Causal relationship of gut microbiota and metabolites on cognitive performance: A mendelian randomization analysis
Neurobiol Dis. 2023 Dec 28;191:106395. doi: 10.1016/j.nbd.2023.106395. Online ahead of print.ABSTRACTEmerging evidence has indicated that the alterations in gut microbiota and metabolites are associated with cognitive performance. However, whether these associations imply a causal relationship remains to be definitively established. Here, we conducted two-sample mendelian randomization (MR) studies to explore the causal effects of gut microbiota and metabolites on cognitive performance, using large-scale genome-wide association studies (GWASs). We identified seven positive causalities between host genetic-driven gut microb...
Source: Neurobiology of Disease - December 30, 2023 Category: Neurology Authors: Wei Cao Manyu Xing Shuang Liang Yufei Shi Zhengyiqi Li Wangyuan Zou Source Type: research
Causal relationship of gut microbiota and metabolites on cognitive performance: A mendelian randomization analysis
Neurobiol Dis. 2023 Dec 28;191:106395. doi: 10.1016/j.nbd.2023.106395. Online ahead of print.ABSTRACTEmerging evidence has indicated that the alterations in gut microbiota and metabolites are associated with cognitive performance. However, whether these associations imply a causal relationship remains to be definitively established. Here, we conducted two-sample mendelian randomization (MR) studies to explore the causal effects of gut microbiota and metabolites on cognitive performance, using large-scale genome-wide association studies (GWASs). We identified seven positive causalities between host genetic-driven gut microb...
Source: Neurobiology of Disease - December 30, 2023 Category: Neurology Authors: Wei Cao Manyu Xing Shuang Liang Yufei Shi Zhengyiqi Li Wangyuan Zou Source Type: research
Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a
Neurobiol Dis. 2023 Dec 26:106393. doi: 10.1016/j.nbd.2023.106393. Online ahead of print.ABSTRACTPhosphodiesterase 2 A (PDE2A) is an enzyme involved in the homeostasis of cAMP and cGMP and is the most highly expressed PDE in human brain regions critical for socio-cognitive behavior. In cerebral cortex and hippocampus, PDE2A expression level is upregulated in Fmr1-KO mice, a model of the Fragile X Syndrome (FXS), the most common form of inherited intellectual disability (ID) and autism spectrum disorder (ASD). Indeed, PDE2A translation is negatively modulated by FMRP, whose functional absence causes FXS. While the pharmacol...
Source: Neurobiology of Disease - December 28, 2023 Category: Neurology Authors: S ébastien Delhaye Marielle Jarjat Asma Boulksibat Clara Sanchez Alessandra Tempio Andrei Turtoi Mauro Giorgi Sandra Lacas-Gervais Gabriele Baj Carole Rovere Viviana Trezza Manuela Pellegrini Thomas Maurin Enzo Lalli Barbara Bardoni Source Type: research
Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a
Neurobiol Dis. 2023 Dec 26:106393. doi: 10.1016/j.nbd.2023.106393. Online ahead of print.ABSTRACTPhosphodiesterase 2 A (PDE2A) is an enzyme involved in the homeostasis of cAMP and cGMP and is the most highly expressed PDE in human brain regions critical for socio-cognitive behavior. In cerebral cortex and hippocampus, PDE2A expression level is upregulated in Fmr1-KO mice, a model of the Fragile X Syndrome (FXS), the most common form of inherited intellectual disability (ID) and autism spectrum disorder (ASD). Indeed, PDE2A translation is negatively modulated by FMRP, whose functional absence causes FXS. While the pharmacol...
Source: Neurobiology of Disease - December 28, 2023 Category: Neurology Authors: S ébastien Delhaye Marielle Jarjat Asma Boulksibat Clara Sanchez Alessandra Tempio Andrei Turtoi Mauro Giorgi Sandra Lacas-Gervais Gabriele Baj Carole Rovere Viviana Trezza Manuela Pellegrini Thomas Maurin Enzo Lalli Barbara Bardoni Source Type: research
Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a
Neurobiol Dis. 2023 Dec 26:106393. doi: 10.1016/j.nbd.2023.106393. Online ahead of print.ABSTRACTPhosphodiesterase 2 A (PDE2A) is an enzyme involved in the homeostasis of cAMP and cGMP and is the most highly expressed PDE in human brain regions critical for socio-cognitive behavior. In cerebral cortex and hippocampus, PDE2A expression level is upregulated in Fmr1-KO mice, a model of the Fragile X Syndrome (FXS), the most common form of inherited intellectual disability (ID) and autism spectrum disorder (ASD). Indeed, PDE2A translation is negatively modulated by FMRP, whose functional absence causes FXS. While the pharmacol...
