Comparing Modified with Conventional Parotidectomy for Benign Parotid Tumors
This study retrospectively analyzed 99 patients who had benign parotid lesions and underwent parotidectomy using either conventional or modified parotidectomy. The operation time, cosmetic outcome, great auricular nerve anesthesia, incidence of Frey syndrome, and secretory function with the two techniques were compared.Results: The mean operation time was shorter and the total complication rate was obviously lower in the modified surgery group (p (Source: ORL)
Source: ORL - September 7, 2017 Category: ENT & OMF Source Type: research

A Retrospective Analysis of & #x03B3; δ T Cell Expression in Chronic Rhinosinusitis and Its Association with Recurrence of Nasal Polyps
Background/Aims: To examine whether #x03B3; δ T cell is expressed in the nasal mucosa of chronic rhinosinusitis (CRS) patients and its potential association with recurrence of nasal polyps.Methods: Thirty-six patients with CRS with nasal polyps (CRSwNP) and 25 patients with CRS without nasal polyps (CRSsNP) were recruited. Twenty-six patients with other nasal diseases served as controls. The CRSwNP group was divided into the eosinophilic CRSwNP and noneosinophilic CRSwNP groups. The expression of #x03B3; δ T cells was detected by immunohistochemistry. The expression of each subtype of #x03B3;δ T cells was...
Source: ORL - August 31, 2017 Category: ENT & OMF Source Type: research

ATF3-Dependent Regulation of EGR1 in vitro and in vivo
Background/Aims: Activating transcription factor 3 (ATF3) and early growth response protein 1 (EGR1) are reported to interact, but their use as prognostic factors in cancer is discussed controversially.Methods: We measured ATF3 and EGR1 gene expression changes in human mini-organ cultures (MOCs) of healthy nasal epithelia, UM-SCC-22B, and FADUDD cells after acid reflux exposure. Next, ATF3 and EGR1 gene expression was analysed in tumour tissues and related to the median expression of autologous reference tissue samples.Results: ATF3 and EGR1 mRNA expression was significantly reduced after consecutive exposure of MOCs at pH (Source: ORL)
Source: ORL - August 11, 2017 Category: ENT & OMF Source Type: research

Factors to Consider When Deciding on the Type of Free-Flap Reconstruction of Head and Neck Soft Tissue Defects
Conclusion: Proper selection of the flap is important for the optimization of the aesthetic and functional outcomes. Ultrasound, the surgeon's experience and the extension and nature of the defect play a key role in the selection of the flap.ORL 2017;79:230-238 (Source: ORL)
Source: ORL - August 3, 2017 Category: ENT & OMF Source Type: research

Comparison between Primary and Secondary Tracheoesophageal Puncture Prosthesis: A Systematic Review
Conclusion: There is a reduction in the risk of leakage around the prosthesis among TEP2 patients.ORL 2017;79:222-229 (Source: ORL)
Source: ORL - July 28, 2017 Category: ENT & OMF Source Type: research

Morbidity and Functional Outcomes following Free Jejunal Flap Reconstruction for Head and Neck Cancer
Conclusion: Postoperative barium swallow examination is helpful to predict long-term anastomotic stenosis. Good functional swallow rehabilitation is achieved following FJF reconstruction after total PLE or a larynx-preserving procedure. However, the speech outcomes are not satisfactory. It raises the demand of enhancement of functional recovery so that quality of life can be improved for these patients in China.ORL 2017;79:212-221 (Source: ORL)
Source: ORL - July 26, 2017 Category: ENT & OMF Source Type: research

Thyroid Surgery: To Drain or Not to Drain, That Is the Problem - A Randomized Clinical Trial
Conclusions: Routine drain emplacement after thyroidectomy is unnecessary.ORL 2017;79:202-211 (Source: ORL)
Source: ORL - July 14, 2017 Category: ENT & OMF Source Type: research

