (Source: ORL)
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

Larynx Preservation Protocols: Long-Term Functional Outcomes in Good Responders to Induction Chemotherapy for Pyriform Sinus Carcinoma
Conclusions: In the long run, patients with pyriform sinus SCC who are candidates for larynx preservation and respond favorably to ICT present a satisfactory functional outcome when treated with adjuvant RT.ORL 2014;76:165-170 (Source: ORL)
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

The Influence of the ‘Patient-to-Patient Model' on Swallowing Problems in Patients with Supraglottic Laryngeal Cancer
Aims: To evaluate the patient-to-patient model and swallowing problems in Chinese patients with supraglottic laryngeal cancer (SLC), and to find a solution to help SLC patients with swallowing problems. Methods: Eighty-nine patients who had undergone operation for horizontal partial laryngectomy were chosen and divided randomly into two groups. The European Organization for Research and Treatment of Cancer (EORTC), Swallow Quality-of-Life (SWAL-QOL) and Visual Analogue Scale (VAS) questionnaires were used to measure the quality of life and swallowing situation of those patients. Results: At 0.5 and 1 months after eating, t...
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

A Vanishing Lymphoma in the Cheek
Conclusion: When a lymphoma is suspected, patient care may be optimized if biopsy is delayed until steroids have been discontinued.ORL 2014;76:189-192 (Source: ORL)
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

Changes in Sleep Characteristics and Airway Obstruction in OSAHS Patients with Multi-Level Obstruction following Simple UPPP, UPPP-GA, or UPPP-TBA: A Prospective, Single-Center, Parallel Group Study
Conclusion: UPPP-GA and UPPP-TBA more effectively improve S3 sleep, and mean AHI, LSO2, and CT90 scores. In addition, they effectively alleviate airway obstruction by improving the cross-sectional area of these regions.ORL 2014;76:179-188 (Source: ORL)
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

Oncologic Validity of Recipient Vessel Preservation in Microvascular Free-Flap Reconstruction
Conclusions: When the recipient vessel appears grossly suspicious, a frozen section biopsy and re-resection should be considered. Recipient vessel trimmings should routinely be sent for permanent pathology since in rare cases, they can be involved by tumor, affecting the margin status, prognosis, and indications for adjuvant therapy.ORL 2014;76:193-198 (Source: ORL)
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

Sinus Mucosal Thickening in Bisphosphonate-Related Osteonecrosis of the Jaws: A Case-Control Study
Osteonecrosis of the jaws is a clinically significant complication of bisphosphonate (BP) medications. Otherwise, the effects of BPs on oral soft tissue or cells remain unknown. The main objective of the present study was to determine whether the presence of sinus mucosal thickening was significantly related to BP-related osteonecrosis of the jaw (BRONJ). A case-control study was conducted on 32 patients who underwent treatment of BRONJ with conventional radiological investigations (panoramic radiographs) and computed tomography. The results indicated that patients with BRONJ had a 5.57-fold greater probability of presenti...
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

SNOT-22 Validation in Greek Patients
Background: Chronic rhinosinusitis (CRS) with or without nasal polyps is a frequent and significant health problem. The 22-item Sinonasal Outcome Test (SNOT-22) is a valid, disease-specific health status instrument translated into several languages. The translation into Greek has been considered essential for the individual assessment of the patients' symptoms and a reliable tool for quality of life evaluation. Methods: Our study included 40 patients with CRS without nasal polyps and 40 healthy individuals as control group recruited from the ENT Allergy and Endoscopy Clinic of Chania General Hospital. Assessment included f...
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

Diffusion-Weighted Intensity Magnetic Resonance in the Preoperative Diagnosis of Cholesteatoma
We have analyzed the preoperative diagnosis of cholesteatoma through the use of diffusion-weighted intensity magnetic resonance (DWI-MR) in 16 consecutive patients suffering from chronic otitis media with clinical and radiological (by computed tomography) suspicion of cholesteatoma. In particular, we compared the radiological data with intraoperative ones, verifying the correspondence (in terms of sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy) between what is reported by DWI-MR and what is actually detectable at the time of surgery. Furthermore, we identified the mos...
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

Isolated Sinonasal Posttransplantation Lymphoproliferative Disorder: A Clinical and Radiographic Invasive Fungal Sinusitis Look-a-Like
ORL 2012;74:339–342 (DOI:10.1159/000346240) (Source: ORL)
Source: ORL - January 31, 2013 Category: ENT & OMF Source Type: research