Source: Neurobiology of Disease - December 28, 2023 Category: Neurology Authors: S ébastien Delhaye Marielle Jarjat Asma Boulksibat Clara Sanchez Alessandra Tempio Andrei Turtoi Mauro Giorgi Sandra Lacas-Gervais Gabriele Baj Carole Rovere Viviana Trezza Manuela Pellegrini Thomas Maurin Enzo Lalli Barbara Bardoni Source Type: research
Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a
Neurobiol Dis. 2023 Dec 26:106393. doi: 10.1016/j.nbd.2023.106393. Online ahead of print.ABSTRACTPhosphodiesterase 2 A (PDE2A) is an enzyme involved in the homeostasis of cAMP and cGMP and is the most highly expressed PDE in human brain regions critical for socio-cognitive behavior. In cerebral cortex and hippocampus, PDE2A expression level is upregulated in Fmr1-KO mice, a model of the Fragile X Syndrome (FXS), the most common form of inherited intellectual disability (ID) and autism spectrum disorder (ASD). Indeed, PDE2A translation is negatively modulated by FMRP, whose functional absence causes FXS. While the pharmacol...
Source: Neurobiology of Disease - December 28, 2023 Category: Neurology Authors: S ébastien Delhaye Marielle Jarjat Asma Boulksibat Clara Sanchez Alessandra Tempio Andrei Turtoi Mauro Giorgi Sandra Lacas-Gervais Gabriele Baj Carole Rovere Viviana Trezza Manuela Pellegrini Thomas Maurin Enzo Lalli Barbara Bardoni Source Type: research
Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a
Neurobiol Dis. 2023 Dec 26:106393. doi: 10.1016/j.nbd.2023.106393. Online ahead of print.ABSTRACTPhosphodiesterase 2 A (PDE2A) is an enzyme involved in the homeostasis of cAMP and cGMP and is the most highly expressed PDE in human brain regions critical for socio-cognitive behavior. In cerebral cortex and hippocampus, PDE2A expression level is upregulated in Fmr1-KO mice, a model of the Fragile X Syndrome (FXS), the most common form of inherited intellectual disability (ID) and autism spectrum disorder (ASD). Indeed, PDE2A translation is negatively modulated by FMRP, whose functional absence causes FXS. While the pharmacol...
Source: Neurobiology of Disease - December 28, 2023 Category: Neurology Authors: S ébastien Delhaye Marielle Jarjat Asma Boulksibat Clara Sanchez Alessandra Tempio Andrei Turtoi Mauro Giorgi Sandra Lacas-Gervais Gabriele Baj Carole Rovere Viviana Trezza Manuela Pellegrini Thomas Maurin Enzo Lalli Barbara Bardoni Source Type: research
Pathologic changes in neuronal intranuclear inclusion disease are linked to aberrant FUS interaction under hyperosmotic stress
Neurobiol Dis. 2023 Dec 23;190:106391. doi: 10.1016/j.nbd.2023.106391. Online ahead of print.ABSTRACTCGG repeat expansion in NOTCH2NLC is the genetic cause of neuronal intranuclear inclusion disease (NIID). Previous studies indicated that the CGG repeats can be translated into polyglycine protein (N2CpolyG) which was toxic to neurons by forming intranuclear inclusions (IIs). However, little is known about the factors governing polyG IIs formation as well as its molecular pathogenesis. Considering that neurogenetic disorders usually involve interactions between genetic and environmental stresses, we investigated the effect ...
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Hui Wang Yilei Zheng Jiaxi Yu Lingchao Meng Wei Zhang Daojun Hong Zhaoxia Wang Yun Yuan Jianwen Deng Source Type: research
Choline metabolism in regulating inflammatory bowel disease-linked anxiety disorders: A multi-omics exploration of the gut-brain axis
This study provides compelling evidence to suggest that choline metabolism plays a crucial role in the development and treatment of mood disorders in IBD. Choline and its metabolites appear to have a significant role in maintaining the stability of the GBA.PMID:38145852 | DOI:10.1016/j.nbd.2023.106390 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Fan Zhang Lingnan Guo Jingjing Shi Hao Jiang Feini Zhou Yanlin Zhou Bin Lv Maosheng Xu Source Type: research
Central role of the habenulo-interpeduncular system in the neurodevelopmental basis of susceptibility and resilience to anxiety in mice
Neurobiol Dis. 2023 Dec 23:106392. doi: 10.1016/j.nbd.2023.106392. Online ahead of print.ABSTRACTHaving experienced stress during sensitive periods of brain development strongly influences how individuals cope with later stress. Some are prone to develop anxiety or depression, while others appear resilient. The as-yet-unknown mechanisms underlying these differences may lie in how genes and environmental stress interact to shape the circuits that control emotions. Here, we investigated the role of the habenulo-interpeduncular system (HIPS), a critical node in reward circuits, in early stress-induced anxiety in mice. We foun...