Transoral Robotic Surgery Total Laryngectomy: Evaluation of Functional and Survival Outcomes in a Retrospective Case Series at a Single Institution
Conclusions: TORS-TL is a feasible and safe treatment option with possible advantages for carefully selected patients in experienced hands.ORL 2017;79:191-201 (Source: ORL)
Source: ORL - June 13, 2017 Category: ENT & OMF Source Type: research

Videolaryngoscopy during Conscious Sedation in Patients Not Suitable for Phonosurgery by Microlaryngoscopy: A Pilot Study
Conclusion: The results suggest that the method is an effective and safe procedure without relevant local and/or general complications.ORL 2017;79:185-190 (Source: ORL)
Source: ORL - June 1, 2017 Category: ENT & OMF Source Type: research

Decrease of Horizontal Canal Vestibulo-Oculomotor Reflex Gain in the Elderly with Dysequilibrium without Lifetime Vertigo
Conclusions: Our data support the hypothesis of a decrease of VOR gain in the elderly. The decrease of canal function may therefore play a role in the risk of falls in the elderly.ORL 2017;79:178-184 (Source: ORL)
Source: ORL - May 10, 2017 Category: ENT & OMF Source Type: research

Adoptive Cellular Gene Therapy for the Treatment of Experimental Autoimmune Polychondritis Ear Disease
In the past, the clinical therapy for autoimmune diseases, such as autoimmune polychondritis ear disease, was mostly limited to nonspecific immunosuppressive agents, which could lead to variable responses. Currently, gene therapy aims at achieving higher specificity and less adverse effects. This concept utilizes the adoptive transfer of autologous T cells that have been retrovirally transduced ex vivo to express and deliver immunoregulatory gene products to sites of autoimmune inflammation. In the animal model of collagen-induced autoimmune polychondritis ear disease (CIAPED), the adoptive transfer of IL-12p40-expressing ...
Source: ORL - May 2, 2017 Category: ENT & OMF Source Type: research

Radiologic Differences between Human Papillomavirus-Related and Human Papillomavirus-Unrelated Oropharyngeal Carcinoma on Diffusion-Weighted Imaging
ORL 2017;79:164-165 (Source: ORL)
Source: ORL - April 26, 2017 Category: ENT & OMF Source Type: research

Role of the Ubiquitin C-Terminal Hydrolase L1-Modulated Ubiquitin Proteasome System in Auditory Cortex Senescence
Conclusion: The results suggest that UCHL1 may modify the aging process in the auditory cortex by regulating UPS- related proteins.ORL 2017;79:153-163 (Source: ORL)
Source: ORL - April 13, 2017 Category: ENT & OMF Source Type: research

A Modified Tracheal Transaction Approach for the Repair of Nonmalignant Tracheoesophageal Fistulas: A Report of 5 Cases
Conclusion: Based on our primary experience, this modified tracheal transection approach can be considered an appropriate choice for the reconstruction of nonmalignant tracheal fistulas.ORL 2017;79:147-152 (Source: ORL)
Source: ORL - April 11, 2017 Category: ENT & OMF Source Type: research

A Clinical and Radiological Approach to the Management of Benign Mesenchymal Sinonasal Tumors
Conclusion: Understanding and recognizing the spectrum of appearances of benign mesenchymal sinonasal tumors will improve patient assessment and clinical management. The pathognomonic neuroradiological signs of a particular tumor entity should be actively sought as the neuroradiological features may be the diagnostic clues. Computed tomography and magnetic resonance imaging play complementary roles in identifying the morphological details and locoregional staging of benign mesenchymal sinonasal tumors.ORL 2017;79:131-146 (Source: ORL)
Source: ORL - April 11, 2017 Category: ENT & OMF Source Type: research

Acknowledgement to Reviewers
ORL 2016;78:361 (Source: ORL)
Source: ORL - April 11, 2017 Category: ENT & OMF Source Type: research

Contents Vol. 78, 2016
ORL 2016;78:I-IV (Source: ORL)
Source: ORL - April 11, 2017 Category: ENT & OMF Source Type: research