Magnet Removal and Reinsertion in a Cochlear Implant Recipient Undergoing Brain MRI
ORL 2013;75:1–5 (DOI:10.1159/000346239) (Source: ORL)
Source: ORL - January 30, 2013 Category: ENT & OMF Source Type: research

The VEGF/VEGF-R Axis in Sporadic Vestibular Schwannomas Correlates with Irradiation and Disease Recurrence
ORL 2012;74:330–338 (DOI:10.1159/000346238) (Source: ORL)
Source: ORL - January 19, 2013 Category: ENT & OMF Source Type: research

Presentation and Publication Rates among Women and Men at AAO-HNS Meetings
ORL 2012;74:325–329 (DOI:10.1159/000345099) (Source: ORL)
Source: ORL - January 5, 2013 Category: ENT & OMF Source Type: research

Labyrinthotomy or Vestibulotomy in Anatomic and Congenital Variations of the Oval Window and Facial Nerve
ORL 2012;74:320–324 (DOI:10.1159/000345714) (Source: ORL)
Source: ORL - January 3, 2013 Category: ENT & OMF Source Type: research

Front & Back Matter
ORL 2012;74:X (DOI:10.1159/000346760) (Source: ORL)
Source: ORL - January 3, 2013 Category: ENT & OMF Source Type: research

Labyrinthotomy or Vestibulotomy in Anatomic and Congenital Variations of the Oval Window and Facial Nerve
ORL 2012;74:320–324 (DOI:10.1159/000345714) (Source: ORL)
Source: ORL - January 3, 2013 Category: ENT & OMF Source Type: research

Front & Back Matter
ORL 2012;74:X (DOI:10.1159/000346760) (Source: ORL)
Source: ORL - January 3, 2013 Category: ENT & OMF Source Type: research

Steady State Auditory Evoked Potentials in Normal Hearing Subjects: Evaluation of Threshold and Testing Time
ORL 2012;74:310–314 (DOI:10.1159/000345497) (Source: ORL)
Source: ORL - December 20, 2012 Category: ENT & OMF Source Type: research

Incidence and Management of Epistaxis after Endoscopic Skull Base Surgery
ORL 2012;74:315–319 (DOI:10.1159/000345500) (Source: ORL)
Source: ORL - December 20, 2012 Category: ENT & OMF Source Type: research

Reconstruction of Pharyngeal Defects with a Submental Island Flap after Hypopharyngeal Carcinoma Ablation
ORL 2012;74:304–309 (DOI:10.1159/000345100) (Source: ORL)
Source: ORL - December 14, 2012 Category: ENT & OMF Source Type: research

Endoscopic Microvascular Decompression: A Stepwise Operative Technique
ORL 2012;74:293–298 (DOI:10.1159/000342795) (Source: ORL)
Source: ORL - December 12, 2012 Category: ENT & OMF Source Type: research

Surgical Closure of Nasoseptal Defects: Postoperative Patient Satisfaction
ORL 2012;74:299–303 (DOI:10.1159/000345499) (Source: ORL)
Source: ORL - December 12, 2012 Category: ENT & OMF Source Type: research

Sino-Nasal Outcome Test Tool Assessment in Patients with Chronic Rhinosinusitis and Obstructive Sleep Apnea
ORL 2012;74:286–289 (DOI:10.1159/000343802) (Source: ORL)
Source: ORL - December 11, 2012 Category: ENT & OMF Source Type: research

The Value of Resident Presentations at Scientific Meetings
ORL 2012;74:290–291 (DOI:10.1159/000343959) (Source: ORL)
Source: ORL - December 11, 2012 Category: ENT & OMF Source Type: research

Different Cilia Response to Adenosine Triphosphate or Benzalkonium Chloride Treatment in Mouse Nasal and Tracheal Culture
ORL 2012;74:280–285 (DOI:10.1159/000343800) (Source: ORL)
Source: ORL - November 13, 2012 Category: ENT & OMF Source Type: research

Removal of Large or Giant Sporadic Vestibular Schwannomas via Translabyrinthine Approach: A Report of 115 Cases
ORL 2012;74:271–277 (DOI:10.1159/000343791) (Source: ORL)
Source: ORL - November 7, 2012 Category: ENT & OMF Source Type: research

Normal Hearing after Trauma with Completely Ectopic Incus – How Possible?
ORL 2012;74:278–279 (DOI:10.1159/000343798) (Source: ORL)
Source: ORL - November 7, 2012 Category: ENT & OMF Source Type: research