Prognostic Value of miR-137 in Children with Medulloblastoma and its Regulatory Effect on Tumor Progression
This study can conclude that miR-137 may be used as a prognostic biomarker of MB. (Source: NeuroMolecular Medicine)
Source: NeuroMolecular Medicine - August 18, 2021 Category: Neurology Source Type: research
Emerging Therapeutic Strategies for Brain Tumors
AbstractNearly thirty thousand incidences of primary and 300 thousand incidences of metastatic brain cancer are diagnosed in the USA each year. It has a high mortality rate and is often unresponsive to the standard of care, which includes surgical resection, radiation, and chemotherapy. These treatment strategies are also hindered by their invasiveness and toxic effects on healthy cells and tissues. Furthermore, the blood –brain/tumor barrier severely limits delivery of anti-cancer therapeutics administered intravenously to brain tumors, resulting in poor tumor response to the treatment. There is a critical need to devel...
Source: NeuroMolecular Medicine - August 18, 2021 Category: Neurology Source Type: research
Correction to: Receptor-Interacting Protein 140 Enhanced Temozolomide-Induced Cellular Apoptosis Through Regulation of E2F1 in Human Glioma Cell Lines
(Source: NeuroMolecular Medicine)
Source: NeuroMolecular Medicine - August 6, 2021 Category: Neurology Source Type: research
Emerging Technologies for Non-invasive Monitoring of Treatment Response to Immunotherapy for Brain Tumors
AbstractGlioblastoma is the most common primary malignant brain tumor and one of the most aggressive tumors across all cancer types with remarkable resistance to any treatment. While immunotherapy has shown a robust clinical benefit in systemic cancers, its benefit is still under investigation in brain cancers. The broader use of immunotherapy in clinical trials for glioblastoma has highlighted the challenges of traditional methods of monitoring progression via imaging. Development of new guidelines, advanced imaging techniques, and immune profiling have emerged to counter premature diagnoses of progressive disease. Howeve...
Source: NeuroMolecular Medicine - July 23, 2021 Category: Neurology Source Type: research
Diagnostic Performance of miR-485-3p in Patients with Parkinson ’s Disease and its Relationship with Neuroinflammation
This study aims to evaluate the clinical significance and biological function of miR-485-3p in the development and progres sion of PD. The expression of miR-485-3p in serum of PD patients was analyzed by quantitative real-time PCR (qRT-PCR). LPS-treated microglia BV2 cells were used to mimic neuroinflammation in the pathogenesis of PD. The levels of inflammatory cytokines, including IL-1β, IL-6 and TNF-α, were detecte d by enzyme-linked immunosorbent assay (ELISA). The diagnosis value of miR-485-3p was evaluated by plotting receiver operating characteristic (ROC) curves. A luciferase reporter assay was performed to demon...
Source: NeuroMolecular Medicine - July 19, 2021 Category: Neurology Source Type: research
Altered Expression of miR-575 in Glioma is Related to Tumor Cell Proliferation, Migration, and Invasion
This study aimed to explore the function of miR-575 in the prognosis and cell biological behavior of glioma. qRT-PCR was used to evaluate the expression of miR-575 in glioma tissues and cells, Kaplan –Meier survival analysis and Cox regression analysis were used to evaluate the prognostic value. The proliferation ability of glioma cells was determined by MTT assay; the invasion and migration abilities were determined by transwell assays. Compared with normal brain tissues, the expression of mi R-575 in glioma tissue cells was significantly up-regulated (P < 0.001). The survival rate of patients in the miR-575 hig...
Source: NeuroMolecular Medicine - July 16, 2021 Category: Neurology Source Type: research
Tranilast, a Transient Receptor Potential Vanilloid 2 Channel (TRPV2) Inhibitor Attenuates Amyloid β-Induced Cognitive Impairment: Possible Mechanisms
In this study, intracerebroventricular administration of β-amyloid (10 μg) to Sprague Dawley rats resulted in cognitive impairment which was evident from the assessment of co gnitive tests. Also, TRPV2 mRNA and protein expression were found to be upregulated, while the expression of Ca2+/calmodulin-dependent protein kinase II (p-CaMKII-Thr-286), glycogen synthase kinase 3 β (p-GSK-3β-Ser-9), cAMP response element-binding protein (p-CREB-Ser-133), and postsynaptic density protein 95 (PSD-95) were downregulated in the hippocampus of β-amyloid-treated animals. Even, β-amyloid-treated animals showed upregulation of mRNA...
Source: NeuroMolecular Medicine - July 6, 2021 Category: Neurology Source Type: research
Influence of Simulated Deep Brain Stimulation on the Expression of Inflammatory Mediators by Human Central Nervous System Cells In Vitro
AbstractDeep brain stimulation (DBS) seems to modulate inflammatory processes. Whether this modulation leads to an induction or suppression of inflammatory mediators is still controversially discussed. Most studies of the influence of electrical stimulation on inflammation were conducted in rodent models with direct current stimulation and/or long impulses, both of which differ from the pattern in DBS. This makes comparisons with the clinical condition difficult. We established an in-vitro model that simulated clinical stimulation patterns to investigate the influence of electrical stimulation on proliferation and survival...
Source: NeuroMolecular Medicine - July 3, 2021 Category: Neurology Source Type: research
Irisin-Associated Neuroprotective and Rehabilitative Strategies for Stroke
AbstractIrisin, a newly discovered protein hormone that is secreted in response to low frequency whole body vibration (LFV), could be a promising post-stroke rehabilitation therapy for patients who are frail and cannot comply with regular rehabilitation therapy. Irisin is generated from a membrane-bound precursor protein fibronectin type III domain-containing protein 5 (FNDC5). Aside from being highly expressed in muscle, FNDC5 is highly expressed in the brain. The cleaved form of FNDC5 was found in the cerebrospinal fluid as well as in various regions of the brain. Numerous studies suggest that irisin plays a key role in ...
Source: NeuroMolecular Medicine - July 3, 2021 Category: Neurology Source Type: research
Stem-Like Cell Populations, p53-Pathway Activation and Mechanisms of Recurrence in Sonic Hedgehog Medulloblastoma
Abstract
While most Sonic Hedgehog-associated medulloblastomas (SHH-MBs) respond to therapeutic intervention, radiation therapy often causes deleterious long-term neurocognitive defects, especially in infants and young children. To limit neurological comorbidities, the development of a reduction-of-therapy treatment or de-escalation approach was investigated. Although retrospective analysis of MBs indicated low-dose therapy was potentially effective, clinical de-escalation trials showed poor outcomes in infant SHH-MBs and was prematurely terminated. Recent studies suggest the existence of cancer-stem-cell (CSC)-like cel...
Source: NeuroMolecular Medicine - June 24, 2021 Category: Neurology Source Type: research
Revealing the Modular Similarities and Differences Among Alzheimer ’s Disease, Vascular Dementia, and Parkinson’s Disease in Genomic Networks
AbstractAlzheimer ’s disease (AD), vascular dementia (VD), and Parkinson’s disease (PD) exert increasingly lethal or disabling effects on humans, but the associations among these diseases at the molecular level remain unclear. In our research, lists of genes related to these three diseases were acquired from publ ic databases. We constructed gene–gene networks of the lists of disease-related genes using the STRING database and selected the plug-in MCODE as the most suitable method to divide the three disease-associated networks into modules through an entropy calculation. Notably, 1173 AD-related, 203 VD-r elated, an...
Source: NeuroMolecular Medicine - June 12, 2021 Category: Neurology Source Type: research
