Human Neutrophil Elastase Mediates MUC5AC Hypersecretion via the Tumour Necrosis Factor- α Converting Enzyme-Epidermal Growth Factor Receptor Signalling Pathway in vivo

Conclusion: Using a newly developed, stable experimental model of nasal hypersecretion in mice, we showed that TAPI-2 or AG1478 inhibited HNE-induced MUC5AC production. This suggests that MUC5AC mucin expression in vivo is mediated by a cascade involving the HNE-TACE-EGFR signalling pathway.ORL

Source: ORL - June 15, 2021 Category: ENT & OMF Source Type: research