Osteopontin Promotes EZH2 Expression and Tumor Progression in Nasopharyngeal Carcinoma
Objective: To evaluate the possible mechanism of osteopontin (OPN) in the tumor progression of nasopharyngeal carcinoma (NPC). Methods: Twenty NPC specimens and 10 normal biopsy specimens were analyzed, and the expression of OPN and enhancer of zeste homolog 2 (EZH2) was examined by immunohistochemical staining. Moreover, the expression of EZH2 in NPC cell lines was examined using quantitative reverse transcription polymerase chain reaction and Western blot analysis in the presence of recombinant human (rh) OPN and specific inhibitors. NPC cell migration and invasion were evaluated using a transwell chamber in the presence...
Source: ORL - November 27, 2014 Category: ENT & OMF Source Type: research

Corticosteroid Regulates Epithelial Occludin Expression in Nasal Polyps through a MKP-1-Dependent Pathway
Objective: To evaluate the regulatory effect of corticosteroid on occludin expression in polyp tissues of chronic rhinosinusitis with nasal polyps (CRSwNP) patients and in vitro. Methods: Twenty CRSwNP patients were enrolled and subjected to prednisone (30 mg/day for 14 days). The expression of occludin in polyp tissues was examined before and after treatment using immunohistochemical staining and quantitative reverse transcription polymerase chain reaction. Moreover, the expression of occludin in polyp-derived epithelial cells (PECs) and human bronchial epithelial cells (BECs) was examined using Western blot analysis in t...
Source: ORL - November 19, 2014 Category: ENT & OMF Source Type: research

Body Mass Index Predicts Success in Patients Undergoing Transoral Robotic Surgery for Obstructive Sleep Apnea
Objective: To determine the predictors of success in patients undergoing transoral robotic surgery (TORS) and multilevel procedures for the management of moderate-to-severe obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: A total of 121 patients (83 male, 38 female) underwent TORS between 2010 and 2013. All patients had robotic assisted lingual tonsillectomy, either as stand-alone surgery or in combination with palatal Z-plasty, lateral pharyngoplasty or uvulopalatopharyngoplasty. The apnea-hypopnea index (AHI) and body mass index (BMI) were measured preoperatively and 3 months postoperatively. Success was defin...
Source: ORL - November 19, 2014 Category: ENT & OMF Source Type: research

Plasma-Assisted Hydrophilization of Cochlear Implant Electrode Array Surfaces Enables Adhesion of Neurotrophin-Secreting Cells
Conclusion: Plasma treatment of CI electrode arrays enhances their biocompatibility and allows for the colonization with hASCs that are known to produce neurotrophic factors.ORL 2014;76:257-265 (Source: ORL)
Source: ORL - November 19, 2014 Category: ENT & OMF Source Type: research

Upregulation of Interleukin-35 Subunits in Regulatory T Cells in a Murine Model of Allergic Rhinitis
Conclusions: Decreased Ebi3 may have a crucial regulatory effect on the nasal mucosa in AR. The increased IL-35 subunit expression in CD4+CD25+ Treg cells may contribute to regulating the pathogenesis of AR.ORL 2014;76:237-247 (Source: ORL)
Source: ORL - November 19, 2014 Category: ENT & OMF Source Type: research

Temporal Bone Malignancies Involving the Jugular Foramen: Diagnosis and Management
Conclusions: Temporal bone malignancies involving the jugular foramen had a poor prognosis, especially in patients with squamous cell carcinoma. Misdiagnoses including glomus jugulare tumor, Bell's palsy and chronic otitis media were frequently encountered. Temporal bone malignancies involving the jugular foramen can be resected, and the choice of the surgical approach should be individualized.ORL 2014;76:227-235 (Source: ORL)
Source: ORL - November 13, 2014 Category: ENT & OMF Source Type: research

Malignant Minor Salivary Gland Carcinomas of the Larynx
Conclusion: Malignant minor salivary gland carcinoma of the larynx is a rare disease that showed male predominance in our study. The carcinomas were most often localised in the subglottic region, and the most common histological types were ACC and MEC. Wide-margin surgery with postoperative radiotherapy is advocated. The overall prognosis is poor compared to squamous cell carcinomas of the same location and tumour stage.ORL 2014;76:222-226 (Source: ORL)
Source: ORL - November 12, 2014 Category: ENT & OMF Source Type: research

Composite Hyoid Bone Graft Interposition for the Treatment of Laryngotracheal Stenosis
Conclusion: This technique allows vascularized stable graft survival with minimal donor site morbidity. Furthermore, it can be performed for thyroid, cricoid, and tracheal stenosis without fear of damage to the recurrent laryngeal nerves.ORL 2014;76:147-152 (Source: ORL)
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

Predictors of Postoperative Complications, Prolonged Length of Hospital Stay, and Short-Term Mortality in Elderly Patients with Malignant Head and Neck Neoplasm
Conclusions: Complications after head and neck cancer surgery in the elderly are common and related to the prolonged length of hospital stay, both being influenced by previous radiotherapy, smoking, functional dependence in instrumental activities of daily living, and nutritional conditions. Such predictors should be considered in a preoperative assessment of elderly patients as these are modifiable risk factors.ORL 2014;76:153-164 (Source: ORL)
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