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Malalaniaina Rakotobe Niels Fjerdingstad Nuria Ruiz-Reig Thomas Lamonerie Fabien D'Autr éaux Source Type: research
Pathologic changes in neuronal intranuclear inclusion disease are linked to aberrant FUS interaction under hyperosmotic stress
Neurobiol Dis. 2023 Dec 23:106391. doi: 10.1016/j.nbd.2023.106391. Online ahead of print.ABSTRACTCGG repeat expansion in NOTCH2NLC is the genetic cause of neuronal intranuclear inclusion disease (NIID). Previous studies indicated that the CGG repeats can be translated into polyglycine protein (N2CpolyG) which was toxic to neurons by forming intranuclear inclusions (IIs). However, little is known about the factors governing polyG IIs formation as well as its molecular pathogenesis. Considering that neurogenetic disorders usually involve interactions between genetic and environmental stresses, we investigated the effect of s...
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Hui Wang Yilei Zheng Jiaxi Yu Lingchao Meng Wei Zhang Daojun Hong Zhaoxia Wang Yun Yuan Jianwen Deng Source Type: research
Choline metabolism in regulating inflammatory bowel disease-linked anxiety disorders: A multi-omics exploration of the gut-brain axis
This study provides compelling evidence to suggest that choline metabolism plays a crucial role in the development and treatment of mood disorders in IBD. Choline and its metabolites appear to have a significant role in maintaining the stability of the GBA.PMID:38145852 | DOI:10.1016/j.nbd.2023.106390 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Fan Zhang Lingnan Guo Jingjing Shi Hao Jiang Feini Zhou Yanlin Zhou Bin Lv Maosheng Xu Source Type: research
Central role of the habenulo-interpeduncular system in the neurodevelopmental basis of susceptibility and resilience to anxiety in mice
Neurobiol Dis. 2023 Dec 23:106392. doi: 10.1016/j.nbd.2023.106392. Online ahead of print.ABSTRACTHaving experienced stress during sensitive periods of brain development strongly influences how individuals cope with later stress. Some are prone to develop anxiety or depression, while others appear resilient. The as-yet-unknown mechanisms underlying these differences may lie in how genes and environmental stress interact to shape the circuits that control emotions. Here, we investigated the role of the habenulo-interpeduncular system (HIPS), a critical node in reward circuits, in early stress-induced anxiety in mice. We foun...
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Malalaniaina Rakotobe Niels Fjerdingstad Nuria Ruiz-Reig Thomas Lamonerie Fabien D'Autr éaux Source Type: research
Pathologic changes in neuronal intranuclear inclusion disease are linked to aberrant FUS interaction under hyperosmotic stress
Neurobiol Dis. 2023 Dec 23:106391. doi: 10.1016/j.nbd.2023.106391. Online ahead of print.ABSTRACTCGG repeat expansion in NOTCH2NLC is the genetic cause of neuronal intranuclear inclusion disease (NIID). Previous studies indicated that the CGG repeats can be translated into polyglycine protein (N2CpolyG) which was toxic to neurons by forming intranuclear inclusions (IIs). However, little is known about the factors governing polyG IIs formation as well as its molecular pathogenesis. Considering that neurogenetic disorders usually involve interactions between genetic and environmental stresses, we investigated the effect of s...
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Hui Wang Yilei Zheng Jiaxi Yu Lingchao Meng Wei Zhang Daojun Hong Zhaoxia Wang Yun Yuan Jianwen Deng Source Type: research
Choline metabolism in regulating inflammatory bowel disease-linked anxiety disorders: A multi-omics exploration of the gut-brain axis
This study provides compelling evidence to suggest that choline metabolism plays a crucial role in the development and treatment of mood disorders in IBD. Choline and its metabolites appear to have a significant role in maintaining the stability of the GBA.PMID:38145852 | DOI:10.1016/j.nbd.2023.106390 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Fan Zhang Lingnan Guo Jingjing Shi Hao Jiang Feini Zhou Yanlin Zhou Bin Lv Maosheng Xu Source Type: research