Contribution of Hyoid and Tonsillar Procedures to Outcome in Multilevel Surgery for Obstructive Sleep Apnea Syndrome
Conclusion: The patients having undergone multilevel surgery without tonsillectomy showed significantly poorer postoperative results, suggesting that the effectiveness of hyoid procedures at the level of the hypopharynx may be limited. However, removal of the tonsils is a major predictive factor for postoperative success.ORL 2016;78:353-360 (Source: ORL)
Source: ORL - March 24, 2017 Category: ENT & OMF Source Type: research

Predictive Success Factors in Selective Upper Airway Stimulation
Obstructive sleep apnea is one of the most common diseases in Western industrialized countries. A variety of conservative and surgical treatment options are available for its treatment. In recent years, selective upper airway stimulation (sUAS) has been shown to be effective and safe. Different biomarkers have been investigated as predictive clinical success factors in a number of clinical trials. Age does not matter in sUAS, as compared to its predictive role in other therapies. Weight seems to play a limited role, depending on drug-induced sleep endoscopy to rule out a complete concentric collapse with an increased body ...
Source: ORL - March 7, 2017 Category: ENT & OMF Source Type: research

Vibration-Induced Nystagmus: A Biomarker for Vestibular Deficits - A Synopsis
A review of more than 20 years of experience with vibratory stimulation in vestibular diseases is given. Vibrations in a frequency frame of 30-60 Hz are applied on the mastoid during 20 s. Eye movements are recorded by video-oculography to detect a vibration-induced nystagmus (VIN). A VIN occurs in cases of a side difference between the peripheral vestibular receptors beating to the side of better excitability. In patients with central lesions, a VIN does not appear generally, only exceptionally if the lesion is located laterally in the brain stem. In healthy subjects, a VIN does not occur. The VIN can be considered as an ...
Source: ORL - March 7, 2017 Category: ENT & OMF Source Type: research

Radiologic Differences between Human Papillomavirus-Related and Human Papillomavirus-Unrelated Oropharyngeal Carcinoma on Diffusion-Weighted Imaging
Conclusion: ADC values were significantly lower in both the primary tumors and lymph node metastases in HPV+ OPCs compared to HPV- OPCs. These results confirm the results of prior studies.ORL 2016;78:344-352 (Source: ORL)
Source: ORL - February 28, 2017 Category: ENT & OMF Source Type: research

Potential Biomarkers for the Diagnosis of Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema
Conclusions: In this small patient population, it could be shown that determination of 6-keto-PGF1 α is feasible. It may prove to be a valuable blood marker for assessing the risk of developing ACEi-AE.ORL 2017;79:85-92 (Source: ORL)
Source: ORL - February 23, 2017 Category: ENT & OMF Source Type: research

Endotypes in Chronic Rhinosinusitis: Biomarkers Based on a Mechanistic Insight for Targeted Treatment?
Chronic rhinosinusitis is an umbrella term for several phenotypes and mechanistically distinct inflammatory diseases of the nose and the paranasal sinuses affecting around 11% of the population in Europe and the USA. Approximately 20% of the patients present with uncontrolled disease despite adequate treatment, and revision surgery is common. While a clinical characterization alone does not improve treatment results, novel but expensive biologics have increasingly become available, but they require a better understanding of the mechanism. Mechanistic markers of disease may help to allocate the optimal drug to a patient, th...
Source: ORL - February 23, 2017 Category: ENT & OMF Source Type: research

Biomarkers in Allergic Airway Disease: Simply Complex
Clinical diagnoses of allergic airway disease need confirmation of a relevant sensitization to allergens. Serum-based component-resolved diagnosis has become increasingly popular and allows the precise assessment of specific IgE to molecular allergens. Molecular allergen diagnosis has improved our understanding of disease phenotypes in allergic patients, including cross-reactive patterns and food allergy. Beyond sensitization profiles, characterization of the (endo-)type and severity of a local allergic disease is useful for targeted therapy with biologics in advanced allergic airway disease. Surrogate markers of treatment...
Source: ORL - February 23, 2017 Category: ENT & OMF Source Type: research