Larynx Preservation Protocols: Long-Term Functional Outcomes in Good Responders to Induction Chemotherapy for Pyriform Sinus Carcinoma
Conclusions: In the long run, patients with pyriform sinus SCC who are candidates for larynx preservation and respond favorably to ICT present a satisfactory functional outcome when treated with adjuvant RT.ORL 2014;76:165-170 (Source: ORL)
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

The Influence of the ‘Patient-to-Patient Model' on Swallowing Problems in Patients with Supraglottic Laryngeal Cancer
Aims: To evaluate the patient-to-patient model and swallowing problems in Chinese patients with supraglottic laryngeal cancer (SLC), and to find a solution to help SLC patients with swallowing problems. Methods: Eighty-nine patients who had undergone operation for horizontal partial laryngectomy were chosen and divided randomly into two groups. The European Organization for Research and Treatment of Cancer (EORTC), Swallow Quality-of-Life (SWAL-QOL) and Visual Analogue Scale (VAS) questionnaires were used to measure the quality of life and swallowing situation of those patients. Results: At 0.5 and 1 months after eating, t...
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

A Vanishing Lymphoma in the Cheek
Conclusion: When a lymphoma is suspected, patient care may be optimized if biopsy is delayed until steroids have been discontinued.ORL 2014;76:189-192 (Source: ORL)
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

Changes in Sleep Characteristics and Airway Obstruction in OSAHS Patients with Multi-Level Obstruction following Simple UPPP, UPPP-GA, or UPPP-TBA: A Prospective, Single-Center, Parallel Group Study
Conclusion: UPPP-GA and UPPP-TBA more effectively improve S3 sleep, and mean AHI, LSO2, and CT90 scores. In addition, they effectively alleviate airway obstruction by improving the cross-sectional area of these regions.ORL 2014;76:179-188 (Source: ORL)
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

Oncologic Validity of Recipient Vessel Preservation in Microvascular Free-Flap Reconstruction
Conclusions: When the recipient vessel appears grossly suspicious, a frozen section biopsy and re-resection should be considered. Recipient vessel trimmings should routinely be sent for permanent pathology since in rare cases, they can be involved by tumor, affecting the margin status, prognosis, and indications for adjuvant therapy.ORL 2014;76:193-198 (Source: ORL)
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

Sinus Mucosal Thickening in Bisphosphonate-Related Osteonecrosis of the Jaws: A Case-Control Study
Osteonecrosis of the jaws is a clinically significant complication of bisphosphonate (BP) medications. Otherwise, the effects of BPs on oral soft tissue or cells remain unknown. The main objective of the present study was to determine whether the presence of sinus mucosal thickening was significantly related to BP-related osteonecrosis of the jaw (BRONJ). A case-control study was conducted on 32 patients who underwent treatment of BRONJ with conventional radiological investigations (panoramic radiographs) and computed tomography. The results indicated that patients with BRONJ had a 5.57-fold greater probability of presenti...
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

SNOT-22 Validation in Greek Patients
Background: Chronic rhinosinusitis (CRS) with or without nasal polyps is a frequent and significant health problem. The 22-item Sinonasal Outcome Test (SNOT-22) is a valid, disease-specific health status instrument translated into several languages. The translation into Greek has been considered essential for the individual assessment of the patients' symptoms and a reliable tool for quality of life evaluation. Methods: Our study included 40 patients with CRS without nasal polyps and 40 healthy individuals as control group recruited from the ENT Allergy and Endoscopy Clinic of Chania General Hospital. Assessment included f...
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

Diffusion-Weighted Intensity Magnetic Resonance in the Preoperative Diagnosis of Cholesteatoma
We have analyzed the preoperative diagnosis of cholesteatoma through the use of diffusion-weighted intensity magnetic resonance (DWI-MR) in 16 consecutive patients suffering from chronic otitis media with clinical and radiological (by computed tomography) suspicion of cholesteatoma. In particular, we compared the radiological data with intraoperative ones, verifying the correspondence (in terms of sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy) between what is reported by DWI-MR and what is actually detectable at the time of surgery. Furthermore, we identified the mos...
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

Isolated Sinonasal Posttransplantation Lymphoproliferative Disorder: A Clinical and Radiographic Invasive Fungal Sinusitis Look-a-Like
ORL 2012;74:339–342 (DOI:10.1159/000346240) (Source: ORL)
Source: ORL - January 31, 2013 Category: ENT & OMF Source Type: research

Magnet Removal and Reinsertion in a Cochlear Implant Recipient Undergoing Brain MRI
ORL 2013;75:1–5 (DOI:10.1159/000346239) (Source: ORL)
Source: ORL - January 29, 2013 Category: ENT & OMF Source Type: research

The VEGF/VEGF-R Axis in Sporadic Vestibular Schwannomas Correlates with Irradiation and Disease Recurrence
ORL 2012;74:330–338 (DOI:10.1159/000346238) (Source: ORL)
Source: ORL - January 18, 2013 Category: ENT & OMF Source Type: research

