Increased IL-6 Levels and the Upregulation of Iron Regulatory Biomarkers Contribute to the Progression of Japanese Encephalitis Virus Infection ’s Pathogenesis
AbstractIntegrated analysis of iron regulatory biomarkers and inflammatory response could be an important strategy for Japanese encephalitis viral (JEV) infection disease management. In the present study, the inflammatory response was assessed by measuring serum Interleukin-6 (IL-6) levels using ELISA, and the transcription levels of iron homeostasis regulators were analyzed via RT-PCR. Furthermore, inter-individual variation in the transferrin gene was analyzed by PCR –RFLP and their association with clinical symptoms, susceptibility, severity, and outcomes was assessed through binary logistic regression and classificat...
Source: NeuroMolecular Medicine - October 31, 2023 Category: Neurology Source Type: research
Author Correction: Potential of Quercetin to Protect Cadmium Induced Cognitive Deficits in Rats by Modulating NMDA ‑R Mediated Downstream Signaling and PI3K/AKT—Nrf2/ARE Signaling Pathways in Hippocampus
(Source: NeuroMolecular Medicine)
Source: NeuroMolecular Medicine - October 20, 2023 Category: Neurology Source Type: research
MicroRNAs as a Tool for Differential Diagnosis of Neuromuscular Disorders
In this study, the diagnostic potential of some species of microRNAs (miRNAs) that are known to play roles in normal and pathological contexts of myocytes (myomiRs) were evaluated to assess their potential in differential diagnosis of NMDs. In this study, seventy-four patients with different neuromuscular disorders along with thirty age-matched healthy control subjects were enrolled. Peripheral blood samples were collected from enrolled subjects followed by miRNA extraction and reverse transcription followed by quantification of the circulating levels of the studied miRNAs (miR-499, miR-206, miR-208a, miR-223, miR-191, miR...
Source: NeuroMolecular Medicine - October 19, 2023 Category: Neurology Source Type: research
Diurnal Characteristics of the Orexin System Genes and Its Effects on Pathology at Early Stage in 3xTg-AD Mice
AbstractOrexin and its receptors are closely related to the pathogenesis of Alzheimer ’s disease (AD). Although the expression of orexin system genes under physiological condition has circadian rhythm, the diurnal characteristics of orexin system genes, and its potential role in the pathogenesis in AD are unknown. In the present study, we hope to elucidate the diurnal characteristi cs of orexin system genes at the early stage of AD, and to investigate its potential role in the development of AD neuropathology. We firstly detected the mRNA levels of orexin system genes, AD risk genes and core clock genes (CCGs) in hypotha...
Source: NeuroMolecular Medicine - October 16, 2023 Category: Neurology Source Type: research
Genetic Variations and Altered Blood mRNA Level of Circadian Genes and BDNF as Risk Factors of Post-Stroke Cognitive Impairment Among Eastern Indians
AbstractPost-stroke cognitive impairment (PSCI) is a clinical outcome in around 30% of post-stroke survivors. BDNF is a major gene in this regard. It is regulated by circadian rhythm. The circadian genes are correlated with stroke timings at molecular level. However, studies suggesting the role of these on susceptibility to PSCI are limited. We aim here to determine: (a) genetic risk variants in circadian clock genes,BDNF and (b) dysregulation in expression level ofCLOCK, BMAL1, andBDNF that may be associated with PSCI.BDNF (rs6265G/A, rs56164415C/T),CLOCK (rs1801260T/C, rs4580704G/C), andCRY2 (rs2292912C/G) genes variants...
Source: NeuroMolecular Medicine - October 9, 2023 Category: Neurology Source Type: research
CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy
AbstractAnxiety manifestations and cognitive dysfunction are common sequelae in patients with sepsis-associated encephalopathy (SAE). Microglia-mediated inflammatory signaling is involved in anxiety, depression, and cognitive dysfunction during acute infection with bacterial lipopolysaccharide (LPS). However, the molecular mechanisms underlying microglia activation and behavioral and cognitive deficits in sepsis have not been in fully elucidated. Based on previous research, we speculated that the CD137 receptor/ligand system modulates microglia function during sepsis to mediate classical neurological SAE symptoms. A murine...
Source: NeuroMolecular Medicine - October 5, 2023 Category: Neurology Source Type: research
Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR
AbstractMedulloblastoma (MB) is a heterogeneous group of malignant pediatric brain tumors, divided into molecular groups with distinct biological features and prognoses. Currently available therapy often results in poor long-term quality of life for patients, which will be afflicted by neurological, neuropsychiatric, and emotional sequelae. Identifying novel therapeutic agents capable of targeting the tumors without jeopardizing patients' quality of life is imperative. Rosmarinic acid (RA) is a plant-derived compound whose action against a series of diseases including cancer has been investigated, with no side effects repo...
Source: NeuroMolecular Medicine - September 23, 2023 Category: Neurology Source Type: research
Fibroblast Growth Factor Receptor 2 (FGFR2), a New Gene Involved in the Genesis of Autism Spectrum Disorder
AbstractAutism spectrum disorder (ASD) is a long-known complex neurodevelopmental disorder, and over the past decades, with the enhancement of the research genomic techniques, has been the object of intensive research activity, and many genes involved in the development and functioning of the central nervous system have been related to ASD genesis. Herein, we report a patient with severe ASD carrying a G > A de novo variant in theFGFR2 gene, determining a missense mutation.FGFR2 encodes for the ubiquitous fibroblast growth factor receptor (FGFR) type 2, a tyrosine kinase receptor implicated in several biological p...
Source: NeuroMolecular Medicine - September 21, 2023 Category: Neurology Source Type: research