Radiomics in Head and Neck Cancer: Extracting Valuable Information from Data beyond Recognition
In oncology, biomarkers that describe the characteristics of a malignancy on different levels (clinical, histological, molecular) and the patient's outcome and treatment response are increasingly integrated into the clinical routine. Extensive screening tools, “omics,” offer incredible opportunities and vast amounts of data. During the last years, the field of “omics” gained a new promising partner, the “radiomics.” Based on radiological imaging, multiple features can be extracted and linked to clinical, genomic, and histopathological data fro m other sources. Extracted traits describe r...
Source: ORL - February 23, 2017 Category: ENT & OMF Source Type: research

Ultrasound Elastography in Diffuse and Focal Parotid Gland Lesions
In Europe, ultrasound (US) is the diagnostic gold standard for the visualisation of parotid gland disorders. While high-resolution B-mode US reliably visualises focal lesions, its diagnostic capacity to distinguish tumour entities or to characterise diffuse lesions remains poor. Strain elastography (SE) and shear wave elastography (SWE) are novel imaging techniques that provide additional information about tissue elasticity. SE analyses the strain or displacement in response to force or compression and, therefore, shows the relative tissue elasticity within a selected region of interest (ROI). Recent studies suggest that S...
Source: ORL - February 23, 2017 Category: ENT & OMF Source Type: research

Biomarkers in Autoimmune Salivary Gland Disorders: A Review
Salivary glands are frequent sites of manifestations of autoimmune disorders in the head and neck. Sj ögren syndrome, sarcoidosis, granulomatosis with polyangiitis, and IgG4-related sialadenitis represent the most important autoimmune salivary gland disorders. Due to the lack of specific symptoms, diagnosis of these conditions remains a challenge. Diagnosis is usually based on classification criter ia involving clinical tests, histopathological evaluation, and serological examinations. Depending on the disease, biomarkers are of different value and have to be interpreted carefully. In Sjögren syndrome, antibodies...
Source: ORL - February 23, 2017 Category: ENT & OMF Source Type: research

CXCR4: A New Player in an Old Scene?
Transmembrane C-X-C chemokine receptor 4 (CXCR4) and its ligand C-X-C motif chemokine 12 (CXCL12) came into focus in many solid cancers, allowing a more fundamental diagnostic and therapeutic approach by modulating the immune response against cancer cells. CXCR4 and CXCL12 mediate cell proliferation, migration, and metastatic outgrowth in head and neck squamous cell carcinoma (HNSCC) and are strongly associated with cancer recurrence and patient survival. Despite recent advances in molecular imaging and cancer therapy in lymphoma using CXCL12 analogues, clinical trials evaluating the diagnostic and therapeutic impact on HN...
Source: ORL - February 23, 2017 Category: ENT & OMF Source Type: research

Checkpoint Inhibition in Head and Neck Cancer: Immune Therapeutic Options, Limitations, and Beyond
The immune system functions to defend the organism against infectious microorganisms but also against transformed cells. This key role of the immune system, in particular cancer-specific T cells, in eliminating cancer cells is compromised by various immune escape strategies employed by cancer cells and the cancer microenvironment. Here, we review the current knowledge about the immune escape mechanisms of cancer and the attempts to reconstitute cancer-specific immunity by using checkpoint inhibitors in head and neck squamous cell carcinoma. We discuss the different options of immune therapy based on a mechanistic understan...
Source: ORL - February 23, 2017 Category: ENT & OMF Source Type: research