Presentation and Publication Rates among Women and Men at AAO-HNS Meetings
ORL 2012;74:325–329 (DOI:10.1159/000345099) (Source: ORL)
Source: ORL - January 4, 2013 Category: ENT & OMF Source Type: research

Labyrinthotomy or Vestibulotomy in Anatomic and Congenital Variations of the Oval Window and Facial Nerve
ORL 2012;74:320–324 (DOI:10.1159/000345714) (Source: ORL)
Source: ORL - January 2, 2013 Category: ENT & OMF Source Type: research

Front & Back Matter
ORL 2012;74:X (DOI:10.1159/000346760) (Source: ORL)
Source: ORL - January 2, 2013 Category: ENT & OMF Source Type: research

Labyrinthotomy or Vestibulotomy in Anatomic and Congenital Variations of the Oval Window and Facial Nerve
ORL 2012;74:320–324 (DOI:10.1159/000345714) (Source: ORL)
Source: ORL - January 2, 2013 Category: ENT & OMF Source Type: research

Front & Back Matter
ORL 2012;74:X (DOI:10.1159/000346760) (Source: ORL)
Source: ORL - January 2, 2013 Category: ENT & OMF Source Type: research

Steady State Auditory Evoked Potentials in Normal Hearing Subjects: Evaluation of Threshold and Testing Time
ORL 2012;74:310–314 (DOI:10.1159/000345497) (Source: ORL)
Source: ORL - December 19, 2012 Category: ENT & OMF Source Type: research

Incidence and Management of Epistaxis after Endoscopic Skull Base Surgery
ORL 2012;74:315–319 (DOI:10.1159/000345500) (Source: ORL)
Source: ORL - December 19, 2012 Category: ENT & OMF Source Type: research

Reconstruction of Pharyngeal Defects with a Submental Island Flap after Hypopharyngeal Carcinoma Ablation
ORL 2012;74:304–309 (DOI:10.1159/000345100) (Source: ORL)
Source: ORL - December 13, 2012 Category: ENT & OMF Source Type: research

Endoscopic Microvascular Decompression: A Stepwise Operative Technique
ORL 2012;74:293–298 (DOI:10.1159/000342795) (Source: ORL)
Source: ORL - December 11, 2012 Category: ENT & OMF Source Type: research

Surgical Closure of Nasoseptal Defects: Postoperative Patient Satisfaction
ORL 2012;74:299–303 (DOI:10.1159/000345499) (Source: ORL)
Source: ORL - December 11, 2012 Category: ENT & OMF Source Type: research

Sino-Nasal Outcome Test Tool Assessment in Patients with Chronic Rhinosinusitis and Obstructive Sleep Apnea
ORL 2012;74:286–289 (DOI:10.1159/000343802) (Source: ORL)
Source: ORL - December 10, 2012 Category: ENT & OMF Source Type: research

The Value of Resident Presentations at Scientific Meetings
ORL 2012;74:290–291 (DOI:10.1159/000343959) (Source: ORL)
Source: ORL - December 10, 2012 Category: ENT & OMF Source Type: research

Different Cilia Response to Adenosine Triphosphate or Benzalkonium Chloride Treatment in Mouse Nasal and Tracheal Culture
ORL 2012;74:280–285 (DOI:10.1159/000343800) (Source: ORL)
Source: ORL - November 12, 2012 Category: ENT & OMF Source Type: research

Removal of Large or Giant Sporadic Vestibular Schwannomas via Translabyrinthine Approach: A Report of 115 Cases
ORL 2012;74:271–277 (DOI:10.1159/000343791) (Source: ORL)
Source: ORL - November 6, 2012 Category: ENT & OMF Source Type: research

Normal Hearing after Trauma with Completely Ectopic Incus – How Possible?
ORL 2012;74:278–279 (DOI:10.1159/000343798) (Source: ORL)
Source: ORL - November 6, 2012 Category: ENT & OMF Source Type: research

Prognostic Significance of Invasion Depth in Oral Tongue Squamous Cell Carcinoma
ORL 2012;74:264–270 (DOI:10.1159/000343796) (Source: ORL)
Source: ORL - November 1, 2012 Category: ENT & OMF Source Type: research

Endoscopic versus Open Resection of Tuberculum Sellae Meningiomas: A Decision Analysis
ORL 2012;74:255–263 (DOI:10.1159/000343794) (Source: ORL)
Source: ORL - October 25, 2012 Category: ENT & OMF Source Type: research

Continuation of Smoking after Treatment of Laryngeal Cancer: An Independent Prognostic Factor?
ORL 2012;74:250–254 (DOI:10.1159/000342685) (Source: ORL)
Source: ORL - October 12, 2012 Category: ENT & OMF Source Type: research

Neuromuscular Choristoma of the Internal Auditory Meatus
ORL 2012;74:246–249 (DOI:10.1159/000342793) (Source: ORL)
Source: ORL - October 10, 2012 Category: ENT & OMF Source Type: research