Response Evaluation in Head and Neck Oncology: Definition and Prediction
Curative treatment of head and neck squamous cell carcinoma includes surgery and/or (chemo)radiation, whereas in the palliative setting, chemotherapy and/or immunotherapy represent(s) the standard approach. With regard to quality control, methods for determining treatment response are sorely needed. For surgical therapy, histopathology is the standard quality control. Established criteria for high-risk patients include resection margins of the primary tumor and extracapsular extension of lymph node metastases. After definitive chemoradiation, treatment response is generally evaluated by tomographic imaging combined with en...
Source: ORL - February 23, 2017 Category: ENT & OMF Source Type: research

Individual Biomarkers Using Molecular Personalized Medicine Approaches
Molecular personalized medicine tries to generate individual predictive biomarkers to assist doctors in their decision making. These are thought to improve the efficacy and lower the toxicity of a treatment. The molecular basis of the desired high-precision prediction is modern “omex” technologies providing high-throughput bioanalytical methods. These include genomics and epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, imaging, and functional analyses. In most cases, producing big data also requires a complex biomathematical analysis. Using molecu lar personalized medicine, the conventiona...
Source: ORL - February 23, 2017 Category: ENT & OMF Source Type: research

Editorial
ORL 2017;79:5-6 (Source: ORL)
Source: ORL - February 23, 2017 Category: ENT & OMF Source Type: research

Clinical Value of the Epstein-Barr Virus and p16 Status in Patients with Nasopharyngeal Carcinoma: A Single-Centre Study in Japan
Background: The clinical significance of the Epstein-Barr virus (EBV) status and p16 expression was unknown in nasopharyngeal carcinoma (NPC).Methods: We retrospectively studied our pathology database for 13 years to determine the prevalence of EBV and p16 expression and their association with prognosis in cases of NPC. We performed immunohistochemistry for the p16 protein and in situ hybridization (ISH) for EBV-encoded small RNAs and human papillomavirus (HPV) DNA.Results: Of the 43 patients with NPC, 27 (63%), 6 (14%), and 10 (23%) cases were EBV positive, EBV negative with keratinization, and EBV negative without kerati...
Source: ORL - February 7, 2017 Category: ENT & OMF Source Type: research

Advanced Squamous Cell Carcinoma of the Head and Neck: The Current Role of Cetuximab
We review clinical trials of squamous cell carcinoma of the head and neck (SCCHN) to address the current and potential uses of cetuximab (CTX). PubMed was reviewed to identify papers published between 2010 and 2016. The search terms used were “cetuximab” and “head and neck cancer.” A total of 634 articles were identified. Phase II or III studies with CTX in patients with advanced SCCHN without treatment or with recurrent/metastatic tumors were selected. Forty-six registries were obtained. Information was critically reviewed and r elevant information presented. As definitive treatment of advanced squ...
Source: ORL - January 26, 2017 Category: ENT & OMF Source Type: research

Single Nucleotide Polymorphisms in Adiponectin Gene Are Not Directly Associated with Increased Risk of Obstructive Sleep Apnea Syndrome in a Chinese Han Population
This study aims to test the possible correlation between single nucleotide polymorphisms (SNPs) in the adiponectin gene and increased risk of obstructive sleep apnea syndrome (OSAS) in a Chinese Han population.Materials and Methods: A total of 266 subjects were enrolled into the study to detect 9 SNPs in the adiponectin gene. Multivariate unconditional logistic regression analysis, adjusted for gender and age, was used to estimate the associations of these SNPs with OSAS risk.Results: No evidence of a direct association was observed between these SNPs and the risk of OSAS in the Chinese Han population. However, the stratif...
Source: ORL - January 9, 2017 Category: ENT & OMF Source Type: research

Effect of Temporal Fascia and Pedicle Inferior Turbinate Mucosal Flap on Repair of Large Nasal Septal Perforation via Endoscopic Surgery
Conclusion: The pedicle inferior turbinate mucosal flap combined with the temporal fascia technique can easily solve this challenging problem, and the current data from this prospective study suggest that this technique shows promising results.ORL 2016;78:303-307 (Source: ORL)
Source: ORL - December 15, 2016 Category: ENT & OMF Source Type: research

Morphology and Ciliary Motion of the Middle Ear Mucosa of Neonatal and Adult Gerbils
Background/Aims: Since the middle ear cavity plays an important role in middle ear effusion, the goal of this study is to examine the morphological and functional development of the middle ear mucosa in neonatal and adult gerbils.Methods: Gerbils aged between postnatal day 1 (P1) and P26 were used for the experiments. The morphological development of the middle ear cavity was measured by using the celloidin embedding method and scanning electronic microscope. Ciliary motion was determined and calibrated by a photodiode-based measurement system.Results: The area of the middle ear increased significantly from 0.42 ± 0...
Source: ORL - November 23, 2016 Category: ENT & OMF Source Type: research

Multilayered Closure of Cerebrospinal Fluid Rhinorrhea with Inlay Fascia Lata, Autologous Fat, and Outlay Fascia Lata: Our Experience
Conclusion: Twenty-one CSF rhinorrhea patients were operated with this technique in our hospital. Two patients had large skull base defects and 15 patients had high-flow CSF leaks. We reached a 100% success rate in the first attempt without any long-term recurrence. Multilayered endoscopic closure with this technique offers satisfactory results with minimal morbidity even in large defects and high-flow CSF leaks.ORL 2016;78:289-295 (Source: ORL)
Source: ORL - November 15, 2016 Category: ENT & OMF Source Type: research

Hearing Restoration for Adults with Vestibular Schwannoma in the Only Hearing Ear: Ipsilateral or Contralateral Cochlear Implantation?
Conclusions: In patients with VS in the only hearing ear, significant hearing deterioration with no obvious tumor growth is a good indication for ipsilateral CI. Long-term deafness in the tumor-free ear is not an absolute contraindication for CI.ORL 2016;78:281-288 (Source: ORL)
Source: ORL - November 11, 2016 Category: ENT & OMF Source Type: research

Morphological Variation of Subarcuate Artery and Canal in Atresia
Conclusions: The variation proposed in microtia was not previously reported in the literature, which may have important implications for the canal reconstruction.ORL 2016;78:276-280 (Source: ORL)
Source: ORL - October 6, 2016 Category: ENT & OMF Source Type: research

Expression of Dopamine Receptor 1A and Cannabinoid Receptor 1 Genes in the Cochlea and Brain after Salicylate-Induced Tinnitus
The purpose of this study was to investigate the mRNA expression of the dopamine receptor 1A (DR1A) and cannabinoid receptor 1 (CR1) genes in mice with tinnitus. Sixteen 3-month-old male SAMP8 mice were randomly and equally divided into two groups (8 mice in each group): a control (saline-treated) group and a tinnitus (salicylate-treated) group. The mRNA expression of the DR1A and CR1 genes in the cochleae and brains of the mice was evaluated after tinnitus had been induced by intraperitoneal injection of sodium salicylate (300 mg/kg body weight). The results showed that 4-day salicylate treatment (unlike 4-day saline trea...
Source: ORL - September 22, 2016 Category: ENT & OMF Source Type: research

Quantitative Assessment of Surgical Anatomy and Three-Dimensional Relationships in the Supralabyrinthine Space
Conclusion: Quantification of surgically relevant anatomic relationships and the morphology of the supralabyrinthine space in three dimensions are very helpful in surgical dissection.ORL 2016;78:259-267 (Source: ORL)
Source: ORL - September 9, 2016 Category: ENT & OMF Source Type: research

Submucosal Abscess of the Esophagus Caused by Piriform Sinus Fistula Treated with Transoral Video Laryngoscopic Surgery
We report a case of esophageal submucosal abscess caused by PSF treated with endoscopic mucosal incision. The patient underwent transoral video laryngoscopic surgery (TOVS), and endoscopy as well as fluoroscopy revealed complete closure of PSF without any complication. TOVS is a novel surgical technique for the definitive treatment of PSF with esophageal submucosal abscess.ORL 2016;78:252-258 (Source: ORL)
Source: ORL - August 24, 2016 Category: ENT & OMF Source Type: research

Nd:YAG Laser Treatment for Extranasal Telangiectasias: A Retrospective Analysis of 38 Patients with Hereditary Hemorrhagic Telangiectasia and Review of the Literature
Conclusion: This study shows that Nd:YAG laser constitutes a fast, safe and efficient therapeutic modality for the treatment of extranasal telangiectasias.ORL 2016;78:245-251 (Source: ORL)
Source: ORL - August 3, 2016 Category: ENT & OMF Source Type: research

What Are the Optimal Monitoring Techniques in Head and Neck Microvascular Reconstruction
Purpose: We evaluated the outcomes for widely used systems in terms of accuracy, salvage rates, and added cost compared to conventional monitoring. Methods: We performed a narrative review of the literature (high-impact report). Results: The overall free flap success for head and neck reconstruction is at least 95% using any type of monitoring. Salvage rates in decreasing frequency of monitoring techniques are 85% with near-infrared spectroscopy (NIRS), 81% with implantable Doppler, and 61.5% with conventional monitoring. False-positive rates in increasing frequency are 0% for NIRS, 0.4% for conventional monitoring, and
Source: ORL - July 27, 2016 Category: ENT & OMF Source Type: research

What Are the Optimal Monitoring Techniques in Head and Neck Microvascular Reconstruction?
Purpose: We evaluated the outcomes for widely used systems in terms of accuracy, salvage rates, and added cost compared to conventional monitoring. Methods: We performed a narrative review of the literature (high-impact report). Results: The overall free flap success for head and neck reconstruction is at least 95% using any type of monitoring. Salvage rates in decreasing frequency of monitoring techniques are 85% with near-infrared spectroscopy (NIRS), 81% with implantable Doppler, and 61.5% with conventional monitoring. False-positive rates in increasing frequency are 0% for NIRS, 0.4% for conventional monitoring, and
Source: ORL - July 26, 2016 Category: ENT & OMF Source Type: research

Clinical Study of 1,515 Patients Presenting with Epistaxis Over the Last 6 Years
Conclusions: Patients showing repeated pulsatile arterial bleeding require hospitalization for surgical therapy, although outpatient therapy is sufficient in most cases. A risk of re-bleeding should be considered if patients show unclarified bleeding points and circulatory diseases.ORL 2016;78:232-240 (Source: ORL)
Source: ORL - July 20, 2016 Category: ENT & OMF Source Type: research

Bacteriology of the Middle Meatus in Chronic Rhinosinusitis with and without Polyposis
In conclusion, patients with CRS have higher rates of bacterial isolates than patients without CRS. CRSwNP is associated with more Gram-negative bacteria than CRSsNP, regardless of disease severity. The relatively high positive culture rate in patients with septal deviation merits investigation.ORL 2016;78:223-231 (Source: ORL)
Source: ORL - July 19, 2016 Category: ENT & OMF Source Type: research

Benefit of Preoperative Oral Steroids during Sinus Surgery when Utilizing Concentrated Topical Epinephrine
Conclusion: When coupled with intraoperative concentrated topical epinephrine use, preoperative oral steroid administration provides no clinically significant benefit with respect to reduced intraoperative bleeding or surgical duration.ORL 2016;78:216-222 (Source: ORL)
Source: ORL - July 6, 2016 Category: ENT & OMF Source Type: research

Reconstruction of Hypopharyngeal and Esophageal Defects Using a Gastric Tube after Total Esophagectomy and Pharyngolaryngectomy
Conclusion: Reconstruction by gastric tube is a dependable one-stage procedure that restores gastrointestinal continuity after total pharyngo-laryngo-esophagectomy.ORL 2016;78:208-215 (Source: ORL)
Source: ORL - July 6, 2016 Category: ENT & OMF Source Type: research